hematology

100問 • 1年前

ユーザ名非公開

通報

問題一覧

1. The activation of PlAsminogen to PlAsmin resulting in the degradation of fibrin occurs by:

tPA

2. A patient presents with the following results:

dysfibrinogenemia

3. A patient with polycythemia vera who is treated by phlebotomy is most likely to develop a deficiency of:

iron

4. The calculated erythrocyte indices on an adult man are MCV = 89fL, MCH = 29pg and MCHC = 38%. The calculations have been rechecked; erythrocytes on the PBS appear normocytic and normochromic with no abnormal forms. The next step is to:

repeat hgb & hct

5. Aspirin affects platelet function by interfering with platelet's metabolism of:

cyclooxygenase

6. The ff results were obtained on an electronic particle counter:What action should be taken to obtain accurate results?

warm spx and recount

7.A px that has lupus anticoagulant may bleed due to:

ab to prothrombin

8. Which of the ff is the standard calibration method for hematology instrumentation against which other methods must be verified?

normal whole blood

9. W/c of the ff platelet reponses is most likely asso. with type IIb vWD?

↑ plt aggregation to ↓ dose ristocetin

10. A 53year old man was in recovery following a triple bypass operation. Oozing was noted from his surgical wound. The ff laboratory data were obtained: The most likely cause of bleeding would be:

dilutional thrombocytopenia

11.To distinguish between hemophilia & vWD,a px w/ von Willebrand will present w/ w/c of the ff test results?

result c

12. A patient presents with a factor VIII level of 2%. The vWF activity (ristocentin cofactor) is <1% with a vWF antigen of 3%. The most likely diagnosis is:

type III vWD

13. Alloantibodies are found in:

congenital hemophilia

14. The BM in the terminal stage of erythroLeukeMiA is often indistinguishable from that seen in:

AML

15. Which of the following have a B cell origin?

Waldenstrom macroglobulinemia

16.W/c of the ff is characteristic of Hodgkin lymphoma?

bimodal age distribution

17. The mechanism causing catecholamine-induced neutrophilia includes:

a shift in granulocytes from the marginating pool to the circulating pool

18.W/c of the ff can affect the PFA-100 closure time?

AOTA

19.A BM shows foam cells ranging from 20-100um in size, vacuolated cytoplasm containing sphingomyelin & is faintly PAS+. This cell type is most characteristic of:

Niemann-Pick dse

20. The ff CBC results were obtained from automated hematology analyzer on a px spx with lipemic plasma: WBC=7.2 X 103/uL Hgb=13.8 g/dL RBC=3.5 X 106/uL Hct=33.5% MCV= 92 fL MCH= 39.4 pg. MCHC= 41.0% Which of the ff tests would probably be in error?

Hgb MCH MCHC

21. Which of the following tumors are associated with erythrocytosis due to excessive erythropoietin prodn?

renal cell carcinoma

22. Which of the ff cells is most likely identified in lesions of mycosis fungoides?

T lymphocytes

23. A px presents w/ a ↓ protein S activity & ↓ total & free protein S ag. The C4b binding protein is normal. This is classified as:

type I

24. W/c of the ff translocations is most commonly asso with Burkitt lymphoma?

t(8;14)

25. A plt aggregation tracing appears to confirm the diagnosis of Glanzmann thrombasthenia in a px presenting w/ a plt disorder. How would these tracings look if they were performed using light transmittance optical density aggregation

markedly↓ aggregation

26. How do ticlopidine and clopidogrel inhibits plt?

ADP mediated plt aggregation

27.The dse state that presents w/ quantitative plt disorder is:

May-Hegglin anomaly

28. vWF serves as a stabilizer for:

factor VIII

29. The characteristic erythrocyte found in pernicious anemia is:

macrocytic

30. The hypoproliferative red cell population in the bone marrow of uremic patients is caused by:

↓ levels of circulating erythropoietin

31. The leukemic phase of T cell lymphoma is marked by the following cellular abnormality:

Sezary cell

32.what class of disorders does Fanconi anemia belong?

hypoproliferative

33. A 20yo F w/ sickle cell anemia whose usual hgb concentration is 8g/dL develops fever, ↑ weakness & malaise. The hgb concentration is 4g/dL & retic count is 0.1%. The most likely explanation (2 answers)

↑hemolysis due to hypersplenism & aplastic crisis

34 The platelet disorder in which the abnormality is due to a defect in platelet aggregation is:

Glanzmann thrombasthenia

⭐️35.The ff results were obtained on an automated hematology analyzer: WBC= 6.5 x 103/uL Hgb= 18.0g/dL RBC= 4.55 X 106/uL Hct= 41.5% MCV= 90.1fl MCH= 39.6pg MCHC= 43.4% The first step in obtaining valid results is to:

correct the hgb for lipemia

36. The most common coagulation factor in which a specific inhibitor can form is:

factor VIII

37. In an electronic or laser particle cell counter, clumped plts may interfere w/ w/c of the ff parameters?

WBC

38. In secondary hemostasis, coagn proteins become activated to form fibrin clot. Prior to these proteins being activated, their inactive proenzymes are known as:

zymogens

39. Heparin induced thrombocytopenia is an immune-mediated complication asso w/ heparin therapy. Ab are produced against:

PF4

40. A new oral anticoagulant apiXaban has been given to a px who was previously on warfarin. This drug directly inhibits:

factor Xa

41. The ff are compounds formed in the synthesis of heme: 1 coproporphyrinogen 3 uroporphyrinogen 2 porphobilinogen 4 protoporphyrinogen Which of the ff responses list these compounds in the order in w/c they are formed

2, 3, 1,4

42. A 48yo male is screened pre-operatively. He has a (+) family history for bleeding. The px is of Ashkenazi Jewish descent. His results are as follows: Based on this history and the results of these tests, this patient's most likely diagnosis is a deficiency in factor:

43. 20yo african-american man has peripheral blood suggesting thalassemia minor. quantitative hgbA2 (N) , but the hgbF 5%( N <2%). This is most consistent w/:

delta-β thalassemia minor

44. Whole blood evaluation of blood clotting can be performed by using thromboelastography. This methodology looks at:

AOTA

45. When there is disparity between the results of fibrinogen ag & the activity,the most likely diagnosis is:

dysfibrinogenemia

46. The anticoagulant that is best directed against plts

tirofiban

47. Which of the ff is asso with mycosis fungoides?

Sezary cells

48.W/c of the ff test results are consistent with PNH?

diminished CD55 on hematopoietic cells

49. W/c of the ff tests provides an appropriate lab confirmation of immune-mediated heparin-induced thrombocytopenia?

serotonin release assay

50. Which of the following types of vWD should not be treated with DDAVP?

type 2B

51. Which of the ff genetic alterations is asso w/ a favorable prognosis in pre-B-ALL?

t(12;21)

52. When using the turbidity method for detecting the presence of hgb S, an incorrect interpretation may be made when there is a(n):

↓ hct

53. W/c one of the ff hypochromic anemias is usually asso with a normal free erythrocyte protoporphyrin lvl?

thalassemia minor

54. Which of the ff is a true statement about megakaryocytes in a BM aspirate?

an average of 2-10 should be found in each LPO

55. In TTP, a deficiency of ADAMTS 13 causes clotting because of:

inability to cleave ULVWM

56. Hemophilia B is a sex-linked recessive disorder that presents with a ↓ in factor:

57.propagation phase of INvivo coagln model includes

final burst of thrombin

58. Only abnormal aPTT would be seen in ff disorder:

anti-factor 8 ab

59. In polycythemia vera, platelet count is

elevated

60. W/c of the ff statements about Hgb D & G is true?

they are clinically abnormal

61. In the cell-based model of coagln the intrinsic pathway operates on the:

activated plt surface to produce the burst of thrombin

62.A px is placed on clopidogrel.The clinician wants to determine if the dose is sufficient to impair plt function.A plt aggregation test is ordered.The agonist w/c results in a ↓ pattern would be:

adenosine diphosphate

63. Biological assays for antithrombin are based on the inhibition of:

serine proteases

64. Which of the ff is characteristic of Hgb H?

it has a lower oxygen affinity than Hgb A

65. W/c of the ff cell surface markers is asso w/ more aggressive subtype of CLL/SLL?

CD38

66.The anticoagulant that directly inhibits thrombin:

argatroban

67. ADAMTS13 deficiency is responsible for thrombocytopenia found in:

ITP

68. The t(8:14) chromosomal translocation brings w/c of the ff 2genes in close proximity?

c-myc & the immunoglobulin heavy chain

69. 2 common causes of acquired pure red cell aplasia

thymoma & parvovirus infection

70. W/c subtype of von Willebrand disease is the most common?

type 1

71. A px who presents w/ renal impairment is being started on oral anticoagulant therapy. The DOAC that should be avoided would be:

dabigatran

72. A factor X assay has the ff results:

inhibitor

73. A deficiency of protein C is asso w/ w/c of the ff?

↑risk of thrombosis

74. W/c of the ff BM findings favor the diagnosis of multiple myeloma?

sheaths of immature plasma cells

75. What does the secondary wave of platelet aggregation seen with the biphasic low dose ADP and epinephrine response represent?

release of plt ganules

76. Hgb are read on a photoelectric colorimeter in the lab.While reading the hgb, a problem of drifting is encountered.To assess the problem,the 1st thing to do is:

check the light source

77. A hypercellular marrow with an M:E ratio of 6:1 is most commonly due to:

granulocytic hyperplasia

78. A 60yo man has painful right knee and a slightly enlarged spleen. Hematology results include: Hgb= 15g/dL Plt ct= 900 x 103 /uL Morphology: normal red cell morphology & indices: slight↑ in bands rare metamyelocyte & myelocyte giant & bizarre-shaped plts. This is most compatible with:

idiopathic thrombocythemia

79.In most cases of hereditary persistence of fetal hgb

gamma chain prodn equals a chain prodn

80. A px develops unexpected bleeding & the ff test results were obtained:

DIC

81. A px with multimer pattern that has all bands present but in ↓ concentrations would be diagnosed /:

type1-vWD

82. At least what percentage of prolymphocytes must be present for a diagnosis of prolymphocytic leukemia?

>55%

83. Px with chronic granulomatous disease suffer from frequent pyogenic infections due to the inability of:

neutrophils to kill phagocytized bacteria

A,B 84. A px presents w/ bleeding 48hrs after tooth extraction. Results are as follows: (2 answers) The cause of bleeding is most likely a deficiency in:

Plasminogen & factor13

85. The direct antiglobulin test can help distinguish:

inherited from acquired spherocytosis

86. The principle of platelet aggregation is based on:

↑ light transmission

87. The hgb variant w/c is seen frequently in the South East Asian population, demonstrates a microcytic blood smear, and migrates with HgbC at pH 8.6 is:

HgbE

88. This hemoglobinopathy results from a fusion product of the delta and beta gene:

Hgb Lepore

89. Bleeding doesn't correlate well w/ factor levels in a deficiency of:

F11

90. Which of the ff is most closely asso w/ idiopathic hemochromatosis?

iron overload in tissue

91. Plt aggregation will occur w/ the end product of:

thromboxane A2

92. W/c of the ff characteristics are common to hereditary spherocytosis, hereditary elliptocytosis, hereditary stomatocytosis, & PNH?

Red cell membrane defects

93. Factors commonly involved in producing anemia in patients with chronic renal disease include:

inadequate erythropoiesis

94. Hereditary persistence of Fetal hgb is due to a loss of expression of this globin chain:

gamma

95. An orthopedic px who is on heparin has a plt count of 50 X 103/uL;his plt count the previous day was 120 X 303/uL.The px is tested for HIT & has a (+) result. The 1st step in the treatment of HIT is:

stop heparin

96. A px presents with a very low platelet count and is diagnosed with acute idiopathic thrombocytopenic purpura (ITP), which statement is asso with acute ITP.

spontaneous remission usually occurs w/in several wks

97.APC resistance is confirmed by molecular test for

FVL

98.The anemia of chronic infection is characterize by:

↓ serum iron levels

99. Anemia secondary to uremia characteristically is:

normo, normo

100

100.W/c CLL/SLL marker is asso w/ poor prognosis?

ZAP-70

clinical microscopy

clinical microscopy

clinical chemistry

clinical chemistry

immunology & serology

ユーザ名非公開 · 99問 · 1年前

immunology & serology

Bloodbank 1

Bloodbank 1

microbiology

microbiology

molecular biology

molecular biology

ASCPi SIMULATED EXAM1

ユーザ名非公開 · 99問 · 1年前

ASCPi SIMULATED EXAM1

99問 • 1年前

ユーザ名非公開

ASCPi STIMULATED EXAM 2

ユーザ名非公開 · 98問 · 1年前

ASCPi STIMULATED EXAM 2

98問 • 1年前

ユーザ名非公開

ASCPi Diagnostic Exam

ユーザ名非公開 · 100問 · 1年前

ASCPi Diagnostic Exam

FINAL COACHING 1

FINAL COACHING 1

FINAL COACHING ASCPI 2

ユーザ名非公開 · 100問 · 1年前

FINAL COACHING ASCPI 2

100問 • 1年前

ユーザ名非公開

ASCPi FINAL COACHING 3

ユーザ名非公開 · 3回閲覧 · 100問 · 1年前

ASCPi FINAL COACHING 3

3回閲覧 • 100問 • 1年前

ユーザ名非公開

cerebro students recalls

ユーザ名非公開 · 100問 · 11ヶ月前

cerebro students recalls

100問 • 11ヶ月前

ユーザ名非公開

cerebro students recalls 2

ユーザ名非公開 · 100問 · 11ヶ月前

cerebro students recalls 2

100問 • 11ヶ月前

ユーザ名非公開

問題一覧

1. The activation of PlAsminogen to PlAsmin resulting in the degradation of fibrin occurs by:

tPA

2. A patient presents with the following results:

dysfibrinogenemia

3. A patient with polycythemia vera who is treated by phlebotomy is most likely to develop a deficiency of:

iron

repeat hgb & hct

5. Aspirin affects platelet function by interfering with platelet's metabolism of:

cyclooxygenase

6. The ff results were obtained on an electronic particle counter:What action should be taken to obtain accurate results?

warm spx and recount

7.A px that has lupus anticoagulant may bleed due to:

ab to prothrombin

8. Which of the ff is the standard calibration method for hematology instrumentation against which other methods must be verified?

normal whole blood

9. W/c of the ff platelet reponses is most likely asso. with type IIb vWD?

↑ plt aggregation to ↓ dose ristocetin

10. A 53year old man was in recovery following a triple bypass operation. Oozing was noted from his surgical wound. The ff laboratory data were obtained: The most likely cause of bleeding would be:

dilutional thrombocytopenia

11.To distinguish between hemophilia & vWD,a px w/ von Willebrand will present w/ w/c of the ff test results?

result c

12. A patient presents with a factor VIII level of 2%. The vWF activity (ristocentin cofactor) is <1% with a vWF antigen of 3%. The most likely diagnosis is:

type III vWD

13. Alloantibodies are found in:

congenital hemophilia

14. The BM in the terminal stage of erythroLeukeMiA is often indistinguishable from that seen in:

AML

15. Which of the following have a B cell origin?

Waldenstrom macroglobulinemia

16.W/c of the ff is characteristic of Hodgkin lymphoma?

bimodal age distribution

17. The mechanism causing catecholamine-induced neutrophilia includes:

a shift in granulocytes from the marginating pool to the circulating pool

18.W/c of the ff can affect the PFA-100 closure time?

AOTA

19.A BM shows foam cells ranging from 20-100um in size, vacuolated cytoplasm containing sphingomyelin & is faintly PAS+. This cell type is most characteristic of:

Niemann-Pick dse

Hgb MCH MCHC

21. Which of the following tumors are associated with erythrocytosis due to excessive erythropoietin prodn?

renal cell carcinoma

22. Which of the ff cells is most likely identified in lesions of mycosis fungoides?

T lymphocytes

23. A px presents w/ a ↓ protein S activity & ↓ total & free protein S ag. The C4b binding protein is normal. This is classified as:

type I

24. W/c of the ff translocations is most commonly asso with Burkitt lymphoma?

t(8;14)

markedly↓ aggregation

26. How do ticlopidine and clopidogrel inhibits plt?

ADP mediated plt aggregation

27.The dse state that presents w/ quantitative plt disorder is:

May-Hegglin anomaly

28. vWF serves as a stabilizer for:

factor VIII

29. The characteristic erythrocyte found in pernicious anemia is:

macrocytic

30. The hypoproliferative red cell population in the bone marrow of uremic patients is caused by:

↓ levels of circulating erythropoietin

31. The leukemic phase of T cell lymphoma is marked by the following cellular abnormality:

Sezary cell

32.what class of disorders does Fanconi anemia belong?

hypoproliferative

↑hemolysis due to hypersplenism & aplastic crisis

34 The platelet disorder in which the abnormality is due to a defect in platelet aggregation is:

Glanzmann thrombasthenia

correct the hgb for lipemia

36. The most common coagulation factor in which a specific inhibitor can form is:

factor VIII

37. In an electronic or laser particle cell counter, clumped plts may interfere w/ w/c of the ff parameters?

WBC

38. In secondary hemostasis, coagn proteins become activated to form fibrin clot. Prior to these proteins being activated, their inactive proenzymes are known as:

zymogens

39. Heparin induced thrombocytopenia is an immune-mediated complication asso w/ heparin therapy. Ab are produced against:

PF4

40. A new oral anticoagulant apiXaban has been given to a px who was previously on warfarin. This drug directly inhibits:

factor Xa

2, 3, 1,4

43. 20yo african-american man has peripheral blood suggesting thalassemia minor. quantitative hgbA2 (N) , but the hgbF 5%( N <2%). This is most consistent w/:

delta-β thalassemia minor

44. Whole blood evaluation of blood clotting can be performed by using thromboelastography. This methodology looks at:

AOTA

45. When there is disparity between the results of fibrinogen ag & the activity,the most likely diagnosis is:

dysfibrinogenemia

46. The anticoagulant that is best directed against plts

tirofiban

47. Which of the ff is asso with mycosis fungoides?

Sezary cells

48.W/c of the ff test results are consistent with PNH?

diminished CD55 on hematopoietic cells

49. W/c of the ff tests provides an appropriate lab confirmation of immune-mediated heparin-induced thrombocytopenia?

serotonin release assay

50. Which of the following types of vWD should not be treated with DDAVP?

type 2B

51. Which of the ff genetic alterations is asso w/ a favorable prognosis in pre-B-ALL?

t(12;21)

52. When using the turbidity method for detecting the presence of hgb S, an incorrect interpretation may be made when there is a(n):

↓ hct

53. W/c one of the ff hypochromic anemias is usually asso with a normal free erythrocyte protoporphyrin lvl?

thalassemia minor

54. Which of the ff is a true statement about megakaryocytes in a BM aspirate?

an average of 2-10 should be found in each LPO

55. In TTP, a deficiency of ADAMTS 13 causes clotting because of:

inability to cleave ULVWM

56. Hemophilia B is a sex-linked recessive disorder that presents with a ↓ in factor:

57.propagation phase of INvivo coagln model includes

final burst of thrombin

58. Only abnormal aPTT would be seen in ff disorder:

anti-factor 8 ab

59. In polycythemia vera, platelet count is

elevated

60. W/c of the ff statements about Hgb D & G is true?

they are clinically abnormal

61. In the cell-based model of coagln the intrinsic pathway operates on the:

activated plt surface to produce the burst of thrombin

62.A px is placed on clopidogrel.The clinician wants to determine if the dose is sufficient to impair plt function.A plt aggregation test is ordered.The agonist w/c results in a ↓ pattern would be:

adenosine diphosphate

63. Biological assays for antithrombin are based on the inhibition of:

serine proteases

64. Which of the ff is characteristic of Hgb H?

it has a lower oxygen affinity than Hgb A

65. W/c of the ff cell surface markers is asso w/ more aggressive subtype of CLL/SLL?

CD38

66.The anticoagulant that directly inhibits thrombin:

argatroban

67. ADAMTS13 deficiency is responsible for thrombocytopenia found in:

ITP

68. The t(8:14) chromosomal translocation brings w/c of the ff 2genes in close proximity?

c-myc & the immunoglobulin heavy chain

69. 2 common causes of acquired pure red cell aplasia

thymoma & parvovirus infection

70. W/c subtype of von Willebrand disease is the most common?

type 1

71. A px who presents w/ renal impairment is being started on oral anticoagulant therapy. The DOAC that should be avoided would be:

dabigatran

72. A factor X assay has the ff results:

inhibitor

73. A deficiency of protein C is asso w/ w/c of the ff?

↑risk of thrombosis

74. W/c of the ff BM findings favor the diagnosis of multiple myeloma?

sheaths of immature plasma cells

75. What does the secondary wave of platelet aggregation seen with the biphasic low dose ADP and epinephrine response represent?

release of plt ganules

76. Hgb are read on a photoelectric colorimeter in the lab.While reading the hgb, a problem of drifting is encountered.To assess the problem,the 1st thing to do is:

check the light source

77. A hypercellular marrow with an M:E ratio of 6:1 is most commonly due to:

granulocytic hyperplasia

idiopathic thrombocythemia

79.In most cases of hereditary persistence of fetal hgb

gamma chain prodn equals a chain prodn

80. A px develops unexpected bleeding & the ff test results were obtained:

DIC

81. A px with multimer pattern that has all bands present but in ↓ concentrations would be diagnosed /:

type1-vWD

82. At least what percentage of prolymphocytes must be present for a diagnosis of prolymphocytic leukemia?

>55%

83. Px with chronic granulomatous disease suffer from frequent pyogenic infections due to the inability of:

neutrophils to kill phagocytized bacteria

A,B 84. A px presents w/ bleeding 48hrs after tooth extraction. Results are as follows: (2 answers) The cause of bleeding is most likely a deficiency in:

Plasminogen & factor13

85. The direct antiglobulin test can help distinguish:

inherited from acquired spherocytosis

86. The principle of platelet aggregation is based on:

↑ light transmission

87. The hgb variant w/c is seen frequently in the South East Asian population, demonstrates a microcytic blood smear, and migrates with HgbC at pH 8.6 is:

HgbE

88. This hemoglobinopathy results from a fusion product of the delta and beta gene:

Hgb Lepore

89. Bleeding doesn't correlate well w/ factor levels in a deficiency of:

F11

90. Which of the ff is most closely asso w/ idiopathic hemochromatosis?

iron overload in tissue

91. Plt aggregation will occur w/ the end product of:

thromboxane A2

92. W/c of the ff characteristics are common to hereditary spherocytosis, hereditary elliptocytosis, hereditary stomatocytosis, & PNH?

Red cell membrane defects

93. Factors commonly involved in producing anemia in patients with chronic renal disease include:

inadequate erythropoiesis

94. Hereditary persistence of Fetal hgb is due to a loss of expression of this globin chain:

gamma

stop heparin

96. A px presents with a very low platelet count and is diagnosed with acute idiopathic thrombocytopenic purpura (ITP), which statement is asso with acute ITP.

spontaneous remission usually occurs w/in several wks

97.APC resistance is confirmed by molecular test for

FVL

98.The anemia of chronic infection is characterize by:

↓ serum iron levels

99. Anemia secondary to uremia characteristically is:

normo, normo

100

100.W/c CLL/SLL marker is asso w/ poor prognosis?

ZAP-70