biopharmaceutics and kinetics

Hannah Angelique Losaria · 100問 · 2年前

通報

問題一覧

What governs the chemical kinetics

rate law

What governs the buffer system, ph of weak acids and bases

henderson hasselbalch equation

Log p

partition coefficient

Ratio of UNIONIZED compound in an organic and aqueous phase

partition coefficient

Overall ratio, ionized and unionized, of a compound in organic and aqueous phase

distribution coefficient

Measure of potency of an antimicrobial agent compared to phenol as reference against a standard microbe, usually s typhi

phenol coefficient

Crystallization due to the presence of a solvent

pseudopolymorphism

Other term for pseudopolymorphism

solvation

Element exist in different molecular forms

allotropy

Drug preparations intended to produce local effects have ___________ absorption in the general circulation

minimal

Most drugs are absorbed by

passive diffusion

Drug absorption applies to all routes of administration except

topical, intravenous

Drugs are absorbed mainly in

small intestine

In severe diarrhea, a drug is

not well absorbed

Aspirin is more ionized in __________ environment

alkaline

High rate and extent of dissolution

faster absorption

High git motility

less absorption

Most drugs enter the cell by

passive diffusion with first order kinetics

Acidic drugs binds to

albumin

Only _______________drugs can diffuse through the capillary wall, provide systemic effects, be metabolized and excreted

unbound

Highly perfused organs enables __________ onset of action

rapid

Lowest perfused organ

addipose tissue

Drug is extensively bound to tissue sites

high vd

Extensive plasma protein binding of drugs

low vd

ACE inhibitors are prodrugs except

captopril, lisinopril

Inactive form of dipivefrin

epinephrine

Inactive form of levodopa

dopamine

___________ are inactive drugs that when metabolized are converted to active metabolites

prodrugs

Drug metabolism aka

biotransformation

Two processes responsible for the decline of the plasma drug concentration over time

drug metabolism, excretion

The elimination of unchanged drug or metabolism from the body

clearance

The hepatic metabolism of oral drugs before reaching the systemic circulation

first pass effect

The process by which the drug is transferred from intravascular spaces to extravascular spaces (tissues)

distribution

The transfer of drugs from the route of administration to the blood circulation

absorption

The metabolism of most drugs will lead to their ___________

inactivation

When taken with omeorazole, the plasma concentration of warfarin ________

increases

The capacity that is present at birth

sulfation, methylation

Metabolic capacity that develops over weeks or months

acetylation, glucuronidation

Most common phase 1 reaction

oxidation

Most common phase 2 reaction

glucuronidation

Can cause peripheral neuritis in slow acetylators

isoniazid

Can cause sle like symptoms in slow acetylators

hydralazine

For fast acetylators, this drug requires higher dose but is more at risk to hepatoxicity due to acetylhydrazine formation

isoniazid

Formation of _________ causes isoniazid to be hepatotoxic

acetylhydrazine

For fast acetylators, this drug requires higher dose to control blood pressure

hydralazine

First order kinetics

most drugs

The rate of metabolism is proportional to the concentration

first order kinetics

The rate of metabolism is constant despite the increase in concentration

zero order kinetics

In zero order kinetics, the enzymes are

saturated

When a drug is more ionized inside the cells, it is more trapped or sequestered hence the volume of distribution is larger. This phenomenon is called

ion trapping

Measure the filtering capacity of the glomerulus

inulin clearance

Most common method to estimate GFR

creatinine clearance

gastro

gastro

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gastro m

gastro m

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lab

lab

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Hannah Angelique Losaria · 94問 · 2年前

94問 • 2年前

Hannah Angelique Losaria · 88問 · 2年前

88問 • 2年前

Hannah Angelique Losaria · 50問 · 2年前

poisons

poisons

50問 • 2年前

Hannah Angelique Losaria · 19問 · 2年前

lec

lec

19問 • 2年前

Hannah Angelique Losaria · 16問 · 2年前

exam

exam

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spec

spec

41問 • 1年前

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midterm

midterm

55問 • 1年前

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PHYSICAL PHARMACY

PHYSICAL PHARMACY

54問 • 1年前

Hannah Angelique Losaria · 29問 · 1年前

PHYSICAL PHARMACY II

PHYSICAL PHARMACY II

29問 • 1年前

Hannah Angelique Losaria · 33問 · 1年前

DDS

DDS

33問 • 1年前

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hallucinogens

hallucinogens

22問 • 1年前

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non volatile poisons

non volatile poisons

42問 • 1年前

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endterm

endterm

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q3 endterm

q3 endterm

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mockboard 2019

mockboard 2019

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mockboard 2019 II

mockboard 2019 II

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miss mel reviewer

miss mel reviewer

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miss roma high yield

miss roma high yield

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micro highlights

micro highlights

12問 • 1年前

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module 6 AUgdguwegfiuwegfu

module 6 AUgdguwegfiuwegfu

24問 • 1年前

Hannah Angelique Losaria · 75問 · 1年前

mod6 sure

mod6 sure

75問 • 1年前

manufacturing

manufacturing

Hannah Angelique Losaria · 94問 · 1年前

module 5

module 5

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mod5

mod5

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5555555555

5555555555

brex

brex

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mod4

mod4

44問 • 1年前

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tox lab

tox lab

69問 • 1年前

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biopharmaceutics

biopharmaceutics

59問 • 1年前

Hannah Angelique Losaria · 86問 · 1年前

toxicology

toxicology

86問 • 1年前

Hannah Angelique Losaria · 49問 · 1年前

non volatile

non volatile

49問 • 1年前

Hannah Angelique Losaria · 15問 · 1年前

gosel and bricker

gosel and bricker

15問 • 1年前

Hannah Angelique Losaria · 19問 · 1年前

management of ADRs bariles

management of ADRs bariles

19問 • 1年前

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quiz 4

quiz 4

16問 • 1年前

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pcol miss gift exam

pcol miss gift exam

63問 • 1年前

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expirement 2- antidotes

expirement 2- antidotes

27問 • 1年前

Hannah Angelique Losaria · 28問 · 1年前

volatile poisons

volatile poisons

28問 • 1年前

Hannah Angelique Losaria · 37問 · 1年前

Drugs acting on the central nercous sytem

Drugs acting on the central nercous sytem

37問 • 1年前

Hannah Angelique Losaria · 20問 · 1年前

anti arrhythmic drugs

anti arrhythmic drugs

20問 • 1年前

Hannah Angelique Losaria · 17問 · 1年前

antiplatelet drugs

antiplatelet drugs

17問 • 1年前

Hannah Angelique Losaria · 31問 · 1年前

Cardiovascular Drugs

Cardiovascular Drugs

31問 • 1年前

Hannah Angelique Losaria · 26問 · 1年前

barbiturates

barbiturates

26問 • 1年前

Hannah Angelique Losaria · 34問 · 1年前

physical pharmacy

physical pharmacy

34問 • 1年前

plasma

plasma

Hannah Angelique Losaria · 73問 · 1年前

endterm

endterm

73問 • 1年前

Hannah Angelique Losaria · 55問 · 1年前

juris

juris

55問 • 1年前

dds

dds

Hannah Angelique Losaria · 92問 · 1年前

92問 • 1年前

Hannah Angelique Losaria · 19問 · 1年前

dddssss

dddssss

19問 • 1年前

Hannah Angelique Losaria · 59問 · 1年前

manuf

manuf

59問 • 1年前

Hannah Angelique Losaria · 67問 · 1年前

qc/qa

qc/qa

67問 • 1年前

Hannah Angelique Losaria · 83問 · 1年前

qc qa identification

qc qa identification

83問 • 1年前

quali/ quanti ppt

quali/ quanti ppt

Hannah Angelique Losaria · 23問 · 1年前

quali/quanti 2

quali/quanti 2

23問 • 1年前

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quali quanti identification

quali quanti identification

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microbiology: introduction and bacterial anatomy

microbiology: introduction and bacterial anatomy

37問 • 1年前

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mocrobiology: bacterial stain, nutrition, bacterial recombination, growth phrases, microbial growth factor, culture media

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microbiology: bacteriology part 1

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microbiology: bacteriology part 2

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48問 • 1年前

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microbiology: mycology

microbiology: mycology

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Hannah Angelique Losaria · 48問 · 1年前

microbio identification 1

microbio identification 1

48問 • 1年前

Hannah Angelique Losaria · 38問 · 1年前

miss gift

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38問 • 1年前

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microbiology 2

microbiology 2

21問 • 1年前

Hannah Angelique Losaria · 18問 · 1年前

microbio 3

microbio 3

18問 • 1年前

microbio 4

microbio 4

Hannah Angelique Losaria · 30問 · 1年前

microbio anatomy

microbio anatomy

30問 • 1年前

Hannah Angelique Losaria · 37問 · 1年前

Drugs acting on the central nercous sytem

Drugs acting on the central nercous sytem

37問 • 1年前

Hannah Angelique Losaria · 17問 · 1年前

microbio5

microbio5

17問 • 1年前

Hannah Angelique Losaria · 13問 · 1年前

microbio6

microbio6

13問 • 1年前

Hannah Angelique Losaria · 34問 · 1年前

pub health 1

pub health 1

34問 • 1年前

Hannah Angelique Losaria · 30問 · 1年前

microbio7

microbio7

30問 • 1年前

Hannah Angelique Losaria · 31問 · 1年前

public health

public health

31問 • 1年前

Hannah Angelique Losaria · 40問 · 1年前

pacop

pacop

40問 • 1年前

Hannah Angelique Losaria · 98問 · 1年前

inorganic pharmaceutical pharmacy

inorganic pharmaceutical pharmacy

98問 • 1年前

transition metal iron triad FE CO NI

transition metal iron triad FE CO NI

Hannah Angelique Losaria · 8問 · 1年前

licensing

licensing

8問 • 1年前

Hannah Angelique Losaria · 26問 · 1年前

most common side effects

most common side effects

26問 • 1年前

chemistry people

chemistry people

pharmacognosy people

pharmacognosy people

Hannah Angelique Losaria · 29問 · 1年前

drug of choice

drug of choice

29問 • 1年前

Hannah Angelique Losaria · 19問 · 1年前

common antidotes

common antidotes

19問 • 1年前

Hannah Angelique Losaria · 25問 · 1年前

vitamin functions and deficiencies

vitamin functions and deficiencies

25問 • 1年前

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inorganic pharmaceutical pharmacy 2

inorganic pharmaceutical pharmacy 2

97問 • 1年前

Hannah Angelique Losaria · 42問 · 1年前

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inorganic pharm chem 3

inorganic pharm chem 3

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Hannah Angelique Losaria · 60問 · 1年前

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Hannah Angelique Losaria · 79問 · 1年前

79問 • 1年前