RENAL FUNCTION TEST

Jef Marc Valencia · 73問 · 2年前

通報

問題一覧

What are the 3 renal function test

GLOMERULAR FILTRATION TEST, TUBULAR REABSORPTION TEST, TUBULAR SECRETION TEST

Procedures performed to determine the ability of the kidneys to carry out its metabolic functions

RENAL FUNCTION TEST

Standard test used to determine the filtering capacity of the glomeruli

CLEARANCE TEST

Process that involves the filtration of blood which leads to the formation of the ultrafiltrate per unit/time

GLOMERULAR FILTRATION RATE

What are the 2 tests performed in Glomerular filtration tests

ENDOGENOUS CLEARANCE, EXOGENOUS CLEARANCE

Test that performed under GFT which detects substances that already present inside the body.

ENDOGENOUS CLEARANCE

Test that performed under GFT which requires infused substances that is administered in the body

EXOGENOUS CLEARANCE

What are the substances that is detected in Endogenous test

UREA, CREATININE, B2 MICROGLOBULIN, CYSTATIN C

What are the substances that is detected in Exogenous test

INULIN, RADIOISOTOPE

The earliest glomerular filtration rate test which substance is first detected. Measures renal functions but not specific for glomerular filtration which no longer performed since it is affected by food intake and changes from day and night

UREA CLEARANCE

Readily-filtered nitrogen waste product of protein present in urine substance but partially reabsorbed by the renal tubules

UREA

Routinely performed for screening glomerular filtration

CREATININE CLEARANCE TEST

Specimen required for CCT

24 HOUR URINE

How to preserve 24 hour urine

REFRIGERATE

What is the greatest source of error in CCT

IMPROPERLY TIMED SPECIMEN

Normal value of CCT in males

107-139 ML/MIN

Normal value of CCT in females

87-107 ML/MIN

CCT is greatly affected by what factors

SEX, PHYSICAL ACTIVITY, AGE

Creatinine Clearance Test Disadvantages 1. Some creatinine is secreted by the tubules, and secretion _____ as blood level rise 2. _______present in human plasma react in the chemical analysis 3. Medications, including , inhibit tubular secretion of creatinine 4. Bacteria will break down urinary creatinine if specimens are kept at _______for extended periods. 5. An increased intake of ____ can raise the urine and plasma levels of creatinine during the 24-hour collection period. 6. Measurement of creatinine clearance is not a reliable indicator in patients suffering from ______or persons involved in heavy exercise or athletes supplementing with creatine. 7. Accurate results depend on the accurate completeness of a _______. 8. It must be corrected for ________, unless normal is assumed, and must always be corrected for children.

INCREASES, CHROMOGEN, GENTAMICIN,CEPHALOSPORIN,CIMETIDINE, ROOM TEMPERATURE, MEAT, MUSCLE WASTING DISEASE, 24 HOUR COLLECTION, BODY SURFACE AREA

What is the product of muscle metabolism

CREATININE

A substance that dissociates from HLA at a constant rate and is rapidly removed from the plasma by glomerular filtration

B2 MICROGLOBULIN

What is the molecular weight of B2 Microglobulin

11 800 KILO DALTON

A test under GFT Endogenous tests which not reliable on patients with a history of immunologic disorders or malignancy

B2 MICROGLOBULIN CLEARANCE

A small protein produced at a constant rate by all nucleated cells which is readily filtered by the glomerulus and reabsorbed and broken down by the renal tubular cells

CYSTATIN C

What is the molecular weight of cystatin c

13 359 KILO DALTON

A test under GFT Endogenous recommended for pediatric, diabetic, geriatric and critically-ill patients which is directly proportional to GFR

CYSTATIN C CLEARANCE

It is the gold standard or reference method for Renal Function Test

INULIN CLEARANCE TEST

A polymer of fructose which is extremely stable exogenous substance, neither reabsorbed nor secreted by the tubules but it is administered IV

INULIN

provides a method for determining glomerular filtration through the plasma disappearance of the radioactive material and enables visualization of the filtration in one or both kidneys.

RADIOISOTOPE

What is the injected radionucleotidein Exogenous Clearance test

125 LIOTHALAMATE

This procedure can be valuable to measure the viability of a transplanted kidney.

RADIOISOTOPE

Formulas developed to provide estimates of the GFR based on the serum creatinine without the urine creatinine

CALCULATED GLOMERULAR FILTRATION ESTIMATE

Most frequently used formula used to evaluate patient placement on kidney transplant lists

COCKCROFT AND GAULT

What is value being multiplied in females in Cockcroft and Gault

0.85

GFR = 170 x serum creatinine - 0.999 x age - 0.176 x 0.822 (if patient is female) x 1.1880(if patient is black) x BUN-0.170 x serum albumin + 0.318

MODIFICATION OF DIET IN RENAL DISEASE SYSTEM

Also known as Tubular Reabsorption Test used to evaluate tubular reabsorption

CONCENTRATION TEST

A concentration test which Patient is deprived of fluid for 24 hours

FISHBERG

What is normal value for Urine SG in fishberg

>1.026

Concentration Test used for volume and specific gravity comparison of day and night urine sample

MOSENTHAL

Influenced by the number and density of particles in a solution.

SPECIFIC GRAVITY

Influenced by the number of particles in a solution that is Based on the measurement of colligative properties

OSMOLALITY

formula used for children in Calculated Glomerular Filtration Tests

SCHWARTZ AND MODIFIED COUNAHAN BARRET

First principle incorporated in osmometers which 1 mol solute will lower the freezing point by 1.86oC

FREEZING POINT

Normal Serum Osmolarity:

275-300 mOsm

Normal Urine Osmolarity:

50-1400 mOsm

Normal Urine to Serum Osmolarity Ratio

1:1-3:1 mOsm

Evaluates the ability of the kidney to respond to the body’s state of hydration

FREE WATER CLEARANCE

Result in Free Water Clearance if less water is being excreted

Result in Free Water Clearance if no renal concentration or dilution

Result in Free Water Clearance if excess water is being excreted

Used primarily to analyze serum and sweat microsamples for disorders not related to renal function, such as cystic fibrosis.

VAPOR PRESSURE OSMOMETER

A c'mon method of osmometer which determine the freezing point of a solution by supercooling a measured amount of sample to approximately 27O C.

FREEZING POINT

1000mOsm/kg of H2O will lower the freezing point of H2O by how many degree celsius

1.86

Clinical osmometers use solutions of _______concentration as their reference standards because a solution of partially ionized substances is more representative of urine and plasma composition.

KNOWN NACL

Osmometer which utilizes depression of dew point temperature by solute parallels the decrease in vapor pressure, thereby providing a measure of this colligative property.

VAPOR PRESSURE

Vapor pressure osmometer uses microsamples of less than_____; therefore, care must be taken to prevent any evaporation of the sample prior to testing

0.01 ML

A tubular secretion and renal blood flow test which substance administered is a Non-toxic loosely bound to plasma proteins which then should be completely removed as the blood passes through the peritubular capillaries

P AMINOHIPPURIC ACID TEST

A tubular secretion and renal blood flow test which was historically used to evaluate tubular secretion and renal blood flow but it is no longer perform as it was obselete and hard to interpret

PHENOLSULFONPHTHALEIN TEST

A tubular secretion and renal blood flow test which evaluates the ability of the kidneys to produce an acid urine by determining the Amount of free H+ and total acidity.

TITRABLE ACIDITY AND URINARY AMMONIA

What is being administered in Titrable Acidity and Urinary Ammonia

ACID LOAD OF ORAL AMMONIUM CHLORIDE

Sample required in Titrable Acidity and Urinary Ammonia is _____collected at 2-hour intervals

FRESH OR TOLUENE PRESERVED URINE

A tubular secretion and renal blood flow test which Evaluates unilateral kidney disease

INDIGO CARMINE TEST

How many mg of Indigo Carmine is administered in the test

100

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