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Isotonic solutions
24問 • 3ヶ月前
  • HERSHEY VALERIE BERNARDINO
    • 通報

    問題一覧

  • 1

    Pharmaceutical solutions that are meant for application to delicate membranes should be adjusted to approximately ___ as that of the body fluids.

    same osmotic pressure

  • 2

    Nasal, ophthalmic, and parenteral solutions should be

    isotonic

  • 3

    Acts as vasoconstrictor in sterile eye drops

    Tetrahydrozaline HCI

  • 4

    Tetrahydrozoline HCI (0.05%) should not be used for 4-5 days as it may cause ___

    rebound hyperemia

  • 5

    It is used as vehicle in sterile eye drops

    purified water

  • 6

    Used as tonicity adjusters

    sodium chloride, boric acid, sodium borate

  • 7

    Tonicity adjusters in sterile eye drop formulation can also be used as ___

    preservatives

  • 8

    Benzalkonium chloride (0.01%) is used as ___

    preservative

  • 9

    Used as chelating agent

    edetate disodium

  • 10

    Method used by adding NaCI or a tonicity adjuster

    Method I

  • 11

    Method used by adding water to make isotonic solution

    Method II

  • 12

    Method I in tonicity adjustment

    NaCl Equivalent Method, Cryoscopic Method

  • 13

    Method II in tonicity adjustment

    White-Vincent Method, Sprowls Method

  • 14

    Also known as the "E-value Method"

    NaCl Equivalent Method

  • 15

    Also known as the "Freezing Point Depression Method"

    Cryoscopic Method

  • 16

    What is the Modified White-Vincent Method?

    Sprowls Method

  • 17

    Formula for Sprowls Method

    V = 0.3g x E value x 111.1

  • 18

    What is the value of a normal saline solution?

    0.9%

  • 19

    Value of a normal saline or NaCl solution

    0.009 g/mL

  • 20

    The E value of any drug can be used to estimate the amount of ___ l or other tonicity agents needed to make a drug solution isotonic.

    NaCI

  • 21

    Steps in Sodium Chloride Method

    Convert the amount of drug in the solution to its equivalent in sodium chloride., Compare this amount with that present in 0.9% sodium chloride solution, Difference between the latter amount and the equivalent amount to compute for the amount needed for tonicity adjustment, Divide the amount in step 3 with the E value of a tonicity adjuster

  • 22

    Appropriate method if water and isotonic solution or buffered isotonic solution are used

    White-Vincent Method

  • 23

    Method in which the volume in mL of isotonic solution that may be prepared by mixing drug with water, followed by another isotonic solution or buffered

    White-Vincent Method

  • 24

    White-Vincent Method formula

    V = g x E x 111.1

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    問題一覧

  • 1

    Pharmaceutical solutions that are meant for application to delicate membranes should be adjusted to approximately ___ as that of the body fluids.

    same osmotic pressure

  • 2

    Nasal, ophthalmic, and parenteral solutions should be

    isotonic

  • 3

    Acts as vasoconstrictor in sterile eye drops

    Tetrahydrozaline HCI

  • 4

    Tetrahydrozoline HCI (0.05%) should not be used for 4-5 days as it may cause ___

    rebound hyperemia

  • 5

    It is used as vehicle in sterile eye drops

    purified water

  • 6

    Used as tonicity adjusters

    sodium chloride, boric acid, sodium borate

  • 7

    Tonicity adjusters in sterile eye drop formulation can also be used as ___

    preservatives

  • 8

    Benzalkonium chloride (0.01%) is used as ___

    preservative

  • 9

    Used as chelating agent

    edetate disodium

  • 10

    Method used by adding NaCI or a tonicity adjuster

    Method I

  • 11

    Method used by adding water to make isotonic solution

    Method II

  • 12

    Method I in tonicity adjustment

    NaCl Equivalent Method, Cryoscopic Method

  • 13

    Method II in tonicity adjustment

    White-Vincent Method, Sprowls Method

  • 14

    Also known as the "E-value Method"

    NaCl Equivalent Method

  • 15

    Also known as the "Freezing Point Depression Method"

    Cryoscopic Method

  • 16

    What is the Modified White-Vincent Method?

    Sprowls Method

  • 17

    Formula for Sprowls Method

    V = 0.3g x E value x 111.1

  • 18

    What is the value of a normal saline solution?

    0.9%

  • 19

    Value of a normal saline or NaCl solution

    0.009 g/mL

  • 20

    The E value of any drug can be used to estimate the amount of ___ l or other tonicity agents needed to make a drug solution isotonic.

    NaCI

  • 21

    Steps in Sodium Chloride Method

    Convert the amount of drug in the solution to its equivalent in sodium chloride., Compare this amount with that present in 0.9% sodium chloride solution, Difference between the latter amount and the equivalent amount to compute for the amount needed for tonicity adjustment, Divide the amount in step 3 with the E value of a tonicity adjuster

  • 22

    Appropriate method if water and isotonic solution or buffered isotonic solution are used

    White-Vincent Method

  • 23

    Method in which the volume in mL of isotonic solution that may be prepared by mixing drug with water, followed by another isotonic solution or buffered

    White-Vincent Method

  • 24

    White-Vincent Method formula

    V = g x E x 111.1