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  • 問題数 99 • 6/20/2024

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    問題一覧

  • 1

    Specify relevance of opioid analgesics and antagonist : A) antagonist B) agonist 1: remifentanil 2:oxycodone 3:naloxone 4:butorphanol 5:naltrexone

    A:3,5 B: 1,2

  • 2

    Drug used in insomnia and epilepsy: 1:Diazepam 2:Lamotrigine 3:Phenobarbital 4:Carbamazepine 5:Brivaracetam

    1,3

  • 3

    Typical for caffeine:

    increasing mental alartness

  • 4

    Use for treatment of depression:

    Amitriptyline, Maprotiline, Imipramine

  • 5

    Antidepressant blocking serotonin-norepinephrine reuptake:

    Levomilnacipran

  • 6

    Psychostimulant is antagonist of endogenous adenosine:

    Caffeine

  • 7

    It is not typical for Amphetamine:

    Treatment of acute psychoses

  • 8

    Not a mechanism of action of Methylxanthines:

    Inhibition reuptake of catecholamines

  • 9

    It is not psychostimulant:

    Clomipramine

  • 10

    Specify relevance: 1) Psychostimulant - Hydroxyzine 2) Anesthetic - Etomidate 3) Opioid - Levorphanol 4) Antipsychotic - Modafinil 5) Anxiolytic - Buspirone

    2,3,5

  • 11

    Actions, not typical for Methylxanthines: 1) Mild diuretic action 2) Stimulation the chemoreceptor trigger zone 3) Stimulation of secretion of gastric acid 4) Relaxation the smooth muscles of the bronchioles 5) Depression of cough center

    2,5

  • 12

    Antidepressant inhibiting selective serotonin reuptake:

    Sertraline

  • 13

    Tricyclic antidepressant:

    Imipramine

  • 14

    Monoamine oxidase inhibitors:

    Imipramine

  • 15

    Specify relevance: 1) Antidepressant - Maprotiline 2) Anesthetic - Gabapentin 3) Psychostimulant - Thioridazine 4) Antipsychotie - Trifluoperazine 5) Anxiolytic - Triazolam

    1,4,5

  • 16

    Clozapine has high affinity for: 1) 5-HT1a receptors 2) D4 receptors 3) 5-HT2 receptors 4) D2 receptors 5) alpha adrenoreceptors 6) D1 receptors

    2,3,5,6

  • 17

    Correct statements: 1) Buspirone have affinity for serotonin receptors 2) Barbiturates inhibits cytochrome Pass microsomal enzymes in the liver 3) Zolpidem binds to GABA, receptors 4) Ramelteon is selective antagonist at the MTi and MTa melatonin receptors 5) Benzodiazepines acts on the ion channel of GABA

    1,3,5

  • 18

    Analgesic caused pupil contraction, vomiting, and constipation:

    Morphine

  • 19

    Which type of receptors blockade Naloxone?

    Opioid

  • 20

    Typical for Carbidopa:

    Inhibition of peripheral dopamine decarboxylase

  • 21

    Does not possess antiepileptic activity:

    Bromocriptine

  • 22

    Second-generation antipsychotics: 1) Risperidone 2) Molindone 3) Clozapine 4) Loxapine 5) Olanzapine 6) Quetiapine

    1,3,5,6

  • 23

    First-generation antipsychotic: 1) Haloperidol 2) Pimozide 3) Cariprazine 4) Chlorpromazine 5) Thiothixene 6) Risperidone

    1,2,4,5

  • 24

    Antagonists of opioid receptors:

    Naloxone, Naltrexone

  • 25

    The correct answer.

    Buprenorphine is semisynthetic opioid

  • 26

    Anti-Parkinson drugs inhibiting cholinergic eftects:

    Trihexyphenidyl, Benztropine

  • 27

    Carbidopa: 1) Does not cross the BBB 2) Crosses the BBB 3) Inhibits dopamine decarbosylase in the brain 4) Inhibits dopamine decarboxylase in peripheral tissu 5) Increase effects of levodopa 6) Decrease effects of levodopa

    1,4,5

  • 28

    Ropinirole is:

    Dopamine receptor agonist

  • 29

    Anti-Parkinson drug, which is contraindicated in Parkinson patients with close angle glaucom:

    trihexyphenidyl

  • 30

    Is not typical for Selegiline:

    Directly stimulates dopamine receptors

  • 31

    Untypical for second-generation antipsychotic:

    Higher risk of extrapyramidal disorders

  • 32

    Anti-Parkinson drugs: 1) Dopamine receptor agonists 2) Cholinergic antagonist 3) Dopamine receptor antagonist 4) Cholinergic agonists

    1,2

  • 33

    Is not "Morphine-like" effect:

    Hypertension

  • 34

    Opioid analgesics:

    Methadone, Sufentanil, Meperidine

  • 35

    Specify relevance A) Selective serotonin reuptake inhibitors B)Serotonin-norepinephrine reuptake inhibitors 1) Fluoxetine 2) Sertraline 3) Duloxetine 4) Venlafaxine 5) Fluvoxamine 6) Levomilnacipran

    A:1,2,5. B:3,4,6

  • 36

    Specify relevance: A)Tricyclic antidepressants B) Serotonin-dopamine antagonists 1) Quetiapine 2) Aripiprazole 3) Amitriptyline 4) Clomipramine 5) Amoxapine 6) Brexpiprazole

    A:3,4,5. B:1,2,6

  • 37

    Specify relevance of antiparkinsonian agents: A) MAO-B inhibitors B) COMT inhibitors 1) Entacapone 2) Safinamide 3) Selegiline 4) Carbidopa

    A:2,3. B:1

  • 38

    Specify relevance of antiparkinsonian agents: A) Dopamine receptor agonists B) Antimuscarinic agents 1) Benztropine 2) Apomorphine 3) Trihexyphenidyl 4) Ropinirole 5) Bromocriptine

    A:2,4,5. B:1,3

  • 39

    Correct statement: 1) Topiramate is used in status epilepticus 2) Lamotrigine stimulates sodium channels 3) Tiagabine blocks GABA uptake into presynaptic neurons 4) Ethosuximide is most effective in treating absence seizures 5) Carbamazepine is benzodiazepine

    3,4

  • 40

    Antiepileptic drugs that can be used for insomnia:

    Diazepam, Phenobarbital

  • 41

    Specify relevance: A) Inhaled general anesthetics B) Intravenous general anesthetics 1) Methohexital 2) Propofol 3) Desflurane 4) Dantrolene 5) Nitrous oxide

    A:3,5. B:1,2

  • 42

    Similarity of Propofol and Ketamine:

    Short acting general anesthetic

  • 43

    Specify relevance: A) Eszopiclone B) Midazolam 1) Nonbenzodiazepine derivative 2) Used for general anesthesia 3) Benzodiazepine derivative 4) Unpleasant taste on the mouth 5) Used for local anesthesia 6) Barbiturate derivative

    A:1,4 B:2,3

  • 44

    Typical for benzodiazepines:

    Increases GABA system activity

  • 45

    Specify relevance: A) Antagonists of opioid receptors B) Agonist-antagonists of opioid receptors 1) Naloxone 2) Pentazocine 3) Alfentanil 4) Naltrexone 5) Butorphanol

    A:1,4. B:2,5

  • 46

    Antagonists of opioid recepters:

    Naloxone, Naltrexone

  • 47

    Effects of Butorphanol: 1) Weak psychotomimetic effects 2) Agonist of opioid receptors 3) Agonist-antagonist of opioid receptors 4) Antagonist of opioid receptors 5) Does not affect the heart

    1,3

  • 48

    Specify relevance: A) Agonists of opioid receptors B) Agonist-antagonists of opioid receptors 1) Nalbuphine 2) Butorphanol 3) Naloxone 4) Buprenorphine 5) Alfentantl 6) Meperidine

    A:5,6 B1,2,4

  • 49

    Incorrect statement regarding Ketamine:

    Lead to long-acting anesthesia

  • 50

    Incorrect statement regarding Propofol:

    Causes an potency analgesic action

  • 51

    Partial agonists of the opioid receptors:

    Buprenorphine, Pentazocine

  • 52

    Buprenorphine is:

    Partial agonist of opioid u-receptor and an antagonist of k-receptors

  • 53

    Incorrect statement regarding benzodiazepines:

    Induct microsomal enzymes

  • 54

    Incorrect statement regarding benzodiazepines:

    Improve memory

  • 55

    Specify relevance of receptors and drug: A) -U_opioid receptor B) D2-dopamine receptor C) Benzodiazepine BZ-receptor 1) Morphine 2) Diazepam 3) Chlorpromazine 4) Selegiline

    A:1 B:3 C:2

  • 56

    Long-acting barbiturate:

    Phenobarbital

  • 57

    False expression for barbiturates:

    Antitussive action

  • 58

    False expression for Phenobarbital:

    Inhibition of microsomal enzymes

  • 59

    Barbiturates mainly affect the system:

    GABA

  • 60

    Does not refer to Isoflurane:

    Hepatotoxicity

  • 61

    Not typical to benzodiazepines:

    Inhibition of P450 enzyme system

  • 62

    Not typical to barbiturates:

    Inhibition of P450 enzyme system

  • 63

    Does not refer to Morphine: 1) Increases the motility and decrease the tone of intestinal circular smooth muscle 2) Releases histamine from mast cells 3) Decreases the strength, duration, and frequency of uterine contractions 4) Causes antivomiting effect 5) Produces dilation of the pupil 6) Leads to opioid-induced androgen deficiency

    1,4,5

  • 64

    Typical for Etomidate: 1) Has analgesic activity 2) May decreased plasma cortisol and aldosterone levels 3) Is short-acting 4) Has slowly induction 5) Weak effect on the heart and systemic vascular resistance

    2,3,5

  • 65

    Benzodiazepine derivative used in anesthesiology:

    Midazolam

  • 66

    Typical to Sevoflurane: 1) Has hypertension action 2) Has a long onset 3) Has low hepatotoxic potential 4) Has strong cardiotoxic potential 5) Has low respiratory imitation

    3,5

  • 67

    Correct answers: 1) Propofol increases intracranial pressure 2) Etomidate has analgesic activity 3) Ketamine stimulates the heart with increased blood pressure 4) Midazolam has strong cardiovascular depressant effects 5) Thiopental may cause a reflex tachycardia

    3,5

  • 68

    Inducers of microsomal enzymes

    Dexamethasone, Rifampin, Phenobarbital

  • 69

    Typical for Isoflurane: 1) Increases the sensitization of myocardium to catecholamine action 2) Produces dose-dependent hypotension 3) Uses as an emulsion 4) Is a halogenated gas 5) Has hepatotoxic action 6) More comfortable for longer surgeries

    2,4,6

  • 70

    Second messenger related receptors:

    M-cholinoreceptors, adrenoreceptors

  • 71

    Part of Pharmacology, which study phannacological effects of drugs, as well as the mechanism of action of drug :

    Pharmacodynamic

  • 72

    Enteral administration:

    Buccal

  • 73

    Pharmacokinetics not studying:

    Interaction with specific receptors

  • 74

    Officinal drugs are:

    Produced by factory technology

  • 75

    Magistral drugs are:

    Prepared in drugstores according to doctor's prescription

  • 76

    Determine the total volume of a 2% solution of pilocarpine hydrochloride per 100 doses for instillation of 2 drops 3 times a day into the conjunctival sac of the damaged eye (in ml):

    10

  • 77

    Determine a single dose of Nitroglycerin for the taking of 1 drop on a piece of sugar under the tongue in 5 ml of 1% solution:

    0.0005

  • 78

    Epinephrine is.characterized by: 1) Bronchodilation 2) Increased peripheral resistance 3) Increased myocardial contractility 4) Decreased lipolysis 5) Reduced blood sugar

    1,2,3

  • 79

    The cause of hyperglycemia caused by Epinephrine: 1) Decrease in insulin secretion as aresult of activation of Bi-adrenergic receptors 2) Increased muscle and liver glycogenolysis due to stimulation of B2-adrenergic receptors 3) Increased release of glucagon by activation of Br-adrenergic receptors 4) Inhibition of insulin release as a result stimulation of az-adrenergic receptors 5) Increased glycogen synthesis as a result of stimulation of a-adrenergic receptors

    2,3,4

  • 80

    Correct statement: 1) Phenylephrine is.used in the treatment of hypertension. 2) Propranolol is used in the treatment of bronchial asthma. 3) Terbutaline is used, for pheochromocytoma. 4) Prazosin is used as an antihypertensive agent. 5) Tamsulosin is used for prostatic hyperplasia.

    4,5

  • 81

    Determine compliance: A) Causes hypertension B) Causes hypotension 1) Epinephrine 2) Atenolol 3) Propranolol 4) Dobutamine 9) Ephedrine

    A:1,4,5. B:2,3

  • 82

    Adrenomimetics are characterized by: 1) Increased intraocular fluid production 2) Stimulates glycogenolysis 3) Increased closure of the bladders sphincter 4) Stimulates lipolysis 5) Increased muscle tone of the bronchi

    2,3,4

  • 83

    Determine the conformity: A). Phenylephrine B) Carvedilol 1) Leads to hypotensive effect 2) Leads to hypertensive effect 3) Causes orthostatic hypotension 4) Causes vasoconstrictor effect 5) Decreases lipid peroxidation

    A:2,4. B:1,3,5

  • 84

    Epinephrine, unlike Phenylephrine, causes: 1) Increased blood pressure 2) Decreased intraocular pressure 3) Causes tachycardia 4) Cause vasoconstrictor effect 5) Causes bronchodilation

    3,5

  • 85

    Epinephrine, unlike Phenylephrine, causes: 1) Vasoconstriction 2) Hypertensive effect 3) Decreased intraocular pressure 4) Hyperglycemia 5) Bronchial dilation

    4,5

  • 86

    Determine the conformity: A) Stimulates B-adrenergic receptors B)Stimulates a-adrenergic receptors 1) Oxymetazoline 2) Terbutaline 3) Epinephrine 4) Clonidine 5) Isoproterenol

    A:2,3,5 B:1,3,4

  • 87

    Determine the conformity: A) Phenylephrine B) Reserpine 1) Reduces blood pressure 2) Increases blood pressure 3) Blocks transport of norepinephrine from the cytoplasm into storage vesicles 4) Indicated in agitated psychotic states 5) Reduces intraocular pressure

    A:2,5. B:1,3,4

  • 88

    Pilocarpine, unlike Timolol: 1) Used in acute attack of glaucoma 2) Changes focus to near vision 3) Effective in diminishing intracular pressure 4) Used topically in the treatment of glaucoma 5) Changes pupil size

    1,2,5

  • 89

    Epinephrine, unlike Norepinephrine, causes: 1) Hypertension 2) Decrease in intraocular pressure 3) Increase in glycogenolysis in muscles and the liver 4) Bronchial dilatation 5) Vasoconstriction

    3,4

  • 90

    Drug contraindicated in bronchial asthman

    Propranolol

  • 91

    Determine the conformity: A) Reserpine B)Ephedrine 1) Acts on release of stored norepinephrine from nerve endings 2) Used to treat hypertension 3) Raises systolic and diastolic blood pressures 4) Relieves symptoms of psychotic arousal in schizophrenia 5) Produces a mild stimulation of the CINS

    A:1,2,4. B1,3,5

  • 92

    Anticholinesterase agent:

    Galantamine

  • 93

    The reason for the increase in intraocular pressure after M-cholinoblockers:

    Violation of the outflow of intracular fluid

  • 94

    M-cholinomimetics: 1) Reduces intracular pressure 2) Causes tachycardia 3) Increases gastrointestinal motility 4) Causes bronchodilator efiect 5) Reduces salivation

    1,3

  • 95

    The mechanism of action of Procaine:

    Blockade of Na+channels

  • 96

    Mechanism of action of Mepivacaine:

    Blockade of Na+channels

  • 97

    For Pilocarpine is not typical:

    vasodilation

  • 98

    Memantine is characterized by: 1) Is plant origin 2) Used for Alzheimer disease 3) Used for bronchial asthma 4) Is an NMDA receptor antagonist 5) Selective agonist of M-cholinergic receptors

    2,4

  • 99

    Used for poisoning with organophosphorus compounds:

    Atropine, Pralidoxime