Slowed Motor Activities

Diminished response to environment

Rigid Muscle posturing

Restlessness

Inability to keep still

Severe muscle spasm

Restless movements of group of muscles

Holding position for a long time before returning

Purposeless Repetitive movement

Tangles and senile plaques in the limbic system (Hippocampus),

Reduced Activity of GABA due to imbalance of endogenous inhibitors, Stimulators of GABA receptor , Imbalance of norEPI and 5-HT responses

Hyperserotonemia with no evidence of central seratonin abnormalities

Complex abnormalities in cholinergic (Acetylcholine),Dopamine ,EPI , Nor EPI, other hormones and neuropeptides, acetylcholine, GABA

Sudden Synchronus activity, high frequency firing by loacalized group of neurons in certain brain areas caused by high activity of glutamine or low activity of GABA

increase in NorEPI and dopamine activity, low 5-HT levels and abnormal glutamine neurotransmission

Inhibition of dopaminergic system due to blockage of dopaminergic receptors by antipsychotic drugs

Increase presynaptic release, synthesis of dopamine, sensitivity

Messages from brain to body through neeve cells

Inhibatory neurotransmitter decreases neuronal excitability producing calming effect

Monoamine neurotransmitter also acting as a hormone. Lack of thus may lead to mania anxiety and depression

Feelings of pleasure satisfaction and motivation

Abundant Excitatory neurotransmitter, learning and memory. Excess may lead to Parkinsons, Alzheimers, and Huntingtons disease linked to autism and schizophrenia

Alzheimer Treatment donepezil, rivastigmine, galantamine

Anxiety Treatment 2

Autism Spectrum disorders Treatment 2

Depression Treatment 2

Parkinsons Treatment

Schizophrenia Treatment Olanzapine, Risperidone, Haloperidol