BIOCHEMZ(ETC)

47問 • 1年前

velante

通報

問題一覧

is the 4th and final stage of aerobic respiration.

electron transport chain

Through ETC, the e- needed for the cellular activities is released in the form of ATP.

remember!

ETC is an O2 dependent process which occurs in the ________membrane.

inner mitochondrial

The energy rich carbohydrates (Glu), FA and AAs undergo a series of metabolic reactions and finally get oxidized to ________?

co2,h2o

contains two membranes: outer membrane permeable to small molecules and an impermeable inner membrane

mitochondria

uses shuttle system that transport NADH electrons across inner mitochondrial membrane.

cystosolic nadh

readily oxidized for ATP production

mitochondrial nadh

Heart Liver Kidney

malate aspartate shuttle

Brain Skeletal muscle

glycerol 3 phosphate shuttle

ATP per cystosolic NADH

1.5

ATP per mitochondrial NADH

2.5

Mitochondrial inner membrane is impermeable to NAD+/NADH but is permeable to ions attached to malate.

malate aspertate shuttle

Requires FAD prosthetic group to transfer electrons to ubiquinone (Q) to enter ETC.

glycerol 3 phosphate

It is faster but less efficient

glycerol 3 phosphate

Electron Transport Chain Location

inner mitochondrial membrane

ETC Overall Reactions

electrons and protons from nadh and fadh2~intermediate carriers~ O2 (to produce H2O) remember!

How many components ETC have?

4 membrane-bound complexes (Complex I-IV), ATP Synthase mobile electron carriers (CoQ and Cyt C)

remember!

Complex I- NADH dehydrogenase Process:

Collects 2e- from the NADH and passes them to ubiquinone (CoQ) to form reduced ubiquinol (CoQH2), which carries the e- to Complex III

Complex I- NADH dehydrogenase Protons pumped

4H+

Complex I- NADH dehydrogenase Co factor:

FMN

Complex II- Succinate dh/ Succinate CoQ oxidoreductase Process:

Part of the TCA cycle which transfers 1e- from FADH2 to CoQ reducing to CoQH2, which carries the e- to Complex III

Complex II- Succinate dh/ Succinate CoQ oxidoreductase Protons pumped:

4H+

Complex II- Succinate dh/ Succinate CoQ oxidoreductase Co factor:

FMN

Non protein membrane of ETC lipid soluble

coenzyme Q

A protein that contains heme group( phorphyrin and fe3+)

cytochrome C

Complex III- (Cyt bc1 complex) Process:

Cyt c passes e- to Complex IV → O2 (final e- acceptor forming H2O.

Complex III- (Cyt bc1 complex) Protons pumped:

2H+

IV (CyT C oxidase) Process:

Cyt c passes e- to Complex IV → O2 (final e- acceptor forming H2O.

IV (CyT C oxidase) Protons pumped:

2H+

ATP synthase (F0 F1 -ATPase), the enzyme that generates ATP, is a multi-subunit enzyme that contains an __________ (F0 ) and a ________(F1 ) that project into the matrix.

inner membrane portion,stalk/headpiece

The ____ c-subunits in the membrane form a rotor that is attached to a central asymmetric shaft composed of the ε- and γ-subunits.

The headpiece is composed of ____ αβ-subunit pairs. Each β-subunit contains a _______for ATP synthesis.

3,catalytic site

The headpiece is held ______ by a δ-subunit attached to a_____ _____ connected to subunit a in the membrane.

stationary,long subunit

ATP Synthase (Complex V) Process:

This moves the H+ that were pumped out of the matrix (coupling)

ATP Synthase (Complex V) membrane spanning domain for proton translocation

ATP Synthase (Complex V) extramembranous domain that carries out production of ATP from ADP and Pi

Mechanism of ATP synthesis

chemiosmosis and OP

the movement of ions across a semipermeable membrane, down their electrochemical gradient

chemiosmosis

the process in w/c ATP is formed because of the transfer of electrons.

oxidative phosphorylation

block complexed through binding with specific e- carriers

inhibitors

I - NADH dh

metformin, retone

II- succinate dh

malonate

III- cyt bc1 oxidase

dimercaprol, antimycin a

IV- cyt c oxidase

cyanide, CO, H2S

V- ATP synthase

oligomycin

disrupts membrane permeability; dissipates H+ gradient

uncouplers

biochem

biochem

inorg

inorg

phychem

phychem

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問題一覧

is the 4th and final stage of aerobic respiration.

electron transport chain

Through ETC, the e- needed for the cellular activities is released in the form of ATP.

remember!

ETC is an O2 dependent process which occurs in the ________membrane.

inner mitochondrial

The energy rich carbohydrates (Glu), FA and AAs undergo a series of metabolic reactions and finally get oxidized to ________?

co2,h2o

contains two membranes: outer membrane permeable to small molecules and an impermeable inner membrane

mitochondria

uses shuttle system that transport NADH electrons across inner mitochondrial membrane.

cystosolic nadh

readily oxidized for ATP production

mitochondrial nadh

Heart Liver Kidney

malate aspartate shuttle

Brain Skeletal muscle

glycerol 3 phosphate shuttle

ATP per cystosolic NADH

1.5

ATP per mitochondrial NADH

2.5

Mitochondrial inner membrane is impermeable to NAD+/NADH but is permeable to ions attached to malate.

malate aspertate shuttle

Requires FAD prosthetic group to transfer electrons to ubiquinone (Q) to enter ETC.

glycerol 3 phosphate

It is faster but less efficient

glycerol 3 phosphate

Electron Transport Chain Location

inner mitochondrial membrane

ETC Overall Reactions

electrons and protons from nadh and fadh2~intermediate carriers~ O2 (to produce H2O) remember!

How many components ETC have?

4 membrane-bound complexes (Complex I-IV), ATP Synthase mobile electron carriers (CoQ and Cyt C)

remember!

Complex I- NADH dehydrogenase Process:

Collects 2e- from the NADH and passes them to ubiquinone (CoQ) to form reduced ubiquinol (CoQH2), which carries the e- to Complex III

Complex I- NADH dehydrogenase Protons pumped

4H+

Complex I- NADH dehydrogenase Co factor:

FMN

Complex II- Succinate dh/ Succinate CoQ oxidoreductase Process:

Part of the TCA cycle which transfers 1e- from FADH2 to CoQ reducing to CoQH2, which carries the e- to Complex III

Complex II- Succinate dh/ Succinate CoQ oxidoreductase Protons pumped:

4H+

Complex II- Succinate dh/ Succinate CoQ oxidoreductase Co factor:

FMN

Non protein membrane of ETC lipid soluble

coenzyme Q

A protein that contains heme group( phorphyrin and fe3+)

cytochrome C

Complex III- (Cyt bc1 complex) Process:

Cyt c passes e- to Complex IV → O2 (final e- acceptor forming H2O.

Complex III- (Cyt bc1 complex) Protons pumped:

2H+

IV (CyT C oxidase) Process:

Cyt c passes e- to Complex IV → O2 (final e- acceptor forming H2O.

IV (CyT C oxidase) Protons pumped:

2H+

ATP synthase (F0 F1 -ATPase), the enzyme that generates ATP, is a multi-subunit enzyme that contains an __________ (F0 ) and a ________(F1 ) that project into the matrix.

inner membrane portion,stalk/headpiece

The ____ c-subunits in the membrane form a rotor that is attached to a central asymmetric shaft composed of the ε- and γ-subunits.

The headpiece is composed of ____ αβ-subunit pairs. Each β-subunit contains a _______for ATP synthesis.

3,catalytic site

The headpiece is held ______ by a δ-subunit attached to a_____ _____ connected to subunit a in the membrane.

stationary,long subunit

ATP Synthase (Complex V) Process:

This moves the H+ that were pumped out of the matrix (coupling)

ATP Synthase (Complex V) membrane spanning domain for proton translocation

ATP Synthase (Complex V) extramembranous domain that carries out production of ATP from ADP and Pi

Mechanism of ATP synthesis

chemiosmosis and OP

the movement of ions across a semipermeable membrane, down their electrochemical gradient

chemiosmosis

the process in w/c ATP is formed because of the transfer of electrons.

oxidative phosphorylation

block complexed through binding with specific e- carriers

inhibitors

I - NADH dh

metformin, retone

II- succinate dh

malonate

III- cyt bc1 oxidase

dimercaprol, antimycin a

IV- cyt c oxidase

cyanide, CO, H2S

V- ATP synthase

oligomycin

disrupts membrane permeability; dissipates H+ gradient

uncouplers