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問題一覧
1
2 Types of Post-natal Hematopoiesis:
Medullary Stage, Extramedullary Stage
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continuation of prenatal hematopoiesis.
Medullary Stage
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In the medullary stage: The birth bone marrow have a total of body weight?
1.5%
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The adult total body weight in bone marrow
3.5% - 6%
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Appendicular and axial skeleton/flat and irregular bones (sternum, ribs, pelvis, iliac crest of pelvis, skull, vertebrae), developing blood cells, Iliac crest of pelvis – Puncture site.
Red Marrow
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filled with fats, fat cell production begins 4 years of age and completed at 18 years of age.
Yellow Marrow
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The fat cell production begins at? And ends in?
4 years, 18 years of age
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• Outside the confines of the bone marrow. • In certain abnormal circumstances, the spleen, liver, and lymph nodes revert back to producing immature blood cells (they can able to produce small amount of blood).
Extramedullary Hematopoiesis
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In certain abnormal circumstances, the spleen, liver, and lymph nodes revert back to producing immature blood cells (they can able to produce small amount of blood). It means the RBC, WBC, and platelet is?
Low
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In the extramedullary hematopoiesis, the spleen, liver and lymph nodes revert back to the immature RBC because of the following reasons:
The bone marrow becomes dysfunctional, The bone marrow is unable to meet the demands
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Bone Marrow becomes dysfunctional in cases such as
Leukemia, Aplastic Anemia
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Infiltration by malignant cells
Aplastic anemia
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Overproliferation of a cell line
Leukemia
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Bone marrow is unable to meet the demands placed on it, as in the
Hemolytic anemia
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The extramedullary hematopoiesis mature in the?
Lymphatic System
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Differentiation and maturation of lymphocytes that originate in the bone marrow.
Lymph Nodes
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(Spleen, bone marrow, thymus, intestinal tract) Gut associated lymphatic tissue.
Lymphatic Island
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Maturation of lymphocytes and monocytes. Reservoir of blood cells which can be released from the pulp (red pulp – RBC) into the circulation on demand.
Spleen
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Are not contained in the peripheral blood, it migrates to the tissues where they become macrophage (mononuclear phagocyte system
Monocytes
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functions to destroy cellular components which the body can still use (iron and globin).
RTS (Reticuloendothelial System Member)
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Cellular components which the body can still use
Iron, Globin
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In the extramedullary hematopoiesis, this organ is not really for differentiation and maturation. -It stores intrinsic factor produced by the stomach.
Liver
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For normal erythropoiesis, we need what type of vitamin?
Vitamin B12
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To absorb the vitamin B12 we need these _______ from the stomach to absorb the Vitamin B12.
Intrinsic factor
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In what organ does the following happen: Absorption of Vitamin B12. Produce intrinsic factor. Vitamin B12 is a normal requirement for the normal erythropoiesis
Stomach