記憶度
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問題一覧
1
Examples of oral drug delivery system (4)
Tablets (Metformin), Capsules, Suspensions, Solutions
2
The rate limiting factors in absorption of intramuscular and subcutaneous
Diffusion through the tissue, Removal by local blood flow, Formulation
3
Factors affecting the selection of the delivery routes (6)
Drug characteristics , Ease of administration, Site of action, Onset of action, Duration of action, Quantity of drug administered
4
Factors affect drug formulation (4)
Particle size, Polymorphism, pH, Solubility
5
Cytochrome P450 enzymes
Phase I reactions, Are embedded in the smooth endoplasmic reticulum of hepatocytes
6
Oral sustained release system (4)
Diffusion sustained systems, Dissolution sustained system, pH-independent formulations, Osmotic pressure-controlled systems
7
Factors affect absorption via oral administration (5)
Size of the drug, Aqueous solubility of the drug, Drug stability, Dosage form, Modified release formulation
8
Examples of nebulizer
Jet nebulizer, Hydrodynamic nebulizer, Ultrasonic nebulizer
9
Side effect of aspirin
Gastric ulcer
10
Enzyme metabolizes more than 50% of drugs in the liver
CYP3A4
11
Types of phase I reaction
Oxidation, Reduction, Hydrolysis, Decarboxylation, N-carboxylation, Alkylation, Dealkylation, Transamination, Ring cyclization, Dimerization, Isomerization
12
Dosage form affect absorption rate (oral administration, 邊個最快）
1. Solution, 2. Emulsion, 3. Suspension, 4. Capsule, 5. Tablet
13
Factors affecting drug delivered by nasal system (6)
Lipophilicity, Molecular size, Nasal pH, Physiological barriers in nasal cavity, Mucociliary clearance (MCC), Nasal blood flow
14
Drug oxidation by Microsoal enzymes involves
NADPH(reducing agent), oxygen(electron acceptor), cytochrome P450 monooxygenase, NADPH-cytochrome P450 reductase
15
Absorption rate controlled by ...?如果係oral administration
Surface area for absorption, Physical state of drug, Blood flow to the site, Gastric emptying time, Dietary contents, Presence of other drugs
16
Types of pulmonary delivery system (3)
Pressurized metered dose inhalers, Dry powder inhalers, Nebulizers
17
Which bonds are susceptible to hydrolysis?
Ester bond, Amide bond
18
Physico-chemical characteristics of the drug (4)
Drug dissolution rate, Solubility , Permeability , Drug size and surface area
19
Movement of drug molecules across cell barriers
Simple diffusion, Filtration, Facilitated diffusion, Active transport, Endocytosis
20
Parenteral drug delivery covers a number of administration routes (5)
Intramuscular, Intravenous, Subcutaneous , Intradermal, Intraperitoneal
21
What drug can penetrate to cell membrane
Hydrophobic drugs
22
Buffering agent
Salts of citric acids, Phosphoric acids, Tartaric acids
23
Factors affecting drug deposition in the airways
Physiological factors, Pharmaceutical factors
24
Factors affecting drug absorption rate
Physico-chemical properties of drug, Routes of administration, Physiological factors
25
Where is an endogenous substance derived from?
Carbohydrate, Protein, Sulfur sources
26
Factors affecting permeation
Lipophilicity of drugs, Solubility, pH and ionization, Drug size
27
Diseases of nasal drug delivery
Allergies, Nasal irritation, Sneezing, Congestion