記憶度
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問題一覧
1
Physico-chemical characteristics of the drug (4)
Drug dissolution rate, Solubility , Permeability , Drug size and surface area
2
Factors affect drug formulation (4)
Particle size, Polymorphism, pH, Solubility
3
Factors affecting the selection of the delivery routes (6)
Drug characteristics , Ease of administration, Site of action, Onset of action, Duration of action, Quantity of drug administered
4
Examples of oral drug delivery system (4)
Tablets (Metformin), Capsules, Suspensions, Solutions
5
Factors affect absorption via oral administration (5)
Size of the drug, Aqueous solubility of the drug, Drug stability, Dosage form, Modified release formulation
6
Dosage form affect absorption rate (oral administration, 邊個最快）
1. Solution, 2. Emulsion, 3. Suspension, 4. Capsule, 5. Tablet
7
Oral sustained release system (4)
Diffusion sustained systems, Dissolution sustained system, pH-independent formulations, Osmotic pressure-controlled systems
8
Buffering agent
Salts of citric acids, Phosphoric acids, Tartaric acids
9
Side effect of aspirin
Gastric ulcer
10
Parenteral drug delivery covers a number of administration routes (5)
Intramuscular, Intravenous, Subcutaneous , Intradermal, Intraperitoneal
11
Diseases of nasal drug delivery
Allergies, Nasal irritation, Sneezing, Congestion
12
Factors affecting drug delivered by nasal system (6)
Lipophilicity, Molecular size, Nasal pH, Physiological barriers in nasal cavity, Mucociliary clearance (MCC), Nasal blood flow
13
Factors affecting drug deposition in the airways
Physiological factors, Pharmaceutical factors
14
Types of pulmonary delivery system (3)
Pressurized metered dose inhalers, Dry powder inhalers, Nebulizers
15
Examples of nebulizer
Jet nebulizer, Hydrodynamic nebulizer, Ultrasonic nebulizer
16
Movement of drug molecules across cell barriers
Simple diffusion, Filtration, Facilitated diffusion, Active transport, Endocytosis
17
Factors affecting permeation
Lipophilicity of drugs, Solubility, pH and ionization, Drug size
18
What drug can penetrate to cell membrane
Hydrophobic drugs
19
Factors affecting drug absorption rate
Physico-chemical properties of drug, Routes of administration, Physiological factors
20
Absorption rate controlled by ...?如果係oral administration
Surface area for absorption, Physical state of drug, Blood flow to the site, Gastric emptying time, Dietary contents, Presence of other drugs
21
The rate limiting factors in absorption of intramuscular and subcutaneous
Diffusion through the tissue, Removal by local blood flow, Formulation
22
Where is an endogenous substance derived from?
Carbohydrate, Protein, Sulfur sources
23
Types of phase I reaction
Oxidation, Reduction, Hydrolysis, Decarboxylation, N-carboxylation, Alkylation, Dealkylation, Transamination, Ring cyclization, Dimerization, Isomerization
24
Drug oxidation by Microsoal enzymes involves
NADPH(reducing agent), oxygen(electron acceptor), cytochrome P450 monooxygenase, NADPH-cytochrome P450 reductase
25
Cytochrome P450 enzymes
Phase I reactions, Are embedded in the smooth endoplasmic reticulum of hepatocytes
26
Enzyme metabolizes more than 50% of drugs in the liver
CYP3A4
27
Which bonds are susceptible to hydrolysis?
Ester bond, Amide bond