Originally developed as antipsychotics (1949), but were found to have no effect in this indication

Inc. NE, Dec. GABA means

Used in depression with significant anxiety and sleep disturbances

MAOIs + BZD/ Alcohol/ Antihistamine can lead to

- reserved for use in bipolar patients with partial or no response to lithium.

diazepam also used as?

Noradrenergic Specific Serotonergic antidepressant ⏤Also inhibits presynaptic α2-adrenergic receptors, which leads to increased central concentrations of norepinephrine and 5-HT.

Cycle between elation and dysthymia

Bipolar formerly known as

CYP3A4

manic or mixed episodes May have other mood episodes

Abnormally elevated arousal energy level

long lasting inhibition (up to 1-2 weeks) despite of the elimination rate of a drug

in TCA it inactive metabolites excreted in the urine

expected to have comparable efficacy in the management of bipolar disorder, with fewer side effects and better tolerability.

An antiepileptic drug used also in bipolar disorder

Block sodium meditate and GABA

Short and intermediate acting drugs used as

Major depressive disorder/ clinical depression

An antiseizure with mood stabilizing activity- adjunctive mood stabilizer.

ultrashort acting drugs used as

CYP2D6

If 5HT2A ANTAGONISTS has a side effects of hepatotoxicity what is the possible drug of choice should be given

when given to normal non-depressed subjects they increase a motor activity and cause euphoria + excitements ⇒ risk of abuse!

Milder form of mania. Mood state or energy level that is elevated above normal, but not so extreme as to cause impairment

In pregnancy what can possibly cause birth defect

acute agitation associated with mania can prescribe what drug

lithium + antipsychotics or BZD will lead to

Reversible inhibitors of MAO-B (e.g. selegiline) are used in the treatment of Parkinson's disease

Sedation, drowsiness, difficulty in concentration - H1-blockade

plant chemical obtained from St. John’s Wort ((Hypericum perforatum)

The first compounds (iproniazide derivatives) - originally developed as antimycobacterial drugs by chemical modification of isoniazid molecule (1950s).

Maintains the normal balance of calcium and sodium= abnormal level will cause mood fluctuation.

Used for Pain disorders (neuropathies, fibromyalgia

Drug for bulimia nervosa

What isbthe treatment for seizure

Noradrenaline and Dopamine Reuptake Inhibitors (NDRI)

lithium + medications that increase 5-HT

First line agents for bipolar

Increase in cortisol level (Cushing’s disease), Thyroid desregulation and Sex steroids (estrogen and testosterone deficiency)

the neurotransmitter levels fluctuate and may be similar or reversed, depending on the patient’s current clinical presentation.

Mao-b is used in?

It can be used as monotherapy in bipolar disorder or as an adjunctive therapy with lithium or another mood stabilizer.

severe depression + smoking cessation treatment

1 + major depressive episodes and 1 + hypomanic episodes Never manic or mixed episode

A mixed episode is the coexistence of manic and depressive symptoms for at least 1 week. This is often referred to as mood incongruent.

What is the treatment for hypertensive crisis

ideations or expansive self-esteem

1st drug available in 1988

Irreversible non-selective (MAOA and MAOB) inhibitors

blockade of H1-receptor, α-receptors, Mreceptors

Prolonged and painful penile erection

It is also used in the management of trigeminal neuralgia

Cycle between elation and dysthymia diagnosed when the depressive and hypomanic symptoms persist for 2 years.

with hepatic toxicity in patients with a history of liver damage.

It is also used in the management of trigeminal neuralgia

is mostly found in blood platelets. ⏤ mainly metabolizes dopamine (DA)

blockade of re-uptake of noradrenaline (NA) and serotonin (5-HT)

Depression is associated with the loss of neurotrophic support from nerve growth factors such as BDN

5HT2A antagonist what receptors

Mao inhibitors are drig reserve for?

What is the Drug of choice in serotonin syndrome

Patients w/ hematologic diseases- CBZ and VPA comb. is not recommended (T/F)

Suggests that depression is related to a deficiency in the amount or function of cortical and limbic 5-HT, NE and dopamine

N -methylated metabolite of loxapine, an older antipsychotic drug.

high excess involvement in pleasurable activities

What is drug of choice in benzodiazepine poisoning

Im case such as Severed depression or suicidal ideation what drug of choice should be given

MAOIs + SSRI/ TCA/ opioids can lead to what disease

is found in the liver, gastrointestinal tract, and placenta. generally metabolizes tyramine, norepinephrine (NE), serotonin (5-HT), and dopamine (DA)

persistent depressive disorder

The most common antidepressant in clinical use. More modern and safe antidepressant

Depression also know as Also known as?

Reversible Inhibitors of MAO-A (RIMA)

Drug for Premenstrual Dysphoric disorder-

A. MAOIs + Tyramine rich food can lead to what Disease

Binds and inhibits both the SERT and NET

Dec. NE

associated with a parkinsonian syndrome due to its D2 -blocking action

An antiseizure that is also used for bipolar- approved for prevention of recurrence

Research suggests that depression is caused by a combination of

may be used if parenteral administration is necessary to manage acute agitation.

Moods which cycle between mania and depression known

Dopamine metabolis what inhibitor