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問題一覧
1
This represents the drug concentration needed to just barely produce a toxic effect:
Minimum Toxic Concentration
2
Which of the following will not cause Extrapyramidal Symptoms in treating psychosis?
Clozapine
3
Which of the following monoamine oxidase inhibitors is indicated for parkinsonism only?
Seleginine
4
The primary mechanism of neurotransmitter release is accomplished by what process?
Exocytosis
5
Which H2-receptor antagonist is the most potent?
Famotidine
6
What is the most important organ for the absorption of orally administered drugs?
Small Intestine
7
Which vasodilator causes hyperglycemia?
Diazoxide
8
The following are incorrect regarding passive transport, except:
C. II, III, IV
9
Based on the lab results, a patient's HDL levels should be increased. Which among the following medications would be the most effective in increasing the HDL levels in the body?
Niacin
10
Primary site of drug excretion
Kidney
11
Which of the follwing is metabolized by MAO-B?
Dopamine
12
Refers to the order of reaction in which the concentration of a drug is decreasing at a rate that is proportional to the concentration of the drug remaining
First
13
What is the antidote for acetaminophen toxictt?
N-acetylcysteine
14
Also known as acetylated morphine.
Heroin
15
Clinical use of ritodine:
Tocolytic
16
This metabotropic receptor works by stimulating adenylyl cyclase this increasing levels of CAMP
Gs
17
What is the most abundant CYP enzyme?
CYP3A4
18
Aldosterone is produced by:
Zona glomerulosa
19
A patient on chronic opioid therapy for pain management is prescribed naloxone. What is the primary purpose of adding naloxone to the treatment regimen?
To counteract opioid overdose
20
What is the neurotransmitter of all preganglionic autonomic fibers and parasympathetic fibers?
Acetylcholine
21
Which of the following drugs should not be used by patients with gout?
Tolmetin
22
The process of drug metabolism and excretion constitute:
Elimination
23
NAPQI is the toxic metabolite of acetaminophen or paracetamol. What does NAPQI stand for?
N-Acetyl p-benzoquinone imine
24
A drug with a narrow therapeutic index means that the drug is:
Unsafe
25
An NSAID that was required to add a black box warning in its label due to increased risk of thrombosis and stroke.
Rofecoxib
26
Insulin is chemically classified as a
Protein
27
Which of the following is a MAO-B specific inhibitor?Which of the following is a MAO-B specific inhibitor?
Selegiline
28
Which of the following COX enzymes is responsible for maintaining homeostasis in the body and is known as the "Housekeeping COX".
COX I
29
This type of evidence can be obtained from the examination of organs and tissues of the dead.
Post-mortem evidence
30
Sodium-glucose cotransporter-2 (SGL2) inhibitors are drugs that are used to treat
Type 2 diabetes
31
All are intermediate acting Benzodiazepines, except: Answer:
Escitalopram
32
It contains the highest concentration and greatest number of prostaglandins.
Seminal fluid
33
Neuromuscular blockers act on:
Nicotinic receptors
34
This drug is not a proton pump inhibitor.
Aripiprazole
35
Which of the following correctly states the factors affecting absorption?
Smaller surface area decreases rate of absorption
36
Which is the drug of choice for status epilepticus?
Lorazepam
37
Lipolysis is due to the activation of which receptor?
Beta-3
38
Which drug of abuse is sold as “angel dust”
Ketamine
39
A prostaglandin analog used to temporarily maintain the patency of ductus arteriosus in neonates?
Alprostadil
40
This element is used in rheumatoid arthritis.
Gold
41
An experienced mountaineer experienced dizziness, insomnia, and headache after quickly reaching the summit. What drug would be recommended for this nerson?
Diamox
42
The following clotting factors are targeted by warfarin, except?
I
43
Which of the following refers to efficacy?
Maximum achievable response
44
Which type of receptor inhibits adenylyl cyclase?
Gi
45
Which of the following is an anticoagulant drug?
Hirudin
46
Carrier-mediated transport is said to be:
Saturable
47
Sotalol is an anti arrhythmic drug classified under
Class III
48
Which of the following drugs is not non-steroidal in structure?
Micacurium
49
The only NSAID that is not a weak acid
Nabumetone
50
“-sartans” are
Angiotensin converting enzyme inhibitors
51
Which of the following is the drug of choice for septic shock?
Norepinephrine
52
The rate limiting favtor in the dissolution of drugs:
Disintegration
53
Dry cough is a side effect of which antihypertensive?
ACE inhibitors
54
A toxicity associated with any chemical substance:
Intoxication
55
High-ceiling diuretics are:
Loop diuretics
56
True about bioavailability:
Greatly affected by drug absorption
57
Which of the following drugs is a mixed adrenergic antagonist?
Labetolol
58
This is used for the Tensilon Test.
Edrophonium
59
Acidic drugs bind to:
Albumin
60
BCS Classification: Low solubility and high permeability
Class II
61
Ondansetron and Granisetron inhibit what receptor?
5HT3
62
Peakless insulin
Glargline
63
Which of the following are autacoids?
Serotonin, Eicosanoids, Bradykinin, Histamine
64
In a drug interaction scenario, what would best describe the result if Drug A induces the metabolism of Drug B?
Decrease in blood level of Drug B
65
Preferred anticoagulant for pregnant patients
Fondaparinux
66
The following are correct regarding active transport, except:
D. III, IV
67
A low molecular weight protein that binds to endogenous substances before contributing to the body's immune response:
Hapten
68
Which of the following parameter/s is/ are required for heparin monitoring?
aPTT
69
What is the mechanism of action of tranexamic acid?
Inhibits plasminogen activation
70
Which of the following is the drug of choice for absence seizure?
Ethosuximide
71
It is defined as a measure of the ability of a drug to evoke an active response.
Intrinsic activity
72
Pharmaceutical equivalents that can be expected to have the same clinical effect and safety profile when administered to patients under the same conditions specified in the labelling:
Therapeutic equivalent
73
A non-purine xanthine oxidase inhibitor.
Febuxostat
74
Drug that is used as hair grower:
Minoxidil
75
This is the first line inotrope for cardiogenic shock.
Dobutamine
76
This occurs within 24 hours
Acute
77
Which H2-receptor antagonist is the prototype?
Cimetidine
78
Which of the following is the drug of choice for hypercholesterolemia?
Simvastatin
79
What type of antagonism is demonstrated when protamine sulfate counters the effects of heparin?What type of antagonism is demonstrated when protamine sulfate counters the effects of heparin?
Chemical antagonism
80
Effects of insecticide poisoning, except
Bronchodilation
81
What does the term “bioavailability “ refer to?
The proportion of the administered drug that reaches the systemic circulation
82
Toxicity due to paracetamol overdose causes depletion of
Glutathione
83
Mechanism of action of activated charcoal for gastrointestinal decontamination
It adsorbs the poison
84
What is the rate-limiting enzyme in the synthesis of catecholamines?
Tyrosine hydroxylase
85
What medication has this chemical structure?
Paracetamol
86
Which is the drug of choice for febrile seizure?
Phenobarbital
87
Branch of pharmacology that deals with the biochemical and physiologic effects of drugs in biological systems and the mechanisms by which these effects were produced:
Pharmacodynamics
88
Which of the following anxiolytics can increase the frequency of chloride channel opening?
Triazolam
89
SSRIs, except:
Fluphenazine
90
What is the basis why acidic drugs are best absorbed in the stomach?
Henderson-Hasselbalch equation
91
Which of the following is not an opiod receptor?
y (inversed)
92
Which of the following is not used for Alzheimer's disease?
Physostigmine
93
Which is/are the indication of the drug Tamoxifen?
Breast cancer
94
Initial pathway of elimination
Metabolism
95
Antiplatelets, except:
Argatroban
96
Which of the following describes an agonist?
Affinity with intrinsic activity
97
Which of the following is the least potent H2 blocker?
Cimetidine
98
The term used to describe the frequency of occurrence of undesirable effects arising from exposure to a physical or chemical agent
Risk
99
Which neurotransmitter is primarily responsible for transmission in the sympathetic nervous system?
Norepinephrine
100
Which of the following is not used as an antiemetic?
Alosetron