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Pharma 2 A1
  • Bianca Audrey Daluro

  • 問題数 100 • 3/15/2024

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    問題一覧

  • 1

    Tylosin is used primarily in the poultry as feed additive. it is included under this family of bacteriostatic antibacterial

    macrolides

  • 2

    this is generallythe most active of the aminoglycosides which is a fermantation product of Micromonospora purpurea. this is often the aminoglycoside of choice for serious g- infections caused by susceptible organisms

    gentamycin

  • 3

    due to its effects of causing aplastic anemia to humans, this antibacterial is now banned in food animals in the philippines

    chloramphenicol

  • 4

    these are considered bacteriostatic by inhibiting the protein synthesis by reversibly binding to 30s ribosomal subunit.they were one of the first to be known as "broad spectrum" antibiotics

    tetracyclines

  • 5

    which of the following is the most appropriate therapy for swine dysentery

    lincomycin

  • 6

    a way of bacteria acquiring resistance through the passage of resistant genes from cell to cell by direct contact through sex pilus or bridge

    conjugation

  • 7

    all of the following are members of the 3rd generation quinolones EXCEPT

    norfloxacin

  • 8

    this is the sulfonamide which is commonly used against urinary tract infection

    sulfisoxazole

  • 9

    all of these are antibacterial that inhibits nucleic acid function EXCEPT

    vancomycin

  • 10

    which of the following combinations is considered irrational or antagonistic systematically

    chlortetracycline and penicillin G

  • 11

    neuromuscular blockade results because of this action of aminoglycosides:

    chelation of Ca

  • 12

    this substance can serve as a flase substrate for penicillinase therefore it can protect a penicillin antibiotic from destruction of penicillinase:

    clavulanic acid

  • 13

    cotrimoxazole is a potentiated sulfonamide which consist of trimethoprim and:

    sulfamethixazole

  • 14

    colistin belongs to the antibiotic group called ___, whose bacterial effect is___

    polymyxin; cidal

  • 15

    lincosamide is contraindicated in this animal

    morgan

  • 16

    what organism produces chloramphenicol

    streptomyces venezuelae

  • 17

    moxalactam is a:

    3rd generation cephalosporin

  • 18

    the most important advantage of potentiated sulfonamides over regular sulfonamide is

    greater potency

  • 19

    sulbactam and clavulanic acid are combined with amoxicillin to:

    hasten amoxicillin action against beta-lactamase-producing bacteria

  • 20

    this is observed when two or more bacteriostatic antibacterial agents are used in combination

    additive effect

  • 21

    which of the following agents is not an inhibitor of DNA synthesis and replication

    rifamycin

  • 22

    penicillins are the most active during which phase of bacterial growth

    logarithmic phase

  • 23

    all of the following are members of the 3rd generation of quinolones EXCEPT:

    norfloxacin

  • 24

    all of the following are bacteriocidal EXCEPT

    erythromycin

  • 25

    macrolide antibiotics and their metabolites are excreted mainly in the:

    bile

  • 26

    this is the primary lesion of aminoglycoside toxicity in the kidney:

    tubular necrosis

  • 27

    which is NOT true about penicillins?

    sodium or potassium salts of penicillin G are highly water soluble are gradually absorbed over 1-3 (or even more) days respectively

  • 28

    this agent is used as growth promoter in pigs, but is now banned for use in food animals because of carcinogenic effect

    carbadox

  • 29

    which of the following is contraindicated when given simultaneously with tetracyclines

    all of the above

  • 30

    what is the mechanismof action of macrolides?

    against 50s

  • 31

    this drug is characterized by cardiac toxicity (tachycardia and decreased contractility

    tilmicosin

  • 32

    in a combination of sulfonamides, as in triple sulfa, the solubility of in water of each sulfonamide

    is indipendent of the other

  • 33

    a dosing regimen of an antimicrobial is based on:

    MIC

  • 34

    which of the ff drug combination is not good

    amoxicillin and chloramphenicol

  • 35

    this is the enzyme inhibited by trimethoprim

    dihydrofolate reductase

  • 36

    which of the ff is not a bacteriostatic drug?

    TMPS

  • 37

    allergies due to penicillin is brought about by:

    penicilloic acid

  • 38

    a third generation cephalosporin which has a gram negative spectrum that is more similar to the fist generation cephalosporin

    ceftiofur

  • 39

    among the synthetic antiviral agents, this agent may inhibit replication of different strains of influenza A virus, influenza C virus, sendai virus and pseudorabies virus at usual concentration

    amantadine

  • 40

    tamiflu ®, which is against many flu strains is

    oseltamivir

  • 41

    these antiviral drugs inhibit viral nucleic acid synthesis

    nucleosides

  • 42

    a systemic antiviral agent, this is active against all herpesviruses and it is more active than acyclovir against cytomegalovirus for instance in a bone marrow transplant recipient

    ganicilovir

  • 43

    this is a purine nucleoside:

    acyclovir

  • 44

    an antiviral that lead to inhibition or delay of the uncoating process that preceds primary transcription

    amantadine

  • 45

    this systemic antiviral agent is used to treat influenza, bovine herpesvirus, canine distemper, blue tongue, Mareks disease and rotavirus

    ribavirin

  • 46

    which of the following agents is a pyrimidine nucleoside

    trifluridine

  • 47

    a polyene antibiotic, this is the first antimycotic antibiotic to be discovered which has a fairly broad spectrum of activity against yeast and various fungi

    nystatin

  • 48

    an azole antibiotic, this agent is used to treat Candida vaginitis in humasn and it is 1% solution is the drug of choice for Aspergillus infections of the comea

    clotrimazole

  • 49

    a systemic antifungal agent, this should not be used in pregnant animals because it is embryo toxic and teratogenic

    ketoconazole

  • 50

    this antifungal can lead to normocytic normochromic anemia

    amphotericin B

  • 51

    aside from being a dewormer, this agent also has antifungal property

    thiabendazole

  • 52

    this antifungal has 100% bioavailability

    fluconazole

  • 53

    what is the most notorious side effect of amphotericin B?

    nephrotoxicity

  • 54

    this is the choice of treatment for disseminated histoplasmosis in dogs and cats

    itraconazole

  • 55

    this is a major adverse effect od griseofulvin

    hepatotoxicity

  • 56

    the mechanism of action of griseofulvin

    disrupts mitotic spindle fibers

  • 57

    this is a group of antineoplastic drugs that form highly reactive intermediate compounds that are able to transfer alkyl group to DNA

    alkylating agents

  • 58

    mitotane causes selective destruction of normal and neoplastic adrenal cortical cells by inhibiting production of steroids induced by adrenocorticotropic hormone, which causes atrophy of the inner zones of the adrenal cortex. it is a derivative of:

    DDT

  • 59

    the canine tumor which is usually treated

    lymphosarcoma

  • 60

    an example of delayed toxicity that is seen in antiviral agents and the patient exhibits increased incidence of infection associated with leukopenia, increased risk of hemorrhage associated with thrombocytopenia and anemia

    myelosuppression

  • 61

    vincristine is an alkaloid product of this plant?

    periwinkle

  • 62

    which of the following antineoplastic agents must be activated in the liver to cytotoxic metabolites?

    cyclophosphamide

  • 63

    5-fluorouracil must be converted to an active 5-fluoro-2'-deoxyuridine-5'-phosphate form to bind the enzyme thymidylate synthase and block or inhibit DNA and RNA synthase. it is a:

    purine analog

  • 64

    this is a semisynthetic glycosides derived from the mandrake plant. it is thought to stimulate DNA cleavage mediated by topo isomerase II which contributes to its antineoplastic action

    epipodophyllotoxine

  • 65

    all of the ff are antineoplastic mitotic inhibitors except:

    bleomycin

  • 66

    the antineoplastic drug taxanes are extracted from what plant?

    yew tree

  • 67

    these are naturally derived pesticides from chrysanthemum flower

    pyrethrin

  • 68

    this probenzimidazole is a metabolized to true benzimidazole but has teratogenic effects in sheep due to its oxfendazole metabolite

    febentel

  • 69

    although it has no effects in roundworms and tapeworms, this benzimidazole has high activity against all stages of liver flukes

    triclabendazole

  • 70

    all of the following are used for treatment of malaria except

    suramin

  • 71

    in cattle, this drug at present is most effective against coccidiosis

    amprolium

  • 72

    this agent is unique among the anthelmintics because it heightens endogenous GABA induced inhibitory actions in worms to cause paralysis

    ivermectin

  • 73

    in cattle, this anthelmintic is 100% effective against all GIT roundworms except nematodirus ostertagia and trichuris

    thiabendazole

  • 74

    ivermectin is contraindicated in this breed of dog because of idiosyncratic reactions which include depression, muscle weakness, blindness, come and death

    collie

  • 75

    diaveridine is a trimethoprim against this parasite:

    coccidia

  • 76

    nematode species that are resistant to ivermectin are also likely to be resistant to:

    milbemycin

  • 77

    which of the following agents would be most effective in treating demotectic mange?

    amitraz

  • 78

    this agent is combined with pyrethroids (including citrus extracts) to act synergistically in the prevention of metabolic inactivation of the pyrethroid within the insect

    piperonyl butoxide

  • 79

    this saltor pyrantel makes it poorly soluble in water, thus allowing the drug to reach and be effective against parasite in the large intestines:

    pamoate

  • 80

    this dewormer act by binding to glutamate gated chloride channel receptors in nematode and arthropod nerve cells allowing an influx of chloride ions:

    doramectin

  • 81

    melarsomine is:

    a heartworm adulticide

  • 82

    heartgard ® contains ivermectin which:

    is used to prevent heartworm infection

  • 83

    what is the mechanism of action of piperazine against helminths?

    it hyperpolarizes the nerve membrane

  • 84

    this is a nicotinic anthelmintic that acts as agonist at nicotinic acetylcholine receptors of nematodes

    levimasole

  • 85

    this refers to killing or removing all forms of microbial life (including endospores) in a metal or aj object

    sanitation

  • 86

    this physical method or microbial control applies pressure to boiling water to prevent steam from escaping

    autoclaving

  • 87

    rubbing alcohol is simply:

    isopropanol

  • 88

    this oxidizing agent has keratolytic and anti seborrheic activity which makes it useful in treating pyoderma in dogs

    benzoyl peroxide

  • 89

    what is the active ingredient of zonrox®?

    sodium hypochlorite

  • 90

    this is a viscid blackish brown liquid, used primarily for antiseptic bandaging of wounds of the hoof and horn:

    pine tar

  • 91

    among the ff acids, which can be used as spermatocide

    lactic acid

  • 92

    which of the following antiseptics can be incorporated in soaps, shampoos, ointments, and surgical scrubs because of its low potential for systemic and dermal toxicity?

    chlorhexidine

  • 93

    benzalkonium chloride is a :

    cationic surfactant

  • 94

    what was the source of the first sulfonamide?

    azo dye

  • 95

    repeated exposure of skin to high concentrations of this agent may lead to sufficient absorption of the antiseptic to cause nervous disorders

    hexachlorophene

  • 96

    lugols solution is

    5% iodine in 10% KI

  • 97

    potassium permanganate as an effective algicide and virucide is classfied as

    oxidizing agent

  • 98

    among the ff agents, which can be used as an astringent?

    silver compounds

  • 99

    which of the ff agents serve as an ideal teat dip?

    iodophor

  • 100

    he is considered as the father of chemotherapy

    paul Ehrlich