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99問 • 1年前問題一覧
1
Autorhythmic cell starts out at resting membrane potential (--60 mV), positive out, negative in. Cell begins depolarizing due to a slow continuous influx of sodium When the membrane potential gets to -40 millivolts, it has reached threshold for initiating an action potential.
2
Calcium channels open and positively-charged calcium ions rush in. Calcium influx produces the rapidly rising phase of the action potential (depolarization), which results in the reversal of membrane potential from negative to positive inside the cell. Depolarization peaks at about +10 mV.
3
Membrane potential goes from +10 mV to resting membrane potential (-60 mV). Potassium channels open, resulting in potassium rapidly leaving the cell.
4
Contractile cells start with a resting membrane potential of about -90'mV. Neighboring cells (either autorhythmic or contractile cells) depolarize. Gap junctions are open and positive ions (Ca*2 and Na*) move in to the contractile cells through gap junctions and trigger a threshold.
5
The entry of positive ions brings the membrane potential to threshold, triggering voltage-gated channels and initiates depolarization. Rapid influx of sodium results in depolarization, resulting in a reversal of charge (depolarization) (to about +25 mV) as sodium moves into the cell.
6
Depolarization also causes opening of slow calcium channels, allowing calcium entry from the extracellular space. This calcium influx triggers additional calcium release from the sarcomplasmic reticulum. Intracellular calcium initiates cell contraction.
7
The calcium channels close while more potassium channels open, allowing potassium to quickly leave the cell, resulting in repolarization.
8
b
9
c
10
a
11
c
12
a
13
b
14
due to efflux of potassium
15
due to influx of sodium
16
due to influx of calcium
17
Na+ leak channel
18
fast ca++ channels
19
k+ channel
20
Phospholipid membrane
21
gap junction
22
gap junction
23
fast na++ channel
24
slow ca++ channel
25
k+ channel
26
Sarcoplasmic reticulum
27
sa node
28
d
29
e
30
a
31
a
32
c
33
e
34
d
35
c
36
a
37
d
38
b
39
b
40
c
41
d
42
c
43
e
44
a
45
d
46
b
47
b
48
d
49
water
50
Fe * from the Heme group
51
Hematocrit
52
EPO
53
B. Megakaryocyte