問題一覧
1
Drug used in acute asthmatic crisis providing immediate bronchodilation:
Albuterol
2
Typical for Codeine:
affect on cough center in CNS
3
Typical for Dextrometorphane 1) synthetic derivative of morphine 2) has a low addictive profile 3) antitussive drug 4) anesthetizes the receptors in the lungs 5) adverse effect is numbness of the tongue
1, 2, 3
4
Typical for Theophylline: 1) Decreases asthma symptoms 2) Possess anti-inflammatory activity 3) Has narrow therapeutic window 4) Antitussive opioid type drug 5) Has broad therapeutic window
1, 2, 3
5
Mechanism of action of corticosteroids:
Inhibition of phospholipase A2
6
Mechanism of action of Ipraropium:
Blockade of muscarinic receptors
7
Typical for cromolyne: 1) Is a prophylactic anti-inflammatory agent 2) Inhibits mast cell degranulation 3) Is bronchodilator 4) Is useful in managing an acute asthma attacks 5) Its short duration of action drug
1, 2, 5
8
Non typical for Montelukast:
inhibits cytochrome isoenzymes
9
Drugs affecting RATS system:
Lizinopril
10
Not typical for ACE inhibitors used in the treatment of hypertention:
reflexively increasing cardiac output
11
Typical for ACE blockers in HF : 1) increase cardiac afterload 2) blockade angiotenzin II syntesis 3) decrease the breakdown of norepinephrine 4) reduce cardiac preload 5) decrease the breakdown of bradikynin
2, 4, 5
12
Undesirable side effects of Hydralazine can be blocked by concomitant use of a:
diuretics, β-adrenergic blockers
13
Hydrochlorthiaside decrease urinary excretion of:
Ca+2
14
Loop diuretic:
Ethacrynic acid
15
Strongest diuretic action:
Loop diuretics
16
The efficacy of thiazides may be diminished with concomitant use of :
NSAIDs
17
The diuretics useful in treating idiopathic hypercalciuria:
Thiazides
18
Pantoprazole unlike Omeprazole:
available in intravenous formulations
19
Omeprzole decrease the effectiveness of clopidogrel because:
prevents convertion to active metabolite
20
Antihistamine drug with antiemetic activity:
Cyclizine
21
Mechanism of antiemetic action of Ondansetron:
block of 5HT3-serotonin receptors
22
Targeting receptors of antiemetic action of Dolasetron:
5HT3 serotonin
23
Antihistamines are often administered in combination with high-dose metoclopramide to reduce:
extrapyramidal reactions
24
Typical for lactulose: 1) semisynthetic disaccharide sugar 2) an osmotic laxative 3) hydrolyzed by Gl enzymes 4) degraded by colonic bacteria 5) emollient laxatives
1, 2, 4
25
Lactulose is also used for the treatment of hepatic encephalopathy, due to its ability to reduce:
ammonia level in collon
26
Inhibitor of folate absorption cause folate deficiency anemia:
Phenobarbital
27
Correct assertion:
Antagonist of Heparin is Protamine sulfate
28
Non-correct assertion for hypolipidemic drugs:
Niacin lower serum HDL and serum triglycerides
29
Drugs that decrease the effectiveness of Levothyroxine: 1) Phenytoin 2) Phenobarbital 3) Cimetidine 4) Rifampin 5) Ketoconazole
1, 2, 4
30
Most appropriate drug for a patient with hyperthyroidism in the first trimester of pregnancy:
Propylthiouracil
31
Drugs effective in blunting the widespread sympathetic stimulation that occurs in hyperthyroidism:
Propranolol
32
Non typical for desmopressin:
has significant anticoagulant activity
33
Establish compliance: I. Short-acting insulin II . Intermediate-acting insulin III Long-acting insulin a) Regular insulin b) Insulin isophane c) insulin glargine
I-a II-b III-c
34
Drugs that should be used concomitantly to prevent NSAID-induced ulcers: 1) Loperamide 2) Misoprostol 3) Ondansetron 4) Metoclopramide 5) Pantoprasol
2, 5
35
Aspirin should be used with caution in patients with asthma because:
increase leukotriene production
36
Antipseudomonal penicillin:
Piperacillin
37
Concentration-dependent killing antimicrobial agents:
Aminoglycosides
38
Typical for Raloxifene : 1) lowers low-density lipoprotein 2) decreases bone resorption 3) increases bone density 4) increases low-density lipoprotein 5) increases bone resorption 6) decreases bone density
1, 2, 3
39
Non typical for Clomiphene:
act as competitive androgen antaqonist
40
Typical for cotrimoxazole: 1) The combination of trimethoprim with sulfa drug 2) Prevents reduction of dihydrofolate to tetrahydrofolate 3) Inhibits the incorporation of PABA into dihydrofolic acid precursors 4) Poorly crosses the blood-brain barrier 5) The combination of trimethoprim with aminosalicylic acid
1, 2, 3
41
Typical for antigelmint Ivermectin: 1) acts on glutamate-gated chloride channel receptors 2) leads to chloride influx and hyperpolarization 3) increases the permeability of the cell membrane to calcium 4) increases release of acetylcholine and inhibition of cholinesterase 5) leads to sodium influx and depolarization
1, 2
42
Pentamidine: 1) stops polyamine production by inhibiting ornithine decarboxylase 2) interferes with the synthesis of RNA, DNA, phospholipids and proteins 3) reduces the permeability of the cell membrane to calcium 4) reacts with sulfhydryl groups of digestive enzymes 5) accumulates in the parasite via an energy-dependent, high-affinity uptake system
2, 5
43
Clomiphene :
partial estrogen agonist
44
Pyrantel pamoate in parasites organism: 1) inhibits glutamate-gated chloride channel receptors 2) decreases the permeability of the cell membrane to calcium 3) depolarizes as a neuromuscular-blocking agent 4) causes release of acetylcholine 5) inhibits of cholinesterase
3, 4, 5
45
Specify accordance between anticancer drugs and action mechanisms: I. Methotrexate -> II. Vinblastine -> 1) alkylating agent 2) monoclonal antibody 3) tyrosine kinase inhibitor 4) antimetabolite 5) microtubule inhibitor
I-4 II-5
46
Calculates the single dose of basic substance ( in gram) of1% 50 ml Aminocapronic acid solution. Rp. : Sol. Acidi Aminocapronici 1%- 100ml D. S. 50 ml for intravenous infusion during the first hour of treatment
0,5
47
Anticancer drug- micropubule inhibitors: 1) Docetaxel 2) Vincristine 3) Carmustine 4) Mitoxantrone 5) Lomustine
1, 2
48
Patient was started on anti-amoebic therapy for treatment of amebas. However, during the treatment, the patient had taken alcohol, which led to disulfiram-like intoxication. Which drug may be the reason of this reaction?
Metronidazole