問題一覧
1
cluster of differentiation of B CELLS
B cell isotyoe switching and memory formation MHC ClassII
CD 40
2
Cluster of differentiation of T cells
Classic T cell marker , sheeo RBC receptor
CD 2
3
Cluster of differentiation of T cells
Part of TCR complex
CD 3
4
Cluster of differentiation of T cells
MhC Class II receptor
CD 4
5
Cluster of differentiation of T cells
MHC class I receptor
CD 8
6
Technique to separate lymphocytes from whole blood. diluted defibrinated or heparinized is carefulky layered on top of the solution and centrifuged
ficoll - hypaque centrifugation
7
Forward in flow cytometry detects
cell size
8
Side scatter in flow cytometry
cell granularity and complexity
9
Gold standard for lymphocytes identification
flow cytometry
10
Cheapest method for lymphocyte identification
rosette technique
11
It detect cells attach to the CD2 antigen,found only on T cells
rosette technique
12
A subtype of T lymphocytes that destroys virally infected and tumor cells through secretion of perforins and granzymes
Tc
13
A subtype of t lymphocytes B cells plasma cells; enhances activity of cytotoxic cells: activates macrophages
Th
14
A subtype of t lymphocytes that limit immune reaction
Ts
15
A sybtype of T lymphocytes that circulate in immunosurveillance and anamnestic response
Tm
16
A subtype of T lymphocyte that oriduces CD 4 ONLY
Th
17
Arrange in order:
A. Deletion of self reactive lymphocyte
b. Expression of both CD4 AND CD 8, making them double positive thymocytes
C. Clonal expression of double psoitive lymphocyte
D. Expression of classical T cell marker
E. Lineage determination
F.EXPRESSION OF UNIQUE t cell receptor as a complex with CD 3
d, b, f, a, c, e
18
Presence of CD 19 AND CD45R
pro b cell
19
Synthesize IgM heavy chains confined to the cytoplasm
pre b cell
20
Light chain rearrangement,
pre b cell
21
Decreased cytoplasmic IgM, surface igM present on the cell surface, CD 19, 20, 21(+)
naive b cell
22
Presence of IgM and IgD
mature b cells
23
Antibody producing cells, derived from b cells which are exposed to various ILs and antigenic stimulation
plasma cells
24
Arrange in order:
1 Naive b cell
2. Plasma cells
3. Mature b cells
4. Pro b cells
5. Pre b cells
5, 4,1,3,2
25
Class I MHC or Class II MHC:
Virally infected cells are recognized T cytotoxic cells(CD8 +)
class I mhc
26
Tc is activated by IL-2 produced by the Th cell
class I mHC
27
APC presents antigenuc fragment through this class of MHC presentation; Th cells produces ill ;IL-2 atimulates actovated Th cell to become TH1 ad IL- stimulates activated Th cell to TH2
class II mhc
28
This produces IFN-y which ativates phagocytes to kill ingested microbes
TH 1
29
Produces IL- which stimulates the production of IgE and IL-5
Th 2
30
This interleukin stimulates the production of IgG4;
IL-4
31
Stimulates the activtaed Th cell to become Th 1
IL-2
32
This interluekin stimulates the activated Th cell to TH2
IL- 4
33
This activates eosinophils in Th2
IL-5
34
This immunoglobulin activates mast cells and coats helminths for destructionn of eosinophils
IgE
35
Ankylosing spondylitis or bamboo spine disease
HLA - BR27
36
SLE, DM I, GRAVES DX, ADDISON DX, myasthenia gravis
HLA- DR3
37
RHEUMATIC ARTHRITIS, DM1
HLA-DR4
38
MYASTHENIA GRAVIS, ADDISON DX, CELIAC DX
HLA-B8
39
WHAT CLASS:
HLA- A, HLA DP, DQ, DR
CLASS I
40
HLA-D HLA-DP, DQ, DR
WHAT GENES
CLASS II GENES
41
Can, C, FACTOR B, TNF
WHAT GENES CLASS
CLASS III
42
Substances that promotes cell-division
mitogens
43
T-cell vs B-cell:
Concanavillin A
Phytohemagglutinin
Pokeweed mitogen
t-cell
44
T-cell vs b-cell:
Lipopolysaccharide
Pokeweed mitogen
b-cell
45
Class I vs class II mhc:
Present in all nucleated cells
class I mhc
46
Presents ag to CD8+ cells( t cells) destruction of virally infected cells, tumors cells, graft rejection
class I mhc
47
Present only in APCs; presents Ag to CD 4+ cells(t helper cells)
class II mhc
48
Donor and recipien cells in tissue matching are reactes with ______
HLA -ABS
49
This is used to inactivate donor lymphocytes
mitomycin c
50
Amount of proliferation is measured using
thymidine 3
51
This test is best for bone marrow graft
mixed lymphocyte reaction
52
MLR is use to tests what hla
hLA-D
53
Also known as restriction fragment lenght polymorphism; this is the FASTEST AND SUPERIOR method for tissue matching
molecular
54
Uses complement mediated microlympocytotoxicity test
tissue typing
55
Stains used in tissue typing
eosin y and trypan blue
56
What type of microscope isused in microlymphocytotoxicity
inverted phase contrast microscope
57
Small, bright and refractil
uninjured cells
58
Flattenedm large dark and nonrefractile
injured cells
59
This type of tissu typing requires the identification of B lymphocytes; it uses nylon woool separation
hla class II typing
60
Also known as carrier molecule; immunogenic and couples with hatenic group
schlepper molecule
61
Factors: the gretaer the difference between the substances and the host, the more potent its antigenic qualities
foreignness
62
Molecules that are<1 kilodalton are
non immunogenic
63
Factors:
The more complex the substance the more immunogenic it will be
chemical composition
64
Substance that can enhance the immune responses
adjuvants
65
This adjuvant is obtaine from sharks oil(hiv VACCINE DEVT)
squaline
66
This adjuvant is water in oil emulsion of killed MTB or B. Pertussis, enhances cell mediated immunity
freund complete adjuvant
67
An antigen from the same individual
autoantigen
68
An antigen from different individual but from same species
alloantigen
69
An anitgen from different species
heteroantigen
70
Heteroantigens that exist in unrelated plants or animals but aeither identical or closely related in structure so that anitbody to one will cross-react with antigen of the other (2 words)
heterophile antigen
71
This is a graft from the same individual
autograft
72
A graft from twins
isograft
73
A graft from different individuals but same species
Ex: fetus on mothers womb
allograft
74
A graft from different species
Ex: pigs heart valves
heterograft
75
Catgeories of graft rejection:
Happens within minutes; it is humoral
hyperacute
76
A type of graft rejection:
Happens within2-5 days; cell-mediated
accelerated
77
Happens within 7-21 days
Graft rejection type
acute
78
This happens within >3 months
chroni graft rejection
79
This is caused by disturbance of host vs graft tolerance
chronic
80
This caused by allogeneic reaction to donor antigens
acute
81
This happens to previous sensitized of donor antigens
accelerated
82
This happens due to preformed cytotoxic antibodies to donor antigens
hyperacute
83
Two light chains are
kappa, lambda
84
What chromosome did lambda came from
chromosome 22
85
What bonds connects the H-H and H-L
disulfide bond
86
What connection is seen in Bnece jones proteins
L-L
87
This islocated in the Constant heavy 1 and Constant heavy2; has high proline content
hinge region
88
The heavy chain of each ig class
isotype
89
The variation in th constant region
allotype
90
The variation in the variable region
idiotype
91
2 Fab+ 1 FC
papain
92
Has a% Ig of 70-75
igg
93
Has a % Ig of 10-15
iga
94
Has a half-life in serum of2-3 days
ige
95
The only pentamer in seerum
igm
96
Early immune response antibody; most often formed in response to gram negative bacteria; responds to CARBOHYDRATE antigens
igM
97
Also known as macroglobulin; acts in opsonization, endotoxin neutralization; antibody present in Rheumatoid factors, cold agglutinins, and allohemagglutinins
igM
98
Major immunoglobulin in normal serum; participate in agglutination and precipitation; target virally infected cell for destruction by ADCC;
Responds best to PROTEIN antigens
igG
99
IgG that is most efficient
igG
100
Most efficient igg in complement fixation
igG3
hema2 pt 2
hema2 pt 2
ユーザ名非公開 · 19問 · 7ヶ月前hema2 pt 2
hema2 pt 2
19問 • 7ヶ月前ユーザ名非公開
immuno 1
immuno 1
ユーザ名非公開 · 100問 · 7ヶ月前immuno 1
immuno 1
100問 • 7ヶ月前ユーザ名非公開
immuno 3
immuno 3
ユーザ名非公開 · 100問 · 7ヶ月前immuno 3
immuno 3
100問 • 7ヶ月前ユーザ名非公開
sero1
sero1
ユーザ名非公開 · 100問 · 7ヶ月前sero1
sero1
100問 • 7ヶ月前ユーザ名非公開
sero2
sero2
ユーザ名非公開 · 44問 · 7ヶ月前sero2
sero2
44問 • 7ヶ月前ユーザ名非公開
問題一覧
1
cluster of differentiation of B CELLS
B cell isotyoe switching and memory formation MHC ClassII
CD 40
2
Cluster of differentiation of T cells
Classic T cell marker , sheeo RBC receptor
CD 2
3
Cluster of differentiation of T cells
Part of TCR complex
CD 3
4
Cluster of differentiation of T cells
MhC Class II receptor
CD 4
5
Cluster of differentiation of T cells
MHC class I receptor
CD 8
6
Technique to separate lymphocytes from whole blood. diluted defibrinated or heparinized is carefulky layered on top of the solution and centrifuged
ficoll - hypaque centrifugation
7
Forward in flow cytometry detects
cell size
8
Side scatter in flow cytometry
cell granularity and complexity
9
Gold standard for lymphocytes identification
flow cytometry
10
Cheapest method for lymphocyte identification
rosette technique
11
It detect cells attach to the CD2 antigen,found only on T cells
rosette technique
12
A subtype of T lymphocytes that destroys virally infected and tumor cells through secretion of perforins and granzymes
Tc
13
A subtype of t lymphocytes B cells plasma cells; enhances activity of cytotoxic cells: activates macrophages
Th
14
A subtype of t lymphocytes that limit immune reaction
Ts
15
A sybtype of T lymphocytes that circulate in immunosurveillance and anamnestic response
Tm
16
A subtype of T lymphocyte that oriduces CD 4 ONLY
Th
17
Arrange in order:
A. Deletion of self reactive lymphocyte
b. Expression of both CD4 AND CD 8, making them double positive thymocytes
C. Clonal expression of double psoitive lymphocyte
D. Expression of classical T cell marker
E. Lineage determination
F.EXPRESSION OF UNIQUE t cell receptor as a complex with CD 3
d, b, f, a, c, e
18
Presence of CD 19 AND CD45R
pro b cell
19
Synthesize IgM heavy chains confined to the cytoplasm
pre b cell
20
Light chain rearrangement,
pre b cell
21
Decreased cytoplasmic IgM, surface igM present on the cell surface, CD 19, 20, 21(+)
naive b cell
22
Presence of IgM and IgD
mature b cells
23
Antibody producing cells, derived from b cells which are exposed to various ILs and antigenic stimulation
plasma cells
24
Arrange in order:
1 Naive b cell
2. Plasma cells
3. Mature b cells
4. Pro b cells
5. Pre b cells
5, 4,1,3,2
25
Class I MHC or Class II MHC:
Virally infected cells are recognized T cytotoxic cells(CD8 +)
class I mhc
26
Tc is activated by IL-2 produced by the Th cell
class I mHC
27
APC presents antigenuc fragment through this class of MHC presentation; Th cells produces ill ;IL-2 atimulates actovated Th cell to become TH1 ad IL- stimulates activated Th cell to TH2
class II mhc
28
This produces IFN-y which ativates phagocytes to kill ingested microbes
TH 1
29
Produces IL- which stimulates the production of IgE and IL-5
Th 2
30
This interleukin stimulates the production of IgG4;
IL-4
31
Stimulates the activtaed Th cell to become Th 1
IL-2
32
This interluekin stimulates the activated Th cell to TH2
IL- 4
33
This activates eosinophils in Th2
IL-5
34
This immunoglobulin activates mast cells and coats helminths for destructionn of eosinophils
IgE
35
Ankylosing spondylitis or bamboo spine disease
HLA - BR27
36
SLE, DM I, GRAVES DX, ADDISON DX, myasthenia gravis
HLA- DR3
37
RHEUMATIC ARTHRITIS, DM1
HLA-DR4
38
MYASTHENIA GRAVIS, ADDISON DX, CELIAC DX
HLA-B8
39
WHAT CLASS:
HLA- A, HLA DP, DQ, DR
CLASS I
40
HLA-D HLA-DP, DQ, DR
WHAT GENES
CLASS II GENES
41
Can, C, FACTOR B, TNF
WHAT GENES CLASS
CLASS III
42
Substances that promotes cell-division
mitogens
43
T-cell vs B-cell:
Concanavillin A
Phytohemagglutinin
Pokeweed mitogen
t-cell
44
T-cell vs b-cell:
Lipopolysaccharide
Pokeweed mitogen
b-cell
45
Class I vs class II mhc:
Present in all nucleated cells
class I mhc
46
Presents ag to CD8+ cells( t cells) destruction of virally infected cells, tumors cells, graft rejection
class I mhc
47
Present only in APCs; presents Ag to CD 4+ cells(t helper cells)
class II mhc
48
Donor and recipien cells in tissue matching are reactes with ______
HLA -ABS
49
This is used to inactivate donor lymphocytes
mitomycin c
50
Amount of proliferation is measured using
thymidine 3
51
This test is best for bone marrow graft
mixed lymphocyte reaction
52
MLR is use to tests what hla
hLA-D
53
Also known as restriction fragment lenght polymorphism; this is the FASTEST AND SUPERIOR method for tissue matching
molecular
54
Uses complement mediated microlympocytotoxicity test
tissue typing
55
Stains used in tissue typing
eosin y and trypan blue
56
What type of microscope isused in microlymphocytotoxicity
inverted phase contrast microscope
57
Small, bright and refractil
uninjured cells
58
Flattenedm large dark and nonrefractile
injured cells
59
This type of tissu typing requires the identification of B lymphocytes; it uses nylon woool separation
hla class II typing
60
Also known as carrier molecule; immunogenic and couples with hatenic group
schlepper molecule
61
Factors: the gretaer the difference between the substances and the host, the more potent its antigenic qualities
foreignness
62
Molecules that are<1 kilodalton are
non immunogenic
63
Factors:
The more complex the substance the more immunogenic it will be
chemical composition
64
Substance that can enhance the immune responses
adjuvants
65
This adjuvant is obtaine from sharks oil(hiv VACCINE DEVT)
squaline
66
This adjuvant is water in oil emulsion of killed MTB or B. Pertussis, enhances cell mediated immunity
freund complete adjuvant
67
An antigen from the same individual
autoantigen
68
An antigen from different individual but from same species
alloantigen
69
An anitgen from different species
heteroantigen
70
Heteroantigens that exist in unrelated plants or animals but aeither identical or closely related in structure so that anitbody to one will cross-react with antigen of the other (2 words)
heterophile antigen
71
This is a graft from the same individual
autograft
72
A graft from twins
isograft
73
A graft from different individuals but same species
Ex: fetus on mothers womb
allograft
74
A graft from different species
Ex: pigs heart valves
heterograft
75
Catgeories of graft rejection:
Happens within minutes; it is humoral
hyperacute
76
A type of graft rejection:
Happens within2-5 days; cell-mediated
accelerated
77
Happens within 7-21 days
Graft rejection type
acute
78
This happens within >3 months
chroni graft rejection
79
This is caused by disturbance of host vs graft tolerance
chronic
80
This caused by allogeneic reaction to donor antigens
acute
81
This happens to previous sensitized of donor antigens
accelerated
82
This happens due to preformed cytotoxic antibodies to donor antigens
hyperacute
83
Two light chains are
kappa, lambda
84
What chromosome did lambda came from
chromosome 22
85
What bonds connects the H-H and H-L
disulfide bond
86
What connection is seen in Bnece jones proteins
L-L
87
This islocated in the Constant heavy 1 and Constant heavy2; has high proline content
hinge region
88
The heavy chain of each ig class
isotype
89
The variation in th constant region
allotype
90
The variation in the variable region
idiotype
91
2 Fab+ 1 FC
papain
92
Has a% Ig of 70-75
igg
93
Has a % Ig of 10-15
iga
94
Has a half-life in serum of2-3 days
ige
95
The only pentamer in seerum
igm
96
Early immune response antibody; most often formed in response to gram negative bacteria; responds to CARBOHYDRATE antigens
igM
97
Also known as macroglobulin; acts in opsonization, endotoxin neutralization; antibody present in Rheumatoid factors, cold agglutinins, and allohemagglutinins
igM
98
Major immunoglobulin in normal serum; participate in agglutination and precipitation; target virally infected cell for destruction by ADCC;
Responds best to PROTEIN antigens
igG
99
IgG that is most efficient
igG
100
Most efficient igg in complement fixation
igG3