Most abundant composition of erythrocyte

Variation ofHgB content showing slight blue tinge , gray-blue and larger than normal

Larger than normal central area of pallor

It causes Iron Deficiency Anemia, Thalassemia, Anemia of CHronic Disease, Sideroblastic Anemia, Myelodysplastic Anemia

Hypochromasia Grading were central pallor is ½ of cell diameter

Hypochromasia Grading were central pallor is ⅔ of cell diameter

Hypochromasia Grading were central pallor is ¾ of cell diameter

Hypochromasia Grading were RBC has a thin line of hemoglobin

Polychromasia Grading when there is 1% of polychromatic cells present in the blood

Polychromasia Grading when there is 3% of polychromatic cells present in the blood

Polychromasia Grading when there is 5% of polychromatic cells present in the blood

Polychromasia Grading when there is greater than 11% of polychromatic cells present in the blood

Egg-like or oval shaped RBC ; Wider than elliptocytes

This poikilocyte is present when there is a reduction in membrane cholesterol. Present in Megaloblastic Bone Marrow and Myelodysplasia

Diseases with a presence of Oval Macrocyte

Diseases with a presence of Round Hypochromic Macrocyte

Diseases with a presence of Blue-Tinged Macrocyte

Also known as ACANTHOCYTES

Spheroid with 3-12 irregular spikes with long projections

Spheroid with 3-12 irregular spikes with long projections

Present in Pyruvate Kinase Deficiency and Abetalipoproteinemia

Also known as BURR CELLS

Regular 10 to 30 scalloped short projection evenly distributed

Present in Anemia with Renal Defiency and Uremia

Other name for Codocyte

Peripheral rim of Hb surrounded by clear area and central hemoglobinized area

Present in Hemoglobinopathies

Low surface area to volume ratio

Defect or loss of membrane: Hereditary spherocytosis, Isoimmune and autoimmune hemolytic anemia, severe burns, banked blood stored for a long time

Mechanisms of Spherocyte Formation

Mouth or slit like pallor areA

Increase permeability of the membrane to sodium: hereditary stomatocytosis, Rh null, Alcoholism, cirrhosis, obstructive liver disease

Rod or cigar shaped

Defect is considered to be in the cytoskeleton, with a decrease in the membrane protein band 4.1

Protein where RBC is defected causing elliptocytes

Fragmentation produced by damage of RBC by fibrin, altered vessel walls, prosthetic heart valves

Schistocyte with horn-like projection is known as…

Present in DIC, TTP, Burns, Microangiopathic hemolytic anemia

Dacryocyte is also known as

Squeezing and fragmentation during splenic passage

Present in Myeloid dysplasia and Hypersplenism

Crescent shaped cells

Polymerization of deoxygenated hemoglobin S

Present in sickle cell anemia, SC disease

Red cell with single or multiple vacuoles or markedly thinned areas at the periphery

Present in Drug-induced anemias G-6-PD Deficiency Thalassemia, Unstable hemoglobinopathies

Also known as DEGMACYTE

Present in megaloblastic anemia, severe hemolytic process, thalassemia, accelerated erythropoiesis

Stain used in Howell-Jolly Bodies

Color of granules in Basophilic Stippling

Also known as “Blueberry Bagel”

Present in Lead poisoning, Pyrimidine-5-nucleotidase deficiency, Heavy metal poisoning

Rings, loops, figure of eight, red to purple

Bell or tall hat shape on scanning EM

Present in Megaloblastic anemia, severe anemia

Deep purple, irregularly shaped inclusions

Present when there is a Defects in HMP, G6PD deficiency, unstable Hb, Splenectomy, Thalassemia

Stain used in Heinz Bodies

Inclusions represent precipitated Hb H

Hb H Inclusions is also known as

Disease where there is alpha thalassemia with moderate hemolytic anemia

Stain used in Hemoglobin H Inclusion

Hexagonal with blunt ends and stain darkly

Dark-hued crystals of condensed Hb distort the red cell membrane

Abnormal Hemoglobin Inclusions

Crystalline projection is often straight with parallel sides and one blunt, pointed protruding end

Nucleated RBC that contains non-heme iron particles

Excessive iron overload in mitochondria of normoblasts

Present in Sideroblastic anemia and MDS

Dark staining iron granules that usually clumped together at periphery of the cell

Present in Defective erythropoiesis

Protozoan transmitted by mosquitoes

Protozoan inclusion, tick bite

Formation seen in a cell with Babesia

“stack of coins” pattern of red cells

Rouleaux happened when there is

Clumping of red cells

cell under granulopoiesis, derived from a metamyelocyte, and leading to a mature granulocyte

increased release of precursors from the bone marrow

characterized by the presence of hypersegmented polymorphonucleocytes

Cells that are temporarily circulating the blood stream

Normal cells in the bloodstream

Blood laminopathy associated with the lamin B receptor.

Nuclei are round oval or bilobed which are spectacle-like, dumbbell or peanut with intense nuclear clumping of chromatin

Acquired anomaly where blood cancers affects the Bone Marrow

Sometimes referred to as a myeloid "right shift".

Large purple-black coarse cytoplasmic granules

Auer rods are found in…

Fused primary granules with pink or red rod shaped structures

Giant red, blue to grayish round inclusions

These bodies are formed by aggregation and fusion of the primary and secondary specific granules.

Complications of Chediak-Higashi Granules

Caused by mutations in the LYST gene.

Single or multiple blue inclusions caused by burns and bacterial infection

Dohle Bodies may confused with

Pale-blue inclusion with the presence of giant platelets

In what gene mutation Mayy-Hegglin is derived from:

Large purple to black granules caused by bacterial infection and inflammation

Neutrophil with large purple homogenous round inclusion