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Antagonist
  • Julia Skellie

  • 問題数 178 • 10/12/2023

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    問題一覧

  • 1

    Esmolol gtt:

    50-300 mcg/kg/min

  • 2

    Beta-blocker that might be preferable in a patient with insulin-dependent diabetes:

    atenolol

  • 3

    combined alpha and beta antagonist:

    labetalol

  • 4

    less preload issues:

    ARB

  • 5

    labetalol dose, onset, duration:

    0.1 - 0.5 mg/kg 5-10 min 5 hours

  • 6

    specific to amide locals:

    propranolol will decrease clearance of amide locals- toxicity risk

  • 7

    first line therapy for htn, chf, and mitral regurgitation:

    ACEI

  • 8

    hypertensive emergency:

    nitroprusside

  • 9

    most likely associated with alpha 1 selective antagonism:

    decrease in IP3 and DAG

  • 10

    beta 1 selective antagonist third generation: select 3

    betaxolol, caliprolol , nebivolol

  • 11

    dose of phentalomine

    30-70 mcg/kg

  • 12

    Heart failure treatment of hypertension:

    thiazide diuretic, BB, ACEI, ARB, aldosterone antagonist

  • 13

    propranolol metabolite:

    4-hydroxy propranolol

  • 14

    Timolol eye drops cause:

    decrease HR, decrease BP, increase airway resistance

  • 15

    ACEI are safe during pregnancy.

    false

  • 16

    first line therapy for htn, chf, and mr:

    ACEI

  • 17

    MOA of ACEI involves what:

    peptidyl-depeptidase

  • 18

    which drug would cause more tachycardia:

    phentalomine

  • 19

    ACEI MOA:

    prevent conversion of angiotensin I to II

  • 20

    where is angiotensinogen synthesized?

    liver

  • 21

    A patient presents with a blood pressure of 160/110 mm Hg. The patient has a history of coronary vascular disease, resulting in angina, but has no evidence of congestive heart failure. The patient also has asthma and has been treated mainly using terbutaline (Brethine), by aerosol inhalation Propranolol (Inderal) was prescribed to manage essential hypertension. Was this action appropriate?

    Propranolol (Inderal) is inappropriate because its use is contraindicated in a patient with asthma.

  • 22

    highest risk for cough and angioedema:

    ACEI

  • 23

    metabolized in liver to glucuronide conjugate:

    labetalol

  • 24

    alpha antagonist that will decrease afterload in heart failure:

    prazosin

  • 25

    what causes orthostatic hypotension caused by alpha antagonist?

    decreased preload

  • 26

    least likely to cause tachycardia:

    prazosin

  • 27

    atenolol dose and duration:

    5-10mg IV 6-7 hours

  • 28

    extensive 1st pass effect:

    propranolol

  • 29

    nonselective beta antagonist first generation: select 5

    Nadolol , penbutolol , pindolol , propranolol, timolol

  • 30

    lisinopril, catapril are examples of what?

    ACE I

  • 31

    fill in the blank: compared to prazosin, tamsulosin is ________ potent and ________ acting.

    less, longer

  • 32

    dose of propranolol IV:

    1-10mg

  • 33

    select adverse effects NOT associated with ACEI: select 5

    hypokalemia , hyperglycemia , hyponatremia , PVD exacerbation , bradycardia

  • 34

    phenoxybenzamine:

    a1 > a2

  • 35

    aldosterone causes:

    Na and water reabsorption in renal distal tubules

  • 36

    another name for angiotensin converting enzyme:

    peptidyl dipeptidase

  • 37

    Areas of concern for administration of anesthetics to patients treated with antihypertensive drugs: EXCEPT

    increased sensitivity to indirect-acting sympathomimetic agents

  • 38

    treats intraop hypertensive emergency (pheochrono. manipulation or autonomic hyperreflexia):

    phentalomine

  • 39

    contraindications of ARB: select 2

    renal artery stenosis , pregnancy

  • 40

    where do BB competively bind?

    postsynaptic receptor

  • 41

    effect of beta blockers on renin levels

    decrease

  • 42

    Timolol:

    B1 = B2

  • 43

    most dangerous med to give to patient in renal failure:

    atenolol

  • 44

    reflex tachycardia risk: 2

    phenoxybenzamine phentalomine

  • 45

    Esmolol E1/2t:

    9 min

  • 46

    select 3 of the following that will occur with beta antagonism:

    decrease in renin , bronchoconstrition , hyperkalemia

  • 47

    aldosterone > acts on this location

    distal convoluted tubules

  • 48

    angiotensin II causes: select 3

    squeeze arteries and veins , increase aldosterone , efferent arteriole vasoconstrion

  • 49

    90 % first pass

    propranolol

  • 50

    what is the prototype ACEI:

    captopril

  • 51

    most protein bound drug:

    propranolol

  • 52

    metoprolol treats: 5

    htn ischemic heart block angina mi a fib

  • 53

    select 2 that are specific to esmolol uses:

    thyroid storm , htn due to laryngoscopy

  • 54

    select 3 that apply to captopril

    decreases SVR, onset 15 min, angioedema

  • 55

    angiotensin I + ACE > ?

    angiotensin II

  • 56

    ARBs block vasoconstriction actions of angiotensin II without effecting what activity?

    angiotensin converting enzyme

  • 57

    associated adverse effect of enalapril:

    NSAID antagonizes effects

  • 58

    safest med to give to patient in liver failure:

    atenolol

  • 59

    associated with alpha 2 selective antagonism:

    increase of cAMP

  • 60

    ACEI cause sodium and water Reabsorbtion ?

    false

  • 61

    prazosin:

    a1>>>>a2

  • 62

    propranolol will cause:

    decrease in cAMP

  • 63

    BP #/# treatment guidelines in adults over 60:

    150/90

  • 64

    onset is 5-10 min:

    labetalol

  • 65

    only available IV:

    Esmolol

  • 66

    hypertensive crisis: select 2

    DBP > 120, evidence of end organ failure

  • 67

    goal and treatment for hypertensive crisis: select 2

    decrease DBP to 100-105 asap, nitroprusside

  • 68

    effects aldosterone levels more:

    ACEI

  • 69

    What Adrenergic antagonist drug bonds covalently?

    phenoxybenzamine

  • 70

    high levels of _______ are associated with ACEI induced cough:

    bradykinin

  • 71

    most likely used in opthalamic procedures to decrease IOP: select 1

    Timolol

  • 72

    labetalol B:A ratio for IV and PO

    IV: BA: 7:1 PO: BA: 3:1

  • 73

    Angiotension II causes:

    increase aldosterone secretion

  • 74

    true regarding phentolamine: select 4

    competive bond , peripheral vasodilation , a1 = a2, increase CO

  • 75

    Hemodynamic responses in anesthetized patients who had been receiving antihypertensive drug treatment:

    excessive responses associated with body position changes

  • 76

    renin made in the ________ interacts with _________ made by the liver.

    kidney angiotensinogen

  • 77

    all the following are true of metoprolol except: select 1

    most selective beta 1 antagonist

  • 78

    more effective in DM pts and can delay progression of renal disease:

    ACEI

  • 79

    select 3 of the alpha 1 selective antagonist:

    tamsulosin , prazosin , terazosin

  • 80

    BP guideline for pt with DM or kidney disease regardless of age:

    140/90

  • 81

    true regarding yohimibine: select 3

    alpha 2 selective blocker , treats orthostatic hypotension , treats impotence

  • 82

    phentalomine dose, onset, and duration:

    30-70 mcg/kg onset 2 min duration 10 min

  • 83

    true regarding beta antagonists:

    influences inotropy and chronotropy , competitive and reversible , chronic use associated with uppregulation , can provoke bronchospams , vasoconstriction of skeletal muscle

  • 84

    should not be taken morning of surgery:

    lisinopril

  • 85

    where does aldosterone effect on kidney:

    distal convoluting tubule

  • 86

    60% first pass:

    metoprolol

  • 87

    NSAID antagonize effect of this drug: specific drug (not class)

    captopril

  • 88

    metabolized in the liver into a glucuronide conjugate:

    labetalol

  • 89

    best to blunt short noxious stimuli:

    Esmolol

  • 90

    hypertensive crisis treatments: select 4

    nitroprusside, nitroglycerin , labetalol , fenoldapam

  • 91

    where does the conversion of angiotensin I to angiotensin II occur?

    lungs

  • 92

    propranolol is a:

    nonselctive beta antagonist

  • 93

    contraindications of beta blockers: 5

    1. pre existing AV heart block 2. cardiac failure 3. DM (no monitors) 4. reactive airway disease 5. hypovolemia

  • 94

    Angiotension converting enzyme is associated with what G protein:

    Gq

  • 95

    more likely to have CNS effects:

    beta antagonists

  • 96

    goal and treatment of hypertensive urgency: select 2

    decrease DBP to 100-105 within 24 hours , clonidine

  • 97

    ARBS metabolized:

    liver

  • 98

    electrolyte imbalance due to beta antagonism most notable:

    hyperkalemia