Two processes responsible for the decline of the plasma drug concentration over time

First order kinetics

The elimination of unchanged drug or metabolism from the body

Most common phase 1 reaction

Log p

Highly perfused organs enables __________ onset of action

The metabolism of most drugs will lead to their ___________

Drug is extensively bound to tissue sites

What governs the buffer system, ph of weak acids and bases

Drug absorption applies to all routes of administration except

Drugs are absorbed mainly in

The hepatic metabolism of oral drugs before reaching the systemic circulation

Element exist in different molecular forms

Can cause peripheral neuritis in slow acetylators

Most drugs enter the cell by

Ratio of UNIONIZED compound in an organic and aqueous phase

Drug metabolism aka

When taken with omeorazole, the plasma concentration of warfarin ________

___________ are inactive drugs that when metabolized are converted to active metabolites

Measure of potency of an antimicrobial agent compared to phenol as reference against a standard microbe, usually s typhi

Inactive form of levodopa

Measure the filtering capacity of the glomerulus

Inactive form of dipivefrin

For fast acetylators, this drug requires higher dose to control blood pressure

Drug preparations intended to produce local effects have ___________ absorption in the general circulation

The rate of metabolism is proportional to the concentration

Other term for pseudopolymorphism

Metabolic capacity that develops over weeks or months

What governs the chemical kinetics

Most common method to estimate GFR

ACE inhibitors are prodrugs except

Crystallization due to the presence of a solvent

Aspirin is more ionized in __________ environment

Extensive plasma protein binding of drugs

The process by which the drug is transferred from intravascular spaces to extravascular spaces (tissues)

For fast acetylators, this drug requires higher dose but is more at risk to hepatoxicity due to acetylhydrazine formation

High git motility

When a drug is more ionized inside the cells, it is more trapped or sequestered hence the volume of distribution is larger. This phenomenon is called

Only _______________drugs can diffuse through the capillary wall, provide systemic effects, be metabolized and excreted

The capacity that is present at birth

Overall ratio, ionized and unionized, of a compound in organic and aqueous phase

Lowest perfused organ

Most drugs are absorbed by

Acidic drugs binds to

Formation of _________ causes isoniazid to be hepatotoxic

In zero order kinetics, the enzymes are

In severe diarrhea, a drug is

The rate of metabolism is constant despite the increase in concentration

Most common phase 2 reaction

Can cause sle like symptoms in slow acetylators

High rate and extent of dissolution

The transfer of drugs from the route of administration to the blood circulation