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Pharmacology 2

Pharmacology 2
32問 • 1年前
  • ユーザ名非公開
    • 通報

    問題一覧

  • 1

    Local anesthetics can bind to the voltage-gated sodium channel when it is in the: (2)

    Active state, Inactive state

  • 2

    Local anesthetics: (2)

    Have no effect on threshold potential, Have no effect on resting membrane potential

  • 3

    Regarding local anesthetics, which binds to the intracellular portion of the sodium channel?

    The conjugate acid

  • 4

    Which characteristic correlates BEST with local anesthetic duration of action?

    Protein binding

  • 5

    Which characteristics correlate BEST with local anesthetic onset?

    pKa

  • 6

    Which characteristic correlates BEST with local anesthetic potency?

    Lipid solubility

  • 7

    Choose the 2 correct answers regarding weak bases:

    In acidic solution - More ionized and water-soluble, In basic solution - More non-ionized and lipid soluble

  • 8

    Choose the 2 answers the correctly describe weak acids:

    In acidic solution - More non-ionized and lipid soluble, In basic solution - More ionized and water soluble

  • 9

    The closer the pka is to the pH of the blood the faster the onset, with the exception of which drug?

    Chloroprocaine

  • 10

    Which route correlates with the higher vascular uptake and plasma concentration?

    Intercostal

  • 11

    Maximum dose of Exparel? (Mg)

    266

  • 12

    Maximum dose for Mepivicaine? (Mg)

    400

  • 13

    Maximum dose for Bupivicaine? (Mg)

    175

  • 14

    Maximum dose for Lidocaine? (Mg)

    300

  • 15

    Maximum dose for Ropivicaine? (Mg)

    200

  • 16

    LAST is more common with:

    Peripheral nerve blocks

  • 17

    One minute following an interscalene block, a 62kg pt has a seizure. How much 20% lipid emulsion should you administer? (mL)

    93

  • 18

    First and foremost when treating LAST:

    Manage the airway

  • 19

    You want to avoid all of the following during treatment for LAST except which? (Choose 2)

    Benzodiazepines, Amiodarone

  • 20

    What is the maximum recommended dose for lipid emulsion therapy? (Ml/kg)

    12

  • 21

    Maximum recommended dose for lidocaine during tumescent anesthesia?

    55 mg/kg

  • 22

    Which locals are MOST likely to produce methemoglobinemia?

    Benzocaine, Cetacaine, EMLA cream

  • 23

    Cyanosis in the presence of a normal PaO2 is highly suggestive of:

    methemoglobinemia

  • 24

    Choose those that resemble S&S of methemoglobinemia: (3)

    Hypoxia, Chocolate-colored blood, Tachypnea

  • 25

    Maximum dose of EMLA cream for 1-6 yo >10kg is: (g)

    10

  • 26

    Maximum dose of EMLA cream for 3-12 month old > 5kg is: (g)

    2

  • 27

    Each additive prolongs the duration of local anesthetic EXCEPT:

    Hyaluronidase

  • 28

    Choose the following that are thought to provide supplemental analgesia when added to local anesthetic solutions: (3)

    Epinephrine, Clonidine, Neiraxial opioids

  • 29

    Which local anesthetic reduces the effectiveness of opioids in the epidural space?

    Chloroprocaine

  • 30

    Which compound is implicated in allergic reactions to ester-type local anesthetic?

    Para-aminobenzoic acid

  • 31

    Successful resuscitation of LAST is LEAST likely following the injection of which local anesthetic?

    Bupivicaine

  • 32

    Which factors have the MOST significant impact on the onset of action of local anesthetic?

    pKa, Dose, Concentration

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    問題一覧

  • 1

    Local anesthetics can bind to the voltage-gated sodium channel when it is in the: (2)

    Active state, Inactive state

  • 2

    Local anesthetics: (2)

    Have no effect on threshold potential, Have no effect on resting membrane potential

  • 3

    Regarding local anesthetics, which binds to the intracellular portion of the sodium channel?

    The conjugate acid

  • 4

    Which characteristic correlates BEST with local anesthetic duration of action?

    Protein binding

  • 5

    Which characteristics correlate BEST with local anesthetic onset?

    pKa

  • 6

    Which characteristic correlates BEST with local anesthetic potency?

    Lipid solubility

  • 7

    Choose the 2 correct answers regarding weak bases:

    In acidic solution - More ionized and water-soluble, In basic solution - More non-ionized and lipid soluble

  • 8

    Choose the 2 answers the correctly describe weak acids:

    In acidic solution - More non-ionized and lipid soluble, In basic solution - More ionized and water soluble

  • 9

    The closer the pka is to the pH of the blood the faster the onset, with the exception of which drug?

    Chloroprocaine

  • 10

    Which route correlates with the higher vascular uptake and plasma concentration?

    Intercostal

  • 11

    Maximum dose of Exparel? (Mg)

    266

  • 12

    Maximum dose for Mepivicaine? (Mg)

    400

  • 13

    Maximum dose for Bupivicaine? (Mg)

    175

  • 14

    Maximum dose for Lidocaine? (Mg)

    300

  • 15

    Maximum dose for Ropivicaine? (Mg)

    200

  • 16

    LAST is more common with:

    Peripheral nerve blocks

  • 17

    One minute following an interscalene block, a 62kg pt has a seizure. How much 20% lipid emulsion should you administer? (mL)

    93

  • 18

    First and foremost when treating LAST:

    Manage the airway

  • 19

    You want to avoid all of the following during treatment for LAST except which? (Choose 2)

    Benzodiazepines, Amiodarone

  • 20

    What is the maximum recommended dose for lipid emulsion therapy? (Ml/kg)

    12

  • 21

    Maximum recommended dose for lidocaine during tumescent anesthesia?

    55 mg/kg

  • 22

    Which locals are MOST likely to produce methemoglobinemia?

    Benzocaine, Cetacaine, EMLA cream

  • 23

    Cyanosis in the presence of a normal PaO2 is highly suggestive of:

    methemoglobinemia

  • 24

    Choose those that resemble S&S of methemoglobinemia: (3)

    Hypoxia, Chocolate-colored blood, Tachypnea

  • 25

    Maximum dose of EMLA cream for 1-6 yo >10kg is: (g)

    10

  • 26

    Maximum dose of EMLA cream for 3-12 month old > 5kg is: (g)

    2

  • 27

    Each additive prolongs the duration of local anesthetic EXCEPT:

    Hyaluronidase

  • 28

    Choose the following that are thought to provide supplemental analgesia when added to local anesthetic solutions: (3)

    Epinephrine, Clonidine, Neiraxial opioids

  • 29

    Which local anesthetic reduces the effectiveness of opioids in the epidural space?

    Chloroprocaine

  • 30

    Which compound is implicated in allergic reactions to ester-type local anesthetic?

    Para-aminobenzoic acid

  • 31

    Successful resuscitation of LAST is LEAST likely following the injection of which local anesthetic?

    Bupivicaine

  • 32

    Which factors have the MOST significant impact on the onset of action of local anesthetic?

    pKa, Dose, Concentration