問題一覧
1
Absolute lymphocytosis (>15,000/uL) of the blood and bone marrow only
Stage 0
2
UNDRITZ ANOMALY IS ALSO KNOWN AS?
Hereditary Hypersegmentation of Neutrophils
3
What are the 6 species that affects Chediak-Higashi Syndrome?
man, mink, cattle, mice, cats, and killer whales
4
RAI CLASSIFICATION OF CLL
RAI CLASSIFICATION OF CLL
5
Condition in which phagocytes ingest but cannot kill catalase positive organisms
CHRONIC GRANULOMATOUS DISEASE LAZY LEUKOCYTE SYNDROME
6
Predominance of megakeryoblasts
M7
7
Naegeli leukemia
M4
8
PELGER-HUET ANOMALY IS RESEMBLES A?
PINCE-NEZ SPECTACLES, PEANUT, DUMBELL
9
What are the two types of Pelger-Huet Anomaly?
True and Pseudo
10
Basic defect in Chediak-Higashi Syndrome
Golgi Complex (packaging)
11
Cell size: Large Chromatin: Homogenous Nuclear Shape: Regular Nucleoli: One or more present
L3
12
It has Partially albinism, More susceptible to infectious agents, Hepatosplenomegaly, liver failure lymphadenopathy (later stages)
CHEDIAK-HIGASHI SYNDROME
13
It is the most common malignant disease in children
ACUTE LYMPHOBLASTIC LEUKEMIA
14
large lymphoid cells with vesicular multilobed nuclei
Popcorn cell
15
Erythrocytic, Myelocytic
M6
16
Characterized by thrombocytosis: >1,000 x 10^9/L
ESSENTIAL THROMBOCYTHEMIA
17
How many lobes in PELGER-HUET ANOMALY?
2
18
Involves mostly B cells, rarely T cells
CHRONIC LYMPHOBLASTIC LEUKEMIA (CLL)
19
Clinical Presentation: Epistaxis, vomiting of blood, easy bleeding after minor dental surgery, GI bleeding
ESSENTIAL THROMBOCYTHEMIA
20
ESSENTIAL THROMBOCYTHEMIA cause ____
JAK2 gene mutation
21
Enumerate the Proper Function of a Granulocyte
Move randomly, Move directionally, Recognize and ingest the offending agent, Release their granule content
22
What is the treatment in POLYCYTHEMIA VERA?
Phlebotomy
23
First recognized because of the presence of giant cytoplasmic granules in the phagocytes and lymphocytes
CHEDIAK-HIGASHI SYNDROME
24
○ Erythrocyte count is high ○ Leukocytosis ○ Thrombocytosis
POLYCYTHEMIA VERA
25
All are Myelocytic, except:
M5
26
ACUTE MYELOID LEUKEMIA (AML) is also known as?
Acute Nonlymphocytic Leukemia (ANLL)
27
Most common form of leukemia in adults
CHRONIC LYMPHOBLASTIC LEUKEMIA (CLL)
28
Cell size: Larhe Chromatin: Heterogenous Nuclear Shape: Irregular Nucleoli: One or more present
L2
29
Secondary or Reactive Thrombocythemia is cause by ____
Infections, Splenectomy
30
POLYCYTHEMIA VERA is also known as?
Primary Polycythemia
31
It is characterized by: ○ Leukopenia ○ Giant platelets ○ Gray-blue spindle-shaped inclusions in the cytoplasm of the granulocytes and monocytes
MAY-HEGGLIN ANOMALY
32
● Proliferation of malignant lymphocytes that are arrested at certain stages of maturation ● Primarily neoplasms of B cells ● Unknown cause ● Spreads in a less predictable way ● Associated with EBV and HTLV-1
NON-HODGKIN’S LYMPHOMA
33
Recurrent chronic pyogenic infections, Healing accompanied by granuloma formation, Recurrent pneumonia (often caused of death)
CHRONIC GRANULOMATOUS DISEASE
34
How many lobes those the Undritz Anomaly have?
4
35
A disease that both random and directed movement of the cells are defective
LAZY LEUKOCYTE SYNDROME
36
Associated with a group of storage diseases “mucopolysaccharidosis”
ALDER-REILLY ANOMALY
37
All are (+) Auer rods, except:
M3
38
What abnormal chromosome known in CML?
philadelphia chromosome
39
Abnormally large azurophilic granules resembling severe toxic granulation in the cytoplasm of granulocytes
ALDER-REILLY ANOMALY
40
It is associated with malignant myeloproliferative disorders. It contain round nuclei. Cytoplasm is hypogranular.
PSEUDO PELGER-HUET ANOMALY
41
It is most common type of ALL; best prognosis
L1
42
Cell size: Small Chromatin: Homogenous Nuclear Shape: Regular Nucleoli: Not Visible
L1
43
Neutropenia is consistent finding, Low-grade fever, Recurrent infections (gums, mouth, and ears)
LAZY LEUKOCYTE SYNDROME
44
Who has problems in the movement?
Job’s Syndrome and Lazy Leukocyte Syndrome
45
Increased in SMUDGE CELLS because cells are more fragile than normal, thus rupture during blood smear prep
CHRONIC LYMPHOBLASTIC LEUKEMIA (CLL)
46
Inability to kill microorganisms secondary to a failure of granule release
CHEDIAK-HIGASHI SYNDROME
47
○ Seen in all age groups (most patients between 50-60 years old) ○ Headaches, vertigo, ringing in the ears, blurred vision, itching eyes, thrombotic events ○ Ruddy cyanotic (reddish-purple appearance)
POLYCYTHEMIA VERA (PV)
48
It is known to be the hyposegmentation of the granulocytes
PELGER-HUET ANOMALY
49
Biblical job is known that the patient suffer from ______ and _____ staphylococcal abscesses
persistent boils and recurrent “cold” staphylococcal abscesses
50
large lymphoid cells with bilobed nucleus and eosinophilic nucleoli (owl’s eye)
Classical HL (+) Reedsternberg cell
51
Best prognosis HL
Lymphocyte-rich
52
(+) Popcorn cell
Nodular Lymphocyte-Predominant HLi
53
2nd most common AML
M4
54
Studies suggest that cells in lazy leukocyte syndrome contain ________
defective actin filaments
55
Least common; worst prognosis HL
Lymphocyte-depleted
56
Di Guglielmo Syndrome
M6
57
Most common subtype of AML
M2
58
POLYCYTHEMIA VERA: Erythrocyte count: ___ in women and ____ in men
Erythrocyte count: >5.9 x 10^12/L in women and 6.6 x 10^12/L in men
59
Most common HL
Nodular sclerosis
60
○ Increased WBC count >50,000/uL (same as leukemoid reaction) ○ Decreased LAP score ○ Basket Cells may be observed
CHRONIC MYELOID LEUKEMIA (CML)
61
What deficiency is related in Undritz Anomaly?
Vitamin B12 and Folic Acid
62
This diseases has a random movement is normal but directional motility is impaired, thus cells respond very slowly to chemotactic agents.
JOB’S SYNDROME
63
WHAT ARE THE MODE/S OF INHERITANCE OF CHRONIC GRANULOMATOUS DISEASE?
Sex-linked and Autosomal recessive