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問題一覧
1
Early thymocytes lack what type of markers?
CD4 and CD8
2
Early thymocytes lack CD4 and CD8 markers?
Double-negative (DN) thymocytes
3
The large DN thymocytes proliferate in the outer cortex under of?
IL-7
4
Rearrangement of the genes that code for the antigen receptor known as the T-cell receptor (TCR) begins at what stage?
Double-Negative Stage
5
Antigen receptor
T-cell receptor
6
The rearrangement of TCR are consists of two specific chains:
alpha (α) and beta (β) chains
7
The TCR consists of two specific chains, called alpha (α) and beta (β) chains, which both contain? - Recognize specific antigens
Variable regions
8
Arrange the following:
T-cell maturation in the thymus. , T-lymphocyte precursors (TP) enter the thymus at the cortico-medullary junction. , They migrate upward in the cortex and begin development of the T-cell receptor. , A small percentage of precursors develop gamma-delta chains., Whereas the majority develop alpha-beta chains and become double-positive (DP) (both CD4 and CD8 are present), Positive and negative selection takes place through the CD3/T-cell receptor for antigen., If positively selected, the T cell becomes single-positive (SP); that is, either CD4+ or CD8+., Further interactions with macrophages or dendritic cells take place to weed out any T cells able to respond to self-antigen. , Surviving CD4+ and CD8+ cells exit the thymus to the peripheral blood.
9
Medulla , Cortex, T-lymphocyte precursors , Double Negative , Gamma Delta , Double Positive , CD4, CD8 , CD3/TCR, Positive selection, CD8, CD4, Singly positive , Negative Selection , CD8, CD4, Mature T cells exits the thymus , Apoptosis
10
The combination of the eight chains is known as the?
CD3/TCR
11
The ________ of the nonspecific CD3 portion of the complex assist in signaling when an antigen binds to the T cells.
Six chains
12
The chains occur in three pairs:
Delta-epsilon (δ–ε), Gamma-epsilon (γ–ε), Tau-tau (ζ–ζ)
13
The TCR are coded for by the selection of certain gene segments and deletion of others in a random fashion.
α and β chains
14
Rearrangement of the β chain coded for on?
Chromosome 7
15
α chain coded for on chromosome?
Chromosome 14
16
Composed of V.D.J gene segments + constant region
Beta chain coded in chromosome 7
17
Composed of V and J gene segments
Alpha chain gene coded in chromosome 14
18
The appearance of a functional α chain on the cell surface sends a signal to suppress any further β chain gene rearrangements. The selection of an allele on one chromosome only is known as?
Allelic exclusion
19
Once functional alpha chain on cell surface appears, rearrangements of beta chain gene stops, this is called?
Allelic exclusion
20
The appearance of beta chain triggers the thymocytes to become?
CD4 and CD8 positive