Pharmacology 3

28問 • 1年前

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通報

問題一覧

Which subunits MUST be occupied to open the nicotinic receptor at the motor end plate?

Alpha and alpha

How is the action of Ach terminated at the postjunctional nicotinic receptor?

Metabolized by acetylcholinesterase, Diffuses away from the receptor

What two ions enter the cell during depolarization?

Calcium, Sodium

All of the following statement regarding extrajunctional nicotinic receptors are true EXCEPT:

An epsilon subunit replaces a gamma subunit

Choose the pathological states that promote the proliferation of extrajunctional receptors: (3)

Spinal cord injury, Burns, Sepsis

How soon should succinylcholine be avoided after an injury that causes extrajunctional receptors to proliferate?

24-48 hours

Fade during train-of-four stimulation is caused by:

Antagonism of presynaptic nicotinic receptors

Identify the statement that demonstrates the MOST accurate understanding of succinycholine: (2)

Hypertension is a normal side effect, Severe sepsis increases the risk of hyperkalemia

Which enzymes hydrolysis succinylcholine? (3)

Butyrylcholinesterase, Pseudocholinesterase, Plasma cholinesterase

Which factors prolong the duration of Succinylcholine?

Metoclopramide, Late-stage pregnancy, Esmolol

A patient with a dibucaine number of 20 received succinylcholine. This patient:

Will be paralyzed for eight hours

Dibucaine number of 70-80:

Typical homozygous

A patient with a Dibucaine number of 55, you can expect the duration of Succinylcholine to last:

20-30 min

Identify the patient at the HIGHEST risk for developing postoperative myalgia following Succinylcholine:

24-year old female for umbilical hernia repair

Which diseases are associated with hyperkalemia following Succinylcholine administration?

Hyperkalemic periodic paralysis, Multiple sclerosis, Guillain-Barre

Hoffman elimination reaction is faster with: (2)

Alkalosis, Hyperthermia

Neuromuscular blockade duration of action is prolonged by: (3)

Volatile anesthetics, Aminoglycosides, Dantrolene

Which of the following does NOT potentiate neuromuscular blockade:

Increased potassium

Which condition precludes the use of pancuronium?

Hypertrophic cardiomyopathy

What type of bond is formed when edrophonium binds to the an ionic site acetylcholinesterase?

Electrostatic

Which side effect is LEAST likely to occur after neostigmine administration?

Mydriasis

Identify the process by which a nociceptor converts a chemical stimulus into an action potential:

Transduction

Molecular mechanisms of opioid receptor stimulation include:

Decreased cAMP production, Increased potassium conductance

Which pharmacological characteristic accounts for the rapid onset of action of alfentanil?

Low degree of ionization

Which agents can be used to attenuate opioid induced hyperalgesia ?

Ketamine, Magnesium sulfate

Intrathecal administration is a contraindication to which opioid?

Remifentanil

Morphine 10mg = Fentanyl __ mcg

100

Fentanyl is how many times stronger than Alfentanil?

Cardiovascular Pathophysiology

ユーザ名非公開 · 28問 · 1年前

Cardiovascular Pathophysiology

Pharmacology

Pharmacology

Inhaled anesthetics

Inhaled anesthetics

Pharmacology 2

Pharmacology 2

Anesthesia Equipment 1

ユーザ名非公開 · 22問 · 1年前

Anesthesia Equipment 1

22問 • 1年前

ユーザ名非公開

問題一覧

Which subunits MUST be occupied to open the nicotinic receptor at the motor end plate?

Alpha and alpha

How is the action of Ach terminated at the postjunctional nicotinic receptor?

Metabolized by acetylcholinesterase, Diffuses away from the receptor

What two ions enter the cell during depolarization?

Calcium, Sodium

All of the following statement regarding extrajunctional nicotinic receptors are true EXCEPT:

An epsilon subunit replaces a gamma subunit

Choose the pathological states that promote the proliferation of extrajunctional receptors: (3)

Spinal cord injury, Burns, Sepsis

How soon should succinylcholine be avoided after an injury that causes extrajunctional receptors to proliferate?

24-48 hours

Fade during train-of-four stimulation is caused by:

Antagonism of presynaptic nicotinic receptors

Identify the statement that demonstrates the MOST accurate understanding of succinycholine: (2)

Hypertension is a normal side effect, Severe sepsis increases the risk of hyperkalemia

Which enzymes hydrolysis succinylcholine? (3)

Butyrylcholinesterase, Pseudocholinesterase, Plasma cholinesterase

Which factors prolong the duration of Succinylcholine?

Metoclopramide, Late-stage pregnancy, Esmolol

A patient with a dibucaine number of 20 received succinylcholine. This patient:

Will be paralyzed for eight hours

Dibucaine number of 70-80:

Typical homozygous

A patient with a Dibucaine number of 55, you can expect the duration of Succinylcholine to last:

20-30 min

Identify the patient at the HIGHEST risk for developing postoperative myalgia following Succinylcholine:

24-year old female for umbilical hernia repair

Which diseases are associated with hyperkalemia following Succinylcholine administration?

Hyperkalemic periodic paralysis, Multiple sclerosis, Guillain-Barre

Hoffman elimination reaction is faster with: (2)

Alkalosis, Hyperthermia

Neuromuscular blockade duration of action is prolonged by: (3)

Volatile anesthetics, Aminoglycosides, Dantrolene

Which of the following does NOT potentiate neuromuscular blockade:

Increased potassium

Which condition precludes the use of pancuronium?

Hypertrophic cardiomyopathy

What type of bond is formed when edrophonium binds to the an ionic site acetylcholinesterase?

Electrostatic

Which side effect is LEAST likely to occur after neostigmine administration?

Mydriasis

Identify the process by which a nociceptor converts a chemical stimulus into an action potential:

Transduction

Molecular mechanisms of opioid receptor stimulation include:

Decreased cAMP production, Increased potassium conductance

Which pharmacological characteristic accounts for the rapid onset of action of alfentanil?

Low degree of ionization

Which agents can be used to attenuate opioid induced hyperalgesia ?

Ketamine, Magnesium sulfate

Intrathecal administration is a contraindication to which opioid?

Remifentanil

Morphine 10mg = Fentanyl __ mcg

100

Fentanyl is how many times stronger than Alfentanil?