Cells in which phase of the cell cycle are least likely to respond to radiation therapy?

Trimethoprim inhibits what enzyme?

A patient undergoes an FdG-PET scan. Will a tumor contain more or less 18fluorodeoxyglucose than normal the surrounding tissue?

Gram positive bacteria lack which structure when compared to Gram negative bacteria?

What is the basis for the selectivity of Gleevec towards cancer cells?

A patient suffering from the early stages of renal failure would be least likely to be prescribed which immunosuppressant?

When treating a tumor with radiotherapy, what part of the tumor generally responds best to treatment? Hint: The outside of a tumor is generally more vascularized. This may not have been clear from the lecture.

Based on their toxicity profiles, what drug is likely to be excluded from use to treat lung cancer?

Angiogenesis is __________________.

Does paclitaxel increase or decrease the amount of microtubules in cells?

A patient has an infection caused by anaerobic Gram negative bacteria. Which antibacterial would be the worst choice to treat this infection?

Production of monoclonal antibodies involves the isolation of cells from which location?

Which bacterial mechanism of resistance is shared by both sulfonamides and trimethoprim?

Are cancers more likely to develop mutation that activate or inactivate Rb?

Which cells will CTL019 kill? Select all that apply

β-Lactams inhibit the proper formation of which part of the bacterial cell wall?

Muromonab is what type of antibody?

Which class of cancer drugs is the least selective towards cancer cells?

Some cancer chemotherapeutics act as immunosupressants most directly through the inhibition of what mechanism?

If a patient is being treated with Osimertinib, what were they likely treated with previously?

Which type of immune cells induce ADCC in cells treated with Cetuximab?

An activated T cell induces T cell proliferation through the production of what signaling molecule?

Which drug should not be given orally for a systemic infection?

Do x-rays have shorter or longer wavelengths than visible light?

Methotrexate targets cells in which phase(s) of the cell cycle?

Enzalutamide blocks the signaling caused by which hormone?

Genetic changes are required for which of the following to occur? Select all that apply.

A dose of Bactrim contains trimethoprim and sulfamethoxazole in a 1:5 ratio. Once in the blood, this is a 1:20 ratio. Which drug has the greater bioavailability?

Which drug is given intramuscularly?

In order to induce an allergic reaction, penicillin must first covalently bind to ____.

Corticosteroids act as immunosupressants most directly through the inhibition of what mechanism?

A tumor contains 109 cells. After a dose of chemotherapy, there are 750,000 cells remaining. When the second chemotherapy dose is given, the tumor has grown to 800,000 cells. How many cells do you expect to remain after the next dose of chemotherapy?

In which type of patient would sulfamethoxazole not be appropriate for treating a bacterial infection?

Cytosine arabinoside directly prevents the formation of ______.

Is chemotherapy generally more effective when tumors are small or large?

Which statement best describes the Warburg effect?

Does drug resistance increase or decrease the therapeutic index of cancer drugs?

A breast cancer patient with a tumor with which characterization would be most likely to respond to Tamoxifen?

What type of immune cell begins the sequence of events that leads to organ transplant rejection?

Sulfonamides can alter concentrations of other drugs in the body. In general, taking sulfonamides would be expected to ______ the plasma concentrations of these other drugs.

Which class of antibacterials is bactericidal?

A patient undergoes outpatient surgery and is given a standard course of antibiotics but ends up back in the hospital a couple of days later with a severe Clostridium difficile infection. This is an example of which toxicity/complication?

Infliximab binds what protein?

What is the most direct target of 5-FU?

Which of the following statements is true regarding apoptosis.

What is the shared target of cyclophosphamide and cisplatin?

Which drug significantly increases the risk of DVTs?

Sulfanilomide inhibits what enzyme?

Which statement best summarizes the treatment ramifications of the Goldie-Coldman hypothesis?

Which β –lactam drug is active against cell wall synthesis in β-lactamase expressing bacteria?

The Epstein-Barr virus, most famous for causing mononucleosis, also plays a prevalent role in the formation of what type of cancer?

What is the target of pembrolizumab?

Which statement best describes how cancer cells overcome the Hayflick limit?

An inhibitor of what enzyme would be expected to increase the sensitivity of cancer cells to vincristine?

Which drug may be used as a noncompetitive inhibitor of β-lactamase?

If a cell expresses a mutant form of EGFR, would this be considered a tumor specific antigen or a tumor associated antigen?

Pieces of Iodine-125 are sometimes placed in the prostate to treat prostate cancer. This type of treatment is called.

What viral protein is capable of inhibiting p53?

What effect would a G12V mutation in Ras have on ERK?

What chemical causes the most cigarette-related DNA mutations?

Which class of drugs could potentially increase estrogen signaling?

What is the process called when two EGFR proteins bind to each other?

What is the endogenous ligand for HER2?

Metabolites of nicotine commonly result in DNA point mutations. Which type of DNA instability is this an example of?

What type of immune cells produce antibodies?

Is inflammation harmful or beneficial to cancer?

If a human cell underwent endoreduplication followed by failed cytokinesis, how many chromosomes would you expect that cell to now contain?

In what location does Cetuximab bind EGFR?

Most DNA damage caused during x-ray radiation therapy is ______.

Which birth scenario will require pharmacological intervention?