問題一覧
1
Pain and inflammatory reaction
Prostaglandins.
2
Arachidonic acid (AA)-derived lipid mediators are called
Eicosanoid.
3
Eicosa means how many carbon attached?
20 carbon.
4
What is the suffix of carboxylic acid?
Oic acid.
5
Why is it called as eicosatetraenoic acid?
Eiocosa- 20 carbon, Tetra- 4, en - double bond and Oic acid - carboxylic acid.
6
the most common precursor of the eicosanoids, is formed by two pathways
Phospholipase C, Phospholipase A
7
concert with diglyceride lipase can also produce free arachidonate
Phospholipase C
8
Mediated production from membrane phospholipids
Phospholipase A
9
What is the scientific name of arachidonic acid.
5,8,11,14 -Eicosatetranoic acid.
10
What are the pathways of Arachidonic Acid
Prostaglandin H synthase (COX) pathway , Lipoxygenase pathway (LOX)
11
In Cox pathway what is the AA intermediate metabolite
PGH2
12
What is the pathway make use of COX
Thromboxane, Primary prostaglandins.
13
What are tha primary prostaglandins
PGE, PGF, PGD, PGI2
14
What are the drug of choice in COX pathway
NSAID.
15
What is the drug of choice in LOX inhibitor
Zileuton, Leukotriene antagonist.
16
This medicine is for broninchial asthma
Zilueton.
17
This medicine used to block leukotriene.
Leukotriene antagonist.
18
This is located in endothelial cells, kidney, gastrointestinal tract, and many other locations
COX 1
19
Found in great abundance in connective tissues.
COX 2
20
expressed at fairly constant levels PGH synthase-1 (COX-1) is expressed constitutively in most cells
COX 1
21
It is highly inducible by numerous factors associated with inflammation
COX 2
22
generates prostanoids for “housekeeping” such as gastric epithelial cytoprotection
COX 1
23
Current theories suggest that the type 2 isoforms is predominantly associated with eicosanoids production in inflammation.
COX 2
24
The eicosanoids all have short plasma half-lives (typically 0.5-5 minutes). Most catabolism occurs in the lung
Prostaglandin H-Pathway.
25
Prostaglandins are metabolized by PDGH to 15-keto metabolites ( T/F)
True.
26
Thromboxane A2 (TXA2) is rapidly hydrated to the less active TXB2. (T/F)
True.
27
PGI2 is hydrolyzed to 6-keto-PGF. (T/F)
True.
28
This pathway is of great interest since it is associated with asthma, anaphylactic shock, and cardiovascular disease
lipoxygenase pathway.
29
What is the primary components of the slow-reacting substance of anaphylaxis (SRS-A)
LTC 4, LTD 4
30
Vasodilation
PGE2, PGI2
31
Arteriolar vasodilation and superficial vein constriction
PGF
32
Vasoconstriction
Thromboxane.
33
Bronchoconstriction
Thromboxane., PGF2
34
Bronchodilation
PGE series.
35
Bronchoconstriction (SRS-A
LTC4 & LTD4
36
Uterine contraction Causes pain in dysmenorrhea
PGE2 , PGF2
37
Increase blood flow and promote but do not cause, edema
PGE2, PGI2
38
Produce LeukotrienesFacilitate T-cell proliferation and act as chemoattractants (T/F)
True.
39
Synthesize PGE2 and TXA2 Causes inflammation in rheumatoid arthritis
Macrophagesm
40
Chemotaxis of eosinophils and neutrophils
Leukotrienes.
41
Chemotaxis of eosinophils and neutrophils
PGF2
42
Cytoprotectant-inhibit acid and pepsinogen secretion in the stomach
PGE2
43
Inhibit platelet aggregation
PGE2, PGI2
44
Induce platelet aggregation
TXA2
45
Stimulate release
5-HPETE
46
Inhibits release
PGD2 , PGI2
47
Increases body temperature
PGE2
48
Induces natural sleep
PGD2
49
Wakefulness
PGE2
50
Derivatives can lower intraocular pressure
PGE, PGF
51
(C22:6)
dicosahexaenoic acids
52
(C20:5)
Eicosapentaenoic
53
corn, safflower, and sunflower oils
Linoleic acid.
54
Non selective cox inhibitor = dec prostaglandins synthesis. = PUD (T/F)
True.
55
Selective inhubition of COX 2 enzyme = dec prostacyclin = INC platelets aggregation (T/F)
True.
56
What are examples of NSAID DRUGS.
Mefenamic , Ibuprofen , Naproxen, Diclofenax.
57
What us is they Generic name of Carboprost.
Hemabale.
58
PGF2 analogue used for therapeutic abortion.
Carboprost (Hemabale)
59
PGI2 analogue for management of pulmonary
Epoprostenol ( Fiolan)
60
What us is they Generic name of Epoprostenol
Fiolan.
61
PGE 1 analogue used for patent ductus arteriosus
Alprostadi( Caverject)
62
PGE 1 analogue used as cytoprotectant and the adverse effects of this is Abortifacient.
Misoprostol (Cytotec)
63
What us is they Generic name of Alprostadil.
Caverject
64
What us is they Generic name of Misoprostol
Cytotect
65
PGE2 analogue used as in abortion and cervical ripening
Dinoprostone ( Cervidil)
66
PGF2 a analogue used in management in glaucoma and has a adverse effects of Brown pigmentation in eyelashes
Lantanoprost (Xalant)
67
What us is they Generic name of Dinoprostone
Cevidil.
68
What us is they Generic name of lantanoprost
Xalantan