immunology & serology

99問 • 1年前

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通報

問題一覧

1.Floculation test for syphilis detect the presence of:

reagin ab

2. MHC class III genes code for

complement

3. Ab class & ab subclass are determined by major physiochemical differences & antigenic variation found primarily in the

constant region of heavy chain

4. A serological test for syphilis that depends upon the detection of cardiolipin-lecithin-cholesterol ag is:

RPR

5. A heterophile antigen is best described as?

existing in an unrelated animal

6. In skin test, a wheal & flare development is:

immediate hypersensitivity

7. Rheumatoid factors are immunoglobulins with specificity for allotypic determinants located on the:

Fc fragment of IgG

8. Immunoglobulin idiotypic diversity is explained by

germ line recombination

9.the ff pattern of aggln was observed in ab titration: This set of reactions most likely resulted from:

prozoning

10. Bone marrow transplant donors & their recipients must be matched for which antigen system(s)?

HLA

11.20nm spheres & filamentous structures of HBV

circulating aggregates of HBsAg

12. Antihistamines like Benadryl:

block H1 histamine receptors

13. Multiplex bead assays for the detection of cytokines are efficient quantifiers of numerous cytokines at one time. One complication of such testing is:

the short half-life of certain cytokines

14.Blood is drawn from a px for a serological test for a viral dse shortly after the time of onset & again 4wks later. The results of the test are considered diagnostic if:

2nd ab titer is at least 4X the 1st

15. The best mtd to detect infections due to rubella, Epstein-Barr & HIV is:

ab detection by EIA

16. Immunodeficiency w/ thrombocytopenia & eczema is often referred to as:

Wiskott-Aldrich syndrome

17. T lymphocytes that possess the CD8 surface marker mediate which of the ff T cell functions?

cytotoxic

18. MHC class I includes which peptides / proteins?

HLA A, B, C

19.The ag marker most closely asso w/ transmissibility of HBV infection is:

HBeAg

20.Ab directed at native DNA are most frequently asso w/ w/c pattern of fluorescence in the IFA-ANA test?

rim

21. The visible serological rxn between soluble ag & its specific ab is:

precipitation

22. The hyperviscosity syndrome is most likely to be seen in monoclonal dse of which of the ff IG classes?

IgM

23.w/c lab technique most frequently use to diagnos & follow the course of therapy of px w/ 2ndary syphilis?

flocculation

25. The ff cold agglutinin titer results are observed:

(+) 1:128

26. On a follow-up visit to her dr, a young woman was given the results of her FTA-ABS test. She had been symptomatic for a couple months b4 this visit, w/ fever swollen cervical lymph nodes, fatigue,& rash affecting the palms of her hands & the soles of her feet,but she was now feeling better.Earlier test strategies that u would expect the dr. to have requested include all of the ff EXCEPT:

RAST

27. IL-4 can stimulate B cells to produce IgE, a major contributor to:

Type I hypersensitivity

28. A px abnormal lymphocytes are CD2(+)ag, lack C3 receptors,& are surface IG(-) This can be classified as a disorder of:

T cells

29.ratio of kappa to lambda light chain producing cells in normal individuals

2:1

30. IMMUNOlogic mtd utilized in the FLOW cytometer?

immunofluorescence

31. In indirect ELISA mtd designed to detect ab to the rubella virus in px serum the conjugate used should be:

anti-human IgG conjugated to an enzyme

32. Incompatibility by which of the ff procedures is an absolute contraindication to allotransplantation?

ABO grouping

33.The enzyme cntrl tube in ASO hemolytic assay exhibits no cell lysis.What is the most likely explanation

reduction of the enzyme

34. The strength of a visible reaction is known as:

avidity

35. The APR that has the fastest response time & can rise 100X is?

CRP

36. procedure has been routinely used for detection of HBsAg because of its high level of sensitivity:

ELISA

37. The kEy Structural difference that distinguishes immunoglobulin subclasses is the:

the sequence of the constant regions

38. W/c of the ff is most useful in establishing a diagnosis in convalescence phase of a viral infection?

serological techniques

39. the test results above,it can be concluded that px #3 has:

acute hepatitis B

40. The J-chain is asso w/ w/c of the ff IG?

IgA

41. Chronic transplant rejection is a cell mediated & humoral immune response that involves all the ff EXCEPT:

antibodies to MHC antigens on white cells

42. serological test that can be modified to selectively detect only specific IgM ab in untreated serum is:

enzyme immunoassay

43. Sera to be tested for IFA-ANA 6days after drawing is best stored at:

5C+2C

44. The most commonly used serological indicator of recent streptococcal infection is the antibody to:

Streptolysin O

45. The primary advantage of the labeled immunoassays compared to unlabeled immunoassays is:

sensitivity

46. SLE px often have which of the ff test results?

high titer of DNA ab

47.Mantoux skin test to identify infxn w/ M. tuberculosis

a cell-mediated response

48. The assembly of the complement "membrane attack unit" is initiated with the binding of:

49. A suspected anthrax lesion was submitted to the lab for preparation and testing. The test of choice

direct immunoassay

50. C3b and Fc receptors are present on:

B lymphocytes & monocytes

51. Hep B, a dse arising from a DNA virus, is diagnosed in its acute phase via serology for HBsAg, HBeAg, IgM alpha-HBC and total alpha-HBc. Once a px reaches chronic HBV infxn, effectiveness of therapy may be evaluated using:

HBV DNA testing w/ real time PCR

52. The area of the IG molecule referred to as the hinge region is located between which domains?

CH1&CH2

53. Biological false(+)VDRL rxn are frequently encountered in px with:

lupus erythematosus

54. Anti-glomerular basement membrane antibody is most often associated with this condition:

Goodpasteur syndrome

55. Which of the ff is an important marker for the presence of immature B cells in px with ALL?

TdT

56. Initiation of the activation mechanism of the alternative complement pathway differs from that of the classical pathway in that:

ag-ab complexes containing IgA or IgE may initiate activation

57. Soluble immune complexes r formed under the condition of:

ag excess

58. A haptenic determinant will react with:

ab but not T cells

59. Components of the complement system most likely to coat a cell are:

C1 & C2

60. A px returns from a camping trip, where he vacationed for several days in a tick-endemic environment.1month after his return home, he visited his health care provider w/ complaints of fatigue, numbness & history of rash surrounding an insect bite that occurred immediately on his return home from vacation. Suspecting Lyme disease, his clinician ordered an ELISA to test for Lyme ab, results of w/c were equivocal on 2 diff tests. His health care provider then ordered follow-up testing with:

Western blot

61.W/c of the ff complement components is a strong chemotactic factor as well as a strong anaphylatoxin?

C5a

62. W/c of the ff is the most common humoral immune deficiency dse?

selective IgA deficiency

63. The technologist observes apparent homogenous staining of nucleus of interphase cells while performing an IFA-ANA, as well as staining of the chromosomes in mitotic cells. This results is:

expected for anti-DNA ab

64.W/c of the ff is an organ specific autoimmune dse

Addison disease

65. A single, reliable screening test for detecting neonatal infection in the absence of clinical signs is:

quantitative serum IgM

66. Cells from a px w/ hairy cell leukemia have immunologic and functional features of:

B lymphocytes & monocytes

67. Cytokines involved in innate immune regulation include all but:

IL-3

68. Macrophages are characterized by:

surface rece[tprs for C3b complement

69.HLA-B8 ag has been asso w/ w/c of ff pairs of dse

myasthenia gravis & celiac dse

70.W/c test is used to evaluate cellular immune system in a px?

skin test for commonly encountered ag

71.A px w/ B cell deficIeNCy will most likely exhibit:

inc bacterial infections

72. W/c of the ff is released during T cell activation?

cytokines

73.Anti-phospholipid ab asso w/ autoimune disorders tend to have IG that belongs to w/c subclasses?

IgG2 & IgG4

74. A 16yo boy w/ infectious mononucleosis has a cold agglutinin titer of 1:2000. An important consideration of this antibody's clinical relevance is the:

thermal range

75. Which of the ff is most likely to activate the alternative patHway of complement activation?

haptens

76. The IIF staining pattern on ethanol-fixed leukocytes slides shows a perinuclear or nuclear staining pattern. This pattern is typically due to:

P-ANCA

77.The result of an ANA test was a titer of 1:320 w/ a peripheral pattern.W/c of the ff sets of results best correlate w/ these results?

anti-dsDNA titer 1:80, & a high titer of ab to Sm

78.W/c of the ff has been asso w/ px who have homozygous C3 deficiency?

a lifelong history of life-threatening infections

79. Hereditary angioedema is characterized by:

dec activity of C1 esterase inhibitor

80. The Mantoux test for M. tuberculosis is based on

Type 4 hypersensitivity rxn

81. The profile that matches the typical test profile for chronic active hepatitis due to hepatitis B virus is:

profile a

82.RheuMatoid factor is most often of w/c of the ff classes:

IgM

83.A (+)ANA w/ pattern of anti-centromere ab is most frequently seen in px with:

CREST syndrome

84. Which of the ff activities is associated with C3b?

opsonization

85. A DPT vaccination is an example of:

active humoral-mediated immunity

86.W/c of the ff IG is the most efficient at aggln?

IgM

87. Antibody allotype is determined by the:

constant regions of heavy & light chain

88. Substances that are antigenic only when coupled to a protein carrier are:

haptens

89. A substrate is first exposed to a px serum, then after washing, anti-human immunoglobulin labeled with a fluorochrome is added. The procedure described is:

indirect fluorescence

90. Methods of target amPlification in molecular testing include all but:

primer amplification

91. The procedure for compatibility testing in organ transplant medicine is very similar for the donor & the recipient. One additional procedure that the recipient must undergo that is not relevant to the donor testing is:

anti-HLA ab testing

92. In hybridoma technology, the desirable fused cell

myeloma-lymphocyte hybrid

93. Immunoassays are based on the principle of:

antibody recognition of homologous antigen

94. Antibody idiotype is dictated by the:

variable regions of heavy & light chain

95. PCR is extremely sensitive, but testing is often complicated by:

contamination of samples yielding false(+) results

96.W/c of the ff is the larger residual split portion of C3?

C3b

97. Polyclonal B cell activation:

can induce autoantibody prodn

98. Tumor-asso transplantation ag are not found in:

bacterial cells

99. For the diagnosis of late latent or tertiary syphilis, the most appropriate assay is:

FTA-ABS

100. What kind of ag-ab rxn would be expected if soluble antigen is added to homologous antibody?

precipitation

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問題一覧

1.Floculation test for syphilis detect the presence of:

reagin ab

2. MHC class III genes code for

complement

3. Ab class & ab subclass are determined by major physiochemical differences & antigenic variation found primarily in the

constant region of heavy chain

4. A serological test for syphilis that depends upon the detection of cardiolipin-lecithin-cholesterol ag is:

RPR

5. A heterophile antigen is best described as?

existing in an unrelated animal

6. In skin test, a wheal & flare development is:

immediate hypersensitivity

7. Rheumatoid factors are immunoglobulins with specificity for allotypic determinants located on the:

Fc fragment of IgG

8. Immunoglobulin idiotypic diversity is explained by

germ line recombination

9.the ff pattern of aggln was observed in ab titration: This set of reactions most likely resulted from:

prozoning

10. Bone marrow transplant donors & their recipients must be matched for which antigen system(s)?

HLA

11.20nm spheres & filamentous structures of HBV

circulating aggregates of HBsAg

12. Antihistamines like Benadryl:

block H1 histamine receptors

13. Multiplex bead assays for the detection of cytokines are efficient quantifiers of numerous cytokines at one time. One complication of such testing is:

the short half-life of certain cytokines

14.Blood is drawn from a px for a serological test for a viral dse shortly after the time of onset & again 4wks later. The results of the test are considered diagnostic if:

2nd ab titer is at least 4X the 1st

15. The best mtd to detect infections due to rubella, Epstein-Barr & HIV is:

ab detection by EIA

16. Immunodeficiency w/ thrombocytopenia & eczema is often referred to as:

Wiskott-Aldrich syndrome

17. T lymphocytes that possess the CD8 surface marker mediate which of the ff T cell functions?

cytotoxic

18. MHC class I includes which peptides / proteins?

HLA A, B, C

19.The ag marker most closely asso w/ transmissibility of HBV infection is:

HBeAg

20.Ab directed at native DNA are most frequently asso w/ w/c pattern of fluorescence in the IFA-ANA test?

rim

21. The visible serological rxn between soluble ag & its specific ab is:

precipitation

22. The hyperviscosity syndrome is most likely to be seen in monoclonal dse of which of the ff IG classes?

IgM

23.w/c lab technique most frequently use to diagnos & follow the course of therapy of px w/ 2ndary syphilis?

flocculation

25. The ff cold agglutinin titer results are observed:

(+) 1:128

RAST

27. IL-4 can stimulate B cells to produce IgE, a major contributor to:

Type I hypersensitivity

28. A px abnormal lymphocytes are CD2(+)ag, lack C3 receptors,& are surface IG(-) This can be classified as a disorder of:

T cells

29.ratio of kappa to lambda light chain producing cells in normal individuals

2:1

30. IMMUNOlogic mtd utilized in the FLOW cytometer?

immunofluorescence

31. In indirect ELISA mtd designed to detect ab to the rubella virus in px serum the conjugate used should be:

anti-human IgG conjugated to an enzyme

32. Incompatibility by which of the ff procedures is an absolute contraindication to allotransplantation?

ABO grouping

33.The enzyme cntrl tube in ASO hemolytic assay exhibits no cell lysis.What is the most likely explanation

reduction of the enzyme

34. The strength of a visible reaction is known as:

avidity

35. The APR that has the fastest response time & can rise 100X is?

CRP

36. procedure has been routinely used for detection of HBsAg because of its high level of sensitivity:

ELISA

37. The kEy Structural difference that distinguishes immunoglobulin subclasses is the:

the sequence of the constant regions

38. W/c of the ff is most useful in establishing a diagnosis in convalescence phase of a viral infection?

serological techniques

39. the test results above,it can be concluded that px #3 has:

acute hepatitis B

40. The J-chain is asso w/ w/c of the ff IG?

IgA

41. Chronic transplant rejection is a cell mediated & humoral immune response that involves all the ff EXCEPT:

antibodies to MHC antigens on white cells

42. serological test that can be modified to selectively detect only specific IgM ab in untreated serum is:

enzyme immunoassay

43. Sera to be tested for IFA-ANA 6days after drawing is best stored at:

5C+2C

44. The most commonly used serological indicator of recent streptococcal infection is the antibody to:

Streptolysin O

45. The primary advantage of the labeled immunoassays compared to unlabeled immunoassays is:

sensitivity

46. SLE px often have which of the ff test results?

high titer of DNA ab

47.Mantoux skin test to identify infxn w/ M. tuberculosis

a cell-mediated response

48. The assembly of the complement "membrane attack unit" is initiated with the binding of:

49. A suspected anthrax lesion was submitted to the lab for preparation and testing. The test of choice

direct immunoassay

50. C3b and Fc receptors are present on:

B lymphocytes & monocytes

HBV DNA testing w/ real time PCR

52. The area of the IG molecule referred to as the hinge region is located between which domains?

CH1&CH2

53. Biological false(+)VDRL rxn are frequently encountered in px with:

lupus erythematosus

54. Anti-glomerular basement membrane antibody is most often associated with this condition:

Goodpasteur syndrome

55. Which of the ff is an important marker for the presence of immature B cells in px with ALL?

TdT

56. Initiation of the activation mechanism of the alternative complement pathway differs from that of the classical pathway in that:

ag-ab complexes containing IgA or IgE may initiate activation

57. Soluble immune complexes r formed under the condition of:

ag excess

58. A haptenic determinant will react with:

ab but not T cells

59. Components of the complement system most likely to coat a cell are:

C1 & C2

Western blot

61.W/c of the ff complement components is a strong chemotactic factor as well as a strong anaphylatoxin?

C5a

62. W/c of the ff is the most common humoral immune deficiency dse?

selective IgA deficiency

63. The technologist observes apparent homogenous staining of nucleus of interphase cells while performing an IFA-ANA, as well as staining of the chromosomes in mitotic cells. This results is:

expected for anti-DNA ab

64.W/c of the ff is an organ specific autoimmune dse

Addison disease

65. A single, reliable screening test for detecting neonatal infection in the absence of clinical signs is:

quantitative serum IgM

66. Cells from a px w/ hairy cell leukemia have immunologic and functional features of:

B lymphocytes & monocytes

67. Cytokines involved in innate immune regulation include all but:

IL-3

68. Macrophages are characterized by:

surface rece[tprs for C3b complement

69.HLA-B8 ag has been asso w/ w/c of ff pairs of dse

myasthenia gravis & celiac dse

70.W/c test is used to evaluate cellular immune system in a px?

skin test for commonly encountered ag

71.A px w/ B cell deficIeNCy will most likely exhibit:

inc bacterial infections

72. W/c of the ff is released during T cell activation?

cytokines

73.Anti-phospholipid ab asso w/ autoimune disorders tend to have IG that belongs to w/c subclasses?

IgG2 & IgG4

74. A 16yo boy w/ infectious mononucleosis has a cold agglutinin titer of 1:2000. An important consideration of this antibody's clinical relevance is the:

thermal range

75. Which of the ff is most likely to activate the alternative patHway of complement activation?

haptens

76. The IIF staining pattern on ethanol-fixed leukocytes slides shows a perinuclear or nuclear staining pattern. This pattern is typically due to:

P-ANCA

77.The result of an ANA test was a titer of 1:320 w/ a peripheral pattern.W/c of the ff sets of results best correlate w/ these results?

anti-dsDNA titer 1:80, & a high titer of ab to Sm

78.W/c of the ff has been asso w/ px who have homozygous C3 deficiency?

a lifelong history of life-threatening infections

79. Hereditary angioedema is characterized by:

dec activity of C1 esterase inhibitor

80. The Mantoux test for M. tuberculosis is based on

Type 4 hypersensitivity rxn

81. The profile that matches the typical test profile for chronic active hepatitis due to hepatitis B virus is:

profile a

82.RheuMatoid factor is most often of w/c of the ff classes:

IgM

83.A (+)ANA w/ pattern of anti-centromere ab is most frequently seen in px with:

CREST syndrome

84. Which of the ff activities is associated with C3b?

opsonization

85. A DPT vaccination is an example of:

active humoral-mediated immunity

86.W/c of the ff IG is the most efficient at aggln?

IgM

87. Antibody allotype is determined by the:

constant regions of heavy & light chain

88. Substances that are antigenic only when coupled to a protein carrier are:

haptens

89. A substrate is first exposed to a px serum, then after washing, anti-human immunoglobulin labeled with a fluorochrome is added. The procedure described is:

indirect fluorescence

90. Methods of target amPlification in molecular testing include all but:

primer amplification

anti-HLA ab testing

92. In hybridoma technology, the desirable fused cell

myeloma-lymphocyte hybrid

93. Immunoassays are based on the principle of:

antibody recognition of homologous antigen

94. Antibody idiotype is dictated by the:

variable regions of heavy & light chain

95. PCR is extremely sensitive, but testing is often complicated by:

contamination of samples yielding false(+) results

96.W/c of the ff is the larger residual split portion of C3?

C3b

97. Polyclonal B cell activation:

can induce autoantibody prodn

98. Tumor-asso transplantation ag are not found in:

bacterial cells

99. For the diagnosis of late latent or tertiary syphilis, the most appropriate assay is:

FTA-ABS

100. What kind of ag-ab rxn would be expected if soluble antigen is added to homologous antibody?

precipitation