Most abundant microparticles in the circulation

microparticles have been found to modulate inflammation, oxidative stress, angiogenesis, and thrombosis

Activated platelets release granular content

VWF binds to GP Ib/Ix/V receptors on platelets, slowing their movement.

Platelets Irreversible cohere

Arterioles and capillaries

Elevated levels of intracellular calcium result in an inhibition of the enzymes responsible for maintaining the asymmetric distribution of phospholipids in the plasma membrane and an activation of intracellular calpain, which cleaves the platelet cytoskeleton.

which cleaves the platelet cytoskeleton.

Thrombin activates platelets through PAR1 and PAR4 receptors.

Disrupts the ECM, exposing collagen.

The stress exerted by flowing blood on the vessel wall, measured in s-1

Platelet Shape Change: Extension of pseudopods and membrane phospholipid reorganization

Platelet adhesion and aggregation require the process of primary hemostasis.

Platelets bind elements of the vascular matrix

Platelets bind elements of the vascular matrix

Damaged endothelial cells release _______, which unrolls and adheres to the injury site.

Stenosed arteries

venules and veins

Shear rate is more than?

Integrin allb and B3 facilitates platelet aggregation by binding fibrinogen and VWF.

Microparticles are membrane-derived vesicles that form in response to an activating stimulus that increases the platelet intracellular concentration of calcium

Type I fibrillar collagen binds to GP VI on platelets.

made up of the plasma membrane and cytosolic material of the parent cell from which they are derived and retain the cell surface proteins found on the parent cell

Tissue injury releases tissue factor, leading to thrombin production.

Lead to the outward blebbing of the plasma membrane and the formation of platelet microparticles

Triggers the release of TXA2 and ADP, which bind to their respective receptors, leading to firm platelet adhesion.

Are formed after exposure of platelets to strong agonists or shear stress