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pcol prelim
  • Julius Aguilar

  • 問題数 50 • 5/8/2024

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    問題一覧

  • 1

    The synthesis pathway of norepinephrine is

    tyrosine-dopamine-norepinephrine-epinephrine

  • 2

    The destruction of norepinephrine and dopamine in the synapses can be prevented by

    monoamine oxidase inhibitors

  • 3

    Schizophrenia is usually a lifelong psychiatric disability but luckily there is a cure for it

    false

  • 4

    Patient suffering from auditory or visual hallucinations, delusions, illogical thought and speech and combative and hostile exhibits which type of symptoms

    positive

  • 5

    A newly diagnosed schizophrenic patient suffering from impoverished speech and thinking, lsck of social drive, flatness of emotional expression, and anhedonia. Which antipsychotic drug will you least recommend to the doctor

    chlorpromazine

  • 6

    A patient exhibited pseudoparkinsonism and akathisia after being started on an antipsychotic medication. Which agent do you think might have caused these adverse effects

    haloperidol

  • 7

    Which atypical antipsychotic is the last resort drug and may increase risk of agranulocytosis

    clozapine

  • 8

    A female schizophrenic patient exhibited galactorrhea, gynecomastia and amenorrhea and doctor wants to know if these are drug related adverse effects. Patient is currently taking haloperidol 20mg twice daily. Which statement is correct regarding haloperidol

    haloperidol can decrease dopamine level which in turn increases prolactin level

  • 9

    Patients who suffered from constipation, blurred vision, urinary retention or dry mouth should avoid which of the following antipsychotics

    thioridazine

  • 10

    Atypical antipsychotics improve the negative symptoms to some extent and have a calmkng effect. Which of the following is not an atypical antipsychotic

    thiothexene

  • 11

    Sedation

    histamine

  • 12

    Orthostatic hypotension

    adrenergic

  • 13

    Urinary retention

    cholinergic

  • 14

    Weight gain

    histamine

  • 15

    Gynecomastia and galactorrhea

    dopamine

  • 16

    This extradyramidal side effect usually occurs when the patient has ben taking antipsychotics for >1 year and occur in various areas of the body - face, tongue, hips, and extremities. Common movement disorders include tounge chewing, lip smacking, and rhythmic movements of the trunk

    tardive dyskinesia

  • 17

    Which drug is not a long acting injetable formulation

    haloperidol lactate

  • 18

    Which statement regarding long acting injectables is correct

    long acting injectable formulations are administered intramuscularly in patients non compliant with oral meds. duration up to 2-4 weeks

  • 19

    Which is a rare and potentially fatal adverse effect of antipsychotics with symptoms that include muscle rigidity, fever with temperature as high as 41⁰c, altered mental status and stupor, unstable blood pressure myoglobinemia with elevated creatinine kinase

    neuroleptic malignant syndrome

  • 20

    Clinical depression os usually caused by an imbalance of neurotransmitters in the brain. Which is the correct statement

    it is caused by a decrease in norepinephrine and serotonin levels

  • 21

    The following drugs block norepinephrine and serotonin reuptake inti the neurons causing improved mood except

    paroxetine

  • 22

    Patient came to your pharmacy with a prescription for sertraline 25mg every morning and phenelzine 50mg in the evening. As a pharmacist, what would you do

    call the doctor regarding potential drug drug interaction

  • 23

    Ssri when guve together with mao inhibitors increase the risk of

    serotonin syndrome

  • 24

    Hypertensive crises occurs when increased levels of ne, vuild in the body, after ingesting tyramine containing foods like wine and cheese or decongestants. Which of the following antidepressants can potentially cause this when taken with these tyramine rich foods

    phenelzine and isocarboxazid

  • 25

    Which antidepressant is fda approved for smoking cessation and inhibits reuptake of norepinephrine and dopamine

    bupropion

  • 26

    The typical antipsychotic agents are the following except

    clozapine

  • 27

    Which of the following antipsychotics have less affinity for dopamine receptors, therefore have less risk for eps

    chlorpromazine and fluphenazine

  • 28

    The following antidepressants selectively inhibit reuptake of serotonin except

    atomoxetine

  • 29

    Which of the following statements are true regarding lithium therapy

    aota

  • 30

    Which of the following drugs are used in the treatment of bipolar disorder

    lithium and valproic acid

  • 31

    Which salt of lithium is available as immediate release, controlled release, or extended release tablets

    carbonate

  • 32

    Which drug has common adverse effects of polydipsia, polyuria, polyphagia, fine hand tremor and dermatologic reactions

    lithium

  • 33

    Which drug is a non benzodiazepine anxiolytic which may be useful in patients unable to take benzodiazepines

    buspirone

  • 34

    The thalamus area of the brain controls response inhibition. It works like gate sending signals to allow or stop behaviors. In adhd, the thalamus gate is broke

    true

  • 35

    The following statements are true regarding adhd

    aota

  • 36

    Adverse effects of stimulant medications include all of the following except

    bradycardia

  • 37

    Stimulant medications block reuptake of both dopamine and norepinephrine. These include the following drigs

    methylphenidate and amphetamine salts

  • 38

    Anxiety is described as a comfortable feeling of vague fear or apprehension accompanied by mental features and physical symptoms

    false

  • 39

    Anxiety is associated with chronic ne overactivity combined with increased activity in the 5ht system

    false

  • 40

    Benzodiazepines potentiate gaba by binding to gaba receptors and provide rapid relief in anxiety attacks. The following bzd used as anxiolytic except

    triazolam

  • 41

    The major drawback to clinical use of benzodiazepines include

    abuse potential and dependence liability

  • 42

    Which neurotransmitters are responsible in promoting sleep

    aota

  • 43

    Bzed receptor agonists have potential for abuse and dependence, hangover effect, and rebound insomnia upon discontinuation. The following drugs are bzd receptor agonists except

    zonisamide

  • 44

    The following drugs are considered firts line therapy for generalized anxiety disorder except

    bupropion

  • 45

    A bipolar patient has been binging on salty foods and is currently on lithium citrate syrup. What is likely goung to happen to this patient

    patient lithium level may decrease and bipolar diseaseay worsen

  • 46

    Non stimulants are considered 2nd line drugs for adhd. Which non stimulant is a selective norepinephrine reuptake inhibitor

    atomoxetine

  • 47

    Alpha 2 agonists works by inhibiting central release of norepinephrine and may be a useful adjunct to stimulants for symptoms of hyperactivity, impulsivity, aggresion, or insomnia. The following are alpha 2 agonists

    clonidine and guanfacine er

  • 48

    The following statement is true regarding ramelteon

    ramelteon is a melatonin receptor agonist

  • 49

    Which hypnotic has been associated with parainsomnia including sleep waling, eating, and driving

    zolpidem

  • 50

    Which hypnotic agent is a tricyclic antidepressant that produces it's effects through histamine blockade

    doxepin