GRANULES

46問 • 4ヶ月前

問題一覧

A dosage form composed of dry aggregates of powder particles that may contain one or more active pharmaceutioocal ingredients, with or without other ingredients

granules

Granules particle size ranges from about ___ sieve size

4 to 10 mesh

Can be dispersed in food or dissolved in water.

granules

Can be used in other dosage form such as making a compacted tablet or filled in the capsule with or without excipients.

granules

Has poor flow properties

powders

Flow well compared to tablets and a good choice for compressing tablet.

granules

Relatively less stable due to increase atmospheric effect.

powders

Has less surface area, more stable to atmospheric effect.

granules

More likely to harden/cake formation on long storage.

powders

Less likely to harden

granules

Some float on the surface; difficult to make solution.

powders

More easily wetted by the solvents; good choice for reconstitution of liquids.

granules

Relatively poor compressibility

powders

Has good compressibility

granules

More chances of non uniform dosing

powders

Relatively more uniformity of contents

granules

More dust due to small particle size

powders

Generate less dust on handling

granules

Comparatively less appealing

powders

Have a more elegant appearance

granules

Relatively simple method of processing/formulation

powders

Involves more processing, exposure to heat, and contact with solvents.

granules

What are the 2 granulation methods? (small letters, "___ and ___")

wet and dry

Dry method is also known as ___ ___ ___ (small letters)

dry fusion method

Wet method is also known as ___ ___ ___ (small letters)

wet fusion method

Production of a moist mass by heating the ingredients sufficiently to drive off the water of hydration from the uneffloresced citric acid, forcing the mass through a case sieve and drying in an oven.

dry method

The product should be dispensed in tightly closed glass container to protect it against humidity and air.

dry method

Route of administration: oral, dispersed in food, and dissolved in water.

dry method

Involves the addition of small amounts of water to the dry salts to obtain a workable mass which is then dried and ground to yield the powder or granule,

wet method

In wet method, what binds the powder?

water and alcohol

Sodium bicarbonate is an effervescent granulated salt

true

Effervescent granulated salt that is sticky and different to granulate.

citric acid

Effervescent granulated salt that looses firmness and crumbles easily.

tartaric acid

Ratio of citric acid and tartaric acid

1 citric acid : 2 tartaric acid

When the effervescent granulated salts are added to water, the acid and water reacts, the granulation effervesces (fizzes) as carbon dioxide is liberated

true

Synonym of sodium phosphate effervescent granule (use proper capitalization, 3 words)

Sodii phosphas effervescentes

Use of sodium phosphate effervescent granule (small letters, 2 words)

saline laxative

Method of preparation of sodium phosphate effervescent granule

dry fusion method

Appropriate container for sodium phosphate effervescent granule

wide mouth bottle

Storage condition of sodium phosphate effervescent granules

protect it against humidity and air

Sodium phosphate acts as

API

Sodium bicarbonate acts as

alkalinizer

Citric acid acts as

acidifier

Tartaric acid acts as

acidifier

What should be the last ingredient to add in the sodium phosphate formulation?

sodium bicarbonate

In the sodium phosphate effervescent granule formulation, which binds the ingredients?

citric acid

POCLEC M1: Overview of Organic Chemistry

HERSHEY VALERIE BERNARDINO · 9問 · 10ヶ月前

POCLEC M1: Overview of Organic Chemistry