biochemistry T/F
問題一覧
1
Bile acids are hydrophobic and require a carrier in the portal blood
true
2
Most of the uric acid enters the blood and is eventually excreted in the urine.
true
3
Citric acid cycle intermediate could participate in Heme Biosynthesis.
true
4
PKU test screens newborn babies on congenital hypothyroidism.
false
5
Reduction of androstenedione at the C17 position results in the formation of Glucagon, the most potent adrenal androgen.
false
6
Creatinine is synthesized in the liver and excreted by the help of kidney.
false
7
Gout is a disorder characterized by low levels of uric acid— the end product of purine catabolism— in blood (hypouricemia)
false
8
Glycogen synthase and DNA synthase require a primer.
true
9
The strand that is being copied in the direction of the advancing replication fork is called the leading strand and is synthesized continuously is Lagging strand
false
10
Initiation codon always encodes amino acid tryphtophan.
false
11
Initiation codon always encodes amino acid tryphtophan
false
12
Thyroglobulin is the transporter plasma protein for thyroid hormones – T3, T4
false
13
The β chains of Insulin is identical in all of these hormones, and distinct α-chain impart hormone uniqueness
false
14
Hormone, which act on intracellular receptors is - Thyroxine.
true
15
Liver's inability to detoxify ammonia, might lead to hepatic encephalopathy
true
16
the obstructive jaundice, it is mainly conjugated bilirubin that increases, because liver is intact.
true
17
Bilirubin and biliverdin, both are the products of heme synthesis
false
18
Dopamine and norepinephrine are synthesized in the brain and function as neurotransmitters
true
19
The catecholamines are synthesized from Alanine
false
20
The bile acids are amphibolic
false
21
The main metalloporphyrin in the body is heme, which has a ferrous Fe 3 iron atom coordinated by protoporphyrin IX
false
22
Heme is synthesized from glycine and succinyl CoA precursors via a complex series of reactions
true
23
Bilirubin is not very water-soluble, so most of it is carried to the liver bound to albumin
true
24
Most of the urobilinogen is oxidized to urobilin , which turns the feces brown
false
25
Bilirubin is conjugated in the gallbladder by glucuronil transferase
false
26
Hyperuricemia is typically asymptomatic and does not lead to gout
true
27
The very first step in pyrimidine synthesis is the formation of carbamoylaspartate, catalyzed by aspartate transcarbamoylase
false
28
Phosphodiester bonds join the 5'-hydroxyl group of the deoxy-pentose of one nucleotide to the 53-hydroxyl group of the deoxy pentose of an adjacent nucleotide through a phosphate group
false
29
Polymerases use only ssDNA as a template
true
30
DNA is negatively charged, histones and Mg2+ions help to neutralize the charge
true
31
Most of the uric acid enters the blood, and is eventually excreted in the urine.
true
32
Estrogens are formed by the aromatization of androgens, which requires O2 and NADPH
true
33
Citrulline is an non-protein amino acid which works as an intermediate in urea biosynthesis
true
34
5-hydroxytryptophan is decarboxylated to MAO , which is also degraded by serotonin
false
35
Ferrochelatase decreases the rate of iron insertion into protoporphyrin IX.
false
36
Hormones may act as coenzymes
false
37
Within cells of the RE system, heme is degraded to bilirubin
true
38
Most of the urobilinogen is oxidized to stercobilin, which turns the urine brown
false
39
Condensation of Gly and succinyl CoA to produce -aminolevulinic acid (ALA) is the rate-limiting step of heme biosynthesis
true
40
Unconjugated bilirubin is normally secreted.
false
41
DOPA is decarboxylated in a reaction requiring pyridoxal phosphate (PLP) to form dopamine
true
42
Progesterone can serve as a precursor for mineralocorticoids.
true
43
Hydroxylases require molecular oxygen and NADPH are essential
true
44
Inside a polysome, ribosomes are translating different types of proteins
false
45
Catecholamine degradation results in the synthesis of S-adenosylmethionine
false
46
Ribonucleotide reductase(ribonucleoside diphosphate reductase) is composed of two nonidentical dimeric subunits
true
47
Cyclic AMP was the first intracellular second messenger signal identified in mammalian cells
true
48
The phosphoprotein dehydrogenase are themselves subject to regulation by phosphorylation dephosphorylation reactions
false
49
The SSB proteins are not enzymes, but rather serve to shift the equilibrium between dsDNA and ssDNA in the direction of the single-stranded forms
true
50
The 3' →5' exonuclease activity that proofreads the newly synthesized DNA chain like DNA polymerase III
true
51
Leucine and lysine are the only exclusively glucogenic amino acids found in proteins
false
52
Creatinine and urea elevation could be an indicator for myocardial infarction
false
53
Aminotransferases are intracellular enzymes and their plasma concentration increase usually indicates pathology
true
54
The main metalloporphyrin in the body is heme, which has a ferrous Fe 3 iron atomcoordinated by protoporphyrin IX
false
55
Theca cells are the source of androstenedione and testosterone
true
56
The phosphate groups are responsible for the positive charges associated with nucleotides, and cause DNA and RNA to be referred to as “nucleic acids
false
57
The purine ring is constructed primarily in the liver
true
58
Regulation of heme synthesis in erythroid cells occurs at enzymes catalyzing several steps of the pathway, including ferrochelatase
true
59
Hemin inhibits ALA synthase only by using an allosteric mechanism
false
60
The β chains of Insulin is identical in all of these hormones, and distinct α-chain impart hormone uniqueness
false
61
Heme synthesis in the liver can be inhibited by drug consumption
false
62
Hormones are only synthesized in specialized organs called glands
false
63
Telomeres are complexes of noncoding DNA plus proteins located at the ends of linear chromosomes
true
64
The main metalloporphyrin in the body is heme, which has a ferrous Fe 3 iron atom coordinated by protoporphyrin IX.
false
65
Phosphatidic acid is the simplest phosphoglyceride
true
66
Genetic disorders associated with an inability to properly degrade the glycosphingolipids result in lysosomal accumulation of these compounds
true
67
The bacteria in the kidney convert bilirubin to urobilins, which gives urine its color.
false
68
Cortisol activates phospholipase A2 activity
false
69
Arachidonic acid turning to PGH2 is catalyzed by prostaglandin endoperoxide synthase.
true
70
Phosphodiester bonds join the 5'-hydroxyl group of the deoxy-pentose of one nucleotide to the 53-hydroxyl group of the deoxy pentose of an adjacent nucleotide through a phosphate group
false
71
Infant RDS (Respiratory distress syndrome) is caused by deficiency of lung surfactant
true
問題一覧
1
Bile acids are hydrophobic and require a carrier in the portal blood
true
2
Most of the uric acid enters the blood and is eventually excreted in the urine.
true
3
Citric acid cycle intermediate could participate in Heme Biosynthesis.
true
4
PKU test screens newborn babies on congenital hypothyroidism.
false
5
Reduction of androstenedione at the C17 position results in the formation of Glucagon, the most potent adrenal androgen.
false
6
Creatinine is synthesized in the liver and excreted by the help of kidney.
false
7
Gout is a disorder characterized by low levels of uric acid— the end product of purine catabolism— in blood (hypouricemia)
false
8
Glycogen synthase and DNA synthase require a primer.
true
9
The strand that is being copied in the direction of the advancing replication fork is called the leading strand and is synthesized continuously is Lagging strand
false
10
Initiation codon always encodes amino acid tryphtophan.
false
11
Initiation codon always encodes amino acid tryphtophan
false
12
Thyroglobulin is the transporter plasma protein for thyroid hormones – T3, T4
false
13
The β chains of Insulin is identical in all of these hormones, and distinct α-chain impart hormone uniqueness
false
14
Hormone, which act on intracellular receptors is - Thyroxine.
true
15
Liver's inability to detoxify ammonia, might lead to hepatic encephalopathy
true
16
the obstructive jaundice, it is mainly conjugated bilirubin that increases, because liver is intact.
true
17
Bilirubin and biliverdin, both are the products of heme synthesis
false
18
Dopamine and norepinephrine are synthesized in the brain and function as neurotransmitters
true
19
The catecholamines are synthesized from Alanine
false
20
The bile acids are amphibolic
false
21
The main metalloporphyrin in the body is heme, which has a ferrous Fe 3 iron atom coordinated by protoporphyrin IX
false
22
Heme is synthesized from glycine and succinyl CoA precursors via a complex series of reactions
true
23
Bilirubin is not very water-soluble, so most of it is carried to the liver bound to albumin
true
24
Most of the urobilinogen is oxidized to urobilin , which turns the feces brown
false
25
Bilirubin is conjugated in the gallbladder by glucuronil transferase
false
26
Hyperuricemia is typically asymptomatic and does not lead to gout
true
27
The very first step in pyrimidine synthesis is the formation of carbamoylaspartate, catalyzed by aspartate transcarbamoylase
false
28
Phosphodiester bonds join the 5'-hydroxyl group of the deoxy-pentose of one nucleotide to the 53-hydroxyl group of the deoxy pentose of an adjacent nucleotide through a phosphate group
false
29
Polymerases use only ssDNA as a template
true
30
DNA is negatively charged, histones and Mg2+ions help to neutralize the charge
true
31
Most of the uric acid enters the blood, and is eventually excreted in the urine.
true
32
Estrogens are formed by the aromatization of androgens, which requires O2 and NADPH
true
33
Citrulline is an non-protein amino acid which works as an intermediate in urea biosynthesis
true
34
5-hydroxytryptophan is decarboxylated to MAO , which is also degraded by serotonin
false
35
Ferrochelatase decreases the rate of iron insertion into protoporphyrin IX.
false
36
Hormones may act as coenzymes
false
37
Within cells of the RE system, heme is degraded to bilirubin
true
38
Most of the urobilinogen is oxidized to stercobilin, which turns the urine brown
false
39
Condensation of Gly and succinyl CoA to produce -aminolevulinic acid (ALA) is the rate-limiting step of heme biosynthesis
true
40
Unconjugated bilirubin is normally secreted.
false
41
DOPA is decarboxylated in a reaction requiring pyridoxal phosphate (PLP) to form dopamine
true
42
Progesterone can serve as a precursor for mineralocorticoids.
true
43
Hydroxylases require molecular oxygen and NADPH are essential
true
44
Inside a polysome, ribosomes are translating different types of proteins
false
45
Catecholamine degradation results in the synthesis of S-adenosylmethionine
false
46
Ribonucleotide reductase(ribonucleoside diphosphate reductase) is composed of two nonidentical dimeric subunits
true
47
Cyclic AMP was the first intracellular second messenger signal identified in mammalian cells
true
48
The phosphoprotein dehydrogenase are themselves subject to regulation by phosphorylation dephosphorylation reactions
false
49
The SSB proteins are not enzymes, but rather serve to shift the equilibrium between dsDNA and ssDNA in the direction of the single-stranded forms
true
50
The 3' →5' exonuclease activity that proofreads the newly synthesized DNA chain like DNA polymerase III
true
51
Leucine and lysine are the only exclusively glucogenic amino acids found in proteins
false
52
Creatinine and urea elevation could be an indicator for myocardial infarction
false
53
Aminotransferases are intracellular enzymes and their plasma concentration increase usually indicates pathology
true
54
The main metalloporphyrin in the body is heme, which has a ferrous Fe 3 iron atomcoordinated by protoporphyrin IX
false
55
Theca cells are the source of androstenedione and testosterone
true
56
The phosphate groups are responsible for the positive charges associated with nucleotides, and cause DNA and RNA to be referred to as “nucleic acids
false
57
The purine ring is constructed primarily in the liver
true
58
Regulation of heme synthesis in erythroid cells occurs at enzymes catalyzing several steps of the pathway, including ferrochelatase
true
59
Hemin inhibits ALA synthase only by using an allosteric mechanism
false
60
The β chains of Insulin is identical in all of these hormones, and distinct α-chain impart hormone uniqueness
false
61
Heme synthesis in the liver can be inhibited by drug consumption
false
62
Hormones are only synthesized in specialized organs called glands
false
63
Telomeres are complexes of noncoding DNA plus proteins located at the ends of linear chromosomes
true
64
The main metalloporphyrin in the body is heme, which has a ferrous Fe 3 iron atom coordinated by protoporphyrin IX.
false
65
Phosphatidic acid is the simplest phosphoglyceride
true
66
Genetic disorders associated with an inability to properly degrade the glycosphingolipids result in lysosomal accumulation of these compounds
true
67
The bacteria in the kidney convert bilirubin to urobilins, which gives urine its color.
false
68
Cortisol activates phospholipase A2 activity
false
69
Arachidonic acid turning to PGH2 is catalyzed by prostaglandin endoperoxide synthase.
true
70
Phosphodiester bonds join the 5'-hydroxyl group of the deoxy-pentose of one nucleotide to the 53-hydroxyl group of the deoxy pentose of an adjacent nucleotide through a phosphate group
false
71
Infant RDS (Respiratory distress syndrome) is caused by deficiency of lung surfactant
true