WBC Anomalies

MAHATHIR ALPHA · 55問 · 2年前

通報

問題一覧

It is the orderly production of mature granulocytes (N,E,B)

Granulocyte production

How long is the maturation sequence of Granulocytes?

About 14 days

What is the Normal range of WBC at birth or infants?

10,000-25,000/uL of blood

What is the Normal range of WBC of Infants upto 1 year of age?

6000-16000/uL of blood

What is the Normal range of WBC of Adults?

4000-11000/uL of blood

Try to Memorize!

It refer to the detection of changes in numbers of circulating WBCs(percentage of each type). It indicates infection, poisoning, leukemia, chemotheraphy, parasites or allergy reactions.

Differential WBC counts

In this stage of the granulocyte, The size of the cell is 15-20 um, has a round/slightly oval nucleus, a fine chromatin and 2-5 Nucleoli.

Myeloblast

In this stage of the granulocyte, the size of the cell is 15-21 um, has a oval/round nucleus, a slightly coarse chromatin and 2-3 Nucleoli.

Promyelocyte

In this stage of the granulocyte, the size of the cell is 12-18 um, has a oval/round nucleus, a coarser and condensed chromatin and no Nucleoli.

Myelocyte

In this stage of the granulocyte, the size of the cell is 10-16 um, has a Unsegmented/bi lobed nucleus, a condensed nucleus and no Nucleoli.

Basophil

What is the cytoplasm staining of Promyelocyte?

Basophilic

What is the cytoplasm staining of myelocyte?

Basophilic acidophilic

What is the cytoplasm staining of Metamyelocyte?

Beige/Salmon

What is the cytoplasm staining of Band?

Beige/Salmond

What is the cytoplasm staining of Neutrophil, eosinophil and basophil?

Beige/Salmond

1st recognizable in granulocytic series

Myeloblast

First appearance of primary granules

Promyelocyte

First appearance of secondary granules

Myelocyte

Youngest stage

Metamyelocyte/juvenile

Youngest cell to appear in peripheral blood

Band

N, E, B

Mature granulocyte

What are the Secondary or Specific Granules found in Neutrophil?

Aminopeptidase, Collagenase, Muramidase, Lactoferrin, Lysozyme, Basic proteins, Plasminogen activator, Alkaline phosphatase

What are the Larger Secondary or Specific granules/Major basic Proteins found in Eosinophil?

Acid hydrolase, Peroxidase, Phospholipase, Cathepsin, Eosinophilic Cationic CHON, Eosinophil-derived neurotoxin

What are the Smaller Secondary or Specific Granules found in Eosinophil?

Arylsulfatase, Peroxidase, Acid phosphatase

What are the Secondary or Specific Granules found in Basophil?

Histamine, Heparin, Peroxidase, Eosinophilic Chemotactic Factor A

What is the other term for Neutrophil?

Polymorphonuclear (PMN)

What are the granules found in Neutrophil?

Pink-rose violet granules

What is the Ratio of primary to secondary granules of Mature neutrophil?

2-3:1

In Neutrophil, it competes with bacteria for Fe (possibly inhibiting growth) and may promote PMN adherence to endothelial cells.

Lactoferrin-Fe binding glycoprotein

What is the life span of Neutrophil/Polymorphonuclear (PMN)?

9-10 days

What are the POOLS of Neutrophils in the body?

Bone marrow-production and maturation, Blood

What are the POOLS of Neutrophils in the Blood?

Circulating pool, Marginating pool

What are the POOLS of Neutrophil in the Bone marrow production and maturation?

Mitotic pool, Maturing pool, Storage pool

What are found in the Mitotic pool?

Myeloblast, Promyelocyte, Myelocyte

What are found in the maturing pool?

Metamyelocyte

What are the Secondary or Specific Granules found in the Storage pool?

Metamyelocyte, Bands, Segmented PMN's

What are found in the Circulating pool?

50% of PMNs circulating freely

What is found in the Marginating pool?

50% PMNs that adhere to the vessel walls or are sequenstered in the capillaries

What are the granules found on Eosinophil?

Reddish-orange with affinity for eosin(acidic)

It responds to parasitic and helminthic infection and allergy.

Eosinophil

True/False: Concentration of Eosinophil is normally high at night or in the afternoon.

True

It is the Major basic CHON -arginine- rich protein that plays a major role in killing parasites

Eosinophil

Its major function is to provide defense against helmenthic parasites and it has a role in allergic reactions by lessening hypersensitivity reactions through the release of an amine oxidase, which neutralizes histamine.

Eosinophil

What does Eosinophil releases that neutralize histamine?

Amine oxidase

It is formed from the disintegration of eosinophils and is made up of lysophospholipase found in the cytoplasm of eosinophils.

Charcot-Leyden Crystal

What is Charcot-Leyden crystal made of?

Lysophospholipase

Charcot-Leyden crystal are seen in what conditions?

Allergic asthma (nasal mucos), Pulmonary eosinophilic infiltrates (pleural fluid), Parasitic infection (stool)

It responds to allergic or hypersensitivity reactions a such as allergic asthma and delayed-onset allergy reaction

Basophil

What are the granules found in Basophil?

Water soluble blue black specific granules with affinity to methylene blue

What makes up 60-80 percent of the lymphoid population?

T lymphocyte

What makes up 10-20 percent of the lymphoid population?

B lymphocytes

What makes up 10 percent percent of the lymphoid population?

Null lymphocyte

Long lived lymphocyte (4-10 years) with cellular-mediated immunity

T lymphocyte

Short-lived lymphocyte with humoral-mediated immunity

B lymphocyte

Lymphocyte with tumor host defense

Null lymphocytes

What are the stages of lymphocyte?

Lymphoblast, Prolymphocyte, Mature small lymphocyte, Medium lymphocyte, Large lymphocyte

What are the stages of Plasma cells?

Plasmablast, Proplasmacyte, Plasmacyte/plasma cell

In this stage of the lymphocyte, the size of the cell is 10-18 um, it has a coarse chromatin, round/oval nucleus, a coarse 1-2 Nucleoli.

Lymphoblast

In this stage of the lymphocyte, the size of the cell is the same as lymphoblast or smaller, it has a more clumped chromatin, round/oval nucleus, a coarse 1-2 Nucleoli.

Prolymphocyte

In this stage of the lymphocyte, the size of the cell is 8-10 um, it has a dense chromatin, round/oval nucleus, a not visible Nucleoli.

Mature small lymphocyte

In this stage of the lymphocyte, the size of the cell is 10-12 um, chromatin not as dense as small lymphocyte.

Medium lymphocyte

In this stage of the lymphocyte, the size of the cell is 12-16 um, it has a round/oval nucleus and nucleoli is not visible, abundant clear and very pale blue cytoplasm

Large lymphocyte

It is a stage of lymphocyte wherein its cytoplasm appears smooth, has no granules and moderate dark blue in color

Lymphoblast

It is a stage of lymphocyte wherein its cytoplasm is nongranular, moderate and darkblue in color

Prolymphocyte

It is a stage of lymphocyte wherein its cytoplasm is thin rim around nucleus and Robin's egg blue.

Mature small lymphocyte

It is a stage of lymphocyte wherein its cytoplasm is more abundant, pale moderate blue in color.

Medium Lymphocyte

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