control of cellular function and transmission of genetic information

Acute Hyperemia

/Joseph Diamond

Detectable of Hb synthesis

RBC characteristics Average lifespan:

Bizarre multinucleated erythroblasts,

Beginning of Hb formation

-the first stage in which the pink color associated with stained hemoglobin can be seen

RBC characteristics Low RBC (only) with normal WBC and platelet

blackfan anemia/

-Increase RBC mass/count

AKA/Imperfecta

Anaerobic ATP production

Affected by warfarin

Affected by superwarfarin

-parasite – causes Megaloblastic anemia, low Vit B12, Macrocytosis

Hypersegmented neutrophil Hallmark of

Migrate with Hemoglobin E

The function of thromboplastin in the prothrombin test is to provide _____ to the assay

Polycythemia vera - ESR?

Production of glutathione that detoxifies peroxide

Lab findings in Megaloblastic anemia

DNA Replication:

, increased unconjugated bilirubin, and ineffective

considered to be the “gold standard” of molecular methods

- Chloramphenicol is the drug most often implicated in

RBC characteristics color

Aplastic Anemia - ESR?

-JAK 2 mutation

/primary red

RBC transfusion is primarily to:

Unique to platelet

Splenectomy Increases? (4)

RBC characteristics thickness

Immature RBC without nucleus

cytokines for stem cell mobilization

LOCATION OF TPO production

Last nucleated stage (RBC)

-Hemoglobin appears for the first time

Meiosis the cells produced contain ? chromosomes

Not detected by PT or PTT

Unstable Hb 2 Zeta and 2 Beta

anemia/

X-linked or sex-linked hemophilia -> Occurs in MALE X chromosome

1. Numerous NRBCs 2. Pronounced POlychormasia 3. Decreased Hb and HCT

Division of the cellular cytoplasm

cell aplasia/

/Erythrogenesis

decrease Vit B12 or folate or both

is used for Reticulocyte count

- is the drug most often implicated in acquired aplastic anemia

Hallmark of Megaloblastic anemia

RBC characteristics average volume

-Treatment with folic acid improves hematologic abnormalities but not neurologic problems

use to amplifies low levels of specific DNA sequences

- Last stage capable of mitosis

Affected by coumadin

Differentiate between Vit B12 deficiency and Folate deficiency

deficiency ? -bite cell

- – lack of castle intrinsic factor leading to LOW VIT B12 ABSORPTION

erythroblastopenia/

-Pancytosis (accd to Harr, it should be panmyelosis)

Stain for Reticulocytes

Hypersegmented neutrophil (nucleus ?)

G6PD deficiency -Hemolysis by ? and ?

-Hemolysis by fava beans and primaquine

RBC characteristics Pallor:

-D.latum – causes (3)

AKA//Chronic

Differential test between Vit B12 deficiency and Folate deficiency

Affected by brodifacoum

Stem cell CD marker

RBC characteristics um

the most frequently used site for bone marrow aspiration and biopsy

the cells produced contain 23 chromosomes

Lifespan of platelet is

MCV is SLIGHTLY HIGHER in ? or ?

-Pernicious anemia – lack of ? factor leading to LOW VIT B12 ABSORPTION

-failure to produce RBC, WBC, and platelets (pancytopenia)

- bone marrow failure syndrome/empty and hypoplastic bone marrow

Miller disc is used for ?

PASSWORD CESS Increase platelet Increase WBC Increase cell inclusion Increase spherocytes

Liver ? production

Last coag in extrinsic and intrinsic pathway

FFP and CP are NOT USED in ANY platelet disorder example is ______

LASER –

Appropriate test for PNH

: : S phase

first hemoglobin-synthesizing cell (hubbard)

Unstable Hb Portland 2 CONTAINS?

-decrease ESR

Reduce ferric to ferrous

-Increase ESR

Megaloblastic anemia -Treatment with ? improves hematologic abnormalities but not neurologic problems

Factor Affected by coumarin

-lymphocyte production is less affected

Last coag factor in extrinsic and intrinsic pathway

is SLIGHTLY HIGHER in Polychromasia or reticulocytosis

AKA/Congenital red

first inherited hematologic disorder to be diagnosed using molecular biologic assay