Accumulation of blasts in extramedullary lesions (eg, bones, central nervous system, lymph nodes, skin), blast counts in blood or bone marrow ≥ 20% in

Hyperplastic syndrome in acute leukemia includes

Intoxication syndrome in acute leukemia includes

Hemorrhagic syndrome in acute leukemia includes

Immunodeficiency syndrome in acute leukemia includes

The first step in the ACS diagnostic algorithm is

When the diagnosis of ACS is unlikely?

It is less likely to confuse chest pain in ACS with the following condition

Which characteristic of chest pain is most consistent with exertional angina

What type of medications is not first line therapy in patients with coronary heart disease and hypertension

The presence of typical chest pain corresponding to angina pectoris FC 3, reduced effectiveness of antianginal therapy, the presence of episodes of ST segment depression during daily ECG monitoring is an indication for

Target LDL-C for patients after myocardial revascularization

The main mechanism for the development of ACS is

At the appointment, the patient, a man, 48 years old, smoking experience 20 years. BMI 31 kg/m2. Levels of total cholesterol 5.6 mmol/l, LDL cholesterol-4.0 mmol/l. In the last month, he notes an increase in blood pressure to 160/90 mm Hg. associated with stress at work. Estimate the level of total cardiovascular risk

At the appointment, the patient, a man, 48 years old, smoking experience 20 years. BMI 31 kg/m2. Levels of total cholesterol 5.6 mmol/l, LDL cholesterol-4.0 mmol/l. In the last month, he notes an increase in blood pressure to 160/90 mm Hg. associated with stress at work. Doctor's tactics:

Prescribe the optimal pharmacological treatment for a 60-year-old patient with arterial hypertension of the 3rd degree, a history of coronary artery disease, gout:

ESCardio recommends that most hypertensive patients should start treatment with

The SECURE study investigated a secondary prevention treatment strategy using a polypill (combination tablet) containing

At the appointment, a patient with arterial hypertension, high pulse pressure, diastolic murmur in the projection of the aortic valve. Laboratory tests normal. On the ECG, a double-humped p wave, high-voltage R waves in V5, V6.

Choose the optimal combination for the treatment of resistant hypertension according to the ESCardio recommendations:

Prescribe the optimal pharmacological treatment for a 35-year-old patient with grade 1 arterial hypertension, with one risk factor:

In a patient with a persistent form of atrial fibrillation, taking warfarin at a dose of 2.5 mg (1 tablet), the INR when measured is 2.5. Doctor's tactics:

In a 20-year-old patient, during an annual screening examination and ECG recording, a single premature atrial contraction was registered, he does not have complaints. Doctor tactics:

With the progression of atrioventricular block in a patient with an existing AV block of the 2nd degree, it is possible to develop

When examining young patients with rhythm disturbances, firstly necessary to exclude:

During a screening preventive examination of a young athlete, 1st degree AV block was detected on the ECG. Doctor's tactics:

With long-term use of the antiarrhythmic drug amiodarone, it is necessary to monitor

CHF with low EF corresponds to

CHF with preserved EF corresponds to

Paroxysmal nocturnal dyspnea (PND) is most commonly associated with…:

Chronic heart failure (CHF) is most commonly associated with…:

Bendopnea is

III class CHF (NYHA classification) matches with the following distance in 6 min walking test

One of the objective signs of heart dysfunction in CHF is cardiomegaly, while the cardiothoracic index is

One of the goals of treatment for terminal stage of CHF is <variant> Preparation for myocardial revascularization

The indication for heart transplantation in CHF is

A 60-year-old man has his appointment with GP with complaints on SoB, pitting edema. Patient and family history: Q wave-MI 2 years ago, smoker for a 20years, T2DM, mother has diabetes, father died from myocardial infarction at age 54. On physical examination his BMI=31 kg/m2. Measured BP 150/90 mm Hg, HR100 bpm, peripheral edema. Skin is pale. On ECG -signs of LVH. Choose most appropriate cause of his complaints:

A 26-month-old boy who presented with neutropenia associated with anemia and thrombocytopenia. There was no history of any hematological disorder. On examination: the patient had pallor and splenic enlargement. Physical examination was otherwise unremarkable. The patient had been suffering from recurrent febrile episodes and nocturnal sweats with weakness and fatigue. Peripheral blood smear examination showed normocytic normochromic red blood cells including few nucleated red blood cells, white blood cells showed left, shift with significant number of blasts. The leukocyte differential count was eosinophils 5%, lymphocytes 62%, and neutrophils 31% and band forms 1%. Bone marrow aspiration and biopsy showed increased abnormal megakaryocytic, Monolobated and multinucleated megakaryocytic with hyper chromatic and pleomorphic nuclei were seen and showed the leukemic cells were positive for CD13, CD33, CD42. What is the diagnosis?

A 26-month-old boy who presented with neutropenia associated with anemia and thrombocytopenia. There was no history of any hematological disorder. On examination: the patient had pallor and splenic enlargement. Physical examination was otherwise unremarkable. The patient had been suffering from recurrent febrile episodes and nocturnal sweats with weakness and fatigue. Peripheral blood smear examination was done. What is the next step in diagnosing?

A 70-year-old man presented to his primary care physician with 2 months of fatigue and 10-kg weight loss. He noted a general sense of malaise and feeling poor. On physical examination, the clinician was able to palpate the spleen 4 cm below the costal margin (splenomegaly) but noted no palpable lymphadenopathy. Family history was noncontributory. CBC: WBC-39 180 /cmm, RBC- 4.37 M/cmm, Hemoglobin-13 g/dL, HCT 40%, MCV 92 fL, MCH 29.7 pg, MCHC 32.5 g/dL, RDW-CV-13.1%, PLT-216,000/cmm. Automated Differential Count: Neutrophils-67%, Bands-9%, Lymphocytes-7%, Monocytes 2%, Eosinophils-3%, Basophils-4%, Metamyelocytes-5%, Myelocytes-3%. Make the preliminary diagnosis

A patient who had a myocardial infarction a year ago applied for an appointment, at the same time an emergency PCI was performed, followed by stenting of the LAD. During the year there were no angina pectoris, he feels well, he receives basic therapy (bisoprolol 2.5 mg, acetylsalicylic acid 75 mg, clopidogrel 75 mg, atorvastatin 10 mg, lisinopril 2.5 mg) came to the dispensary examination. In the analyzes: blood glucose-4.9 mmol/l, blood creatinine-68 µmol/l, total cholesterol-5.5 mmol/l, LDL cholesterol-2.6 mmol/l. Coagulogram within normal limits. Doctor’s tactics:

In a patient with chronic coronary artery disease, angina attacks became more frequent regardless therapy. Patient also complaints on knees pain for which the patient constantly takes ibuprofen. Choose the correct doctor's tactics:

A 36-year-old male patient came to the appointment for a preventive examination. In the family history, the father has early coronary artery disease (under the age of 55 years). Smokes electronic cigarettes, works in a bank, travels mainly by car, BMI 29 kg/m2. Laboratory and instrumental examinations without pathology. Doctor's tactics:

A 58-year-old woman came to the appointment with complaints of ankle edema, no other complaints. From the anamnesis it is known that she is hypertensive, receives basic therapy, does not remember the name. Physical examination: BP 125/75 mm Hg. Heart rate 68 beats per minute. Heart sounds are normal, regular. ECG normal. Echocardiogram showed normal ejection fraction, global and local myocardial contractility is normal, heart chambers are not dilated, valves are intact. Which medication is most likely associated with ankle edema in this patient?

A 58-year-old woman visit her doctor with complaints of dry cough, no other complaints. From the anamnesis it is known that she is hypertensive, takes constant basic therapy, does not remember the name. Physical examination: BP 125/75 mm Hg. Heart rate 68 beats per minute. Heart sounds are normal, rhythmic. Vesicular breathing in the lungs. ECG without features. X-ray of the lungs without pathology. Spirometry showed no abnormalities. Which drug is most likely associated with cough in this patient?

A 58-year-old woman came to the doctor with complaints of pain in the knee joints. From the anamnesis it is known that she is hypertensive, takes constant basic therapy: lisinopril, hydrochlorothiazide, amlodipine, atorvastatin, bisoprolol. In laboratory data, the level of uric acid is increased (510 µmol/l). Which drug of the named should be discontinued?

A 52-year-old man came to the doctor with complaints of a feeling of interruptions, "fading" in the heart area. Previously, according to the words, he suffered from rhythm disturbance, he does not receive basic therapy. Last year, he suffered an ischemic stroke, with transient left-sided hemiparesis. The doctor ordered an ECG. What pathology is more likely to be diagnosed in a patient?

A 52-year-old man came to the doctor with complaints of a feeling of interruptions, "fading" in the heart area. Previously, he had rhythm disorder, he does not receive basic therapy. Last year, he suffered an ischemic stroke, with transient left-sided hemiparesis. Select the optimal list of pharmacological therapy, taking into account the most likely diagnosis and patient history:

A patient with a permanent form of atrial fibrillation came to the appointment. The patient takes basic therapy. Recently, episodes of nosebleeds have become more frequent. What medication is this complication associated with?

A 52-year-old man came to the doctor with complaints of a feeling of interruptions, "fading" in the heart area. Previously, according to the words, he suffered from rhythm disturbance, he does not receive basic therapy. Last year, he suffered an ischemic stroke, with transient left-sided hemiparesis. The doctor ordered an ECG. What pathology is more likely to be diagnosed in a patient?

A 52-year-old man came to the doctor with complaints of a feeling of interruptions, "fading" in the heart area. Previously, he had rhythm disorder, he does not receive basic therapy. Last year, he suffered an ischemic stroke, with transient left-sided hemiparesis. Select the optimal list of pharmacological therapy, taking into account the most likely diagnosis and patient history:

A patient with a permanent form of atrial fibrillation came to the appointment. The patient takes basic therapy. Recently, episodes of nosebleeds have become more frequent. What medication is this complication associated with?

A 60-year-old man has his appointment with GP with complaints on SoB, pitting edema. Patient and family history: Q wave-MI 2 years ago, smoker for a 20years, T2DM, mother has diabetes, father died from myocardial infarction at age 54. On physical examination his BMI=31 kg/m2. Measured BP 150/90 mm Hg, HR100 bpm, peripheral edema. Skin is pale. On ECG -signs of LVH. Choose most appropriate cause of his complaints:

A 60-year-old man has his appointment with GP with complaints on SoB, pitting edema. Patient and family history: Q wave-MI 2 years ago, smoker for a 20years, T2DM, mother has diabetes, father died from myocardial infarction at age 54. On physical examination his BMI=31 kg/m2. Measured BP 150/90 mm Hg, HR100 bpm, peripheral edema. RR 21, Skin is pale. On ECG -signs of LVH. His BNP level is 600 pg/mL. On TTE- LV EF is 42%. Choose most appropriate drugs combination for this patient:

A 60-year-old man has his appointment with GP with complaints on SoB, pitting edema. Patient and family history: Q wave-MI 2 years ago, smoker for a 20years, T2DM, mother has diabetes, father died from myocardial infarction at age 54. On physical examination his BMI=31 kg/m2. Measured BP 150/90 mm Hg, HR100 bpm, peripheral edema. Skin is pale. On ECG -signs of LVH. Choose next step in patient management:

The three main symptoms of acute pyelonephritis are:

Inflammatory diseases of the urogenital system leading to chronic renal failure:

The most characteristic changes in the blood in chronic renal failure:

The main focus of the chronic renal failure diet:

Method of treating end-stage chronic renal failure

An exacerbation of chronic glomerulonephritis is characterised by:

The morphological variant of chronic glomerulonephritis can be determined reliably:

Indicate the correct sequence of pathogenesis of nephrotic edema:

The low specific gravity of urine observed over a 24-hour period is called:

The main sign of nephrotic syndrome:

A group of metabolic diseases characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action, or both”:

One of the long-term consequences of diabetes includes:

Type 1 diabetes mellitus should be treated

Which indicator is the most reliable criterion for the degree of compensation of diabetes mellitus in the follow-up examination?

A possible cause of hypoglycaemia in diabetes mellitus is:

Type 1 diabetes mellitus is characterised by:

What is the secretion of thyroid hormone in diffuse toxic goiter:

A set of disorders that involve excess synthesis and secretion of thyroid hormones by the thyroid gland, which leads to the hypermetabolic condition:

A disorder resulting from deficiency of thyroid hormone:

Therapy with antithyroid drugs is recommended for the following conditions:

Therapy with levothyroxine is recommended for the following conditions:

A chronic recurrent disease due to impaired gastro-esophageal motorevacuation function, characterised by spontaneous or regularly recurrent aspiration of gastric or duodenal contents into the oesophagus, leading to the development of inflammatory changes in the distal oesophagus and/or characteristic clinical symptoms:

A chronic disease morphologically characterised by inflammatory and dystrophic processes in the gastric mucosa and a variety of clinical signs:

A chronic relapsing disease, with alternating periods of exacerbation and remission, the leading manifestation of which is the formation of a defect (ulcer) in the stomach wall:

The occurrence of pain syndrome in the epigastric region immediately after eating is characteristic of:

The occurrence of pain syndrome in the epigastric region 2-3 hours after eating, hunger pains, night pains are characteristic of:

In urine test the specific gravity is 1026, protein - traces, WBC up to 100, RBC - 2-3, bacteria +++, mucus +++. This urine test is most characteristic for which of the following diseases:

A young woman consulted a doctor with complaints of weakness, fever up to 39.2 °C, pain in the lumbar region, frequent and painful urination in small quantities. Past medical history: considers herself ill since the age of 15 years, when she first noted the occurrence of the above complaints, was treated. In the next 2 years she was repeatedly hospitalised with similar complaints. At the age of 17 years the patient was offered sanatorium treatment, which gave positive results. Condition worsened about 2 weeks ago, when after hypothermia she experienced chills, fever up to 39°С, severe intermittent pains in the lumbar region, which radiated downwards to the abdomen, accompanied by frequent painful urination. Рreliminary diagnosis:

A young woman complains of lumbar pain and fever for the past two days. She has been having pains when urinating for the last week and the pronounced pain and fever occurred yesterday. The pain was predominantly localized to the right side of the lower back, it was constant, blunt and without irradiation. She took 400mg ibuprofen last night for sleep, but the pain persisted and she decided to go and see the GP in the morning. Patient is married and has regular menstrual periods, last one week ago. She uses an intrauterine device as contraception. She denies genital tract discharge. Urination 5-7 times a day, urine is excreted in usual amounts, cloudy and frothy over the last two days. Objectively: body temperature 38.3° C, heart rate 112 per minute, BP 120/70 mmHg, respiratory rate 15 per minute. On palpation of the right rib-vertebral angle there is pronounced painfulness, tapping in the renal area is sharply painful on the right side. There is no swelling. Physical examination reveals no other abnormalities.Рreliminary diagnosis:

In urine test: colour turbid, specific gravity - 1008, protein - 0.066g/l, white blood cells – a lot, red blood cells - 3-6, bacteria++++, renal epithelial cells - 2-3. This urine test is most characteristic for which of the following diseases:

A young woman came to her doctor for pain in the lumbar region. Urinalysis showed crystals. A radiograph shows multiple, slightly contrasting homogeneous concrements in the abdominal projection. On an excretory urogram the stones are visualised as filling defects. What disease can be suspected:

A young woman, a housewife, complained of aching pain in the lumbar region, which persisted after taking antispasmodics and analgesics. Her urine was constantly alkaline (pH above 7.0), protein 0.06-0.3, leukocytes 8-12, erythrocytes 30-40, bacteria+++. An excretory urogram shows a coral stone in the left kidney. What kind of disease can be suspected:

A middle-aged woman complained of fever up to 38°C, frequent painful urination, dull aching pain in the right lumbar region without irradiation, headache, weakness and chills. Past medical history: 20 years ago, during pregnancy she had urine abnormalities (leucocytes and protein), but was not examined afterwards. Preliminary diagnosis:

A middle-aged woman from the age of 25 has been in repeatedly treated for chronic pyelonephritis. In addition to medical treatment, what dietary recommendations would you suggest:

A young woman consulted her GP with complaints of weakness, rapid fatigue, weight loss of 5 kg. Past medical history: she became ill 3 months ago when the above complaints appeared, edema appeared in the face and lower extremities, blood pressure increased to 150/95 mmHg. Examination: massive swelling of the lower legs, lumbar region. Urinalysis: specific gravity - 1015, waxy and hyaline cylinders, erythrocytes - 15-20, protein - 6 g/day. Preliminary diagnosis:

A woman complains of urine the colour of meat slop, discomfort in the lumbar region, headache. Daily urine output is 1.2 litres. Past medical history: the above complaints appeared 6 weeks ago after an acute respiratory infection. Examination: pastous legs, BP 140/95 mmHg. Tapping symptom is positive on both sides. In the urinalysis: red blood cells - 30-45, cylinders waxy, protein -2.8 g/l.

A middle-aged female presented to her GP complains of puffiness of face in the morning, also she noticed some blood in urine (or sometimes brown urine) moreover, she started urinating less than usual, and sometimes the increase in blood pressure occurs. Your tactic in this case:

Urinalysis: urine’s amount – 150 ml, color – brown, specific gravity – 1000, protein- 3,8 g, erythrocytes- 11-12, leukocytes – 9. Indicate a possible diagnosis:

Urine analysis: specific gravity 1006, reaction - alkaline, urine colour – dark brown, protein - 3g / l, erythrocytes 10-12, granular cylinders (+).Indicate a possible diagnosis:

A middle-aged man from the age of 24 has been in repeatedly treated for chronic glomerulonephritis. He has been suffering from high blood pressure for many years. In addition to the main medical treatment, what treatment for high blood pressure would you suggest:

A middle-aged woman from the age of 20 has been in repeatedly treated for chronic glomerulonephritis. In addition to medical treatment, what dietary recommendations would you suggest:

A middle-aged patient has been suffering from chronic glomerulonephritis for a long time. His GFR is 65. Define the stage of chronic kidney disease:

A middle-aged patient has been suffering from chronic glomerulonephritis. His GFR is 92. Define the stage of chronic kidney disease:

A middle-aged patient has been suffering from chronic glomerulonephritis for a long time. His GFR is 50. Define the stage of chronic kidney disease:

A middle-aged patient has been suffering glomerulonephritis for a long time. His GFR is 37. Define the stage of chronic kidney disease: