Condition in which there is a peripheral blood pancytopenia

Diagnostic Criteria for Severe Aplastic Anemia

Classification of Aplastic Anemia

● Lack in diet ● Abnormal absorption (tropical sprue)

● Intestinal malabsorption ● D. latum infection ● Deficiency in IF

Associated with vitamin B12 deficiency > secretion of IF is reduced or eliminated

What is the test for Vitamin B12?

Deletions on Chromosome 16

Mutations on Chromosome 11

1 deleted genes

2 deleted genes

3 deleted genes

4 deleted genes

2 mutated beta chains

1 mutated beta chains

● Diverse groups identified by the common feature of abnormal iron kinetics ● Results in excess accumulation of iron > deposited in the mitochondria of normoblasts

Iron deposits are identified using?

spooning of nails

urge to eat inedible substances

Low iron in diet ○ Malabsorption ○ Chronic blood loss: menstruation, BI bleeding