問題一覧
1
IgG that does not fix complement
igG4
2
Major immunoglobulin in anamnestic response
igG
3
Predominant Ig in secretions
IgA
4
Second to be present in B-cell suface; mature bcell
Serves as a function in immunoregulation;
ig A
5
Mediates some type of hypersensitivity reactions, allergies and anaphylaxis; responsible for immunity in invading parasites;
Binds strongly to a receptor on mast cells and basophils; mediates release of histamine
igE
6
Another name for igE
reagin
7
tHis complement functions in opsonization
C 3b
8
Complemment acting in cell lysis
C3b6789
9
A regulatroy protein that cleaves C3b and C4b
factor I
10
Cofactor with Factor i to inactivate C 3B; prevents binding of B to C3b
factor h
11
Acts as a cofactor with factor I to inactivate C4b
C4
12
Prevents attachment to C5b67 complex to cell membranes
s protein
13
Block assembly of MAC; membrane inhibitor of reactive lysis
CD59
14
Binds to C8 therefore prevents formation of MAC
homologous restriction factor
15
Prevents assembly of C3 convertase
decay accelerating factor
16
Trimolecular structure stabilized by calcium
C 1
17
6 globular structure, 2 of which must attach to Fc
c1 q
18
Activation unit in classical pathway
c4, c3, c2
19
Membrane attack complex is composed of: C56789 ; what is the start?
c5b
20
This pathway is initiated by iga aggregates; yeast cells; and a cobra venom factor
alternate pathway
21
This pathway is initiated by microorganisms with mannose
lectin pathway
22
what are the anaphylatoxins in the complements
c3a, c4a, c5a
23
What are the opsonins in the complement
c3b, c4b, c5b
24
This complement increases permeability
c2b
25
This ion stabilizes C1 complex
ca
26
This complement is involved in chemotaxin
c5a
27
Deficiency in this complement:
Hereditary angioneurotic edema( hane)
c1 inh
28
Deficiency in this complement:
Glomerulonephritis
c3
29
Deficiency in this complement:
Recurrent infections in neisseria spp
c5, 6, 7, 8
30
No known disease asociation
c9
31
Complements involved in PNH except
c1 inh
32
Complements involved in Lupus like syndrome
c3
33
The most common deficiency
c2
34
Most severe deficiency
c3
35
A method used for screen for individual complement components
radial immunodiffusion
36
This measures concentation according to the amount of light scattered by a solution containin an antibody and a measured patient sample
nephelometry
37
Most commonly used functional assay; this measures the amount if px serum required to lyse 50% of a standardized cooncentration of antibody-sensitized sheep erythrocytes
hemolytic titration
38
An additional CH50 test that has been developed based on the lysis of liposomes; most accurate tha traditional CH50
liposome lysis
39
Rabbit red blood cell that have been sensitized with antibody are implanted in agarose, and patient serum is added to wells punched in the gel
radial hemolysis
40
Solid-phase igM attached to the walls of microtiter plates is used to initiate complement activation. Antihuman antibody to c9 conjugated to alkaline phosphatase is the indicator of complement activation
ELISA
41
Th beset screen for complement abnormalities
ELISA
42
An alternate pathway assa that is performed in the same manner as CH50 , except magnesium chloride and edta, and calcium is left out; indicator: RABBIT RED CELLS
ah50
43
Tests that uses complement as the reagent; can detect the presence of antigen or antibody in the sample; used for the detection f viral, fungal and rickettsial antibodies
complement fixation tessts
44
Tumor marker involved in medullary thyroid cancer
calcitonin
45
Head and neck tumors, lung cancer, for the detection of stage IV breast cancer, recurrence and metastasis
CYFRA 21-2
46
Nonseminomatous testicular cancer, CHORIOCARCINOMA
HCG
47
tHe antibodies involved are anti-glutamic acid decarboxylase , anti-insulin , anti-insulinoma antigen 2 abs, IL- 2 ba(phogrin) ICA ( islet cells abs)
HLA -DR3 and HLA- DR4
type I DM
48
HLA involved is HLA-DR4
rheumatoid arthritis
49
Antibodies involved are:
Anti-tsh receptor antibodies, elevated T 3 and T4 are first tested, low TSH levels, increased radioactive iodine uptake
grave's disease
50
Antibodies involved:
Anti-thyroidd peroxidase
Anti-thyroglobulin antibodies
hashimoto's disease
51
Antibodies involved are anti-parietal cells, anti-intrinsic factor antibodies
pernicious anemia
52
HLA involved in graves disease
hla-dr3
53
A neuromuscular transmission disorder due to antibodies that inhibit and block acetylcholine binding
myasthenia gravis
54
Skin fibroblasts reproduce faster and secrete more collagen
scleroderma
55
Clinically presents as dry eys and mouth; hla-dr3
sjogren's syndrome
56
Antibody involved in antiglomerular basement membrane antibodies
goodpasture's syndrome
57
Antineutrophilic cytoplasmic antibodies
wegener's granulomatosus
58
Antimitochondrial antibodies
primary billiary cirrhosis
59
Antismooth muscle antibodies
chronic active hepatitis
60
Hla involved in chronic active hepatitis
HLA B8
61
A benign or malignant condition that results from a single clone of lymphoid-plasma cels producig elevated levels of a single class of and type of immunglobulin
monoclonal gammopathy
62
Malignancy of mature plasma cells; excess plasma cells in the bone marrow, and lytic bone lesions
multiple myeloma
63
Malignant proliferation of igM-producing lymphocytes and corresponds to lymphoplasmacytoid lymphoma
waldenstrom macroglobulinemia
64
X-linked recessive disorder; defect in NADPH oxidase system; reduced intracellular killing of ingested organisms; NBT is used for diagnosis
Chronic granulomatous disease
65
Deficiency of an enzyme that is important in microbicidal agent in neutrophils
myeloperoxidase deficiency
66
Impaired chemotaxis and phagosom degranulation; presence if giant granules in WBCs
chediak-higashi syndrome
67
Neutrophils demonstrate defective chemotaxis
job's syndrome
68
Defective chemotactic and random movement by neutrophils
lazy leukocyte syndrome
69
Deficiency of a phagocytosis-promoting serum tetrapeptide that is cleave from an ig like molecule, leukokinin n the spleen
tuftsin deficiency
70
Lack of CD18
leukocyte adhesion deficiency
71
Genetic defect in th long arm of x chromosome; block in the maturation of pre b cells; recurrent infections involved: strep, staph, pseudomonas, and hemophilus
bruton's x-linked aggamaglobulinemia
72
Arrest in the develoment of b-cells is the culprit
selective Ig deficiency(dysgammaglobulinemia)
73
Recurrent sinopulmonary infections; iga levels lower than5 mg/dl
selective Ig A deficiencye
74
Results when the onset of Ig synthesis is delayed; common in infants between5th and 6ht months of life
transient hypogammaglobulinemia
75
Mostcommon form of selective ig deficiency
selective Ig A deficiency
76
Faulty development of3rd nd th pharyngeal pouches; associated with defect of chromosome22
digeorges syndrome
77
Conegnital thymic hypoplasia
digeorge syndrome
78
Impaired synthesis of MIf by T-cells; migratory inhibitory factor
chronic cutaneous candidiasis
79
Dificeincy in th e epxression of MHC II gene products in the tcells surface leading to failure of antigen presentation
bare lymphocyte syndrome
80
A combined b cell and t cell disorded that has a combined defetct of both humoral and cell mediated immunity; autosomal recessive type is associated deaminase deficiency; rarely survive beyond age1
severe combined immunodeficiency disease
81
Thymic dysplasia resulting in decreased to absent t-cell immunity; usually have marked lymphadenopathy and hepatosplenomegaly
nezelof's syndrome
82
Mutation in the WASP gene
wiskott aldrich syndrome
83
Result of specific genetic defect that affects DNA repair
ataxia telangiectasia
84
Mutation in SH2 DAI/ SAP gene resulting in weakening both cellular and humoral immunity; vulnerability to EBV infection
x liked lymphoproliferative diseases
85
A type of hypersensitivity:
Anaphylactic; no complement; igE mediated; hay fever, asthma, food allergies
type1
86
A type of hypersensitivity:
Cytotoxic; Complement involved; IgG or IgM mediated; transfusion reactions, HDN, autoimmune Hemolytic anemia
type 2
87
A type of hypersensitivity; immune complex; complement involved; neutrophils and monocytes; IMMUN COMPLEX DEPOSIITON; SLE
type 3
88
A type of hypersensitivity:
T cell dependent; no complement and no antibody involved; release of CYTOKINES
type 4
89
PSOT STRP GN; ARTHUS REAX; FARMER'S LUNGS
SERUM SICKNESS are examples of what type of hypersensitivity
type 3
90
DAT test and IAT test are test for what type of hypersensitivity
type 2
91
Contact dermatitis; mantoux reax; hypersensitivity pneumolith are what type of hypersensitivity
type 4
92
Gold standard for contact dermatitis(type4)
patch test
93
Most severe formof allergic response; low BP; low blood volume; caused by stings or food allergies
anaphylaxis
94
Measures total IgE
Radio immunosorbent assay
95
Masures antigen-specific IgE
RAST
96
Triggered by antigens found on cell surfaces
type2 hypersensitivity
97
Used to identify th presence of igG, C3B and C3d
monospecific AHG
98
A mixtures of antibodies to detect igG , C3b and C3d
polyspecific ahg
99
Th 1 plays the major role in this type of hypersensitivity
type4 hypersensitivity
100
Positive result: induration measuring>/= 5mm
mantoux reax
hema2 pt 2
hema2 pt 2
ユーザ名非公開 · 19問 · 7ヶ月前hema2 pt 2
hema2 pt 2
19問 • 7ヶ月前ユーザ名非公開
immuno 1
immuno 1
ユーザ名非公開 · 100問 · 7ヶ月前immuno 1
immuno 1
100問 • 7ヶ月前ユーザ名非公開
immuno 2
immuno 2
ユーザ名非公開 · 100問 · 7ヶ月前immuno 2
immuno 2
100問 • 7ヶ月前ユーザ名非公開
sero1
sero1
ユーザ名非公開 · 100問 · 7ヶ月前sero1
sero1
100問 • 7ヶ月前ユーザ名非公開
sero2
sero2
ユーザ名非公開 · 44問 · 7ヶ月前sero2
sero2
44問 • 7ヶ月前ユーザ名非公開
問題一覧
1
IgG that does not fix complement
igG4
2
Major immunoglobulin in anamnestic response
igG
3
Predominant Ig in secretions
IgA
4
Second to be present in B-cell suface; mature bcell
Serves as a function in immunoregulation;
ig A
5
Mediates some type of hypersensitivity reactions, allergies and anaphylaxis; responsible for immunity in invading parasites;
Binds strongly to a receptor on mast cells and basophils; mediates release of histamine
igE
6
Another name for igE
reagin
7
tHis complement functions in opsonization
C 3b
8
Complemment acting in cell lysis
C3b6789
9
A regulatroy protein that cleaves C3b and C4b
factor I
10
Cofactor with Factor i to inactivate C 3B; prevents binding of B to C3b
factor h
11
Acts as a cofactor with factor I to inactivate C4b
C4
12
Prevents attachment to C5b67 complex to cell membranes
s protein
13
Block assembly of MAC; membrane inhibitor of reactive lysis
CD59
14
Binds to C8 therefore prevents formation of MAC
homologous restriction factor
15
Prevents assembly of C3 convertase
decay accelerating factor
16
Trimolecular structure stabilized by calcium
C 1
17
6 globular structure, 2 of which must attach to Fc
c1 q
18
Activation unit in classical pathway
c4, c3, c2
19
Membrane attack complex is composed of: C56789 ; what is the start?
c5b
20
This pathway is initiated by iga aggregates; yeast cells; and a cobra venom factor
alternate pathway
21
This pathway is initiated by microorganisms with mannose
lectin pathway
22
what are the anaphylatoxins in the complements
c3a, c4a, c5a
23
What are the opsonins in the complement
c3b, c4b, c5b
24
This complement increases permeability
c2b
25
This ion stabilizes C1 complex
ca
26
This complement is involved in chemotaxin
c5a
27
Deficiency in this complement:
Hereditary angioneurotic edema( hane)
c1 inh
28
Deficiency in this complement:
Glomerulonephritis
c3
29
Deficiency in this complement:
Recurrent infections in neisseria spp
c5, 6, 7, 8
30
No known disease asociation
c9
31
Complements involved in PNH except
c1 inh
32
Complements involved in Lupus like syndrome
c3
33
The most common deficiency
c2
34
Most severe deficiency
c3
35
A method used for screen for individual complement components
radial immunodiffusion
36
This measures concentation according to the amount of light scattered by a solution containin an antibody and a measured patient sample
nephelometry
37
Most commonly used functional assay; this measures the amount if px serum required to lyse 50% of a standardized cooncentration of antibody-sensitized sheep erythrocytes
hemolytic titration
38
An additional CH50 test that has been developed based on the lysis of liposomes; most accurate tha traditional CH50
liposome lysis
39
Rabbit red blood cell that have been sensitized with antibody are implanted in agarose, and patient serum is added to wells punched in the gel
radial hemolysis
40
Solid-phase igM attached to the walls of microtiter plates is used to initiate complement activation. Antihuman antibody to c9 conjugated to alkaline phosphatase is the indicator of complement activation
ELISA
41
Th beset screen for complement abnormalities
ELISA
42
An alternate pathway assa that is performed in the same manner as CH50 , except magnesium chloride and edta, and calcium is left out; indicator: RABBIT RED CELLS
ah50
43
Tests that uses complement as the reagent; can detect the presence of antigen or antibody in the sample; used for the detection f viral, fungal and rickettsial antibodies
complement fixation tessts
44
Tumor marker involved in medullary thyroid cancer
calcitonin
45
Head and neck tumors, lung cancer, for the detection of stage IV breast cancer, recurrence and metastasis
CYFRA 21-2
46
Nonseminomatous testicular cancer, CHORIOCARCINOMA
HCG
47
tHe antibodies involved are anti-glutamic acid decarboxylase , anti-insulin , anti-insulinoma antigen 2 abs, IL- 2 ba(phogrin) ICA ( islet cells abs)
HLA -DR3 and HLA- DR4
type I DM
48
HLA involved is HLA-DR4
rheumatoid arthritis
49
Antibodies involved are:
Anti-tsh receptor antibodies, elevated T 3 and T4 are first tested, low TSH levels, increased radioactive iodine uptake
grave's disease
50
Antibodies involved:
Anti-thyroidd peroxidase
Anti-thyroglobulin antibodies
hashimoto's disease
51
Antibodies involved are anti-parietal cells, anti-intrinsic factor antibodies
pernicious anemia
52
HLA involved in graves disease
hla-dr3
53
A neuromuscular transmission disorder due to antibodies that inhibit and block acetylcholine binding
myasthenia gravis
54
Skin fibroblasts reproduce faster and secrete more collagen
scleroderma
55
Clinically presents as dry eys and mouth; hla-dr3
sjogren's syndrome
56
Antibody involved in antiglomerular basement membrane antibodies
goodpasture's syndrome
57
Antineutrophilic cytoplasmic antibodies
wegener's granulomatosus
58
Antimitochondrial antibodies
primary billiary cirrhosis
59
Antismooth muscle antibodies
chronic active hepatitis
60
Hla involved in chronic active hepatitis
HLA B8
61
A benign or malignant condition that results from a single clone of lymphoid-plasma cels producig elevated levels of a single class of and type of immunglobulin
monoclonal gammopathy
62
Malignancy of mature plasma cells; excess plasma cells in the bone marrow, and lytic bone lesions
multiple myeloma
63
Malignant proliferation of igM-producing lymphocytes and corresponds to lymphoplasmacytoid lymphoma
waldenstrom macroglobulinemia
64
X-linked recessive disorder; defect in NADPH oxidase system; reduced intracellular killing of ingested organisms; NBT is used for diagnosis
Chronic granulomatous disease
65
Deficiency of an enzyme that is important in microbicidal agent in neutrophils
myeloperoxidase deficiency
66
Impaired chemotaxis and phagosom degranulation; presence if giant granules in WBCs
chediak-higashi syndrome
67
Neutrophils demonstrate defective chemotaxis
job's syndrome
68
Defective chemotactic and random movement by neutrophils
lazy leukocyte syndrome
69
Deficiency of a phagocytosis-promoting serum tetrapeptide that is cleave from an ig like molecule, leukokinin n the spleen
tuftsin deficiency
70
Lack of CD18
leukocyte adhesion deficiency
71
Genetic defect in th long arm of x chromosome; block in the maturation of pre b cells; recurrent infections involved: strep, staph, pseudomonas, and hemophilus
bruton's x-linked aggamaglobulinemia
72
Arrest in the develoment of b-cells is the culprit
selective Ig deficiency(dysgammaglobulinemia)
73
Recurrent sinopulmonary infections; iga levels lower than5 mg/dl
selective Ig A deficiencye
74
Results when the onset of Ig synthesis is delayed; common in infants between5th and 6ht months of life
transient hypogammaglobulinemia
75
Mostcommon form of selective ig deficiency
selective Ig A deficiency
76
Faulty development of3rd nd th pharyngeal pouches; associated with defect of chromosome22
digeorges syndrome
77
Conegnital thymic hypoplasia
digeorge syndrome
78
Impaired synthesis of MIf by T-cells; migratory inhibitory factor
chronic cutaneous candidiasis
79
Dificeincy in th e epxression of MHC II gene products in the tcells surface leading to failure of antigen presentation
bare lymphocyte syndrome
80
A combined b cell and t cell disorded that has a combined defetct of both humoral and cell mediated immunity; autosomal recessive type is associated deaminase deficiency; rarely survive beyond age1
severe combined immunodeficiency disease
81
Thymic dysplasia resulting in decreased to absent t-cell immunity; usually have marked lymphadenopathy and hepatosplenomegaly
nezelof's syndrome
82
Mutation in the WASP gene
wiskott aldrich syndrome
83
Result of specific genetic defect that affects DNA repair
ataxia telangiectasia
84
Mutation in SH2 DAI/ SAP gene resulting in weakening both cellular and humoral immunity; vulnerability to EBV infection
x liked lymphoproliferative diseases
85
A type of hypersensitivity:
Anaphylactic; no complement; igE mediated; hay fever, asthma, food allergies
type1
86
A type of hypersensitivity:
Cytotoxic; Complement involved; IgG or IgM mediated; transfusion reactions, HDN, autoimmune Hemolytic anemia
type 2
87
A type of hypersensitivity; immune complex; complement involved; neutrophils and monocytes; IMMUN COMPLEX DEPOSIITON; SLE
type 3
88
A type of hypersensitivity:
T cell dependent; no complement and no antibody involved; release of CYTOKINES
type 4
89
PSOT STRP GN; ARTHUS REAX; FARMER'S LUNGS
SERUM SICKNESS are examples of what type of hypersensitivity
type 3
90
DAT test and IAT test are test for what type of hypersensitivity
type 2
91
Contact dermatitis; mantoux reax; hypersensitivity pneumolith are what type of hypersensitivity
type 4
92
Gold standard for contact dermatitis(type4)
patch test
93
Most severe formof allergic response; low BP; low blood volume; caused by stings or food allergies
anaphylaxis
94
Measures total IgE
Radio immunosorbent assay
95
Masures antigen-specific IgE
RAST
96
Triggered by antigens found on cell surfaces
type2 hypersensitivity
97
Used to identify th presence of igG, C3B and C3d
monospecific AHG
98
A mixtures of antibodies to detect igG , C3b and C3d
polyspecific ahg
99
Th 1 plays the major role in this type of hypersensitivity
type4 hypersensitivity
100
Positive result: induration measuring>/= 5mm
mantoux reax