Last coag factor in extrinsic and intrinsic pathway

Last coag in extrinsic and intrinsic pathway

Affected by coumadin

Factor Affected by coumarin

Affected by warfarin

Affected by brodifacoum

Affected by superwarfarin

The function of thromboplastin in the prothrombin test is to provide _____ to the assay

Not detected by PT or PTT

LASER –

Lifespan of platelet is

RBC transfusion is primarily to:

Appropriate test for PNH

X-linked or sex-linked hemophilia -> Occurs in MALE X chromosome

FFP and CP are NOT USED in ANY platelet disorder example is ______

Unique to platelet

Immature RBC without nucleus

Migrate with Hemoglobin E

Acute Hyperemia

control of cellular function and transmission of genetic information

DNA Replication:

: : S phase

Division of the cellular cytoplasm

the cells produced contain 23 chromosomes

Meiosis the cells produced contain ? chromosomes

first inherited hematologic disorder to be diagnosed using molecular biologic assay

use to amplifies low levels of specific DNA sequences

considered to be the “gold standard” of molecular methods

cytokines for stem cell mobilization

Stem cell CD marker

Unstable Hb Portland 2 CONTAINS?

Unstable Hb 2 Zeta and 2 Beta

LOCATION OF TPO production

Liver ? production

PASSWORD CESS Increase platelet Increase WBC Increase cell inclusion Increase spherocytes

Splenectomy Increases? (4)

the most frequently used site for bone marrow aspiration and biopsy

- bone marrow failure syndrome/empty and hypoplastic bone marrow

-failure to produce RBC, WBC, and platelets (pancytopenia)

-lymphocyte production is less affected

- is the drug most often implicated in acquired aplastic anemia

- Chloramphenicol is the drug most often implicated in

-decrease ESR

-JAK 2 mutation

-Pancytosis (accd to Harr, it should be panmyelosis)

-Increase ESR

Polycythemia vera - ESR?

Aplastic Anemia - ESR?

-Increase RBC mass/count

decrease Vit B12 or folate or both

-Treatment with folic acid improves hematologic abnormalities but not neurologic problems

Megaloblastic anemia -Treatment with ? improves hematologic abnormalities but not neurologic problems

- – lack of castle intrinsic factor leading to LOW VIT B12 ABSORPTION

-Pernicious anemia – lack of ? factor leading to LOW VIT B12 ABSORPTION

-parasite – causes Megaloblastic anemia, low Vit B12, Macrocytosis

-D.latum – causes (3)

Hallmark of Megaloblastic anemia

Hypersegmented neutrophil Hallmark of

Hypersegmented neutrophil (nucleus ?)

Lab findings in Megaloblastic anemia

Differential test between Vit B12 deficiency and Folate deficiency

Differentiate between Vit B12 deficiency and Folate deficiency

Beginning of Hb formation

first hemoglobin-synthesizing cell (hubbard)

Detectable of Hb synthesis

-Hemoglobin appears for the first time

-the first stage in which the pink color associated with stained hemoglobin can be seen

- Last stage capable of mitosis

Last nucleated stage (RBC)

is SLIGHTLY HIGHER in Polychromasia or reticulocytosis

MCV is SLIGHTLY HIGHER in ? or ?

1. Numerous NRBCs 2. Pronounced POlychormasia 3. Decreased Hb and HCT

Stain for Reticulocytes

is used for Reticulocyte count

Miller disc is used for ?

RBC characteristics um

RBC characteristics thickness

RBC characteristics average volume

RBC characteristics color

RBC characteristics Pallor:

RBC characteristics Average lifespan:

RBC characteristics Low RBC (only) with normal WBC and platelet

AKA/Congenital red

AKA//Chronic

AKA/Imperfecta

blackfan anemia/

anemia/

/Erythrogenesis

/primary red

erythroblastopenia/

cell aplasia/

/Joseph Diamond

Bizarre multinucleated erythroblasts,

, increased unconjugated bilirubin, and ineffective

Anaerobic ATP production

Production of glutathione that detoxifies peroxide

Reduce ferric to ferrous

deficiency ? -bite cell

-Hemolysis by fava beans and primaquine

G6PD deficiency -Hemolysis by ? and ?