問題一覧
1
Typical for Carbidopa:
Inhibition of peripheral dopamine decarboxylase
2
The mechanism of action of Procaine:
Blockade of Na+channels
3
Similarity of Propofol and Ketamine:
Short acting general anesthetic
4
The correct answer.
Buprenorphine is semisynthetic opioid
5
For Pilocarpine is not typical:
vasodilation
6
Specify relevance: 1) Antidepressant - Maprotiline 2) Anesthetic - Gabapentin 3) Psychostimulant - Thioridazine 4) Antipsychotie - Trifluoperazine 5) Anxiolytic - Triazolam
1,4,5
7
Specify relevance of antiparkinsonian agents: A) Dopamine receptor agonists B) Antimuscarinic agents 1) Benztropine 2) Apomorphine 3) Trihexyphenidyl 4) Ropinirole 5) Bromocriptine
A:2,4,5. B:1,3
8
Typical to Sevoflurane: 1) Has hypertension action 2) Has a long onset 3) Has low hepatotoxic potential 4) Has strong cardiotoxic potential 5) Has low respiratory imitation
3,5
9
Correct statements: 1) Buspirone have affinity for serotonin receptors 2) Barbiturates inhibits cytochrome Pass microsomal enzymes in the liver 3) Zolpidem binds to GABA, receptors 4) Ramelteon is selective antagonist at the MTi and MTa melatonin receptors 5) Benzodiazepines acts on the ion channel of GABA
1,3,5
10
False expression for barbiturates:
Antitussive action
11
Anti-Parkinson drug, which is contraindicated in Parkinson patients with close angle glaucom:
trihexyphenidyl
12
Long-acting barbiturate:
Phenobarbital
13
Is not "Morphine-like" effect:
Hypertension
14
Specify relevance of opioid analgesics and antagonist : A) antagonist B) agonist 1: remifentanil 2:oxycodone 3:naloxone 4:butorphanol 5:naltrexone
A:3,5 B: 1,2
15
Determine a single dose of Nitroglycerin for the taking of 1 drop on a piece of sugar under the tongue in 5 ml of 1% solution:
0.0005
16
Specify relevance A) Selective serotonin reuptake inhibitors B)Serotonin-norepinephrine reuptake inhibitors 1) Fluoxetine 2) Sertraline 3) Duloxetine 4) Venlafaxine 5) Fluvoxamine 6) Levomilnacipran
A:1,2,5. B:3,4,6
17
Does not refer to Morphine: 1) Increases the motility and decrease the tone of intestinal circular smooth muscle 2) Releases histamine from mast cells 3) Decreases the strength, duration, and frequency of uterine contractions 4) Causes antivomiting effect 5) Produces dilation of the pupil 6) Leads to opioid-induced androgen deficiency
1,4,5
18
Used for poisoning with organophosphorus compounds:
Atropine, Pralidoxime
19
The cause of hyperglycemia caused by Epinephrine: 1) Decrease in insulin secretion as aresult of activation of Bi-adrenergic receptors 2) Increased muscle and liver glycogenolysis due to stimulation of B2-adrenergic receptors 3) Increased release of glucagon by activation of Br-adrenergic receptors 4) Inhibition of insulin release as a result stimulation of az-adrenergic receptors 5) Increased glycogen synthesis as a result of stimulation of a-adrenergic receptors
2,3,4
20
Specify relevance: A) Inhaled general anesthetics B) Intravenous general anesthetics 1) Methohexital 2) Propofol 3) Desflurane 4) Dantrolene 5) Nitrous oxide
A:3,5. B:1,2
21
Incorrect statement regarding benzodiazepines:
Improve memory
22
Enteral administration:
Buccal
23
It is not typical for Amphetamine:
Treatment of acute psychoses
24
Partial agonists of the opioid receptors:
Buprenorphine, Pentazocine
25
Actions, not typical for Methylxanthines: 1) Mild diuretic action 2) Stimulation the chemoreceptor trigger zone 3) Stimulation of secretion of gastric acid 4) Relaxation the smooth muscles of the bronchioles 5) Depression of cough center
2,5
26
Determine the conformity: A) Reserpine B)Ephedrine 1) Acts on release of stored norepinephrine from nerve endings 2) Used to treat hypertension 3) Raises systolic and diastolic blood pressures 4) Relieves symptoms of psychotic arousal in schizophrenia 5) Produces a mild stimulation of the CINS
A:1,2,4. B1,3,5
27
Not a mechanism of action of Methylxanthines:
Inhibition reuptake of catecholamines
28
Epinephrine, unlike Phenylephrine, causes: 1) Vasoconstriction 2) Hypertensive effect 3) Decreased intraocular pressure 4) Hyperglycemia 5) Bronchial dilation
4,5
29
Specify relevance: A) Antagonists of opioid receptors B) Agonist-antagonists of opioid receptors 1) Naloxone 2) Pentazocine 3) Alfentanil 4) Naltrexone 5) Butorphanol
A:1,4. B:2,5
30
Not typical to barbiturates:
Inhibition of P450 enzyme system
31
Specify relevance: 1) Psychostimulant - Hydroxyzine 2) Anesthetic - Etomidate 3) Opioid - Levorphanol 4) Antipsychotic - Modafinil 5) Anxiolytic - Buspirone
2,3,5
32
Anticholinesterase agent:
Galantamine
33
Antiepileptic drugs that can be used for insomnia:
Diazepam, Phenobarbital
34
It is not psychostimulant:
Clomipramine
35
Correct answers: 1) Propofol increases intracranial pressure 2) Etomidate has analgesic activity 3) Ketamine stimulates the heart with increased blood pressure 4) Midazolam has strong cardiovascular depressant effects 5) Thiopental may cause a reflex tachycardia
3,5
36
Antagonists of opioid receptors:
Naloxone, Naltrexone
37
Monoamine oxidase inhibitors:
Imipramine
38
Specify relevance: A)Tricyclic antidepressants B) Serotonin-dopamine antagonists 1) Quetiapine 2) Aripiprazole 3) Amitriptyline 4) Clomipramine 5) Amoxapine 6) Brexpiprazole
A:3,4,5. B:1,2,6
39
Clozapine has high affinity for: 1) 5-HT1a receptors 2) D4 receptors 3) 5-HT2 receptors 4) D2 receptors 5) alpha adrenoreceptors 6) D1 receptors
2,3,5,6
40
Incorrect statement regarding Propofol:
Causes an potency analgesic action
41
False expression for Phenobarbital:
Inhibition of microsomal enzymes
42
Correct statement: 1) Phenylephrine is.used in the treatment of hypertension. 2) Propranolol is used in the treatment of bronchial asthma. 3) Terbutaline is used, for pheochromocytoma. 4) Prazosin is used as an antihypertensive agent. 5) Tamsulosin is used for prostatic hyperplasia.
4,5
43
Tricyclic antidepressant:
Imipramine
44
Memantine is characterized by: 1) Is plant origin 2) Used for Alzheimer disease 3) Used for bronchial asthma 4) Is an NMDA receptor antagonist 5) Selective agonist of M-cholinergic receptors
2,4
45
First-generation antipsychotic: 1) Haloperidol 2) Pimozide 3) Cariprazine 4) Chlorpromazine 5) Thiothixene 6) Risperidone
1,2,4,5
46
Incorrect statement regarding Ketamine:
Lead to long-acting anesthesia
47
Antagonists of opioid recepters:
Naloxone, Naltrexone
48
Drug contraindicated in bronchial asthman
Propranolol
49
Untypical for second-generation antipsychotic:
Higher risk of extrapyramidal disorders
50
Antidepressant blocking serotonin-norepinephrine reuptake:
Levomilnacipran
51
Second-generation antipsychotics: 1) Risperidone 2) Molindone 3) Clozapine 4) Loxapine 5) Olanzapine 6) Quetiapine
1,3,5,6
52
Determine the conformity: A). Phenylephrine B) Carvedilol 1) Leads to hypotensive effect 2) Leads to hypertensive effect 3) Causes orthostatic hypotension 4) Causes vasoconstrictor effect 5) Decreases lipid peroxidation
A:2,4. B:1,3,5
53
Determine the conformity: A) Stimulates B-adrenergic receptors B)Stimulates a-adrenergic receptors 1) Oxymetazoline 2) Terbutaline 3) Epinephrine 4) Clonidine 5) Isoproterenol
A:2,3,5 B:1,3,4
54
Buprenorphine is:
Partial agonist of opioid u-receptor and an antagonist of k-receptors
55
Specify relevance of antiparkinsonian agents: A) MAO-B inhibitors B) COMT inhibitors 1) Entacapone 2) Safinamide 3) Selegiline 4) Carbidopa
A:2,3. B:1
56
Second messenger related receptors:
M-cholinoreceptors, adrenoreceptors
57
Part of Pharmacology, which study phannacological effects of drugs, as well as the mechanism of action of drug :
Pharmacodynamic
58
Not typical to benzodiazepines:
Inhibition of P450 enzyme system
59
Opioid analgesics:
Methadone, Sufentanil, Meperidine
60
M-cholinomimetics: 1) Reduces intracular pressure 2) Causes tachycardia 3) Increases gastrointestinal motility 4) Causes bronchodilator efiect 5) Reduces salivation
1,3
61
Adrenomimetics are characterized by: 1) Increased intraocular fluid production 2) Stimulates glycogenolysis 3) Increased closure of the bladders sphincter 4) Stimulates lipolysis 5) Increased muscle tone of the bronchi
2,3,4
62
Which type of receptors blockade Naloxone?
Opioid
63
Anti-Parkinson drugs inhibiting cholinergic eftects:
Trihexyphenidyl, Benztropine
64
Determine the conformity: A) Phenylephrine B) Reserpine 1) Reduces blood pressure 2) Increases blood pressure 3) Blocks transport of norepinephrine from the cytoplasm into storage vesicles 4) Indicated in agitated psychotic states 5) Reduces intraocular pressure
A:2,5. B:1,3,4
65
Effects of Butorphanol: 1) Weak psychotomimetic effects 2) Agonist of opioid receptors 3) Agonist-antagonist of opioid receptors 4) Antagonist of opioid receptors 5) Does not affect the heart
1,3
66
Epinephrine, unlike Phenylephrine, causes: 1) Increased blood pressure 2) Decreased intraocular pressure 3) Causes tachycardia 4) Cause vasoconstrictor effect 5) Causes bronchodilation
3,5
67
Pharmacokinetics not studying:
Interaction with specific receptors
68
Pilocarpine, unlike Timolol: 1) Used in acute attack of glaucoma 2) Changes focus to near vision 3) Effective in diminishing intracular pressure 4) Used topically in the treatment of glaucoma 5) Changes pupil size
1,2,5
69
Incorrect statement regarding benzodiazepines:
Induct microsomal enzymes
70
Does not refer to Isoflurane:
Hepatotoxicity
71
Determine the total volume of a 2% solution of pilocarpine hydrochloride per 100 doses for instillation of 2 drops 3 times a day into the conjunctival sac of the damaged eye (in ml):
10
72
Epinephrine is.characterized by: 1) Bronchodilation 2) Increased peripheral resistance 3) Increased myocardial contractility 4) Decreased lipolysis 5) Reduced blood sugar
1,2,3
73
Does not possess antiepileptic activity:
Bromocriptine
74
Typical for Isoflurane: 1) Increases the sensitization of myocardium to catecholamine action 2) Produces dose-dependent hypotension 3) Uses as an emulsion 4) Is a halogenated gas 5) Has hepatotoxic action 6) More comfortable for longer surgeries
2,4,6
75
Benzodiazepine derivative used in anesthesiology:
Midazolam
76
The reason for the increase in intraocular pressure after M-cholinoblockers:
Violation of the outflow of intracular fluid
77
Analgesic caused pupil contraction, vomiting, and constipation:
Morphine
78
Epinephrine, unlike Norepinephrine, causes: 1) Hypertension 2) Decrease in intraocular pressure 3) Increase in glycogenolysis in muscles and the liver 4) Bronchial dilatation 5) Vasoconstriction
3,4
79
Mechanism of action of Mepivacaine:
Blockade of Na+channels
80
Drug used in insomnia and epilepsy: 1:Diazepam 2:Lamotrigine 3:Phenobarbital 4:Carbamazepine 5:Brivaracetam
1,3
81
Determine compliance: A) Causes hypertension B) Causes hypotension 1) Epinephrine 2) Atenolol 3) Propranolol 4) Dobutamine 9) Ephedrine
A:1,4,5. B:2,3
82
Is not typical for Selegiline:
Directly stimulates dopamine receptors
83
Specify relevance: A) Agonists of opioid receptors B) Agonist-antagonists of opioid receptors 1) Nalbuphine 2) Butorphanol 3) Naloxone 4) Buprenorphine 5) Alfentantl 6) Meperidine
A:5,6 B1,2,4
84
Specify relevance: A) Eszopiclone B) Midazolam 1) Nonbenzodiazepine derivative 2) Used for general anesthesia 3) Benzodiazepine derivative 4) Unpleasant taste on the mouth 5) Used for local anesthesia 6) Barbiturate derivative
A:1,4 B:2,3
85
Barbiturates mainly affect the system:
GABA
86
Specify relevance of receptors and drug: A) -U_opioid receptor B) D2-dopamine receptor C) Benzodiazepine BZ-receptor 1) Morphine 2) Diazepam 3) Chlorpromazine 4) Selegiline
A:1 B:3 C:2
87
Officinal drugs are:
Produced by factory technology
88
Typical for benzodiazepines:
Increases GABA system activity
89
Antidepressant inhibiting selective serotonin reuptake:
Sertraline
90
Typical for caffeine:
increasing mental alartness
91
Typical for Etomidate: 1) Has analgesic activity 2) May decreased plasma cortisol and aldosterone levels 3) Is short-acting 4) Has slowly induction 5) Weak effect on the heart and systemic vascular resistance
2,3,5
92
Carbidopa: 1) Does not cross the BBB 2) Crosses the BBB 3) Inhibits dopamine decarbosylase in the brain 4) Inhibits dopamine decarboxylase in peripheral tissu 5) Increase effects of levodopa 6) Decrease effects of levodopa
1,4,5
93
Ropinirole is:
Dopamine receptor agonist
94
Inducers of microsomal enzymes
Dexamethasone, Rifampin, Phenobarbital
95
Magistral drugs are:
Prepared in drugstores according to doctor's prescription
96
Psychostimulant is antagonist of endogenous adenosine:
Caffeine
97
Use for treatment of depression:
Amitriptyline, Maprotiline, Imipramine
98
Correct statement: 1) Topiramate is used in status epilepticus 2) Lamotrigine stimulates sodium channels 3) Tiagabine blocks GABA uptake into presynaptic neurons 4) Ethosuximide is most effective in treating absence seizures 5) Carbamazepine is benzodiazepine
3,4
99
Anti-Parkinson drugs: 1) Dopamine receptor agonists 2) Cholinergic antagonist 3) Dopamine receptor antagonist 4) Cholinergic agonists
1,2