1. The activation of PlAsminogen to PlAsmin resulting in the degradation of fibrin occurs by:

2. A patient presents with the following results:

3. A patient with polycythemia vera who is treated by phlebotomy is most likely to develop a deficiency of:

4. The calculated erythrocyte indices on an adult man are MCV = 89fL, MCH = 29pg and MCHC = 38%. The calculations have been rechecked; erythrocytes on the PBS appear normocytic and normochromic with no abnormal forms. The next step is to:

5. Aspirin affects platelet function by interfering with platelet's metabolism of:

6. The ff results were obtained on an electronic particle counter:What action should be taken to obtain accurate results?

7.A px that has lupus anticoagulant may bleed due to:

8. Which of the ff is the standard calibration method for hematology instrumentation against which other methods must be verified?

9. W/c of the ff platelet reponses is most likely asso. with type IIb vWD?

10. A 53year old man was in recovery following a triple bypass operation. Oozing was noted from his surgical wound. The ff laboratory data were obtained: The most likely cause of bleeding would be:

11.To distinguish between hemophilia & vWD,a px w/ von Willebrand will present w/ w/c of the ff test results?

12. A patient presents with a factor VIII level of 2%. The vWF activity (ristocentin cofactor) is <1% with a vWF antigen of 3%. The most likely diagnosis is:

13. Alloantibodies are found in:

14. The BM in the terminal stage of erythroLeukeMiA is often indistinguishable from that seen in:

15. Which of the following have a B cell origin?

16.W/c of the ff is characteristic of Hodgkin lymphoma?

17. The mechanism causing catecholamine-induced neutrophilia includes:

18.W/c of the ff can affect the PFA-100 closure time?

19.A BM shows foam cells ranging from 20-100um in size, vacuolated cytoplasm containing sphingomyelin & is faintly PAS+. This cell type is most characteristic of:

20. The ff CBC results were obtained from automated hematology analyzer on a px spx with lipemic plasma: WBC=7.2 X 103/uL Hgb=13.8 g/dL RBC=3.5 X 106/uL Hct=33.5% MCV= 92 fL MCH= 39.4 pg. MCHC= 41.0% Which of the ff tests would probably be in error?

21. Which of the following tumors are associated with erythrocytosis due to excessive erythropoietin prodn?

22. Which of the ff cells is most likely identified in lesions of mycosis fungoides?

23. A px presents w/ a ↓ protein S activity & ↓ total & free protein S ag. The C4b binding protein is normal. This is classified as:

24. W/c of the ff translocations is most commonly asso with Burkitt lymphoma?

25. A plt aggregation tracing appears to confirm the diagnosis of Glanzmann thrombasthenia in a px presenting w/ a plt disorder. How would these tracings look if they were performed using light transmittance optical density aggregation

26. How do ticlopidine and clopidogrel inhibits plt?

27.The dse state that presents w/ quantitative plt disorder is:

28. vWF serves as a stabilizer for:

29. The characteristic erythrocyte found in pernicious anemia is:

30. The hypoproliferative red cell population in the bone marrow of uremic patients is caused by:

31. The leukemic phase of T cell lymphoma is marked by the following cellular abnormality:

32.what class of disorders does Fanconi anemia belong?

33. A 20yo F w/ sickle cell anemia whose usual hgb concentration is 8g/dL develops fever, ↑ weakness & malaise. The hgb concentration is 4g/dL & retic count is 0.1%. The most likely explanation (2 answers)

34 The platelet disorder in which the abnormality is due to a defect in platelet aggregation is:

⭐️35.The ff results were obtained on an automated hematology analyzer: WBC= 6.5 x 103/uL Hgb= 18.0g/dL RBC= 4.55 X 106/uL Hct= 41.5% MCV= 90.1fl MCH= 39.6pg MCHC= 43.4% The first step in obtaining valid results is to:

36. The most common coagulation factor in which a specific inhibitor can form is:

37. In an electronic or laser particle cell counter, clumped plts may interfere w/ w/c of the ff parameters?

38. In secondary hemostasis, coagn proteins become activated to form fibrin clot. Prior to these proteins being activated, their inactive proenzymes are known as:

39. Heparin induced thrombocytopenia is an immune-mediated complication asso w/ heparin therapy. Ab are produced against:

40. A new oral anticoagulant apiXaban has been given to a px who was previously on warfarin. This drug directly inhibits:

41. The ff are compounds formed in the synthesis of heme: 1 coproporphyrinogen 3 uroporphyrinogen 2 porphobilinogen 4 protoporphyrinogen Which of the ff responses list these compounds in the order in w/c they are formed

42. A 48yo male is screened pre-operatively. He has a (+) family history for bleeding. The px is of Ashkenazi Jewish descent. His results are as follows: Based on this history and the results of these tests, this patient's most likely diagnosis is a deficiency in factor:

43. 20yo african-american man has peripheral blood suggesting thalassemia minor. quantitative hgbA2 (N) , but the hgbF 5%( N <2%). This is most consistent w/:

44. Whole blood evaluation of blood clotting can be performed by using thromboelastography. This methodology looks at:

45. When there is disparity between the results of fibrinogen ag & the activity,the most likely diagnosis is:

46. The anticoagulant that is best directed against plts

47. Which of the ff is asso with mycosis fungoides?

48.W/c of the ff test results are consistent with PNH?

49. W/c of the ff tests provides an appropriate lab confirmation of immune-mediated heparin-induced thrombocytopenia?

50. Which of the following types of vWD should not be treated with DDAVP?

51. Which of the ff genetic alterations is asso w/ a favorable prognosis in pre-B-ALL?

52. When using the turbidity method for detecting the presence of hgb S, an incorrect interpretation may be made when there is a(n):

53. W/c one of the ff hypochromic anemias is usually asso with a normal free erythrocyte protoporphyrin lvl?

54. Which of the ff is a true statement about megakaryocytes in a BM aspirate?

55. In TTP, a deficiency of ADAMTS 13 causes clotting because of:

56. Hemophilia B is a sex-linked recessive disorder that presents with a ↓ in factor:

57.propagation phase of INvivo coagln model includes

58. Only abnormal aPTT would be seen in ff disorder:

59. In polycythemia vera, platelet count is

60. W/c of the ff statements about Hgb D & G is true?

61. In the cell-based model of coagln the intrinsic pathway operates on the:

62.A px is placed on clopidogrel.The clinician wants to determine if the dose is sufficient to impair plt function.A plt aggregation test is ordered.The agonist w/c results in a ↓ pattern would be:

63. Biological assays for antithrombin are based on the inhibition of:

64. Which of the ff is characteristic of Hgb H?

65. W/c of the ff cell surface markers is asso w/ more aggressive subtype of CLL/SLL?

66.The anticoagulant that directly inhibits thrombin:

67. ADAMTS13 deficiency is responsible for thrombocytopenia found in:

68. The t(8:14) chromosomal translocation brings w/c of the ff 2genes in close proximity?

69. 2 common causes of acquired pure red cell aplasia

70. W/c subtype of von Willebrand disease is the most common?

71. A px who presents w/ renal impairment is being started on oral anticoagulant therapy. The DOAC that should be avoided would be:

72. A factor X assay has the ff results:

73. A deficiency of protein C is asso w/ w/c of the ff?

74. W/c of the ff BM findings favor the diagnosis of multiple myeloma?

75. What does the secondary wave of platelet aggregation seen with the biphasic low dose ADP and epinephrine response represent?

76. Hgb are read on a photoelectric colorimeter in the lab.While reading the hgb, a problem of drifting is encountered.To assess the problem,the 1st thing to do is:

77. A hypercellular marrow with an M:E ratio of 6:1 is most commonly due to:

78. A 60yo man has painful right knee and a slightly enlarged spleen. Hematology results include: Hgb= 15g/dL Plt ct= 900 x 103 /uL Morphology: normal red cell morphology & indices: slight↑ in bands rare metamyelocyte & myelocyte giant & bizarre-shaped plts. This is most compatible with:

79.In most cases of hereditary persistence of fetal hgb

80. A px develops unexpected bleeding & the ff test results were obtained:

81. A px with multimer pattern that has all bands present but in ↓ concentrations would be diagnosed /:

82. At least what percentage of prolymphocytes must be present for a diagnosis of prolymphocytic leukemia?

83. Px with chronic granulomatous disease suffer from frequent pyogenic infections due to the inability of:

A,B 84. A px presents w/ bleeding 48hrs after tooth extraction. Results are as follows: (2 answers) The cause of bleeding is most likely a deficiency in:

85. The direct antiglobulin test can help distinguish:

86. The principle of platelet aggregation is based on:

87. The hgb variant w/c is seen frequently in the South East Asian population, demonstrates a microcytic blood smear, and migrates with HgbC at pH 8.6 is:

88. This hemoglobinopathy results from a fusion product of the delta and beta gene:

89. Bleeding doesn't correlate well w/ factor levels in a deficiency of:

90. Which of the ff is most closely asso w/ idiopathic hemochromatosis?

91. Plt aggregation will occur w/ the end product of:

92. W/c of the ff characteristics are common to hereditary spherocytosis, hereditary elliptocytosis, hereditary stomatocytosis, & PNH?

93. Factors commonly involved in producing anemia in patients with chronic renal disease include:

94. Hereditary persistence of Fetal hgb is due to a loss of expression of this globin chain:

95. An orthopedic px who is on heparin has a plt count of 50 X 103/uL;his plt count the previous day was 120 X 303/uL.The px is tested for HIT & has a (+) result. The 1st step in the treatment of HIT is:

96. A px presents with a very low platelet count and is diagnosed with acute idiopathic thrombocytopenic purpura (ITP), which statement is asso with acute ITP.

97.APC resistance is confirmed by molecular test for

98.The anemia of chronic infection is characterize by:

99. Anemia secondary to uremia characteristically is:

100.W/c CLL/SLL marker is asso w/ poor prognosis?