問題一覧
1
What percentage of the cytoplasmic content of red blood cells (RBCs) is made up of hemoglobin?
95%
2
Heme consist of a ring of carbon, hydrogen, and nitrogen atoms called?
Protoporphyrin IX
3
Which hemoglobin chain is represented by the symbol ε?
Epsilon
4
Each globin chain is divided into how many helices?
Eight helice
5
How many amino acids are there in each globin chain?
141 to 146
6
Which hemoglobin chain is represented by the symbol θ?
Theta
7
What does the primary structure of hemoglobin refer to?
The amino acid sequence of the polypeptide chains
8
How many oxygen molecule is bined with the ferrous iron in each heme group?
one oxygen molecule
9
Which hemoglobin chain is represented by the symbol γB?
Gamma B
10
How is free hemoglobin in the plasma managed by the body?
It is salvaged to preserve iron and amino acids
11
Which method was first used to describe the structure of hemoglobin?
X-ray crystallography
12
In the YA (Gamma A) hemoglobin chain, which amino acid is found in position 136?
Alanine
13
Which hemoglobin chain is represented by the symbol α?
Alpha
14
Where are the heme groups located in the hemoglobin molecule?
Imbedded in the four polypeptide chains
15
What is oxidized hemoglobin called?
Methemoglobin
16
Which hemoglobin chain is represented by the symbol δ?
Delta
17
Which hemoglobin chain is represented by the symbol ζ?
Zeta
18
How many globin chains make up a hemoglobin molecule?
Two pairs of identical chains
19
This globin chains consist of 146 amino acids?
Beta, Gamma A, Gamma G, Delta, Episilon
20
Which amino acid occupies position 136 in the YG (Gamma G) hemoglobin chain?
Glycine
21
Hemoglobin helps maintain acid-base balance by:
Binding and releasing hydrogen ions
22
What is the molecular weight of hemoglobin?
64,000 Daltons
23
Which hemoglobin chain is represented by the symbol γA?
Gamma A
24
How many heme groups are present in a hemoglobin molecule?
Four
25
What happens when ferrous iron (Fe²⁺) is oxidized to ferric iron (Fe³⁺)?
Hemoglobin can no longer bind oxygen
26
What does the secondary structure of hemoglobin describe?
The arrangement of helices and nonhelices
27
What is the tertiary structure of hemoglobin?
The pretzel-like arrangement of helices
28
At what concentration is hemoglobin found within red blood cells (RBCs)?
34 g/dL
29
What gives rise to different types of globin chains?
Variations in amino acid sequences
30
What type of iron is found in the center of the heme group?
Ferrous iron (Fe²⁺)
31
Quaternary structure is also called?
Tetramer
32
How many polypeptide chains make up the hemoglobin molecule?
Two different pairs
33
What does hemoglobin transport, apart from oxygen and carbon dioxide?
Nitric oxide
34
What designations are given to the helices in the globin chain?
A to H
35
This globin chains consist of 141 amino acids?
Alpha and Zeta
36
What segment connects the A and B helices in the globin chain?
AB
37
Which segment connects the H helix to the C-terminus?
HC
38
What type of protein is hemoglobin?
Globular protein
39
Where is each heme group positioned within the hemoglobin molecule?
In a pocket of the polypeptide chain near the surface
40
What is hemoglobin’s main function in the body?
To transport oxygen and carbon dioxide
41
What is the sequence between the N-terminus and the A helix called?
NA
42
The helices is separated by?
Seven nonhelical segments
43
Which hemoglobin chain is represented by the symbol β?
Beta
44
What does the quaternary structure of hemoglobin refer to?
Complete hemoglobin molecule
45
Which hemoglobin chain has an unknown number of amino acids?
Theta (θ)