chapter 6.3 part 2

chapter 6.3 part 2
10問 • 1年前
  • Ishil Arsalan
  • 通報

    問題一覧

  • 1

    Where were many of the negative cell-cycle regulatory proteins discovered?

    In cells that had become cancerous

  • 2

    What do tumor suppressor genes code for?

    Negative regulator proteins

  • 3

    What happens when the negative regulator proteins encoded by tumor suppressor genes are activated?

    The cell cycle is halted until certain events are completed

  • 4

    What is the collective function of the best-understood tumor suppressor gene proteins, such as RB1, p53, and p21?

    To put up a roadblock to cell-cycle progress until certain events are completed

  • 5

    What might happen to a cell that carries a mutated form of a negative regulator?

    The cell might not be able to halt the cell cycle if there is a problem

  • 6

    What percentage of human tumor cells have been found to have mutated p53 genes?

    More than half

  • 7

    Why is it not surprising that mutated p53 genes are common in human tumor cells?

    Because p53 plays multiple roles at the G1 checkpoint

  • 8

    What are some of the roles that the p53 protein plays at the G1 checkpoint?

    Activating genes whose products halt the cell cycle, participate in DNA repair, or initiate cell death

  • 9

    What can happen when a p53 gene is damaged?

    The cell behaves as if there are no mutations

  • 10

    What is a consequence of a damaged p53 gene in cancer cells?

    The damaged version of p53 cannot trigger cell death

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    問題一覧

  • 1

    Where were many of the negative cell-cycle regulatory proteins discovered?

    In cells that had become cancerous

  • 2

    What do tumor suppressor genes code for?

    Negative regulator proteins

  • 3

    What happens when the negative regulator proteins encoded by tumor suppressor genes are activated?

    The cell cycle is halted until certain events are completed

  • 4

    What is the collective function of the best-understood tumor suppressor gene proteins, such as RB1, p53, and p21?

    To put up a roadblock to cell-cycle progress until certain events are completed

  • 5

    What might happen to a cell that carries a mutated form of a negative regulator?

    The cell might not be able to halt the cell cycle if there is a problem

  • 6

    What percentage of human tumor cells have been found to have mutated p53 genes?

    More than half

  • 7

    Why is it not surprising that mutated p53 genes are common in human tumor cells?

    Because p53 plays multiple roles at the G1 checkpoint

  • 8

    What are some of the roles that the p53 protein plays at the G1 checkpoint?

    Activating genes whose products halt the cell cycle, participate in DNA repair, or initiate cell death

  • 9

    What can happen when a p53 gene is damaged?

    The cell behaves as if there are no mutations

  • 10

    What is a consequence of a damaged p53 gene in cancer cells?

    The damaged version of p53 cannot trigger cell death