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Pathogenesis Part 2
  • MAHATHIR ALPHA

  • 問題数 72 • 10/16/2023

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    問題一覧

  • 1

    It is the ability of microorganisms to cause diseases. Also refers to the degree of pathogenicity.

    Virulence

  • 2

    What are factors influencing Microbial Virulence?

    Toxic factors, Enzymatic factors, Cellular structure

  • 3

    What are the Host Resistance Factors?

    Physical barriers, Cleansing mechanisms, Antimicrobial substance, Microbiota, Phagocytosis, Inflammation, Immune response

  • 4

    What are the two types of Microbiota?

    Resident microbiota, Transient microbiota

  • 5

    They temporarily inhabit, multiply in, and colonize an area for months or years

    Resident microbiota

  • 6

    They inhabit (but do not multiply) and colonize an area until they are eliminated by either the host's inherent immune defense or competition with the resident microbiota.

    Transient microbiota

  • 7

    It is the process by which certain cells called phagocytes engulf and dispose of microorganisms and cell debris.

    Phagocytosis

  • 8

    PMN leukocytes and macrophages are examples of what?

    Phagocytes

  • 9

    They ingest and destroy bacteria and other foreign particles through a process known as endocytosis.

    Phagocytes

  • 10

    It is a condition that serves as a reinforcement mechanism against microbial survival and proliferation in tissues and organs.

    Inflammation

  • 11

    What are some signs that may indicate an inflammation?

    Swelling, Redness, Burning sensation, Pain in affected areas

  • 12

    What are the components of Inflamation?

    Phagocytes, Complement system, Coagulation system, Cytokines

  • 13

    What are the Microbiotas located on the Skin?

    Staphylococcus, Propionobacteria, Diphtheroids

  • 14

    It is also known as Diphtheroids

    Corynebacterium

  • 15

    What are the Microbiota located at the Mouth and Oral Cavity?

    Streptococci viridans

  • 16

    What are the Microbiota located at the Upper Respiratory Tract?

    Streptococci viridans, Diphtheroids, Staphylococcus epidermidis

  • 17

    What are the Microbiota located at the Nasopharynx?

    Staphylococcus aureus, Staphylococcus epi, Neisseria miningitidis

  • 18

    What are the Microbiota located at the Colon?

    Escherichia coli, Bacteroides, Lactobacilli

  • 19

    What are Microbiota that can be located at the Urethra?

    Diphtheroids, Staphylococcus epidermidis, Staphylococcus alpha, Non-haemolytic Streptococci

  • 20

    It provides the human host with the ability to create a specific protective response against microorganisms. And "memorizes" all of the encountered microorganisms.

    Immune response

  • 21

    How long does it takes for the normal immune system to remove the bacteria from the blood?

    30 to 45 minutes

  • 22

    What may possibly reduce and alter the host's immune response?

    Immunocompressive drugs, Chemotheraphy, Radiation

  • 23

    What are two types of specific immunity?

    Humoral immunity, Cellular immunity

  • 24

    This type of immunity is antibody-mediated.

    Humoral immunity

  • 25

    This type of immunity is cell mediated.

    Cellular immunity

  • 26

    It is based on the action of soluble proteins called antibodies that occur in the body fluids and on the plasma membrane of B-lymphocytes.

    Humoral immunity

  • 27

    It is based on the action of specific kinds of T-lymphocytes that directly attack the cells that are infected with viruses, parasites, cancer cells, or transplanted cells.

    Cellular immunity

  • 28

    It is the protection of susceptible humans and domestic animals from communicable diseases through the administration of vaccines.

    Active immunization

  • 29

    It is the specific response of the host to an invading organism.

    Acquired active immunity

  • 30

    It is the ability of the B-lymphocytes to recall pathogens during the primary encounter leading to a higher antibody response on the second encounter.

    Anamnestic immunity

  • 31

    It is a major genetically determined change in the antigenic property of an organism in which it becomes unrecognizable by the host's immune system.

    Antigenic shift

  • 32

    It is a minor antigenic change as a result of mutation in the organism strains. And facilitates the pathogen in avoiding host-immune responses.

    Antigenic drift

  • 33

    These are antibodies that are attached to the surface of pathogens and which kill the bacteria by lysis.

    Complement-fixing antibodies

  • 34

    This is the non-specific response that activates chemotaxis, or the process which phagocytes are directed to the site of replication and engulf the invading organism.

    Natural immunity

  • 35

    They are are attached to the surface of microorganism and which block surface receptors.

    Neutralizing antibodies

  • 36

    It is the transient type immunization that is administered to individuals without fully activating the person's immune system to create the corresponding antibodies to diseases.

    Passive immunization

  • 37

    These are attached to the surface of microorganisms and which render pathogens susceptible phagocytosis.

    Opsonizing antibodies

  • 38

    What are the Infectious Agents factors?

    Adherence, Proliferation, Tissue damage, Production of toxins, Invasion, Dissemination

  • 39

    What are the two types of toxins?

    Exotoxin, Endotoxin

  • 40

    It is known to be one of the most lethal substances. Mostly present in Gram positive and Gram negative bacteria. •do not require bacterial death to be released into circulation. •do not produce fever to the host

    Exotoxin

  • 41

    Exotoxin are either secreted or excreted by what?

    Living microorganisms

  • 42

    Give some examples of Exotoxin.

    Cytotoxins, Neurotoxins, Enterotoxins

  • 43

    What bacteria produces Exotoxin?

    Clostridium botulinum, Corynebacterium diphtheria, Staphylococcus aureus, Streptococcus pyogenes

  • 44

    It is composed of the LPS of the cell wall and present only in Gram negative bacteria. It stimulates the fever center in the hypothalamus.

    Endotoxin

  • 45

    True/False: Endotoxins are released when bacteria dies and cell wall undergo lysis.

    True

  • 46

    True/False: The toxicity of Endotoxin is NOT due to the lipid A portion of the LPS.

    False

  • 47

    It is the process of penetrating and growing in tissues.

    Invasion

  • 48

    it is the spread of microorganisms to distant body sites.

    Dissemination

  • 49

    What are the Routes of Transmission of Infectious agents?

    Airborne transmission, Transmission by food and water, Close contact, Cuts and bites, Arthropods, Zoonoses

  • 50

    What diseases can be acquired through Inhalation?

    Tuberculosis, Brucellosis, Tularemia, Plague

  • 51

    Microorganisms that can be transmitted by food and water

    Salmonella, Campylobacter, Escherichia coli

  • 52

    True/False: Gastric enzymes and juices in the stomach prevent the survival of most organisms

    True

  • 53

    It refers to the passage of organism through salivary, skin, and genital contact.

    Close contact

  • 54

    It cause infection through the normal oral microbiota

    Cuts and bites

  • 55

    The infection multiply within the ______________ which transmits the microorganisms while feeding off a human host

    Arthropods

  • 56

    These animal diseases that depends on the contact with animals or animal by-product for transmission

    Zoonoses

  • 57

    It is the study of occurence, distribution and cause of disease or injury.

    Epidemiology

  • 58

    What are the factors contributing to Epidemiology?

    Carrier, Likelihood of becoming endemic, Likelihood of becoming epidemic, Likelihood of becoming pandemic, Incidence rate, Incubation period, Morbidity rate, Mortality rate, Reservoir

  • 59

    What are the 4 types of Carrier

    Casual/acute/transient carrier, Chronic carrier, Convalescent carrier, Active carrier

  • 60

    They harbors the microorganisms temporarily for a few days or weeks.

    Casual carrier

  • 61

    They remains infected for a relatively long time sometimes throughout its entire life.

    Chronic carrier

  • 62

    An individual who has recovered from infection but continues to harbour large numbers of the pathogen.

    Convalescent carrier

  • 63

    An individual who has an overt clinical case of the disease

    Active carrier

  • 64

    The organism or disease are indigenous to or constantly present in a geographic area or population

    Endemic

  • 65

    It affects a significantly large number of people in a short period of time.

    Epidemic

  • 66

    It affects huge population across the regions like several countries or a continent

    Pandemic

  • 67

    It is the number of times a new event occurs in a given period.

    Incidence rate

  • 68

    It is the time between the exposure to a pathogen and the onset of symptoms.

    Incubation period

  • 69

    It is the number of cases of a disease in a specified population during a defined time interval.

    Morbidity rate

  • 70

    It is the number of deaths due to a disease in a population

    Mortality rate

  • 71

    It is the source of an infection, which may be a person, animal or any object from the environment.

    Reservoir

  • 72

    Phagocytes ingest and destroy bacteria and other foreign particles through a process known as _________________.

    Endocytosis