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問題一覧
1
What is the neurotransmitter of all preganglionic autonomic fibers and parasympathetic fibers?
Acetylcholine
2
What is the rate-limiting enzyme in the synthesis of catecholamines?
Tyrosine hydroxylase
3
Which of the following is a MAO-B specific inhibitor?Which of the following is a MAO-B specific inhibitor?
Selegiline
4
Which of the following is not used for Alzheimer's disease?
Physostigmine
5
This is the first line inotrope for cardiogenic shock.
Dobutamine
6
This metabotropic receptor works by stimulating adenylyl cyclase this increasing levels of CAMP
Gs
7
Ondansetron and Granisetron inhibit what receptor?
5HT3
8
Which of the following is not used as an antiemetic?
Alosetron
9
Which of the following is the least potent H2 blocker?
Cimetidine
10
Which of the following is the drug of choice for hypercholesterolemia?
Simvastatin
11
Effects of insecticide poisoning, except
Bronchodilation
12
An NSAID that was required to add a black box warning in its label due to increased risk of thrombosis and stroke.
Rofecoxib
13
Which of the following COX enzymes is responsible for maintaining homeostasis in the body and is known as the "Housekeeping COX".
COX I
14
NAPQI is the toxic metabolite of acetaminophen or paracetamol. What does NAPQI stand for?
N-Acetyl p-benzoquinone imine
15
What medication has this chemical structure?
Paracetamol
16
Also known as acetylated morphine.
Heroin
17
A non-purine xanthine oxidase inhibitor.
Febuxostat
18
Based on the lab results, a patient's HDL levels should be increased. Which among the following medications would be the most effective in increasing the HDL levels in the body?
Niacin
19
Which of the following will not cause Extrapyramidal Symptoms in treating psychosis?
Clozapine
20
Which of the following anxiolytics can increase the frequency of chloride channel opening?
Triazolam
21
This element is used in rheumatoid arthritis.
Gold
22
This is used for the Tensilon Test.
Edrophonium
23
Which H2-receptor antagonist is the most potent?
Famotidine
24
Which H2-receptor antagonist is the prototype?
Cimetidine
25
The following clotting factors are targeted by warfarin, except?
I
26
This drug is not a proton pump inhibitor.
Aripiprazole
27
Which of the following is the drug of choice for septic shock?
Norepinephrine
28
Which of the following drugs is not non-steroidal in structure?
Micacurium
29
Neuromuscular blockers act on:
Nicotinic receptors
30
Clinical use of ritodine:
Tocolytic
31
SSRIs, except:
Fluphenazine
32
All are intermediate acting Benzodiazepines, except: Answer:
Escitalopram
33
What is the mechanism of action of tranexamic acid?
Inhibits plasminogen activation
34
A drug with a narrow therapeutic index means that the drug is:
Unsafe
35
The primary mechanism of neurotransmitter release is accomplished by what process?
Exocytosis
36
Dry cough is a side effect of which antihypertensive?
ACE inhibitors
37
High-ceiling diuretics are:
Loop diuretics
38
It is defined as a measure of the ability of a drug to evoke an active response.
Intrinsic activity
39
Antiplatelets, except:
Argatroban
40
Branch of pharmacology that deals with the biochemical and physiologic effects of drugs in biological systems and the mechanisms by which these effects were produced:
Pharmacodynamics
41
Which of the following monoamine oxidase inhibitors is indicated for parkinsonism only?
Seleginine
42
Aldosterone is produced by:
Zona glomerulosa
43
Which neurotransmitter is primarily responsible for transmission in the sympathetic nervous system?
Norepinephrine
44
Which of the following describes an agonist?
Affinity with intrinsic activity
45
Which type of receptor inhibits adenylyl cyclase?
Gi
46
Which of the following drugs should not be used by patients with gout?
Tolmetin
47
Lipolysis is due to the activation of which receptor?
Beta-3
48
What type of antagonism is demonstrated when protamine sulfate counters the effects of heparin?What type of antagonism is demonstrated when protamine sulfate counters the effects of heparin?
Chemical antagonism
49
Drug that is used as hair grower:
Minoxidil
50
Peakless insulin
Glargline
51
Which of the following is the drug of choice for absence seizure?
Ethosuximide
52
Which of the following are autacoids?
Serotonin, Eicosanoids, Bradykinin, Histamine
53
It contains the highest concentration and greatest number of prostaglandins.
Seminal fluid
54
The only NSAID that is not a weak acid
Nabumetone
55
A prostaglandin analog used to temporarily maintain the patency of ductus arteriosus in neonates?
Alprostadil
56
Preferred anticoagulant for pregnant patients
Fondaparinux
57
Which of the following parameter/s is/ are required for heparin monitoring?
aPTT
58
Sodium-glucose cotransporter-2 (SGL2) inhibitors are drugs that are used to treat
Type 2 diabetes
59
Which of the following drugs is a mixed adrenergic antagonist?
Labetolol
60
Insulin is chemically classified as a
Protein
61
Sotalol is an anti arrhythmic drug classified under
Class III
62
An experienced mountaineer experienced dizziness, insomnia, and headache after quickly reaching the summit. What drug would be recommended for this nerson?
Diamox
63
Which vasodilator causes hyperglycemia?
Diazoxide
64
Which of the following is an anticoagulant drug?
Hirudin
65
Which of the following is not an opiod receptor?
y (inversed)
66
“-sartans” are
Angiotensin converting enzyme inhibitors
67
Which is/are the indication of the drug Tamoxifen?
Breast cancer
68
Which is the drug of choice for status epilepticus?
Lorazepam
69
Which is the drug of choice for febrile seizure?
Phenobarbital
70
The process of drug metabolism and excretion constitute:
Elimination
71
Primary site of drug excretion
Kidney
72
BCS Classification: Low solubility and high permeability
Class II
73
The rate limiting favtor in the dissolution of drugs:
Disintegration
74
The following are incorrect regarding passive transport, except:
C. II, III, IV
75
Which of the follwing is metabolized by MAO-B?
Dopamine
76
The following are correct regarding active transport, except:
D. III, IV
77
This represents the drug concentration needed to just barely produce a toxic effect:
Minimum Toxic Concentration
78
What is the most abundant CYP enzyme?
CYP3A4
79
Acidic drugs bind to:
Albumin
80
Initial pathway of elimination
Metabolism
81
Which of the following correctly states the factors affecting absorption?
Smaller surface area decreases rate of absorption
82
Carrier-mediated transport is said to be:
Saturable
83
Which of the following refers to efficacy?
Maximum achievable response
84
Pharmaceutical equivalents that can be expected to have the same clinical effect and safety profile when administered to patients under the same conditions specified in the labelling:
Therapeutic equivalent
85
What does the term “bioavailability “ refer to?
The proportion of the administered drug that reaches the systemic circulation
86
What is the most important organ for the absorption of orally administered drugs?
Small Intestine
87
Refers to the order of reaction in which the concentration of a drug is decreasing at a rate that is proportional to the concentration of the drug remaining
First
88
In a drug interaction scenario, what would best describe the result if Drug A induces the metabolism of Drug B?
Decrease in blood level of Drug B
89
True about bioavailability:
Greatly affected by drug absorption
90
What is the basis why acidic drugs are best absorbed in the stomach?
Henderson-Hasselbalch equation
91
What is the antidote for acetaminophen toxictt?
N-acetylcysteine
92
A toxicity associated with any chemical substance:
Intoxication
93
A low molecular weight protein that binds to endogenous substances before contributing to the body's immune response:
Hapten
94
This type of evidence can be obtained from the examination of organs and tissues of the dead.
Post-mortem evidence
95
This occurs within 24 hours
Acute
96
Mechanism of action of activated charcoal for gastrointestinal decontamination
It adsorbs the poison
97
A patient on chronic opioid therapy for pain management is prescribed naloxone. What is the primary purpose of adding naloxone to the treatment regimen?
To counteract opioid overdose
98
The term used to describe the frequency of occurrence of undesirable effects arising from exposure to a physical or chemical agent
Risk
99
Toxicity due to paracetamol overdose causes depletion of
Glutathione
100
Which drug of abuse is sold as “angel dust”
Ketamine