問題一覧
1
What are tha primary prostaglandins
PGE, PGF, PGD, PGI2
2
Vasoconstriction
Thromboxane.
3
Selective inhubition of COX 2 enzyme = dec prostacyclin = INC platelets aggregation (T/F)
True.
4
It is highly inducible by numerous factors associated with inflammation
COX 2
5
What are examples of NSAID DRUGS.
Mefenamic , Ibuprofen , Naproxen, Diclofenax.
6
concert with diglyceride lipase can also produce free arachidonate
Phospholipase C
7
Current theories suggest that the type 2 isoforms is predominantly associated with eicosanoids production in inflammation.
COX 2
8
This medicine is for broninchial asthma
Zilueton.
9
PGE 1 analogue used as cytoprotectant and the adverse effects of this is Abortifacient.
Misoprostol (Cytotec)
10
Bronchoconstriction
Thromboxane., PGF2
11
Inhibit platelet aggregation
PGE2, PGI2
12
Prostaglandins are metabolized by PDGH to 15-keto metabolites ( T/F)
True.
13
Non selective cox inhibitor = dec prostaglandins synthesis. = PUD (T/F)
True.
14
expressed at fairly constant levels PGH synthase-1 (COX-1) is expressed constitutively in most cells
COX 1
15
What us is they Generic name of Epoprostenol
Fiolan.
16
generates prostanoids for “housekeeping” such as gastric epithelial cytoprotection
COX 1
17
Found in great abundance in connective tissues.
COX 2
18
In Cox pathway what is the AA intermediate metabolite
PGH2
19
(C22:6)
dicosahexaenoic acids
20
Pain and inflammatory reaction
Prostaglandins.
21
Derivatives can lower intraocular pressure
PGE, PGF
22
(C20:5)
Eicosapentaenoic
23
What are the pathways of Arachidonic Acid
Prostaglandin H synthase (COX) pathway , Lipoxygenase pathway (LOX)
24
What us is they Generic name of lantanoprost
Xalantan
25
Produce LeukotrienesFacilitate T-cell proliferation and act as chemoattractants (T/F)
True.
26
PGI2 analogue for management of pulmonary
Epoprostenol ( Fiolan)
27
Mediated production from membrane phospholipids
Phospholipase A
28
What us is they Generic name of Misoprostol
Cytotect
29
Arteriolar vasodilation and superficial vein constriction
PGF
30
PGF2 analogue used for therapeutic abortion.
Carboprost (Hemabale)
31
What is the suffix of carboxylic acid?
Oic acid.
32
Wakefulness
PGE2
33
What us is they Generic name of Dinoprostone
Cevidil.
34
This pathway is of great interest since it is associated with asthma, anaphylactic shock, and cardiovascular disease
lipoxygenase pathway.
35
the most common precursor of the eicosanoids, is formed by two pathways
Phospholipase C, Phospholipase A
36
Chemotaxis of eosinophils and neutrophils
PGF2
37
Synthesize PGE2 and TXA2 Causes inflammation in rheumatoid arthritis
Macrophagesm
38
Thromboxane A2 (TXA2) is rapidly hydrated to the less active TXB2. (T/F)
True.
39
This medicine used to block leukotriene.
Leukotriene antagonist.
40
Vasodilation
PGE2, PGI2
41
This is located in endothelial cells, kidney, gastrointestinal tract, and many other locations
COX 1
42
PGE 1 analogue used for patent ductus arteriosus
Alprostadi( Caverject)
43
PGI2 is hydrolyzed to 6-keto-PGF. (T/F)
True.
44
What us is they Generic name of Alprostadil.
Caverject
45
What is the drug of choice in LOX inhibitor
Zileuton, Leukotriene antagonist.
46
What is the pathway make use of COX
Thromboxane, Primary prostaglandins.
47
Inhibits release
PGD2 , PGI2
48
Induce platelet aggregation
TXA2
49
Bronchodilation
PGE series.
50
The eicosanoids all have short plasma half-lives (typically 0.5-5 minutes). Most catabolism occurs in the lung
Prostaglandin H-Pathway.
51
Stimulate release
5-HPETE
52
What is the primary components of the slow-reacting substance of anaphylaxis (SRS-A)
LTC 4, LTD 4
53
Arachidonic acid (AA)-derived lipid mediators are called
Eicosanoid.
54
corn, safflower, and sunflower oils
Linoleic acid.
55
What are the drug of choice in COX pathway
NSAID.
56
Eicosa means how many carbon attached?
20 carbon.
57
Uterine contraction Causes pain in dysmenorrhea
PGE2 , PGF2
58
Bronchoconstriction (SRS-A
LTC4 & LTD4
59
Induces natural sleep
PGD2
60
What is the scientific name of arachidonic acid.
5,8,11,14 -Eicosatetranoic acid.
61
PGF2 a analogue used in management in glaucoma and has a adverse effects of Brown pigmentation in eyelashes
Lantanoprost (Xalant)
62
Increases body temperature
PGE2
63
What us is they Generic name of Carboprost.
Hemabale.
64
Increase blood flow and promote but do not cause, edema
PGE2, PGI2
65
Why is it called as eicosatetraenoic acid?
Eiocosa- 20 carbon, Tetra- 4, en - double bond and Oic acid - carboxylic acid.
66
Chemotaxis of eosinophils and neutrophils
Leukotrienes.
67
Cytoprotectant-inhibit acid and pepsinogen secretion in the stomach
PGE2
68
PGE2 analogue used as in abortion and cervical ripening
Dinoprostone ( Cervidil)