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Clearance
24問 • 4ヶ月前
  • Almira Coleen
    • 通報

    問題一覧

  • 1

    Clearance

    mL/min

  • 2

    Removal of a substance from plasma into urine over a fixed time.

    Clearance (mL/min)

  • 3

    Relationship:

    Plasma concentration and clearance are inversely proportional.

  • 4

    24-Hour Creatinine Clearance Formula:

    Creatinine Clearance = (U x V) / P x (1.73 / A)

  • 5

    - Formula: ​ - Creatinine Clearance = (U x V) / P x (1.73 / A) U - V - P - A -

    Creatinine concentration in the 24-hour urine sample (mg/dL), 24-hour urine volume (mL) per minute (calculated as V/1440 mL/minute), Plasma creatinine concentration (mg/dL), Correction factor for body surface area (obtained from a height-weight chart)

  • 6

    Routinely Done? Not typically performed due to the need for continuous IV infusion.

    Inulin Clearance

  • 7

    Inulin Clearance values:

    Higher in males.

  • 8

    Inulin Clearance Procedure: - Priming Dose: - Continuous Infusion:

    25mL of 10% inulin solution., 500mL of 1.5% inulin solution.

  • 9

    Inulin Clearance - Reference Values: Males: Females:

    127 mL/min, 118 mL/min

  • 10

    Creatinine Clearance Production and excretion of creatinine are directly related to?

    Muscle mass

  • 11

    Creatinine Clearance

    Excretion is generally not affected by diet; typically, 1.2-1.5 g of creatinine is excreted per day.

  • 12

    Estimation: Provides an estimate of the amount of plasma that flows through the kidney glomeruli per minute.

    Creatinine Clearance

  • 13

    Measurement: Considered an excellent measurement of renal function.

    Creatinine Clearance

  • 14

    Measurement depends on the completeness of a 24-hour urine collection.

    Creatinine Clearance

  • 15

    Limitation: Accuracy of urine collection is a major limitation.

    Creatinine Clearance

  • 16

    Creatinine Clearance - Males: - Females:

    85-125 mL/min, 75-112 mL/min

  • 17

    Increased Creatinine Clearance Conditions that may lead to increased creatinine clearance:

    High Cardiac Output, Pregnancy, Burns, Carbon Monoxide Poisoning

  • 18

    Decreased Creatinine Clearance Conditions that may lead to decreased creatinine clearance:

    Impaired Kidney Function, Shock, Dehydration, Hemorrhage, Congestive Heart Failure

  • 19

    First Renal Analyte to Increase:

    Urea Clearance

  • 20

    - Indicator of Disease Progression/Therapy Response: Monitoring the levels can help demonstrate the progression of renal disease or how a patient is responding to treatment.

    Urea Clearance

  • 21

    - Affected by Protein Diet: a byproduct of protein metabolism, so its levels are significantly affected by dietary protein intake. A high protein diet can lead to higher _____ levels, even with normal kidney function.

    Urea

  • 22

    Filtration and Reabsorption: Urea is freely filtered by the _______, but it is also variably reabsorbed by the ________. This variable reabsorption makes it less ideal for precisely estimating GFR.

    Glomeruli, Renal tubules

  • 23

    Reliability for GFR: Due to its variable reabsorption, urea clearance does not give a reliable estimate of the?

    Glomerular Filtration Rate (GFR)

  • 24

    Clearance Tests: Relationship with Urine Flow:

    The faster the rate of urine flow, the less urea is reabsorbed, and vice versa. This means that hydration status can influence urea clearance measurements.

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    問題一覧

  • 1

    Clearance

    mL/min

  • 2

    Removal of a substance from plasma into urine over a fixed time.

    Clearance (mL/min)

  • 3

    Relationship:

    Plasma concentration and clearance are inversely proportional.

  • 4

    24-Hour Creatinine Clearance Formula:

    Creatinine Clearance = (U x V) / P x (1.73 / A)

  • 5

    - Formula: ​ - Creatinine Clearance = (U x V) / P x (1.73 / A) U - V - P - A -

    Creatinine concentration in the 24-hour urine sample (mg/dL), 24-hour urine volume (mL) per minute (calculated as V/1440 mL/minute), Plasma creatinine concentration (mg/dL), Correction factor for body surface area (obtained from a height-weight chart)

  • 6

    Routinely Done? Not typically performed due to the need for continuous IV infusion.

    Inulin Clearance

  • 7

    Inulin Clearance values:

    Higher in males.

  • 8

    Inulin Clearance Procedure: - Priming Dose: - Continuous Infusion:

    25mL of 10% inulin solution., 500mL of 1.5% inulin solution.

  • 9

    Inulin Clearance - Reference Values: Males: Females:

    127 mL/min, 118 mL/min

  • 10

    Creatinine Clearance Production and excretion of creatinine are directly related to?

    Muscle mass

  • 11

    Creatinine Clearance

    Excretion is generally not affected by diet; typically, 1.2-1.5 g of creatinine is excreted per day.

  • 12

    Estimation: Provides an estimate of the amount of plasma that flows through the kidney glomeruli per minute.

    Creatinine Clearance

  • 13

    Measurement: Considered an excellent measurement of renal function.

    Creatinine Clearance

  • 14

    Measurement depends on the completeness of a 24-hour urine collection.

    Creatinine Clearance

  • 15

    Limitation: Accuracy of urine collection is a major limitation.

    Creatinine Clearance

  • 16

    Creatinine Clearance - Males: - Females:

    85-125 mL/min, 75-112 mL/min

  • 17

    Increased Creatinine Clearance Conditions that may lead to increased creatinine clearance:

    High Cardiac Output, Pregnancy, Burns, Carbon Monoxide Poisoning

  • 18

    Decreased Creatinine Clearance Conditions that may lead to decreased creatinine clearance:

    Impaired Kidney Function, Shock, Dehydration, Hemorrhage, Congestive Heart Failure

  • 19

    First Renal Analyte to Increase:

    Urea Clearance

  • 20

    - Indicator of Disease Progression/Therapy Response: Monitoring the levels can help demonstrate the progression of renal disease or how a patient is responding to treatment.

    Urea Clearance

  • 21

    - Affected by Protein Diet: a byproduct of protein metabolism, so its levels are significantly affected by dietary protein intake. A high protein diet can lead to higher _____ levels, even with normal kidney function.

    Urea

  • 22

    Filtration and Reabsorption: Urea is freely filtered by the _______, but it is also variably reabsorbed by the ________. This variable reabsorption makes it less ideal for precisely estimating GFR.

    Glomeruli, Renal tubules

  • 23

    Reliability for GFR: Due to its variable reabsorption, urea clearance does not give a reliable estimate of the?

    Glomerular Filtration Rate (GFR)

  • 24

    Clearance Tests: Relationship with Urine Flow:

    The faster the rate of urine flow, the less urea is reabsorbed, and vice versa. This means that hydration status can influence urea clearance measurements.