問題一覧
1
The other day, I was walking through Walmart and saw something that was on my list but was not on the appropriate shelf. I assumed something was wrong with it and continued to where the item should have been. It turned out that they were sold out and the misplaced item I had seen was the only one left in the store. I then had to remember where I had seen it and go back to get it, relying on my spatial memory. Would a CB1 agonist be expected to make this task easier or more difficult?
More Difficult
2
Which compound appears to be the primary endocannabinoid responsible for the prevention of nausea under normal conditions?
AEA
3
With our current knowledge, does cannabis use in adolescence cause adult psychosis?
We cannot yet tell with certainty
4
CB1 receptors are primarily found on _________ neurons.
presynaptic
5
Drugs that increase the expression of which class of drug metabolizing enzymes would be expected to decrease the half-life of THC in the body of users?
CYPs
6
Endocannabinoids are primarily produced in ________ neurons.
postsynaptic
7
In what year did marijuana become outlawed at the federal level for all uses?
1971
8
Where in the body are endocannabinoids stored
They are not stored in the body
9
With our current knowledge, can cannabis be used to reduce psychotic symptoms?
Yes
10
The primary species of tobacco plant used for smoking purposes is _______.
Nicotiana tabacum
11
In which region of the brain would you expect to see the effects of CB1 agonists on the memory?
The center
12
Is THC expected to increase or decrease short-term memory?
Decrease
13
You work for a company that has a strict “no-drugs” policy. A person that you are in the process of hiring takes a drug test that comes back positive for marijuana. They tell you that they have not consumed any form of cannabis or THC in the past few weeks. Is it possible that they are telling the truth?
Yes
14
Which term refers to the vegetative portion of a cannabis plant from a strain containing low levels of THC?
Hemp
15
Based on our current understanding, does CBD prevent seizures though its effects on glutamatergic or GABAergic neurons?
Glutamatergic
16
A patient successfully uses intermittent THC consumption to control panic attacks. This is most likely due to its ________.
inhibition of glutamatergic neurons
17
A patient successfully uses intermittent THC consumption to control panic attacks. This is most likely due to its ________.
AEA
18
In which century did the cigarette industry begin booming throughout Europe?
1800s
19
Cannabis may be useful in the treatment of strokes by preventing neuron death caused by which mechanisms? Select all that apply.
Ischemia, Inflammation, Excitotoxicity
20
Neuropeptide Y _______ appetite.
Increases
21
In general, it appears that cannabis use _______ depressive symptoms. Correct!
Increase
22
For which source of pain would CBD be least effective as a single-agent therapy?
A patient in the ER with a gunshot wound
23
In which century did the recreational tobacco industry begin in Europe?
1500s
24
The reward response received from eating is primarily dependent on which endocannabinoid receptor?
CB1
25
For which source of pain would a CB2 agonist be least effective as a single-agent therapy?
A patient in the ER with a gunshot wound
26
Which endocannabinoid receptor is responsible for the psychoactive effects of cannabis?
CB1
27
Rimonabant would be expected to ______ levels of melanocortin.
Increase
28
Is nicotine best described as an acid or base?
Base
29
A physician aims to reduce nausea in a patient by using CBDA. Which route of administration of cannabis are they most likely to prescribe?
Tincture
30
What is the composition of Epidiolex?
CBD
31
Which statement best describes the physiological role of the endocannabinoid system in learning extinction?
Activation of the CB1 receptor increases learning extinction
32
Cigarettes have two sources of smoke. Which contains the more toxic compounds?
Sidestream smoke
33
From which part of the world did the plant that serves as the current primary source of tobacco originate?
Americas
34
Which endocannabinoid exerts the largest control in the human body
2-AG
35
A cigarette smoker that has successfully quit smoking, begins smoking marijuana. Does this make them more or less likely to restart smoking cigarettes?
More Likely
36
Which compound appears to be the primary endocannabinoid responsible for the reduction of nausea once it has occurred?
2-AG
37
With which current analgesic would cannabis show a synergistic effect?
Fentanyl
38
Based on our current understanding, which would work best as an anti-emetic?
CB1 Agonist
39
You take a blood sample from a long-term epilepsy patient immediately following a seizure. What levels of endocannabinoids do you expect to find?
Normal
40
With our current knowledge, does cannabis cause persistent psychosis?
We cannot yet tell with certainty
41
Which cannabinoids are psychoactive? Select all that apply.
∆9-THC
42
Administration of which dose would be most likely to increase acute vomiting (ignore hyperemesis)?
200 mg/kg CBD
43
Is cannabis addictive?
Yes
44
Endocannabinoids most directly reduce the expression of which hormone?
Leptin
45
Would THC be expected to increase or decrease the measured time in a mouse tail-flick experiment?
Increase
46
Roughly how much nicotine is found in the average cigarette?
1 mg
47
A patient successfully uses regular, moderate consumption of CBD containing beverages to control general anxiety. This is most likely due to its ________.
activation of the serotonin receptor
48
THC metabolites are primarily eliminated from the body through which process?
Defecation
49
Are high or low doses of THC expected to cause a larger reward response?
Low
50
Which treatment would you expect to show the most efficacy in the treatment of Huntington’s disease?
THC:CBD
51
THC’s effect on which intracellular molecule/ion has the most direct neuroprotective effect?
CA2+
52
Which method of tobacco consumption utilizes acidic tobacco to increase absorption?
Cigarrete
53
In which century did cigars start to become popular?
1700s
54
Which drug would be the most likely to show positive effects in the treatment of multiple sclerosis?
CB1 agonist
55
Activation of the CB1 receptor causes a(n) _______ in the production of cAMP.
decrease
56
THC’s pro-convulsant effects are most likely mediated through which type of neuron?
GABAergic
57
Which conditions will lead to the highest absorption of nicotine when smoked?
Acidic during combustion, basic during inhalation
58
With our current knowledge, does cannabis cause acute psychosis?
Yes
59
Which carcinogen is found in the highest concentrations in smokeless tobacco?
Anabasine/Anatabine