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Clinical Chemistry
  • EJ Nicole Bonghanoy

  • 問題数 100 • 2/7/2024

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    問題一覧

  • 1

    Which of the following is an example of an antiarrhythmic drug that has a metabolite with the same action?

    Procainamide

  • 2

    Of the following analytic methods, which is most commonly used as the confirmatory method for identification of drugs of abuse?

    GC with mass spectrometry

  • 3

    Which of the following is the major contributor to the colloid osmotic pressure of the intravascular fluid?

    Albumin

  • 4

    The most common form of congenital adrenal hyperplasia is 21-hydroxylase deficiency which is detected by demonstrating elevated levels of:

    17-OH-progesterone

  • 5

    A patient presenting with symptoms of jaundice, hepatic pain, and chalky-appearing stools had the following laboratory values: elevated conjugated bilirubin, ALP, and GGT. These findings are most likely due to:

    Cholelithiasis

  • 6

    Which of the following analytes would be most greatly affected by a non-fasting sample?

    Triglyceride

  • 7

    What is the enzyme deficiency responsible for von Gierke's disease?

    Glucose-6-phosphatase

  • 8

    Antidiuretic hormone is synthesized by the:

    Hypothalamus

  • 9

    Which of the following is the correct formula for A/G ratio?

    Albumin / (Total protein - Albumin)

  • 10

    Deterioration of reagents is a problem encountered in what phase of laboratory testing?

    Analytical phase

  • 11

    Which of the following is associated with arteriosclerotic cardiovascular failure signifying grave prognosis and impending death?

    LD-6

  • 12

    Which form of mercury is an environmental pollutant and is extremely toxic?

    Alkyl

  • 13

    Which statement regarding glycated hemoglobin (Hb A1c) is true?

    Reflects the average glucose level 8-12 weeks prior to sampling

  • 14

    The largest fraction of thyroxine in the blood circulates bound to:

    Thyroxine-binding globulin

  • 15

    Which of the following is an autosomal recessive disorder involving mutations in the MTTP gene with absolute nonexistent levels of apo-B lipoprotein?

    Bassen-Kornzweig syndrome

  • 16

    The following conditions are associated with hyperkalemia ECEPT:

    Hyperaldosteronism

  • 17

    Hyponatremia due to increased water retention is associated with the following conditions EXCEPT:

    Diabetic ketoacidosis

  • 18

    The pH meter used in arterial blood gas analysis is calibrated using:

    Phosphate buffers

  • 19

    Which of the following are components of the Biuret reagent for protein determination?

    CuS04, Rochelle salt, NaOH, KI

  • 20

    Which of the following may be used to distinguish between normochloremic and hyperchloremic metabolic acidosis?

    Anion gap

  • 21

    Which apolipoprotein is associated with an increased risk of cardiovascular disease?

    Apo B

  • 22

    Kinetic enzymatic assays are best performed during which phase of an enzymatic reaction?

    Linear phase

  • 23

    Which of the following may serve as second substrates for enzymatic reactions?

    Coenzymes

  • 24

    In the Jaffe reaction, a red-orange chromogen is formed when creatinine reacts with:

    Alkaline picrate solution

  • 25

    In nephrotic syndrome and protein-losing enteropathy, the densitometric pattern for albumin and a2 are respectively:

    Decreased, increased

  • 26

    Which of the following hormones is not produced in the adrenal cortex?

    Epinephrine

  • 27

    The metabolite 11-nor-tetrahydrocannabinol-9-COOH can be detected by immunoassay 3-5 days after a single use of:

    Marijuana

  • 28

    The following are associated with decreased creatinine clearance ЕХСЕРТ:

    High cardiac output

  • 29

    Convert 250 mg/dL transferrin to g/L.

    2.5

  • 30

    To maintain electric neutrality, chloride diffuses into the red cells in exchange for:

    Bicarbonate

  • 31

    During chemotherapy for leukemia using cytotoxic agents, which of the following analytes would most likely be elevated in the blood?

    Uric Acid

  • 32

    Given the following information, interpret the creatinine clearance: 24-hour urine volume: 1100 mL; serum creatinine: 2.0 mg/dL urine creatinine: 180 mg/dL

    69 mL/min

  • 33

    Which ALP isoenzyme is the most heat stable?

    Placenta

  • 34

    Which of the following is a non-destructive method for determining the structure of organic compounds and is adapted for lipoprotein particle measurements?

    Nuclear magnetic resonance spectroscopy

  • 35

    Which of the following laboratory tests is the best marker for diabetic nephropathy?

    Microalbuminuria

  • 36

    Which of the following is considered the target of therapy among high-risk patients and is used in making diet and medication decisions?

    LDL

  • 37

    Which of the following represents the light chain component of class | major histocompatibility complex?

    ß2-microglobulin

  • 38

    Which of the following reagents directly reacts with urea forming a yellow product?

    Diacetyl

  • 39

    Given the following results for a lipid profile calculate LDL cholesterol using the Friedewald formula. HDL: 50 mg/dL Total cholesterol: 300 mg/dL Triglycerides: 200 mg/dL

    210

  • 40

    Which of the following is used as a marker for congestive heart failure?

    BNP

  • 41

    What factor should be used to convert mg/dL to mmol/L concentration of serum LDL-cholesterol?

    0.026

  • 42

    Which of the following lipoprotein fractions has a high level of homology with plasminogen and is associated with an increased risk for MI and stroke?

    Lp(a)

  • 43

    In Hashimoto's thyroiditis, which of the following levels are true of the total T4, T3U, and TSH respectively?

    Decreased, decreased, increased

  • 44

    Malate dehydrogenase is added to the AST assay to catalyze the conversion of:

    Oxaloacetate to malate

  • 45

    Which of the following is used to subtract the intrinsic absorbance caused by hemolysis, icterus, turbidity, or drug interference during analysis?

    Sample blank

  • 46

    What is the basic SI unit for thermodynamic temperature?

    Kelvin

  • 47

    Which of the following correctly ranks electromagnetic radiation from low energy to high energy?

    Microwaves, infrared, visible, UV, x-rays, gamma

  • 48

    What hormone stimulates the secretion glucocorticoids?

    ACTH

  • 49

    Which of the following biochemical processes are promoted by insulin?

    Cellular uptake of glucose and glycolysis

  • 50

    Which of the following represents the Henderson-Hasselbalch equation as applied to blood pH?

    6.1 + log HCO3-/(PCO2 × 0.03)

  • 51

    The positive acute-phase reactant proteins include the following EXCEPT:

    Transferrin

  • 52

    When an enzymatic reaction is performed under zero-order kinetics:

    the rate of the reaction is dependent of the enzyme concentration

  • 53

    What is the enzyme classification of G6PD?

    Oxidoreductase

  • 54

    Which of the following apoproteins is inversely related to risk for coronary heart disease and is a surrogate marker for HDL?

    Apo A-1

  • 55

    Which of the following types of chemistry analyzer allows the use of reagents from different manufacturers?

    Open-system

  • 56

    Which of the following mechanisms accounts for the elevated plasma level of ß-lipoproteins seen in Fredrickson type lla hyperlipoproteinemia?

    LDL receptor defect

  • 57

    Following acute myocardial infarction, in what order will the markers become elevated in plasma?

    Myoglobin, troponin, CK, AST, LD

  • 58

    Which of the following are causes of random error? i. Improper mixing of sample and reagent ii. Voltage fluctuation iii. Pipetting error iv. Deteriorating light source

    і, ii, iii

  • 59

    Which of the following is not consistent with diabetes mellitus?

    Serum osmolality <300 mOsm/kg

  • 60

    Mental confusion and strongly impaired motor skills are associated with which of the following blood alcohol concentrations (% w/v)?

    0.18-0.30

  • 61

    Convert 0.2 microliter to deciliter.

    0.000002

  • 62

    A new CA 125 test for ovarian cancer gave positive results in 21 of 24 malignant patients and negative results in 61 of 62 benign patients. What are the sensitivity, specificity, PPV, and NPV values respectively?

    87.5%, 98.4%, 95.5%, 95.3%

  • 63

    High serum total protein in conjunction with low serum albumin is usually seen in:

    Multiple Myeloma

  • 64

    The following are routes of lead exposure EXCEPT:

    Animal bite

  • 65

    Which of the following describes the cholesterol concentrations in hyperthyroidism and hypothyroidism respectively?

    Decreased, increased

  • 66

    Which testing situation is appropriate for the use of point-of-care whole blood glucose methods?

    Monitoring of blood glucose control in type 1 and type 2 diabetics

  • 67

    What is the compensatory mechanism for metabolic alkalosis?

    Hypoventilation

  • 68

    Which of the following proteins migrates to the beta region in electrophoresis?

    Hemopexin

  • 69

    If the value for level 1 control is above the +2s and the value for level 2 control is below the - 1s, which course of action is appropriate?

    Check other Westgard rules

  • 70

    Calculate the cholesterol concentration given the following data: Astandard: 0.679 Asample: 0.729 Acontrol: 0.650 Cstandard: 200 mg/dL

    215 mg/dL

  • 71

    If a patient scheduled for venipuncture has an arteriovenous fistula in one arm, what is the most appropriate course of action?

    Use the opposite arm

  • 72

    What step in the Abell-Kendall method for cholesterol measurement is meant to convert cholesterol esters to free cholesterol?

    Saponification

  • 73

    Which of the following serum glucose concentrations is expected to result in glucosuria?

    175 mg/dL

  • 74

    Which enzyme is common to all enzymatic methods for triglyceride measurement?

    Glycerol kinase

  • 75

    Xanthelasmas are yellow periorbital papules commonly associated with:

    Hypercholesterolemia

  • 76

    When should blood samples for trough drug levels be collected?

    Immediately before the next dose is given

  • 77

    What is the normal bicarbonate/carbonic acid ratio?

    20:1

  • 78

    Which of the following would have significantly decreased level when determined by indirect ISE in lipemic serum?

    Sodium

  • 79

    A patient's arterial blood gas results are as follows: pH 7.33; pCO2, 75 mmHg; HCO3-, 37 mmol/L. These values are consistent with:

    Partially compensated respiratory acidosis

  • 80

    Electrolytes, glucose, BUN, creatinine and serum osmolality measurements have been performed on a patient suspected of ingesting intoxicating amounts of ethanol. What can be done to help reveal this condition without additional testing?

    Osmolal gap

  • 81

    A technologist obtains a BUN value of 28 mg/dL and a serum creatinine value of 1.1 mg/dL on a male patient. These results are consistent with:

    Pre-renal azotemia

  • 82

    Which of the following are true about type 1 diabetes? i. represents <10% of diabetes cases ii. ketoacidosis is common ili. results from autoimmune destruction B islet cells iv. high C-peptide level

    i, ii, iii

  • 83

    When a range is set by taking the mean value plus or minus two standard deviations, the percentage of values of the normal population excluded from the acceptable range is:

    5%

  • 84

    Which of the following represents the correct order of draw in multiple blood collection using the evacuated system?

    Blue, red, green, lavender

  • 85

    In cases of hemolytic uremic syndrome, which test would be most appropriate to measure the patient's hemolytic episode?

    Hemopexin

  • 86

    The reference method for glucose determination is based on the measurement of:

    Increase in absorbance at 340 nm

  • 87

    Which of the Westgard rules is violated in the control data below?

    4 1s

  • 88

    Which method for uric acid is specific and is not subject to interference by reducing agents?

    Enzymatic-UV

  • 89

    Which of the following are components of routine electrolyte panel and are used to determine anion gap? i. Bicarbonate ii. Sodium iii. Chloride iv. Potassium

    i, ii, iii, iv

  • 90

    Given a plasma glucose result of 100 mg/dL, the corresponding whole blood glucose level is approximately:

    87 mg/dL

  • 91

    In the laboratory procedure for the quantification of HDL, the purpose of the dextran sulfate is to:

    Precipitate all Apo B containing lipoproteins

  • 92

    What are the electrolytes involved in myocardial rhythm and contractility? i. Magnesium ii. Potassium iii. Calcium iv. Sodium

    i, ii, iii

  • 93

    Which of the following are threshold substances? i. Glucose ii. Potassium iii. Sodium iv. Albumin

    i, iii

  • 94

    What is the end product in the Folin-Wu method of glucose determination?

    Phosphomolybdenum

  • 95

    Calculate the osmolal gap given the following serum chemistry results: Sodium - 140 mmol/L; BUN - 24 mg/dL; Glucose - 100 mg/dL; Freezing point osmolality - 320 mOsm/kg

    27 mOsm/kg

  • 96

    What is the most abundant LD isoenzyme in normal serum?

    LD2

  • 97

    What is the six sigma colored belt designation for project team members who contribute approximately 20% of their time to QI projects while delivering their normal job functions?

    Green belt

  • 98

    Which of the following lipoproteins is involved in reverse cholesterol transport?

    HDL

  • 99

    What is the major interferent in dry reagent formats that use the uricase-peroxidase reaction for uric acid assay?

    Ascorbic acid

  • 100

    In the Beer's equation A = abc, what does b represent?

    Light path length