Post-Natal Hematopoiesis

Almira Coleen · 28問 · 1年前

通報

問題一覧

2 Types of Post-natal Hematopoiesis:

Medullary Stage, Extramedullary Stage

continuation of prenatal hematopoiesis.

Medullary Stage

In the medullary stage: The birth bone marrow have a total of body weight?

1.5%

The adult total body weight in bone marrow

3.5% - 6%

Appendicular and axial skeleton/flat and irregular bones (sternum, ribs, pelvis, iliac crest of pelvis, skull, vertebrae), developing blood cells, Iliac crest of pelvis – Puncture site.

Red Marrow

filled with fats, fat cell production begins 4 years of age and completed at 18 years of age.

Yellow Marrow

The fat cell production begins at? And ends in?

4 years, 18 years of age

• Outside the confines of the bone marrow. • In certain abnormal circumstances, the spleen, liver, and lymph nodes revert back to producing immature blood cells (they can able to produce small amount of blood).

Extramedullary Hematopoiesis

In certain abnormal circumstances, the spleen, liver, and lymph nodes revert back to producing immature blood cells (they can able to produce small amount of blood). It means the RBC, WBC, and platelet is?

Low

In the extramedullary hematopoiesis, the spleen, liver and lymph nodes revert back to the immature RBC because of the following reasons:

The bone marrow becomes dysfunctional, The bone marrow is unable to meet the demands

Bone Marrow becomes dysfunctional in cases such as

Leukemia, Aplastic Anemia

Infiltration by malignant cells

Aplastic anemia

Overproliferation of a cell line

Leukemia

Bone marrow is unable to meet the demands placed on it, as in the

Hemolytic anemia

The extramedullary hematopoiesis mature in the?

Lymphatic System

Differentiation and maturation of lymphocytes that originate in the bone marrow.

Lymph Nodes

(Spleen, bone marrow, thymus, intestinal tract) Gut associated lymphatic tissue.

Lymphatic Island

Maturation of lymphocytes and monocytes. Reservoir of blood cells which can be released from the pulp (red pulp – RBC) into the circulation on demand.

Spleen

Are not contained in the peripheral blood, it migrates to the tissues where they become macrophage (mononuclear phagocyte system

Monocytes

functions to destroy cellular components which the body can still use (iron and globin).

RTS (Reticuloendothelial System Member)

Cellular components which the body can still use

Iron, Globin

In the extramedullary hematopoiesis, this organ is not really for differentiation and maturation. -It stores intrinsic factor produced by the stomach.

Liver

For normal erythropoiesis, we need what type of vitamin?

Vitamin B12

To absorb the vitamin B12 we need these _______ from the stomach to absorb the Vitamin B12.

Intrinsic factor

In what organ does the following happen: Absorption of Vitamin B12. Produce intrinsic factor. Vitamin B12 is a normal requirement for the normal erythropoiesis

Stomach

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