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  • 問題数 100 • 4/16/2024

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    問題一覧

  • 1

    A 21 year lady was on Carbamazepine and Phenytoin, but recurrent episode happened so she changed the medicine to Valproate, then she doesn’t have any seizures for the last five years, her husband come to pharmacy for medicine and he said she try to conceive. What advice will give you regarding medication

    Consult a neurologist before conceiving and take opinion about continuation of Valproate

  • 2

    A 21 year lady was on Carbamazepine and Phenytoin, but recurrent episode happened so she changed the medicine to Valproate, then she doesn’t have any seizures for the last five years, her husband come to pharmacy for medicine and he said she try to conceive. What advice will give you regarding medication

    Stop sodium valproate and wait for 14 days washout period then plan / switch to lamotrigine

  • 3

    A 21 year lady was on Carbamazepine and Phenytoin, but recurrent episode happened so she changed the medicine to Valproate, then she doesn’t have any seizures for the last five years, her husband come to pharmacy for medicine and he said she try to conceive. What advice will give you regarding medication

    Withdraw valproate slowly prior to conception, by discussing with neurologist

  • 4

    Female on valproate wants to get pregnant what is your advice:

    Ask prescriber to change to lamotrigine

  • 5

    A 28-year-old woman with seizure is planning to start a family. She is taking folic acid 400 mcg per day. She is asking about safe epilepsy medications during pregnancy. Which of the following would be the best medication?

    Lamotrigine

  • 6

    A physician would like to replace patient's valproic acid with immediate release lamotrigine. What is the recommended maximum initial dose?

    200 mg

  • 7

    A 28-year-old woman with a history of seizures that well controlled on valproic acid is asking for advice regarding her medications. She is planning to start a family and is now taking folic acid. She wants to optimize the medications before her pregnancy. What would be the best recommendation?

    Introduce well controlled slowly and titrate the dose of valproic acid to discontinue before pregnancy

  • 8

    Which one of the following is considered first line therapy for the management of partial seizures?

    Carbamazepine

  • 9

    Which one of the following parameters should be monitored regularly when starting a patient on clozapine?

    Absolute neutrophil count

  • 10

    What is the appropriate treatment of poisoning by organophosphate nerve agents?

    Pralidoxime

  • 11

    28-year-old woman has been taking fluoxetine for depression and now has worsening depressive episodes. The resident doctor on the floor has been asked by consultant to stop fluoxetine and initiate phenelzine. How long should the washout period be before starting phenelzine?

    5 weeks

  • 12

    Drug is secreted at Brest fed infant and cause hypnosis.

    Diazepam

  • 13

    A 70-year-old woman is taking multiple drugs According to Beers criteria, which one of the following drugs is potentially inappropriate since it might be associated with increased cognitive decline?

    Amitriptyline

  • 14

    Most drug to cause side effects Associated with multiple adverse drug reactions:

    Quetiapine fumarate

  • 15

    Which one of the following drugs is considered first line treatment for Alzheimer's disease?

    Donepezil

  • 16

    24-year-old man is diagnosed with psychosis. He agrees to start drug therapy, however, he is asking for the least sedating medication. Which of the following drugs will be most appropriate?

    Risperidone

  • 17

    Which of the following medications can be used for narcotic addiction?

    Methadone

  • 18

    Pt. came to the pharmacy complaining about dizziness, resting tremors and difficulty in stepping the leg. She also has QT prolongation. These symptoms appears one week ago when the patient toke the restless leg syndrome medication. The pharmacy inspected the bottle of medicine the patient brought and saw that the label indicated Quinine sulfate but the appearance of the tablets didn’t match the medicine. What had contributed to this adverse effect

    Quetiapine 200m

  • 19

    Which of the following is a drug with concern

    Zopiclone

  • 20

    Patient with high degree of insomnia what is the most suitable option for him

    Zopiclone for 28 days

  • 21

    A 75-year-old woman comes to the pharmacy with a new prescription for zolpidem. What is the maximum dose she can receive?

    5 mg

  • 22

    Which of the following groups is with high physical dependence

    Benzodiazepines

  • 23

    patient is for opioid withdrawal treatment but with QT prolongation, which will be the best drug for him

    Buprenorphine

  • 24

    A diabetic patient on antipsychotic (Olanzapine) , and the doctor wants to change it to another antipsychotic, what is the best alternative?

    Aripiprazole

  • 25

    Pt taking parkinsons disease medication, have symptoms dizziness, fatigue, heavy breathing his hb is 7 what to give him

    Darbepoetin s.c every 3 weeks

  • 26

    Patient is on Capecitabine having lethargy and shortness of breath Hb in lab was 7.7

    Darbepoetin

  • 27

    A 10-year-old obese girl with newly diagnosed depressive illness is being advised to start antidepressant treatment. Which of the following is best to initiate?

    Bupropion

  • 28

    Which one of the following parameters should be monitored regularly when starting a patient on clozapine?

    Absolute neutrophil count

  • 29

    Which of the following medication is most appropriate in a 71-year-old man to treat extrapyramidal effects emerging out of neuroleptics?

    Benztropine

  • 30

    What is the effect of smoking on serum olanzapine levels?

    Decrease in serum olanzapine levels

  • 31

    Which antidepressant drug must be avoided in a 21-year-old female with a history of seizure disorder?

    Bupropion

  • 32

    What information should be provided to a patient on fentanyl transdermal patches?

    Avoid increase in body core temperature

  • 33

    A 25-year-old man presents to the emergency room after ingesting 30 tablets of Alprazolam what should be the appropriate antidote?

    Flumazenil

  • 34

    A 25-year-old man presents to the emergency room after ingesting 30 tablets of Alprazolam what should be the appropriate antidote?

    Flumazenil

  • 35

    Diazepam bottle finished. Which antidote?

    Flumazenil

  • 36

    Diazepam bottle finished. Which antidote?

    Physostigmine

  • 37

    Patient took overdose of diazepam and treated with Flumazenil but patient is still hypnotized.. Why?

    flumazenil dose is not enough

  • 38

    An 18-year-old boy with a history of illicit drug use is suspected to have an overdose of benzodiazepines and is experiencing ataxia, drowsiness and nystagmus. What would be the best antidote?

    Flumazenil 300 mcg intravenously

  • 39

    A 21-year-old man with a history of illicit drug use is suspected to have overdose of an opioid and is experiencing severe toxicity with respiratory depression and pin-point pupils. What would be the best antidote?

    Naloxone 400 mcg intramuscularly

  • 40

    A 68-year-old woman with type 2 diabetes, neuropathy, and seizures has been newly diagnosed with depressive illness. Which medication would be best to initiate?

    Duloxetine

  • 41

    An elderly man presented to the Emergency Room with dizziness, altered consciousness, respiratory depression, and rhabdomyolysis. He was recently prescribed a medication for inability to sleep. Which is the most likely drug toxicity?

    Benzodiazepines

  • 42

    An elderly patient is suffering from depression was given St. John's wort. Which of the following drug if administered concomitantly will have clinically significant interaction?

    Sertraline

  • 43

    Steve-Johnson syndrome that will appear when giving phenytoin IV after

    7-14 days after 1st dose

  • 44

    An 18-year-old girl is diagnosed with seizures. She is prescribed low dose lamotrigine, the dose to be increased slowly to reach the target dose. She is asking why she cannot take the full dose immediately. What is the reason?

    Rash is a dose related side effect

  • 45

    A 28 year-old man who was well controlled on phenytoin is brought to the Emergency Department in a state of status epilepticus. What would be the best recommendation?

    Intravenous lorazepam and stop phenytoin

  • 46

    A 79-year-old man with Alzheimer's disease has mild to moderate dementia and is on oral rivastigmine 6 mg twice daily. He is not able to tolerate the medication due to nausea and vomiting. What would be the best recommendation?

    Change to transdermal application of rivastigmine 4.6 mg/ 24-hours

  • 47

    patient took iv infusion phenytoin dr changed to tablet 200 mg once daily. The blood level of phenytoin is 6 the ideal between 20-10. What should the dr do to achieve the optimum level Tablet half-life is 22 hours?

    Change to 200 mg bid (bioavailability difference 10 percent)

  • 48

    Patient took IV infusion phenytoin. The doctor changed to tablet 200 mg once daily. The blood level of phenytoin is 6 and the ideal level is between 10-20. What should the doctor do to achieve the optimum level (Tablet half-life is 22 hours)?

    Change to 200 mg bid

  • 49

    A 42 year old male has been admitted to the high dependency unit following a severe head injury and require phenytoin for seizer. He is initially prescribed by phenytoin infusion and then change to phenytoin orally. He has a total phenytoin time trough level of 6 microgram per ml three days after the initiation of treatment. Using the information below. What is the most appropriate action. target trough 10-20 those prescribed 200 mg once daily half life 22hra.

    increase the dose to 200 mg twice daily and Retake level in 2 day's

  • 50

    increase the doors to 400 mg once daily and Retake level in 3 days.

    wrong (choose this)

  • 51

    A Patient has high level of free drug level of phenytoin because of what?

    Hypoalbuminemia

  • 52

    The physician is asking pharmacist about the effects of low albumin and acute renal failure on phenytoin serum concentration. The patient is receiving phenytoin 300 mg once daily. What should be the most appropriate suggestion?

    In hypoalbuminemia and acute renal failure obtain free phenytoin serum concentration.

  • 53

    patient with serum phenytoin level is 11 mg/dl ( normal 10-20 ) what is your intervention?

    no need to dose adjustments

  • 54

    Which route of administration results in faster absorption?

    Rectal

  • 55

    A 48-year-old man is on phenytoin 100 mg TID for epilepsy. His dose is adjusted to 150 mg TID. When will it be appropriate to do plasma phenytoin concentration at the new steady state?

    7 days

  • 56

    Which of the following signs correlate with phenytoin level of 200 micromole/L?

    Coma

  • 57

    which of the following is an addictive drug?

    fentanyl

  • 58

    Drug overdose caused agitation and irritability :

    Cannabinoids

  • 59

    A 23-year-old drug addict man was brought to the Emergency Room with severe agitation and excitement. He was administered intravenous diazepam, with no improvement in his condition. Which of the following is the mostly likely drug the patient was addicted on?

    Cannabinoids

  • 60

    A 75 year old lady with gfr greater than 75 ml /mint ,treatment including diazepam,indepamide Patient experience headache,dizziness,fainting and changes in pulse and heart rate ,what is not a least appropriate reason for patient fall ?

    additive effect due to combination use of diazepam and indapamide

  • 61

    Patient taking drug “maybe Levodopa” he went to pharmacy to get some vitamins what vitamin you should concern about?

    Vit B6

  • 62

    Which of the following drugs should be administered at the same time daily:

    Levodopa

  • 63

    When dosing levodopa/carbidopa, on which component should the dose be based on?

    Dose should be based on levodopa

  • 64

    A Parkinsonism patient have surgery . He have to go nil by mouth for 2 days what treatment have to be followed ?( he taking medicine 200mg 3 times a day before surgery)

    Change cobeneldopa to levodopa equivalent dose and advice equivalent roticotine patch / Rotigotine

  • 65

    In Parkinson’s Disease which antiemetic can be used?

    Domperidone

  • 66

    What is the effect of thiazide dietetics on serum lithium concentration?

    Concentration will increase

  • 67

    A 45-year-old man with bipolar disorder has been stable on lithium for 12 months. He is due for his routine laboratory work up. Which of the following electrolyte imbalances will predispose him to lithium toxicity?

    Na

  • 68

    A schizophrenic patient is on Lithium carbonate 300mg TID, his plasma level concentration of lithium found to be 0.7mcg/ml. In the next day plasma concentration. Comes down in to 0.4mcg/ml, what will do in the dose adjustment

    Lithium carbonate 400mg TID

  • 69

    A 55-year-old man with bipolar disorder is stable on lithium for the last 12 months. Which of the following tests should be ordered on routine follow up?

    Thyroid function tests

  • 70

    Effect of Loop Diuretics on lithium level

    Minor variable effect

  • 71

    What is the best time to do lithium levels after the dose is administered

    12 hours

  • 72

    Sumatriptan is known to be effective for migraine. Which of these situations are contraindicated from taking it?

    Pt. with a cardiovascular disease

  • 73

    A 25-year-old woman with history of migraine associated with aura has taken ergotamine 2mg sublingual tablets at first sign of migraine, then 2 mg every 30 minutes as needed. What is the maximum number of ergotamine tablets that can be used in one week?

    5

  • 74

    A 20-year-old woman with a history of periodic acute migraine attacks associated with aura is having another acute attack. What would be the first-choice drug?

    Sumatriptan 50 mg at the onset of migraine

  • 75

    A 21-year-old woman with a history of chronic migraine associated with aura is asking to for medication to prevent another attack. What would be the recommended prophylaxis?

    Propranolol 20 mg twice daily

  • 76

    A patient with a prescription of methotrexate and latanoprost come to you. What is the diagnosis:

    Rheumatoid arthritis & glaucoma

  • 77

    Which of the following is an adverse drug reaction:

    Alendronate acid increase osteonecrosis

  • 78

    Which one side effects is known to bisphosphonates?

    Osteonecrosis of the jaw

  • 79

    The high prevalence of osteoporosis in the elderly results which incidence in geriatric population?

    Bone fractures

  • 80

    A 65-year-old woman received a diagnosis of RA 1 year ago. At the time of her diagnosis, her RF titer was 1:64; she presented with joint inflammation in both hands and about 45 minutes of morning stiffness. She began therapy with oral methotrexate and currently receives 15 mg weekly, folic acid 2 mg daily, ibuprofen 800 mg three times daily, and omeprazole 20 mg daily. At today’s clinic visit, the patient reports the recur- rence of her symptoms. Radiographic evaluation of her hand joints shows progression of joint space narrow- ing and bone erosion. Which is the next best step for this patient’s treatment?

    Administer etanercept.

  • 81

    is a 55-year-old woman with rheumatoid arthritis. On diagnosis 1 year ago, F.A. had an RF titer of 1:64 signs and symptoms of inflammation in the joints of both hands, and about 45 minutes of morning stiffness. She began therapy with methotrexate, and she is presently receiving 15 mg every week, folic acid 2 mg/day, ibuprofen 800 mg 3 times/day, and omeprazole 20 mg/day. At today’s clinic visit, F.A. reports a recurrence of her symptoms. Radiographic evaluation of her hand joints shows progression of joint space narrowing and bone erosion. Which one of the following is the best next step in therapy for F.A.?

    Administer etanercept. (Trade name Enbrel)

  • 82

    Which one of the following medications for osteoporosis will significantly reduce the risk of hip fracture?

    Risedronate

  • 83

    A 48-year-old women with rheumatoid arthritis and on ibuprofen and ranitidine for three months has been advised to start a DMARD therapy. Which of the following would be the recommended DMARD therapy?

    Methotrexate 7.5 mg weekly with folic acid 5 mg weekly on any other day

  • 84

    Which one of the following medications can be dispensed without prescription?

    Ibuprofen 400 mg

  • 85

    Side effect of Ibuprofen?

    Heart burn

  • 86

    What is the total maximum daily dose of over-the-counter Ibuprofen?

    1200 mg

  • 87

    20 years old male with mild knee pain because last week he was injured while playing football. He took full dose of paracetamol but didn’t relief him, Nurse asked the pharmacist what is the best analgesia for his condition?

    Ibuprofen 400mg TID

  • 88

    20 years old male admitted to ER because of Asthma exacerbation. He has been taking salbutamol for 10 years. After getting better, he said to the nurse that he is having a mild knee pain because last week he was injured while playing football. He took full dose of paracetamol but didn’t relief him, Nurse asked the pharmacist what is the best analgesia for his condition?

    Colchicine 500mcg three times a day

  • 89

    What is the total maximum daily dose of the over-the-counter paracetamol?

    4g

  • 90

    Which of the following indications is appropriate for misoprostol

    Misoprostol is effective for preventing NSAIDs-induced ulcer

  • 91

    What is the antidote of acetaminophen?

    N-Acetylcysteine

  • 92

    Which of the following NSAIDs has the gastrointestinal side effect?

    Naproxen

  • 93

    A 54-year-old man with reduced ejection fraction heart failure presented to the pharmacy with mild pain in his knees and requesting an OTC pain killer. Which of the following is the best OTC medication?

    Paracetamol

  • 94

    A 60-year-old man with a history of angina pectoris is complaining of shoulder pain. Which of the following analgesics inversely affect his condition?

    Celecoxib

  • 95

    morphine and opioids cause which of the following:

    Increase pain threshold

  • 96

    A patient is in some sort of pain and he is allergic to diazepam. He needs analgesic. Which of the following he should take:

    Amitriptyline

  • 97

    Patient is taking morphine tablets 60mg every 12 hours and a breakthrough dose when needed.. Doctor switched the patient to Fentanyl patch.. What would be the dose:

    30 mcg every 12 hours

  • 98

    which of the following not used in treatment of acute pain.?

    naloxone

  • 99

    Patient with depression and have headache that do go away although he used a lot of analgesics. What contributes to his headache? Patient with depression and have headache that do go away although he used a lot of analgesics. What contributes to his headache?

    Headache is due to misuse of analgesics

  • 100

    A 75-year-old obese man has been recently diagnosed with osteoarthritis of the knee. He has tried non- pharmacological measures such as weight loss and various aids to improve symptoms, but he still has pain in the knee while walking. What would be the best initial treatment

    Topical NSAIDs