問題一覧
1
Disrupts the ECM, exposing collagen.
Vascular Injury
2
Damaged endothelial cells release _______, which unrolls and adheres to the injury site.
VWF
3
VWF binds to GP Ib/Ix/V receptors on platelets, slowing their movement.
Platelet Tethering
4
Type I fibrillar collagen binds to GP VI on platelets.
Collagen Binding
5
Triggers the release of TXA2 and ADP, which bind to their respective receptors, leading to firm platelet adhesion.
Internal Activation
6
Platelets bind elements of the vascular matrix
Adhesion
7
Platelets Irreversible cohere
Aggregation
8
Activated platelets release granular content
Secretion
9
The stress exerted by flowing blood on the vessel wall, measured in s-1
Shear Forces
10
venules and veins
500 s-1
11
Arterioles and capillaries
5000 s-1
12
Stenosed arteries
40,000s-1
13
Shear rate is more than?
1000s-1
14
Platelet adhesion and aggregation require the process of primary hemostasis.
When the shear rate is more than 1000s-1
15
Platelets bind elements of the vascular matrix
Adhesion
16
Tissue injury releases tissue factor, leading to thrombin production.
Aggregation
17
Thrombin activates platelets through PAR1 and PAR4 receptors.
Aggregation
18
Integrin allb and B3 facilitates platelet aggregation by binding fibrinogen and VWF.
Aggregation
19
Platelet Shape Change: Extension of pseudopods and membrane phospholipid reorganization
Aggregation
20
Microparticles are membrane-derived vesicles that form in response to an activating stimulus that increases the platelet intracellular concentration of calcium
Platelets
21
Elevated levels of intracellular calcium result in an inhibition of the enzymes responsible for maintaining the asymmetric distribution of phospholipids in the plasma membrane and an activation of intracellular calpain, which cleaves the platelet cytoskeleton.
Platelets
22
which cleaves the platelet cytoskeleton.
Calpain
23
Lead to the outward blebbing of the plasma membrane and the formation of platelet microparticles
Platelets
24
Most abundant microparticles in the circulation
Platelet microparticles
25
Are formed after exposure of platelets to strong agonists or shear stress
Platelet microparticles
26
made up of the plasma membrane and cytosolic material of the parent cell from which they are derived and retain the cell surface proteins found on the parent cell
Platelet microparticles
27
microparticles have been found to modulate inflammation, oxidative stress, angiogenesis, and thrombosis
Platelet microparticles