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Platelet Activation
  • Almira Coleen

  • 問題数 27 • 12/13/2024

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    問題一覧

  • 1

    Disrupts the ECM, exposing collagen.

    Vascular Injury

  • 2

    Damaged endothelial cells release _______, which unrolls and adheres to the injury site.

    VWF

  • 3

    VWF binds to GP Ib/Ix/V receptors on platelets, slowing their movement.

    Platelet Tethering

  • 4

    Type I fibrillar collagen binds to GP VI on platelets.

    Collagen Binding

  • 5

    Triggers the release of TXA2 and ADP, which bind to their respective receptors, leading to firm platelet adhesion.

    Internal Activation

  • 6

    Platelets bind elements of the vascular matrix

    Adhesion

  • 7

    Platelets Irreversible cohere

    Aggregation

  • 8

    Activated platelets release granular content

    Secretion

  • 9

    The stress exerted by flowing blood on the vessel wall, measured in s-1

    Shear Forces

  • 10

    venules and veins

    500 s-1

  • 11

    Arterioles and capillaries

    5000 s-1

  • 12

    Stenosed arteries

    40,000s-1

  • 13

    Shear rate is more than?

    1000s-1

  • 14

    Platelet adhesion and aggregation require the process of primary hemostasis.

    When the shear rate is more than 1000s-1

  • 15

    Platelets bind elements of the vascular matrix

    Adhesion

  • 16

    Tissue injury releases tissue factor, leading to thrombin production.

    Aggregation

  • 17

    Thrombin activates platelets through PAR1 and PAR4 receptors.

    Aggregation

  • 18

    Integrin allb and B3 facilitates platelet aggregation by binding fibrinogen and VWF.

    Aggregation

  • 19

    Platelet Shape Change: Extension of pseudopods and membrane phospholipid reorganization

    Aggregation

  • 20

    Microparticles are membrane-derived vesicles that form in response to an activating stimulus that increases the platelet intracellular concentration of calcium

    Platelets

  • 21

    Elevated levels of intracellular calcium result in an inhibition of the enzymes responsible for maintaining the asymmetric distribution of phospholipids in the plasma membrane and an activation of intracellular calpain, which cleaves the platelet cytoskeleton.

    Platelets

  • 22

    which cleaves the platelet cytoskeleton.

    Calpain

  • 23

    Lead to the outward blebbing of the plasma membrane and the formation of platelet microparticles

    Platelets

  • 24

    Most abundant microparticles in the circulation

    Platelet microparticles

  • 25

    Are formed after exposure of platelets to strong agonists or shear stress

    Platelet microparticles

  • 26

    made up of the plasma membrane and cytosolic material of the parent cell from which they are derived and retain the cell surface proteins found on the parent cell

    Platelet microparticles

  • 27

    microparticles have been found to modulate inflammation, oxidative stress, angiogenesis, and thrombosis

    Platelet microparticles