Neurodevelopment, neurodegeneration & recovery

formation of NS, brain development, birth of neurones, neuronal migration, formation of cc, axonal pathways, myelination

formation of neural plate, neural action, neural plate folds, neural tube, CNS

from progenitor cells that divide to form new neurones (proliferation & neurogenesis)

neurons move & group together

form axons to extend to correct target regions then synaptogenesis

apopotosis which is automatic

oligodendrocytes, nerve impulse conduction & comm, regional variation in patterns of wm pathways

FAS, ADHD, autism, Sx, tourette’s

the 2nd most common NG disease

MPTP broke down to MPP+, imported acros cell via transporter, killed from apoptosis & kills dopamine

p= rapid cell division, n= birth of neurones

born neurones don’t resemble ones that produce specific NTs so need neurochemical changes to specialise during differentiation

brain changes increasingly until 20s then reverse effects

generation of new neurones that proliferate & be functional

4

present through whole lifespan despite brain changes

death of neurones, loss of synaptic connections

general cause of n loss, lack oxygen, no energy, die

general cause of n loss, excitotoxic lesions

non beneficial apoptosis

mutation in a single gene initially in basal ganglia

enables elimination of cells damaged by other things

sporadic, late onset, genetic & env

abnormal accumulation of beta-amyloid & tu roteins= amyloid plaques & neurofibrillary tangles

motor tremors, stiffness, slow move, cog deficits

idiopathic

degeneration of dopamine neurons in substantial nigra