HEMATOPOIESIS
問題一覧
1
The process of blood cell production, differentiation and development
Hematopoiesis
2
The most common versatile, they can develop unto any human cell. type.
Totipotential stem cell
3
These are the cells that are present several days after fertilization. Can develop into any cell type except fetus.
Pluripotential stem cell
4
Are derived from femoral pluripotential stem cell, they can be found in adult but limites into specific type of cell for tissues example are the bone marrow stem cells
Multipotential stem cell
5
Site of primitive hematopoiesis.
Form during first 2 to 8 weeks of life
Yolk Sac (Mesoblastic)
6
Begins 5-7 gestational weeks of 6 weeks
Major hematopoietic organ of early and midfetal life.
Liver ( Hepathic Phase)
7
Begins 4th month of gestation
Found within the cavities of all bones and may present in 2 forms
Bone Marrow ( Medullary Phase)
8
Normally inactive and composed mostly of adipose tissue
Yellow Marrow
9
Broad, fat cells that form a single continuous layer along the inner surface of the arteries, veins and vascular sinuses
Endothelial Cells
10
Are large cells w/ single fat vacuole
Play a role in regulating the volume of the marrow in which active hematopoiesis occurs
Adipocytes
11
Function in phagocytosis and both macrophages and lymphoncytes secrete various cytokines that regulate hematopoiesis
Macrophages
12
Bone-forming cells
Osteoblasts
13
Bone-resorbing cells
Osteoclasts
14
Nucleated precursors in the bone marrow called
erythroblast
15
Developing nucleated cells with normal appearance can be called
normoblasts
16
Can be recognized as maturational unit.
Maturing cells spend an average of 3 to 6 days in the proliferating pool. Liffe span of 6 to 10 hrs in circulation
Granulopoiesis
17
occurs in distant anatomical sites called erythropoietic islands, specialized niches in which erythroid precursors proliferate, differentiate and enucleate
Erythropoiesis
18
Takes place adjacent to the sinus endothelium, develop into platelets in approximately 5 days
Megakaryopoiesis
19
used as signaling molecules in many cells of the body
Interleukins
20
Largest of the erythroid precursors. (The mother cell)
Rubriblast
21
“Dawn of hemoglobinization” Last stage capable of mitosis
Rubricyte
22
Nucleated RBC
MITOSIS NO LONGER POSSIBLE
Metarubricyte
23
Called reticulocytes when stained witha. vital stain.
No nucleus
Polychromatic Erythrocyte
24
N:C ration: 4-1
Chromatin: Fine and dark staining
Nucleoli: 1-2
CYTOPLASM: heterogeneous
dark blue
no granules
Pronormoblast/ Rubriblast
25
N:C ratio: 4:1
Chromatin: Partially clumped
Nucleoli: Absent
Cytoplasm:
deeply Basophilic
No granules
Prorubricytes/ Basophilic Normoblasts
26
N: C: 1:1
Chromatin: Increasingly clumped
Nucleoli: absent
Cytoplasm:
Mixtures of red staining of hemoglobin with the blue RNA in varying shades of gray.
Rubricyte/ Polychromatic Normoblast
27
N:C ratio: ???
low chromatin: pyknotic
Nucleoli: Absent
Cytoplasm:
Acidophilix( reddish pink) cytoplasm
salmon pink color
metarubricyte/ orthochromic normoblast
28
earliest recognizable cell in series
promomonocyte
29
Most immature cell
2-6 nuclei
overlapping nuclear lobes and small amount of basophilic cytoplasm
Megakaryoblast
30
A large cell of 80 um w dense alpha and lysosomal granules
Nuclear lobularity first becomes apparent as an indentation
Promegakaryocyte
31
Largest bone marrow cells
N:C ratio:1:12
multilobular nit multinucleated
Megakaryocyte
32
“Dawn of neutrophilia”
Last stage capable of cell division
Myelocyte
33
Production of azurophilic granules
Promyelocyte
34
Synthesis of tertiary granules
Metamyelocyte
35
can appear at the myelocytic stages and move through the maturation sequence
Eosinophil
36
can appear at the myelocytic dtages and move through the maturation sequence.
SHAPE: COARSE, clumped bilobed
Basophil
37
No nucleus
light blue, with evenly dispersed fine red -purple granules
life span of 7-10days
formed by proplstelet process
Platelets
問題一覧
1
The process of blood cell production, differentiation and development
Hematopoiesis
2
The most common versatile, they can develop unto any human cell. type.
Totipotential stem cell
3
These are the cells that are present several days after fertilization. Can develop into any cell type except fetus.
Pluripotential stem cell
4
Are derived from femoral pluripotential stem cell, they can be found in adult but limites into specific type of cell for tissues example are the bone marrow stem cells
Multipotential stem cell
5
Site of primitive hematopoiesis.
Form during first 2 to 8 weeks of life
Yolk Sac (Mesoblastic)
6
Begins 5-7 gestational weeks of 6 weeks
Major hematopoietic organ of early and midfetal life.
Liver ( Hepathic Phase)
7
Begins 4th month of gestation
Found within the cavities of all bones and may present in 2 forms
Bone Marrow ( Medullary Phase)
8
Normally inactive and composed mostly of adipose tissue
Yellow Marrow
9
Broad, fat cells that form a single continuous layer along the inner surface of the arteries, veins and vascular sinuses
Endothelial Cells
10
Are large cells w/ single fat vacuole
Play a role in regulating the volume of the marrow in which active hematopoiesis occurs
Adipocytes
11
Function in phagocytosis and both macrophages and lymphoncytes secrete various cytokines that regulate hematopoiesis
Macrophages
12
Bone-forming cells
Osteoblasts
13
Bone-resorbing cells
Osteoclasts
14
Nucleated precursors in the bone marrow called
erythroblast
15
Developing nucleated cells with normal appearance can be called
normoblasts
16
Can be recognized as maturational unit.
Maturing cells spend an average of 3 to 6 days in the proliferating pool. Liffe span of 6 to 10 hrs in circulation
Granulopoiesis
17
occurs in distant anatomical sites called erythropoietic islands, specialized niches in which erythroid precursors proliferate, differentiate and enucleate
Erythropoiesis
18
Takes place adjacent to the sinus endothelium, develop into platelets in approximately 5 days
Megakaryopoiesis
19
used as signaling molecules in many cells of the body
Interleukins
20
Largest of the erythroid precursors. (The mother cell)
Rubriblast
21
“Dawn of hemoglobinization” Last stage capable of mitosis
Rubricyte
22
Nucleated RBC
MITOSIS NO LONGER POSSIBLE
Metarubricyte
23
Called reticulocytes when stained witha. vital stain.
No nucleus
Polychromatic Erythrocyte
24
N:C ration: 4-1
Chromatin: Fine and dark staining
Nucleoli: 1-2
CYTOPLASM: heterogeneous
dark blue
no granules
Pronormoblast/ Rubriblast
25
N:C ratio: 4:1
Chromatin: Partially clumped
Nucleoli: Absent
Cytoplasm:
deeply Basophilic
No granules
Prorubricytes/ Basophilic Normoblasts
26
N: C: 1:1
Chromatin: Increasingly clumped
Nucleoli: absent
Cytoplasm:
Mixtures of red staining of hemoglobin with the blue RNA in varying shades of gray.
Rubricyte/ Polychromatic Normoblast
27
N:C ratio: ???
low chromatin: pyknotic
Nucleoli: Absent
Cytoplasm:
Acidophilix( reddish pink) cytoplasm
salmon pink color
metarubricyte/ orthochromic normoblast
28
earliest recognizable cell in series
promomonocyte
29
Most immature cell
2-6 nuclei
overlapping nuclear lobes and small amount of basophilic cytoplasm
Megakaryoblast
30
A large cell of 80 um w dense alpha and lysosomal granules
Nuclear lobularity first becomes apparent as an indentation
Promegakaryocyte
31
Largest bone marrow cells
N:C ratio:1:12
multilobular nit multinucleated
Megakaryocyte
32
“Dawn of neutrophilia”
Last stage capable of cell division
Myelocyte
33
Production of azurophilic granules
Promyelocyte
34
Synthesis of tertiary granules
Metamyelocyte
35
can appear at the myelocytic stages and move through the maturation sequence
Eosinophil
36
can appear at the myelocytic dtages and move through the maturation sequence.
SHAPE: COARSE, clumped bilobed
Basophil
37
No nucleus
light blue, with evenly dispersed fine red -purple granules
life span of 7-10days
formed by proplstelet process
Platelets