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1
Development of an infection and disease
Pathogenesis
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It involves the growth and multiplication of microorganisms that causes damage to the host.
Infection
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It is the bodily invasion of pathogenic microorganisms that reproduce, multiply, and then cause diseases through local cellular injury, toxin secretion or antigen-antibody reaction in the host.
Infection
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What are the types of Infection according to the Cause?
Autogenous infection, Iatrogenic infection, Opportunistic infection, Nosocomial infection
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This type of infection is caused by a microorganism from the microbiota of the host.
Autogenous infection
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This type of infection is an infection that occurs as the result of some medical treatment or procedure
Iatrogenic infection
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This type of infection is an infection that affects immunocompromised host but not the individual with a normal immune system
Opportunistic infection
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This type of infection is also known as the hospital- acquired infection and is a acquired at a healthcare facility
Nosocomial infection
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It still considered as the cornerstone of modern infection control programs
Handwashing
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What are the 4 common types of Nosocomial Infections?
Urinary tract infection, Lung infection, Surgical site infection, Blood stream infection
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What are the Predisposing factors to Nosocomial Infection?
Wide variety of microbes in the hospital environment, Weakened or immuno compromised patients
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Chain of transmission of Nosocomial Infection
From health worker to patients, From patients to patients, Use of fomites, Airborne transmission, Vector-borne transmission
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What are the types of Infection according to Host Distribution?
Local infection, Focal infection, Systemic infection
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In this type of infection, the signs and symptoms are confined in one area.
Local infection
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This type of infection starts as an local infection before spreading to the other parts of the body.
Focal infection
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In this type of infection, the microbes spread throughout the body through the blood or lymph.
Systemic infection
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What are the types of systematic infections?
Bacteremia, Septicemia, Pyremia
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The presence of bacteria in blood
Bacteremia
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True/False: Organisms invade the bloodstream with Active Multiplication
False
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True/False: The highest concentration of bacteria in the blood occurs before the fever spikes.
True
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Active multiplication of the invading bacteria in the blood
Septicemia
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It is a condition wherein pus-producing organisms reapetedly invade the bloodstream and become localized at different parts of the body.
Pyremia
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What are the extent of Infection?
Primary infection, Secondary infection, Latent infection, Mixed infection, Acute infection, Chronic infection
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It is the initial infection that causes the illness
Primary infection
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Give an example of primary infection
Common cold
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It is an infection caused by opportunistic pathogens after the primary infection has weakened the host's immune system
Secondary infection
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Give examples of secondary infections
Pneumonia, Bronchitis
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It is an infection which is clinically silent inside the body and causes no noticable illness in the host. Then severe and acute infraction manifest.
Latent infection
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Give an example of Latent infection
Asymptomatic type polio infection
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It is an infection caused by two or more organisms
Mixed infection
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Give an example of Mixed infection
Wound infection
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Type of infection that develops and progresses slowly
Acute infection
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Example of an Acute infection
Whooping cough
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An infection which develops slowly with milder but long lasting symptoms
Chronic infection
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Give an example of chronic infection
Tuberculosis
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Give the routes of infections through Direct Transmission
Congenital contact, Sexual contact, Infectious respiratory secretions, Hand to hand transmission
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Microbes that are transmitted through Congenital Contact
Streptococcus agalactiae , Neisseria gonorrhoeae, Treponema pallidum
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Microbes that are transmitted through sexual contact
Neisseria gonorrhoeae, Treponema pallidum
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Microbes that are transmitted through Infectious respiratory secretions or droplets.
Streptococcus pyogenes, Neisseria meningitidis
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Microbes transmitted through hand to hand transmission
Rhinovirus
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Give the routes of infections through Indirect Transmission
Fomites, Water, Arthropod vectors
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A specific illness or disorder that is characterized by a recognizable signs and symptoms which are attributable to heredity, infection, and environment.
Disease
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It results when the infection produces notable changes in the human physiology, specifically those that cause damage to the body's organ system
Disease
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List down the Classification of Infectious Diseases
Communicable disease, Non-communicable disease
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This type of disease spreads from one host to another, either directly or indirectly.
Communicable disease
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Give examples of Communicable diseases.
Tuberculosis, Herpes, Flu, Chicken pox
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This type of disease does not spread from one host to another. And caused by external microbes or by opportunistic pathogens living in the body.
Non-communicable disease
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Give examples of Non-communicable disease
Tetanus, Botulism
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List down the Classification of Disease According to Occurence
Sporadic disease, Endemic disease, Epidemic disease, Pandemic disease
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This type of disease occurs ocassionally
Sporadic disease
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This type of disease is constantly present in a particular location or population.
Endemic disease
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This type of disease is a disease that affects a large number of people in a population within a short period of time
Epidemic disease
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This is a disease that affects populations across large regions around the world.
Pandemic disease
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These are objective changes that can be measured. Examples are fever, redness, swelling, and paralysis
Signs
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These are subjective indications of the disease in a person. Examples are pain and malaise.
Symptoms
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It is a group of signs and symptoms that are associated with a disease. Example is AIDS.
Syndrome
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The Phases of Infectious Disease
Incubation period, Prodromal period, Clinical period or illness period, Decline period, Convalescence or the period of recovery
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The time between the exposure to a pathogenic organism and the onset of symptoms.
Incubation period
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In this phase of infectious disease, the signs and symptoms would appear
Prodromal period
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The peak of characteristic signs and symptoms of an infection or a disease.
Clinical or illness period
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The period in which the signs and symptoms begin to subside as the host's condition improves.
Decline period
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The period in which the surviving host is recuperating towards full recovery.
Convalescence or the period of recovery
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List down the Predisposing Factors of Diseases
Gender, Genetic factors, Climate and weather, Nutrition, Fatigue/stress, Environment, Lifestyle, Age, Occupation
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Give the 2 General Classes of Pathogenic Microorganisms
True pathogen, Opportunistic pathogens
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Give examples of Opportunistic pathogens
Neisseria meningitidis, Escherichia coli
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These organisms are able to invade the tissues of healthy individuals through some inherent ability causing various diseases. normally found outside the host.
True pathogen
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These organisms normally do not cause diseases in their natural habitat in healthy person. They cause diseases if the host is immunocompromised or if they enter a different part of the body.
Opportunistic pathogens
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Types of Host-microbe Relationship
Symbiosis, Mutualism, Commensalism, Parasitism
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It is the association of two organisms living in close proximity.
Symbiosis
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It is a symbiotic relationship in which both organisms benefit from each other.
Mutualism
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It is a relationship in which one organism benefits while there is no beneficial or harmful effect to the other.
Commensalism
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It is a relationship in which one organism (parasite) benefits at the expense of its host.
Parasitism
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It is a complex interaction between the host, indwelling device, and bacteria and is a key component in bacterial pathogenesis.
Biofilm production
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It pertains to the ability of a pathogenic agent to produce a disease in a susceptible individual.
Pathogenicity
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Give some examples of Focal Infection.
Tooth infection, Tonsillitis, Appendicitis, Wound infection
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Tooth infection, tonsillitis, appendicitis and wound infections are caused by what?
Clostridium tetani
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Give some examples of Local Infection.
Infected wounds, Boils, Abscesses
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"memory cell" of the immune system
B- lymphocyte