åé¡äžèЧ
1
å€ãã®åäœã«è¬ç©ãæäžãããšãããã®50%ã®åäœãæ»äº¡ãããšæšå®ãããéãLDâ âãšãã
2
è¬ç©ãçµå£æäžãããšããè¡äžæ¿åºŠãšæéã®é¢ä¿ãç€ºãæ²ç·ã®é¢ç©ã衚ãããã®ãæ¿åºŠæ²ç·äžé¢ç©(AUC)ãšãã
3
å®è¬ãšåã圢ç¶ã¯ããŠãããæå¹æåãå«ãŸãªã補åãæäžããæã广ãå¯äœçšãèŠãããããšãããããããããã©ã»ã广ãšãã
4
è¬ç©ã®åžåäœçšãšã¯è¡äžã«åã蟌ãŸããŠäœçšã衚ãããšã§ããã
5
è¬ç©ãçŽè žå æäžãããšååéé广ãåããããšã¯ãªãã
6
è¬ç©ã®éèå æäžã¯äœçšãæé«è¡äžæ¿åºŠããã¯ããŸã
7
æèè¬ã¯æçç©è³ªãšåææèãããªã
8
现èå£ã®åæã劚ããæçç©è³ªã¯ããã·ãªã³Gãã¢ã³ãã·ãªã³ããã
9
çµæ žã®æ²»çã«ã€ãœãã¢ãžãããªãã¡ã³ãã·ã³ã®äœµçšã«ããé·æéã®æ²»çãè¡ãªããã
10
äžè¬åã«ã¯ãäžçä¿å¥æ©æ§ã«ç»é²ãããåœéäžè¬åãšæ¥æ¬ã ãã®å»è¬åå称調æ»äŒæ¿èªåããã
11
çµæ žã®æ²»çã«ã€ãœãã¢ãžãããªãã¡ã³ãã·ã³ã®äœµçšã«ããé·æéã®æ²»çãè¡ãªããã
12
ã¡ããã¬ããµãŒã-------çœè¡ç
13
éºäŒåã¯ãããªãã·ãªãæ žé ž(DNA)ã®é åãšäºããã
14
ã·ã¯ããã¹ãã¡ããã¯ç现èã®éºäŒååæãæå¶ãã
15
ã¡ããã¬ããµãŒã---------çœè¡ç
16
B现èã¯ãæåã«ç¹ç°çãªæäœãç£çãã现èã§ãã
17
ãã¹ã¿ãã³ã¯è¥æºçްèããç£çãããæåæäœåå¿ã«ãã£ãŠçްèå€ã«æŸåºãããè²ã ãªã¢ã¬ã«ã®ãŒçç¶ãçºçŸãã
18
ã¢ã¹ããªã³-----ã·ã¯ããªãã·ã²ããŒãŒ
19
éã¹ããã€ãæ§æççè¬(NSADs)ã¯ããã¹ã¿ã°ã©ã³ãžã³(PG)ãããã³ãããµã³(TX)ã®çæãæå¶ãã
20
PGE2ã¯èŠåºäžéšã«ãããŠçºç±ãèµ·ãã
21
ã¢ã¹ããªã³-----ã·ã¯ããªãã·ã²ããŒãŒ
22
B现èã¯ãæåã«ç¹ç°çãªæäœãç£çãã现èã§ãã
23
ãã¹ã¿ãã³ã¯è¥æºçްèããç£çãããæåæäœåå¿ã«ãã£ãŠçްèå€ã«æŸåºãããè²ã ãªã¢ã¬ã«ã®ãŒçç¶ãçºçŸãã
24
éã¹ããã€ãæ§æççè¬(NSADs)ã¯ããã¹ã¿ã°ã©ã³ãžã³(PG)ãããã³ãããµã³(TX)ã®çæãæå¶ãã
25
ç¥çµçްèã®æ å ±äŒéã¯ç¥çµé¡ç²ã«å«ãŸããååŠäŒéç©è³ªãæŸåºãããæ¯é ãã现èã®å容äœã«äœçšããŠè¡ãããã
26
ãšããããªã³ã®å容äœã¯Î±å容äœãšÎ²å容äœãããã
27
β1å容äœ-----ã¢ããããŒã«
28
ã¢ããããŒã«-----çå¿ç
29
ãã«ãšããããªã³ã¯è¡å§äžæäœçšãèµ·ãã
30
äžæŽèã®æ²»ç
31
ã¯ãã«ããããžã³ã¯çµ±å倱調çã«çšãã
32
ã»ããã«ã©ã³ã¯åžå ¥éº»é è¬ã§ãã
33
ãžã¢ãŒãã ã¯REMç¡ç ã«åœ±é¿ãäžãé£ã
34
ãŠãããçºäœã¯äž¡åŽæ§ã«çããå šè¬çºäœãšçåŽããå§ãŸãéšåçºäœããã
35
ãã§ããã€ã³
36
ã¬ãããã¯ããŒãã³ãœã³ç ã®æ²»çè¬ã§ãã
37
ã³ãã€ã³ã¯åŒ±ãªããªã€ãã§ãã
38
ãããã°ãªã»ãªã³ã¯çå¿çæ²»çè¬ã§ãã
39
ããã§ãžãã³ã¯ã«ã«ã·ãŠã æ®æè¬ã§é«è¡å§ã®æ²»çã«çšãããã
40
ããã§ãžãã³ã¯ã«ã«ã·ãŠã æ®æè¬ã§é«è¡å§ã®æ²»çã«çšãããã
41
ã«ããããªã«ã¯ã¢ã³ã®ãªãã³ã·ã³IIã®çæãæå¶ãã
42
ãããªã³ã¯è¡æ¶²ååºãæå¶ãã
43
ã€ã³ã¹ãªã³ã¯è¡äžã®ãããŠç³ã现èã«åã蟌ãŸããç³ã®å©çšãä¿é²ããã
44
SUå€ã§ããã°ãªã¹ã³ãã©ããã¯èµèããã€ã³ã¹ãªã³ã®åæ³ãä¿ã
45
ãã©ãã¹ã¿ãã³ã¯èèã§ã®HMG-CoAéå é µçŽ ãé»å®³ããã³ã¬ã¹ãããŒã«ã®åæãæå¶ãã
46
çé¢šã®æ²»çã«ã¯å°¿é žã®çæãæå¶ããã¢ãããªãããŒã«ãçšãã
47
SUå€ã§ããã°ãªã¹ã³ãã©ããã¯èµèããã€ã³ã¹ãªã³ã®åæ³ãä¿ã
48
è¬ç©ã«ãã£ãŠçºçŸãããäœçšãå¯äœçšãšãã
49
çŸç ã«ãšããªãçç¶ã®ç·©åã軜æžãè¡ãæ²»çæ³ã察ççæ³ãšãã
50
è¬ç©ãçµå£æäžãããšããè¡äžæ¿åºŠãšæéã®é¢ä¿ãç€ºãæ²ç·ã®é¢ç©ã衚ãããã®ãæ¿åºŠæ²ç·äžé¢ç©(AUC)ãšãã
51
æ¶æ¯çšãšã¿ããŒã«ã®ãšã¿ããŒã«æ¿åºŠã¯çŽ80v/v%ã§ãã
ðè¬çããè¬ç©ãšå»è¬åã
ðè¬çããè¬ç©ãšå»è¬åã
HARUKAð€ · 31å · 1幎åðè¬çããè¬ç©ãšå»è¬åã
ðè¬çããè¬ç©ãšå»è¬åã
31å ⢠1幎åðè¬çããè¬ç©ã®äœçšã
ðè¬çããè¬ç©ã®äœçšã
HARUKAð€ · 51å · 1幎åðè¬çããè¬ç©ã®äœçšã
ðè¬çããè¬ç©ã®äœçšã
51å ⢠1幎åðè¬çããè¬ç©ã®é©çšã
ðè¬çããè¬ç©ã®é©çšã
HARUKAð€ · 45å · 1幎åðè¬çããè¬ç©ã®é©çšã
ðè¬çããè¬ç©ã®é©çšã
45å ⢠1幎åðè¬ç ãå»çäºæ ã
ðè¬ç ãå»çäºæ ã
HARUKAð€ · 10å · 1幎åðè¬ç ãå»çäºæ ã
ðè¬ç ãå»çäºæ ã
10å ⢠1幎åðè¬çããæææçè¬ã
ðè¬çããæææçè¬ã
HARUKAð€ · 32å · 1幎åðè¬çããæææçè¬ã
ðè¬çããæææçè¬ã
32å ⢠1幎åðè¬çããææªæ§è «çè¬ã
ðè¬çããææªæ§è «çè¬ã
HARUKAð€ · 16å · 1幎åðè¬çããææªæ§è «çè¬ã
ðè¬çããææªæ§è «çè¬ã
16å ⢠1幎åðè¬çããå ç«ã»ççåå¿ã«é¢é£ããè¬ç©ã
ðè¬çããå ç«ã»ççåå¿ã«é¢é£ããè¬ç©ã
HARUKAð€ · 14å · 1幎åðè¬çããå ç«ã»ççåå¿ã«é¢é£ããè¬ç©ã
ðè¬çããå ç«ã»ççåå¿ã«é¢é£ããè¬ç©ã
14å ⢠1幎åðè¬çããæ«æ¢¢ç¥çµç³»ã«äœçšããè¬ç©ã
ðè¬çããæ«æ¢¢ç¥çµç³»ã«äœçšããè¬ç©ã
HARUKAð€ · 15å · 1幎åðè¬çããæ«æ¢¢ç¥çµç³»ã«äœçšããè¬ç©ã
ðè¬çããæ«æ¢¢ç¥çµç³»ã«äœçšããè¬ç©ã
15å ⢠1幎åðè¬çããäžæ¢ç¥çµç³»ã«äœçšããè¬ç©ã
ðè¬çããäžæ¢ç¥çµç³»ã«äœçšããè¬ç©ã
HARUKAð€ · 18å · 1幎åðè¬çããäžæ¢ç¥çµç³»ã«äœçšããè¬ç©ã
ðè¬çããäžæ¢ç¥çµç³»ã«äœçšããè¬ç©ã
18å ⢠1幎åðè¬çãã埪ç°åšã»è¡æ¶²ç³»ã«äœçšããè¬ç©ãè¡æ¶²è£œå€ã
ðè¬çãã埪ç°åšã»è¡æ¶²ç³»ã«äœçšããè¬ç©ãè¡æ¶²è£œå€ã
HARUKAð€ · 15å · 1幎åðè¬çãã埪ç°åšã»è¡æ¶²ç³»ã«äœçšããè¬ç©ãè¡æ¶²è£œå€ã
ðè¬çãã埪ç°åšã»è¡æ¶²ç³»ã«äœçšããè¬ç©ãè¡æ¶²è£œå€ã
15å ⢠1幎åðè¬çãã11ç« ãŸã§ã
ðè¬çãã11ç« ãŸã§ã
HARUKAð€ · 10å · 1幎åðè¬çãã11ç« ãŸã§ã
ðè¬çãã11ç« ãŸã§ã
10å ⢠1幎åðè¬çãã詊éšå¯Ÿçã
ðè¬çãã詊éšå¯Ÿçã
HARUKAð€ · 35å · 1幎åðè¬çãã詊éšå¯Ÿçã
ðè¬çãã詊éšå¯Ÿçã
35å ⢠1幎åðè¬çããå詊éšã
ðè¬çããå詊éšã
HARUKAð€ · 32å · 1幎åðè¬çããå詊éšã
ðè¬çããå詊éšã
32å ⢠1幎åð人äœâ ã詊éšå¯Ÿçã
ð人äœâ ã詊éšå¯Ÿçã
HARUKAð€ · 46å · 1幎åð人äœâ ã詊éšå¯Ÿçã
ð人äœâ ã詊éšå¯Ÿçã
46å ⢠1幎åð人äœâ ããã¹ããã¹ãã
ð人äœâ ããã¹ããã¹ãã
HARUKAð€ · 55å · 1幎åð人äœâ ããã¹ããã¹ãã
ð人äœâ ããã¹ããã¹ãã
55å ⢠1幎åð人äœâ ããã¹ããã¹ã2ã
ð人äœâ ããã¹ããã¹ã2ã
HARUKAð€ · 45å · 1幎åð人äœâ ããã¹ããã¹ã2ã
ð人äœâ ããã¹ããã¹ã2ã
45å ⢠1幎åð人äœII ãè 尿路系ã«å±ããåšå®
ð人äœII ãè 尿路系ã«å±ããåšå®
HARUKAð€ · 26å · 1幎åð人äœII ãè 尿路系ã«å±ããåšå®
ð人äœII ãè 尿路系ã«å±ããåšå®
26å ⢠1幎åð人äœâ ¡ ãè å°¿è·¯ç³»ã®æ©èœã
ð人äœâ ¡ ãè å°¿è·¯ç³»ã®æ©èœã
HARUKAð€ · 15å · 1幎åð人äœâ ¡ ãè å°¿è·¯ç³»ã®æ©èœã
ð人äœâ ¡ ãè å°¿è·¯ç³»ã®æ©èœã
15å ⢠1幎åð人äœâ ¡ ã女æ§ã®çæ®åšã
ð人äœâ ¡ ã女æ§ã®çæ®åšã
HARUKAð€ · 31å · 1幎åð人äœâ ¡ ã女æ§ã®çæ®åšã
ð人äœâ ¡ ã女æ§ã®çæ®åšã
31å ⢠1幎ååé¡äžèЧ
1
å€ãã®åäœã«è¬ç©ãæäžãããšãããã®50%ã®åäœãæ»äº¡ãããšæšå®ãããéãLDâ âãšãã
2
è¬ç©ãçµå£æäžãããšããè¡äžæ¿åºŠãšæéã®é¢ä¿ãç€ºãæ²ç·ã®é¢ç©ã衚ãããã®ãæ¿åºŠæ²ç·äžé¢ç©(AUC)ãšãã
3
å®è¬ãšåã圢ç¶ã¯ããŠãããæå¹æåãå«ãŸãªã補åãæäžããæã广ãå¯äœçšãèŠãããããšãããããããããã©ã»ã广ãšãã
4
è¬ç©ã®åžåäœçšãšã¯è¡äžã«åã蟌ãŸããŠäœçšã衚ãããšã§ããã
5
è¬ç©ãçŽè žå æäžãããšååéé广ãåããããšã¯ãªãã
6
è¬ç©ã®éèå æäžã¯äœçšãæé«è¡äžæ¿åºŠããã¯ããŸã
7
æèè¬ã¯æçç©è³ªãšåææèãããªã
8
现èå£ã®åæã劚ããæçç©è³ªã¯ããã·ãªã³Gãã¢ã³ãã·ãªã³ããã
9
çµæ žã®æ²»çã«ã€ãœãã¢ãžãããªãã¡ã³ãã·ã³ã®äœµçšã«ããé·æéã®æ²»çãè¡ãªããã
10
äžè¬åã«ã¯ãäžçä¿å¥æ©æ§ã«ç»é²ãããåœéäžè¬åãšæ¥æ¬ã ãã®å»è¬åå称調æ»äŒæ¿èªåããã
11
çµæ žã®æ²»çã«ã€ãœãã¢ãžãããªãã¡ã³ãã·ã³ã®äœµçšã«ããé·æéã®æ²»çãè¡ãªããã
12
ã¡ããã¬ããµãŒã-------çœè¡ç
13
éºäŒåã¯ãããªãã·ãªãæ žé ž(DNA)ã®é åãšäºããã
14
ã·ã¯ããã¹ãã¡ããã¯ç现èã®éºäŒååæãæå¶ãã
15
ã¡ããã¬ããµãŒã---------çœè¡ç
16
B现èã¯ãæåã«ç¹ç°çãªæäœãç£çãã现èã§ãã
17
ãã¹ã¿ãã³ã¯è¥æºçްèããç£çãããæåæäœåå¿ã«ãã£ãŠçްèå€ã«æŸåºãããè²ã ãªã¢ã¬ã«ã®ãŒçç¶ãçºçŸãã
18
ã¢ã¹ããªã³-----ã·ã¯ããªãã·ã²ããŒãŒ
19
éã¹ããã€ãæ§æççè¬(NSADs)ã¯ããã¹ã¿ã°ã©ã³ãžã³(PG)ãããã³ãããµã³(TX)ã®çæãæå¶ãã
20
PGE2ã¯èŠåºäžéšã«ãããŠçºç±ãèµ·ãã
21
ã¢ã¹ããªã³-----ã·ã¯ããªãã·ã²ããŒãŒ
22
B现èã¯ãæåã«ç¹ç°çãªæäœãç£çãã现èã§ãã
23
ãã¹ã¿ãã³ã¯è¥æºçްèããç£çãããæåæäœåå¿ã«ãã£ãŠçްèå€ã«æŸåºãããè²ã ãªã¢ã¬ã«ã®ãŒçç¶ãçºçŸãã
24
éã¹ããã€ãæ§æççè¬(NSADs)ã¯ããã¹ã¿ã°ã©ã³ãžã³(PG)ãããã³ãããµã³(TX)ã®çæãæå¶ãã
25
ç¥çµçްèã®æ å ±äŒéã¯ç¥çµé¡ç²ã«å«ãŸããååŠäŒéç©è³ªãæŸåºãããæ¯é ãã现èã®å容äœã«äœçšããŠè¡ãããã
26
ãšããããªã³ã®å容äœã¯Î±å容äœãšÎ²å容äœãããã
27
β1å容äœ-----ã¢ããããŒã«
28
ã¢ããããŒã«-----çå¿ç
29
ãã«ãšããããªã³ã¯è¡å§äžæäœçšãèµ·ãã
30
äžæŽèã®æ²»ç
31
ã¯ãã«ããããžã³ã¯çµ±å倱調çã«çšãã
32
ã»ããã«ã©ã³ã¯åžå ¥éº»é è¬ã§ãã
33
ãžã¢ãŒãã ã¯REMç¡ç ã«åœ±é¿ãäžãé£ã
34
ãŠãããçºäœã¯äž¡åŽæ§ã«çããå šè¬çºäœãšçåŽããå§ãŸãéšåçºäœããã
35
ãã§ããã€ã³
36
ã¬ãããã¯ããŒãã³ãœã³ç ã®æ²»çè¬ã§ãã
37
ã³ãã€ã³ã¯åŒ±ãªããªã€ãã§ãã
38
ãããã°ãªã»ãªã³ã¯çå¿çæ²»çè¬ã§ãã
39
ããã§ãžãã³ã¯ã«ã«ã·ãŠã æ®æè¬ã§é«è¡å§ã®æ²»çã«çšãããã
40
ããã§ãžãã³ã¯ã«ã«ã·ãŠã æ®æè¬ã§é«è¡å§ã®æ²»çã«çšãããã
41
ã«ããããªã«ã¯ã¢ã³ã®ãªãã³ã·ã³IIã®çæãæå¶ãã
42
ãããªã³ã¯è¡æ¶²ååºãæå¶ãã
43
ã€ã³ã¹ãªã³ã¯è¡äžã®ãããŠç³ã现èã«åã蟌ãŸããç³ã®å©çšãä¿é²ããã
44
SUå€ã§ããã°ãªã¹ã³ãã©ããã¯èµèããã€ã³ã¹ãªã³ã®åæ³ãä¿ã
45
ãã©ãã¹ã¿ãã³ã¯èèã§ã®HMG-CoAéå é µçŽ ãé»å®³ããã³ã¬ã¹ãããŒã«ã®åæãæå¶ãã
46
çé¢šã®æ²»çã«ã¯å°¿é žã®çæãæå¶ããã¢ãããªãããŒã«ãçšãã
47
SUå€ã§ããã°ãªã¹ã³ãã©ããã¯èµèããã€ã³ã¹ãªã³ã®åæ³ãä¿ã
48
è¬ç©ã«ãã£ãŠçºçŸãããäœçšãå¯äœçšãšãã
49
çŸç ã«ãšããªãçç¶ã®ç·©åã軜æžãè¡ãæ²»çæ³ã察ççæ³ãšãã
50
è¬ç©ãçµå£æäžãããšããè¡äžæ¿åºŠãšæéã®é¢ä¿ãç€ºãæ²ç·ã®é¢ç©ã衚ãããã®ãæ¿åºŠæ²ç·äžé¢ç©(AUC)ãšãã
51
æ¶æ¯çšãšã¿ããŒã«ã®ãšã¿ããŒã«æ¿åºŠã¯çŽ80v/v%ã§ãã