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Erythrocyte Disorders and Inclusions
  • MAHATHIR ALPHA

  • 問題数 32 • 11/4/2023

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  • 1

    RBC with blunt or pointed, short projections that are usually evenly spaced over the surface of cell; present in all fields of blood film but in variable numbers per field.

    Burr cell (echinocyte)

  • 2

    Commonly associated disease states with Burr cell (Echinocyte).

    Uremia, Pyruvate kinase deficiency

  • 3

    Commonly associated disease states with Teardrop cell (Dacryocyte).

    Primary myelofibrosis, Myelophthisic anemia, Thalassemia, Megaloblastic anemia

  • 4

    RBC with a single pointed extension resembling a teardrop or pear.

    Teardrop cell (dacryocyte)

  • 5

    Appearance in Supravital stain: Dark blue granules and filaments in cytoplasm (seen in reticulocyte)

    Diffuse basophilia

  • 6

    Appearance in Supravital stain: Dark blur-purple, fine or coarse punctate granules distributed throughout the cytoplasm

    Basophilic stippling

  • 7

    Appearance in Supravital stain: Dark blue-purple, round granule, usually one per cell; occasionally multiple.

    Howell-Jolly body

  • 8

    Round, dark-purple granule attached to inner RBC membrane.

    Heinz bodies

  • 9

    Appearance in Supravital stain: Irregular clusters of small, light to dark granules often near periphery of cell.

    Pappenheimer bodies

  • 10

    Appearance in Supravital stain: Rings or figure-eights

    Cabot ring

  • 11

    Appearance in Supravital stain: Fine, evenly dispersed, dark blue granules, imparts "golf ball" appearance to RBCs.

    Hemoglobin H

  • 12

    What is the appearance of Diffuse basophilia in Wright stain?

    Bluish tinge throughout cytoplasm, also called polychromasia (seen in polychromatic erythrocytes).

  • 13

    What is the appearance of Basophilic stippling in Wright stain?

    Dark blue-purple, fine or course punctate granules distributed throughout cytoplasm.

  • 14

    What is the appearance of Howell-Jolly body in Wright stain?

    Dark blue-purple dense, round granule, usually one per cell; occasionaly multiple

  • 15

    What is the appearance of Heinz body in Wright stain?

    Not visible

  • 16

    What is the appearance of Hemoglobin H in Wright stain?

    Not visible

  • 17

    What is the appearance of Cabot ring in Wright stain?

    Blue rings or figure-eights

  • 18

    What is the appearance of Pappenheimer bodies in Wright stain?

    Irregular clusters of small, light to dark granules, often near periphery of cell

  • 19

    What is the composition of Diffuse basophilia?

    RNA

  • 20

    What is the composition of Basophilic stippling?

    Precipitated RNA

  • 21

    What is the composition of Howell-Jolly body?

    DNA(nuclear fragment)

  • 22

    What is the composition of Heinz body?

    Denatured hemoglobin

  • 23

    What is the composition of Pappenheimer bodies?

    Iron

  • 24

    What is the composition of Cabot ring?

    Mitotic spindle remnant

  • 25

    What is the composition of Hemoglobin H?

    Precipitated B-globin chains of hemoglobin

  • 26

    Associated diseases/conditions of Diffuse basophilia

    Hemolytic anemia, Folate deficiency

  • 27

    Associated diseases/conditions of Basophilic stippling

    Lead poisoning, Thalassemias, Hemoglobinopathies, Megaloblastic anemia, Myelodysplastic syndromes

  • 28

    Associated diseases/conditions of Howell-Jolly body

    Hyposplenism, Postsplenectomy, Megaloblastic anemia, Thalassemia, Myelodysplastic syndromes

  • 29

    Associated diseases/conditions of Heinz bodies

    Glucose-6-phosphate dehydrogenase deficiency, Unstable hemoglobin, Oxidant drugs/chemicals

  • 30

    Associated diseases/conditions of Pappenheimer bodies

    Sideroblastic anemia, Hemoglobinopathies, Thalassemia, Megablastic anemia, Myelodysplastic syndrome, Hyposplenism, Postsplenectomy

  • 31

    Associated diseases/conditions of Cabot ring

    Megaloblastic anemia, Myelodysplastic syndrome

  • 32

    Associated diseases/conditions of Hemoglobin H

    Hemoglobin H disease