記憶度
3問
7問
0問
0問
0問
アカウント登録して、解答結果を保存しよう
問題一覧
1
Composed of V and J gene segments
Alpha chain gene coded in chromosome 14
2
Early thymocytes lack what type of markers?
CD4 and CD8
3
Medulla , Cortex, T-lymphocyte precursors , Double Negative , Gamma Delta , Double Positive , CD4, CD8 , CD3/TCR, Positive selection, CD8, CD4, Singly positive , Negative Selection , CD8, CD4, Mature T cells exits the thymus , Apoptosis
4
The combination of the eight chains is known as the?
CD3/TCR
5
Antigen receptor
T-cell receptor
6
Arrange the following:
T-cell maturation in the thymus. , T-lymphocyte precursors (TP) enter the thymus at the cortico-medullary junction. , They migrate upward in the cortex and begin development of the T-cell receptor. , A small percentage of precursors develop gamma-delta chains., Whereas the majority develop alpha-beta chains and become double-positive (DP) (both CD4 and CD8 are present), Positive and negative selection takes place through the CD3/T-cell receptor for antigen., If positively selected, the T cell becomes single-positive (SP); that is, either CD4+ or CD8+., Further interactions with macrophages or dendritic cells take place to weed out any T cells able to respond to self-antigen. , Surviving CD4+ and CD8+ cells exit the thymus to the peripheral blood.
7
α chain coded for on chromosome?
Chromosome 14
8
Rearrangement of the β chain coded for on?
Chromosome 7
9
Composed of V.D.J gene segments + constant region
Beta chain coded in chromosome 7
10
The rearrangement of TCR are consists of two specific chains:
alpha (α) and beta (β) chains
11
The large DN thymocytes proliferate in the outer cortex under of?
IL-7
12
The ________ of the nonspecific CD3 portion of the complex assist in signaling when an antigen binds to the T cells.
Six chains
13
The TCR are coded for by the selection of certain gene segments and deletion of others in a random fashion.
α and β chains
14
Once functional alpha chain on cell surface appears, rearrangements of beta chain gene stops, this is called?
Allelic exclusion
15
Early thymocytes lack CD4 and CD8 markers?
Double-negative (DN) thymocytes
16
The TCR consists of two specific chains, called alpha (α) and beta (β) chains, which both contain? - Recognize specific antigens
Variable regions
17
Rearrangement of the genes that code for the antigen receptor known as the T-cell receptor (TCR) begins at what stage?
Double-Negative Stage
18
The appearance of beta chain triggers the thymocytes to become?
CD4 and CD8 positive
19
The appearance of a functional α chain on the cell surface sends a signal to suppress any further β chain gene rearrangements. The selection of an allele on one chromosome only is known as?
Allelic exclusion
20
The chains occur in three pairs:
Delta-epsilon (δ–ε), Gamma-epsilon (γ–ε), Tau-tau (ζ–ζ)