問題一覧
1
The ____ c-subunits in the membrane form a rotor that is attached to a central asymmetric shaft composed of the ε- and γ-subunits.
12
2
The headpiece is composed of ____ αβ-subunit pairs. Each β-subunit contains a _______for ATP synthesis.
3,catalytic site
3
ATP Synthase (Complex V) Process:
This moves the H+ that were pumped out of the matrix (coupling)
4
readily oxidized for ATP production
mitochondrial nadh
5
ATP Synthase (Complex V) extramembranous domain that carries out production of ATP from ADP and Pi
F1
6
A protein that contains heme group( phorphyrin and fe3+)
cytochrome C
7
Complex I- NADH dehydrogenase Protons pumped
4H+
8
the process in w/c ATP is formed because of the transfer of electrons.
oxidative phosphorylation
9
Electron Transport Chain Location
inner mitochondrial membrane
10
I - NADH dh
metformin, retone
11
ATP per mitochondrial NADH
2.5
12
Brain Skeletal muscle
glycerol 3 phosphate shuttle
13
III- cyt bc1 oxidase
dimercaprol, antimycin a
14
Complex III- (Cyt bc1 complex) Protons pumped:
2H+
15
IV- cyt c oxidase
cyanide, CO, H2S
16
The energy rich carbohydrates (Glu), FA and AAs undergo a series of metabolic reactions and finally get oxidized to ________?
co2,h2o
17
ATP Synthase (Complex V) membrane spanning domain for proton translocation
F0
18
Mechanism of ATP synthesis
chemiosmosis and OP
19
It is faster but less efficient
glycerol 3 phosphate
20
the movement of ions across a semipermeable membrane, down their electrochemical gradient
chemiosmosis
21
Mitochondrial inner membrane is impermeable to NAD+/NADH but is permeable to ions attached to malate.
malate aspertate shuttle
22
Non protein membrane of ETC lipid soluble
coenzyme Q
23
Complex II- Succinate dh/ Succinate CoQ oxidoreductase Protons pumped:
4H+
24
Complex II- Succinate dh/ Succinate CoQ oxidoreductase Co factor:
FMN
25
4 membrane-bound complexes (Complex I-IV), ATP Synthase mobile electron carriers (CoQ and Cyt C)
remember!
26
How many components ETC have?
4
27
V- ATP synthase
oligomycin
28
contains two membranes: outer membrane permeable to small molecules and an impermeable inner membrane
mitochondria
29
block complexed through binding with specific e- carriers
inhibitors
30
disrupts membrane permeability; dissipates H+ gradient
uncouplers
31
Complex III- (Cyt bc1 complex) Process:
Cyt c passes e- to Complex IV → O2 (final e- acceptor forming H2O.
32
Heart Liver Kidney
malate aspartate shuttle
33
Complex II- Succinate dh/ Succinate CoQ oxidoreductase Process:
Part of the TCA cycle which transfers 1e- from FADH2 to CoQ reducing to CoQH2, which carries the e- to Complex III
34
ATP per cystosolic NADH
1.5
35
Complex I- NADH dehydrogenase Co factor:
FMN
36
Through ETC, the e- needed for the cellular activities is released in the form of ATP.
remember!
37
Complex I- NADH dehydrogenase Process:
Collects 2e- from the NADH and passes them to ubiquinone (CoQ) to form reduced ubiquinol (CoQH2), which carries the e- to Complex III
38
II- succinate dh
malonate
39
ETC Overall Reactions
electrons and protons from nadh and fadh2~intermediate carriers~ O2 (to produce H2O) remember!
40
ATP synthase (F0 F1 -ATPase), the enzyme that generates ATP, is a multi-subunit enzyme that contains an __________ (F0 ) and a ________(F1 ) that project into the matrix.
inner membrane portion,stalk/headpiece
41
IV (CyT C oxidase) Protons pumped:
2H+
42
uses shuttle system that transport NADH electrons across inner mitochondrial membrane.
cystosolic nadh
43
ETC is an O2 dependent process which occurs in the ________membrane.
inner mitochondrial
44
IV (CyT C oxidase) Process:
Cyt c passes e- to Complex IV → O2 (final e- acceptor forming H2O.
45
is the 4th and final stage of aerobic respiration.
electron transport chain
46
Requires FAD prosthetic group to transfer electrons to ubiquinone (Q) to enter ETC.
glycerol 3 phosphate
47
The headpiece is held ______ by a δ-subunit attached to a_____ _____ connected to subunit a in the membrane.
stationary,long subunit