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問題一覧
1
What is the compensatory mechanism for metabolic alkalosis?
Hypoventilation
2
Which of the following is the correct formula for A/G ratio?
Albumin / (Total protein - Albumin)
3
Which of the following biochemical processes are promoted by insulin?
Cellular uptake of glucose and glycolysis
4
Convert 0.2 microliter to deciliter.
0.000002
5
Calculate the cholesterol concentration given the following data: Astandard: 0.679 Asample: 0.729 Acontrol: 0.650 Cstandard: 200 mg/dL
215 mg/dL
6
Which enzyme is common to all enzymatic methods for triglyceride measurement?
Glycerol kinase
7
What factor should be used to convert mg/dL to mmol/L concentration of serum LDL-cholesterol?
0.026
8
Which of the following is an autosomal recessive disorder involving mutations in the MTTP gene with absolute nonexistent levels of apo-B lipoprotein?
Bassen-Kornzweig syndrome
9
Which form of mercury is an environmental pollutant and is extremely toxic?
Alkyl
10
Which ALP isoenzyme is the most heat stable?
Placenta
11
Which of the following types of chemistry analyzer allows the use of reagents from different manufacturers?
Open-system
12
Xanthelasmas are yellow periorbital papules commonly associated with:
Hypercholesterolemia
13
Mental confusion and strongly impaired motor skills are associated with which of the following blood alcohol concentrations (% w/v)?
0.18-0.30
14
Deterioration of reagents is a problem encountered in what phase of laboratory testing?
Analytical phase
15
Which of the Westgard rules is violated in the control data below?
4 1s
16
What is the enzyme classification of G6PD?
Oxidoreductase
17
Which of the following apoproteins is inversely related to risk for coronary heart disease and is a surrogate marker for HDL?
Apo A-1
18
Which of the following are components of the Biuret reagent for protein determination?
CuS04, Rochelle salt, NaOH, KI
19
Which of the following are threshold substances? i. Glucose ii. Potassium iii. Sodium iv. Albumin
i, iii
20
What is the basic SI unit for thermodynamic temperature?
Kelvin
21
What are the electrolytes involved in myocardial rhythm and contractility? i. Magnesium ii. Potassium iii. Calcium iv. Sodium
i, ii, iii
22
Which of the following is used to subtract the intrinsic absorbance caused by hemolysis, icterus, turbidity, or drug interference during analysis?
Sample blank
23
The following are routes of lead exposure EXCEPT:
Animal bite
24
Which of the following lipoproteins is involved in reverse cholesterol transport?
HDL
25
The pH meter used in arterial blood gas analysis is calibrated using:
Phosphate buffers
26
Antidiuretic hormone is synthesized by the:
Hypothalamus
27
Which apolipoprotein is associated with an increased risk of cardiovascular disease?
Apo B
28
Which of the following analytes would be most greatly affected by a non-fasting sample?
Triglyceride
29
Kinetic enzymatic assays are best performed during which phase of an enzymatic reaction?
Linear phase
30
Which of the following proteins migrates to the beta region in electrophoresis?
Hemopexin
31
Which of the following is not consistent with diabetes mellitus?
Serum osmolality <300 mOsm/kg
32
The following conditions are associated with hyperkalemia ECEPT:
Hyperaldosteronism
33
Which of the following is associated with arteriosclerotic cardiovascular failure signifying grave prognosis and impending death?
LD-6
34
What is the major interferent in dry reagent formats that use the uricase-peroxidase reaction for uric acid assay?
Ascorbic acid
35
If the value for level 1 control is above the +2s and the value for level 2 control is below the - 1s, which course of action is appropriate?
Check other Westgard rules
36
Which of the following represents the correct order of draw in multiple blood collection using the evacuated system?
Blue, red, green, lavender
37
Which of the following hormones is not produced in the adrenal cortex?
Epinephrine
38
What is the end product in the Folin-Wu method of glucose determination?
Phosphomolybdenum
39
Which of the following is considered the target of therapy among high-risk patients and is used in making diet and medication decisions?
LDL
40
Which of the following describes the cholesterol concentrations in hyperthyroidism and hypothyroidism respectively?
Decreased, increased
41
When a range is set by taking the mean value plus or minus two standard deviations, the percentage of values of the normal population excluded from the acceptable range is:
5%
42
A new CA 125 test for ovarian cancer gave positive results in 21 of 24 malignant patients and negative results in 61 of 62 benign patients. What are the sensitivity, specificity, PPV, and NPV values respectively?
87.5%, 98.4%, 95.5%, 95.3%
43
Which of the following are causes of random error? i. Improper mixing of sample and reagent ii. Voltage fluctuation iii. Pipetting error iv. Deteriorating light source
і, ii, iii
44
What is the six sigma colored belt designation for project team members who contribute approximately 20% of their time to QI projects while delivering their normal job functions?
Green belt
45
If a patient scheduled for venipuncture has an arteriovenous fistula in one arm, what is the most appropriate course of action?
Use the opposite arm
46
In the Beer's equation A = abc, what does b represent?
Light path length
47
Which statement regarding glycated hemoglobin (Hb A1c) is true?
Reflects the average glucose level 8-12 weeks prior to sampling
48
Which testing situation is appropriate for the use of point-of-care whole blood glucose methods?
Monitoring of blood glucose control in type 1 and type 2 diabetics
49
What is the enzyme deficiency responsible for von Gierke's disease?
Glucose-6-phosphatase
50
What step in the Abell-Kendall method for cholesterol measurement is meant to convert cholesterol esters to free cholesterol?
Saponification
51
Which of the following correctly ranks electromagnetic radiation from low energy to high energy?
Microwaves, infrared, visible, UV, x-rays, gamma
52
Which of the following reagents directly reacts with urea forming a yellow product?
Diacetyl
53
In the Jaffe reaction, a red-orange chromogen is formed when creatinine reacts with:
Alkaline picrate solution
54
The following are associated with decreased creatinine clearance ЕХСЕРТ:
High cardiac output
55
Which of the following is the major contributor to the colloid osmotic pressure of the intravascular fluid?
Albumin
56
Which of the following represents the light chain component of class | major histocompatibility complex?
ß2-microglobulin
57
In nephrotic syndrome and protein-losing enteropathy, the densitometric pattern for albumin and a2 are respectively:
Decreased, increased
58
Which of the following is used as a marker for congestive heart failure?
BNP
59
When should blood samples for trough drug levels be collected?
Immediately before the next dose is given
60
During chemotherapy for leukemia using cytotoxic agents, which of the following analytes would most likely be elevated in the blood?
Uric Acid
61
Which of the following may serve as second substrates for enzymatic reactions?
Coenzymes
62
What is the most abundant LD isoenzyme in normal serum?
LD2
63
Which of the following mechanisms accounts for the elevated plasma level of ß-lipoproteins seen in Fredrickson type lla hyperlipoproteinemia?
LDL receptor defect
64
Malate dehydrogenase is added to the AST assay to catalyze the conversion of:
Oxaloacetate to malate
65
Hyponatremia due to increased water retention is associated with the following conditions EXCEPT:
Diabetic ketoacidosis
66
To maintain electric neutrality, chloride diffuses into the red cells in exchange for:
Bicarbonate
67
Which of the following are components of routine electrolyte panel and are used to determine anion gap? i. Bicarbonate ii. Sodium iii. Chloride iv. Potassium
i, ii, iii, iv
68
Electrolytes, glucose, BUN, creatinine and serum osmolality measurements have been performed on a patient suspected of ingesting intoxicating amounts of ethanol. What can be done to help reveal this condition without additional testing?
Osmolal gap
69
What is the normal bicarbonate/carbonic acid ratio?
20:1
70
What hormone stimulates the secretion glucocorticoids?
ACTH
71
The largest fraction of thyroxine in the blood circulates bound to:
Thyroxine-binding globulin
72
The most common form of congenital adrenal hyperplasia is 21-hydroxylase deficiency which is detected by demonstrating elevated levels of:
17-OH-progesterone
73
The metabolite 11-nor-tetrahydrocannabinol-9-COOH can be detected by immunoassay 3-5 days after a single use of:
Marijuana
74
Of the following analytic methods, which is most commonly used as the confirmatory method for identification of drugs of abuse?
GC with mass spectrometry
75
In the laboratory procedure for the quantification of HDL, the purpose of the dextran sulfate is to:
Precipitate all Apo B containing lipoproteins
76
Given the following results for a lipid profile calculate LDL cholesterol using the Friedewald formula. HDL: 50 mg/dL Total cholesterol: 300 mg/dL Triglycerides: 200 mg/dL
210
77
Which of the following serum glucose concentrations is expected to result in glucosuria?
175 mg/dL
78
Which of the following laboratory tests is the best marker for diabetic nephropathy?
Microalbuminuria
79
Given a plasma glucose result of 100 mg/dL, the corresponding whole blood glucose level is approximately:
87 mg/dL
80
Which of the following are true about type 1 diabetes? i. represents <10% of diabetes cases ii. ketoacidosis is common ili. results from autoimmune destruction B islet cells iv. high C-peptide level
i, ii, iii
81
The reference method for glucose determination is based on the measurement of:
Increase in absorbance at 340 nm
82
Convert 250 mg/dL transferrin to g/L.
2.5
83
High serum total protein in conjunction with low serum albumin is usually seen in:
Multiple Myeloma
84
Which method for uric acid is specific and is not subject to interference by reducing agents?
Enzymatic-UV
85
The positive acute-phase reactant proteins include the following EXCEPT:
Transferrin
86
A patient's arterial blood gas results are as follows: pH 7.33; pCO2, 75 mmHg; HCO3-, 37 mmol/L. These values are consistent with:
Partially compensated respiratory acidosis
87
A patient presenting with symptoms of jaundice, hepatic pain, and chalky-appearing stools had the following laboratory values: elevated conjugated bilirubin, ALP, and GGT. These findings are most likely due to:
Cholelithiasis
88
When an enzymatic reaction is performed under zero-order kinetics:
the rate of the reaction is dependent of the enzyme concentration
89
Which of the following would have significantly decreased level when determined by indirect ISE in lipemic serum?
Sodium
90
In Hashimoto's thyroiditis, which of the following levels are true of the total T4, T3U, and TSH respectively?
Decreased, decreased, increased
91
A technologist obtains a BUN value of 28 mg/dL and a serum creatinine value of 1.1 mg/dL on a male patient. These results are consistent with:
Pre-renal azotemia
92
Which of the following lipoprotein fractions has a high level of homology with plasminogen and is associated with an increased risk for MI and stroke?
Lp(a)
93
In cases of hemolytic uremic syndrome, which test would be most appropriate to measure the patient's hemolytic episode?
Hemopexin
94
Following acute myocardial infarction, in what order will the markers become elevated in plasma?
Myoglobin, troponin, CK, AST, LD
95
Given the following information, interpret the creatinine clearance: 24-hour urine volume: 1100 mL; serum creatinine: 2.0 mg/dL urine creatinine: 180 mg/dL
69 mL/min
96
Which of the following may be used to distinguish between normochloremic and hyperchloremic metabolic acidosis?
Anion gap
97
Calculate the osmolal gap given the following serum chemistry results: Sodium - 140 mmol/L; BUN - 24 mg/dL; Glucose - 100 mg/dL; Freezing point osmolality - 320 mOsm/kg
27 mOsm/kg
98
Which of the following is a non-destructive method for determining the structure of organic compounds and is adapted for lipoprotein particle measurements?
Nuclear magnetic resonance spectroscopy
99
Which of the following represents the Henderson-Hasselbalch equation as applied to blood pH?
6.1 + log HCO3-/(PCO2 × 0.03)
100
Which of the following is an example of an antiarrhythmic drug that has a metabolite with the same action?
Procainamide